Paleontology provides insights into the history of the planet, from the origins of life billions of years ago to the biotic changes of the Recent. The scope of paleontological research is as vast as it is varied, and the field is constantly evolving. In an effort to identify “Big Questions” in paleontology, experts from around the world came together to build a list of priority questions the field can address in the years ahead. The 89 questions presented herein (grouped within 11 themes) represent contributions from nearly 200 international scientists. These questions touch on common themes including biodiversity drivers and patterns, integrating data types across spatiotemporal scales, applying paleontological data to contemporary biodiversity and climate issues, and effectively utilizing innovative methods and technology for new paleontological insights. In addition to these theoretical questions, discussions touch upon structural concerns within the field, advocating for an increased valuation of specimen-based research, protection of natural heritage sites, and the importance of collections infrastructure, along with a stronger emphasis on human diversity, equity, and inclusion. These questions offer a starting point—an initial nucleus of consensus that paleontologists can expand on—for engaging in discussions, securing funding, advocating for museums, and fostering continued growth in shared research directions.

Conflict-related sexual violence and the rights of female victims have received scholarly attention, but the same cannot be said of post-conflict rejection and re-victimization of the victims and the violation of their rights. This article examines the rejection and re-victimization of the returnee victims / survivors of Nigeria’s Boko Haram’s sexual terrorism. It discusses how this violates their fundamental human rights as contained in various UN conventions and other legal frameworks. Relying on a legal-doctrinal approach, it examines these violations and the difficulty in enforcing such rights. Findings reveal that these human rights violations continue through the rejection and re-victimization of victims / survivors by family and community members. Despite these obvious rights violations, it has been difficult to seek legal redress for enforcing such rights due to the absence of political will on the part of the government.

Childlessness in late male adulthood is increasingly prevalent in rural China, indicating a need to understand the factors contributing to it. This group is often overlooked in gerontological and childlessness research. While existing studies have explored individual-level predictors of childlessness over the lifecourse and implications of broader societal conditions at the population level, little is known about how lifecourse and structural factors interact to shape pathways to childlessness. This study aims to investigate structural factors contributing to childlessness among older men in a rural area of northern China. It focuses on the life stories of 13 childless older men and the effects of history, timing and life-domain interdependencies, finding that some participants experienced intense disruptive life events or critical turning points – early-life care-giving responsibilities, disability or withdrawal from school – that altered their life trajectories. These events often intersected with structural factors, including unstable and low-paid employment, lack of social protection and prevailing social norms, which reinforced one another and jointly constrained prospects for marriage and parenthood. These trajectories unfolded within shifting policy contexts; institutional arrangements across different historical periods shaped and often produced disadvantages in the marriage market. This study advances theoretical understanding of the structural factors contributing to male childlessness by recognizing life trajectories, structural shifts and social relations as linked factors shaping cumulative disadvantage in union formation and childbearing. Its policy implications surround supporting individuals who intend to form families during critical life transitions and addressing the broader structural barriers that shape male childlessness in rural areas.

Advancing community engagement and participatory research approaches necessitates shifting cultural norms. The paper describes a program designed to explicitly embed and reinforce a culture of engagement through resource allocation, modeling, and recognition that was initiated by a Clinical and Translational Science Institute Community Engagement Program CE Program. Resources were allocated to the relationship development process between researchers and community partners. Funded partnerships were provided with guidance to support the equitable distribution of resources. Partnerships received additional reinforcement through participation in a learning collaborative, intended to support community partnership development, model best practices in community engagement and to build a network of community engaged, and participatory researchers at the institution. Investigators reported the learning collaborative “gave them permission” to focus on the process. Overall, lessons learned indicate embedding and reinforcing practices that center relationship and reward time spent building partnerships is a promising strategy to buffer against cultural norms that favor outcomes and over process.

Weed Risk Assessments (WRAs) aim to distinguish potentially invasive plants from non-invasive plants using traits such as the likelihood that the species will be introduced, establish, spread, and/or have negative impacts and (sometimes) whether it can be managed effectively. International standards for the criteria used to assess risk have been proposed to improve the sharing and transferability of WRA results. However, it is unclear whether existing WRAs follow these standards. Here, we compiled a global database of national-level and subnational-level (state/province) WRAs and evaluated their assessment criteria relative to an amended list of proposed minimum standards. We searched for WRAs in 240 countries and retrieved 20 unique assessments associated with 81 countries. The most comprehensive WRA was the “Guidelines for the Generic Ecological Impact Assessment of Alien Species” created by Norway, which satisfied 23 of 24 standards. The International Plant Protection Convention (IPPC) Pest Risk Analysis Framework and the European and Mediterranean Plant Protection Organization (EPPO) Express Pest Risk Analysis were also comprehensive, fulfilling 21 of 24 standards. All national-level WRAs included a description of the focal species’ taxonomy, a description of risk assessment area, an assessment of the likelihood of spread of the focal species, and an assessment of the likelihood of impact of the focal species. Conversely, it was rare for WRAs to include a history of spread of the focal species or an evaluation of the possible effects of climate change. States/provinces showed a similar pattern (i.e., rarely discussed climate change), but also frequently lacked assessment of impact on ecosystem services and metrics of uncertainty. Many WRAs are shared between countries, but few are shared between states/provinces. Adopting similar WRA standards would allow policymakers and governing bodies to more effectively share information and results from completed WRAs, improving consistency of regulated plants across jurisdictional borders.

Approximately 25% of older adult residents who experience an acute change in health status are transferred from Long-Term Care (LTC) to Emergency Departments (ED). We explored the use of an intervention (i.e., LTC to ED) care and referral pathway, INTERACT® Change in Condition cards, and STOP AND WATCH tool, in informing decision making regarding resident transfers. We conducted 22 semi-structured interviews with Health care Providers (HCPs) involved in the LTC to ED care pathway in Western Canada. Thematic analysis of the qualitative interviews was used to evaluate the use of the pathway and tools. We identified six themes influencing decision making around resident transfers including interprofessional practice and conflict, ambiguous and clear medical cases, ageism, health care providers’ goals, family involvement in resident care, and intervention tools. The intervention may be useful in streamlining, documenting, and increasing transparency in complicated LTC resident care and transfer decisions.

Thyroglobulin (Tg) has been considered a measure of iodine status, but there is no global guidance. This analysis examines the relationship between serum Tg and spot urinary iodine concentration (UIC) data to identify Tg concentrations that correspond to current WHO thresholds for population iodine status. We analysed data from 730 non-pregnant Guatemalan women aged 15–49 years who had both UIC and Tg measurements. Correlations were examined. Bootstrap stratified finite sampling with replacement was used to generate cluster k-medians of UIC (mUIC) and Tg (mTg) that served as the population unit of analyses. Non-linear restricted cubic spline regression dose–response curve functions and ordinary differential equations were then used to derive the Tg threshold corresponding to WHO definitions for UIC. Mean age was 30·2 (sd 9·3) years. mTg was 10·4 ng/ml (9·9, 10·8), and mUIC was 148·7 μg/l (139·1, 161·0). Correlations between spot UIC and Tg were NS at the individual level, but correlations based on population k-medians were significant (Spearman r = −0·21 to −0·06, each P < 0·0001) and demonstrated a U-shaped relationship according to WHO categories. Derived mTg cutoffs were 14·2 ng/ml predictive of UIC insufficiency, 10·2 ng/ml for UIC adequacy, 8·5 ng/ml for UIC above adequate and 10·8 ng/ml for UIC excess. The significant and graded mUIC–mTg correlations suggest that Tg concentrations predictive of UIC categories are obtainable for non-pregnant Guatemalan women aged 15–49 years. The newly derived mTg cutoff may be more discriminant at a lower spectrum of UIC in terms of identifying iodine-deficient women, more so than in the UIC excess category.

Psychiatric disorders lead to disability, premature mortality and economic burden, highlighting the urgent need for more effective treatments. The understanding of psychiatric disorders as conditions of large-scale brain networks has created new opportunities for developing targeted, personalised, and mechanism-based therapeutic interventions. Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), can directly modulate dysfunctional neural networks, enabling treatments tailored to the individual’s unique functional network patterns.

As NIBS techniques depend on our understanding of the neural networks involved in psychiatric disorders, this review offers a neural network-informed perspective on their applications. We focus on key disorders, including depression, schizophrenia, and obsessive-compulsive disorder, and examine the role of NIBS on cognitive impairment, a transdiagnostic feature that does not respond to conventional treatments. We discuss the advancements in identifying NIBS response biomarkers with the use of electrophysiology and neuroimaging, which can inform the development of optimised, mechanism-based, personalised NIBS treatment protocols.

We address key challenges, including the need for more precise, individualised targeting of dysfunctional networks through integration of neurophysiological, neuroimaging and genetic data and the use of emerging techniques, such as low- intensity focused ultrasound, which has the potential to improve spatial precision and target access. We finally explore future directions to improve treatment protocols and promote widespread clinical use of NIBS as a safe, effective and patient-centred treatment for psychiatric disorders.

The Mexican Cristero experience constituted a political laboratory and a school of resistance providing blueprints of action later exercised in Spain. With barely ten years between their own countries’ conflicts, the ladies of Catholic Action—in Mexico and then in Spain—organized themselves, first, as a passive resistance, and then both used the same justifications to support the use of political violence. News of the Mexican Catholic women’s experience had arrived across the Atlantic in the chronicles of Spanish newspapers beginning in the late 1920s and in the edifying, right-leaning novels that were spread, above all, in Spanish Catholic schools during the 1930s. This helps us understand the parallels between the actions, liaisons, informants, and weapons suppliers of the Brigades and other Catholic organizations in Mexico and the members of the women’s fifth column in Spain. Perhaps the contemporary presence in the public sphere of European fascists resonated more among young urban Madrid or Barcelona women during the Spanish Civil War, but, without a doubt, the social origin, experience, and cultural heritage of Mexican women was more in line with the efforts of conservative Spanish women all over the country during the conflict. In both cases, the defence of religion and their Catholic identity was at the forefront of their efforts and gave coherence to what might, at times, appear to be diverse political projects.

The aim of this paper is to illustrate both analytically and numerically the interplay of two fundamentally distinct non-Hermitian mechanisms in the deep subwavelength regime. Considering a parity-time symmetric system of one-dimensional subwavelength resonators equipped with two kinds of non-Hermiticity – an imaginary gauge potential and on-site gain and loss – we prove that all but two eigenmodes of the system pass through exceptional points and decouple. By tuning the gain-to-loss ratio, the system changes from a phase with unbroken parity-time symmetry to a phase with broken parity-time symmetry. At the macroscopic level, this is observed as a transition from symmetrical eigenmodes to condensated eigenmodes at one edge of the structure. Mathematically, it arises from a topological state change. The results of this paper open the door to the justification of a variety of phenomena arising from the interplay between non-Hermitian reciprocal and nonreciprocal mechanisms not only in subwavelength wave physics but also in quantum mechanics, where the tight-binding model coupled with the nearest neighbour approximation can be analysed with the same tools as those developed here.

A company with n geographically widely dispersed sites seeks an insurance policy that pays off if m out of the n sites experience rarely occurring catastrophes (e.g., earthquakes) during a year. This study compares three strategies for an insurance company wishing to offer such an m-out-of-n policy, assuming the existence of markets for insurance on the individual sites with coverage periods of various lengths of a year or less. Strategy A is static: at the beginning of the year it buys a reinsurance policy on each individual site covering the entire year and makes no later adjustments. By contrast, Strategies S and C are dynamic and adaptive, exploiting the availability of individual-site policies for shorter periods than a year to make changes in the coverage on individual sites as quakes occur during the year. Strategy S uses the payoff from reinsurance when a quake occurs at a particular site to increase coverage for the remainder of the year on the sites that have not yet had quakes. Strategy C buys individual-site policies covering successive time periods of fixed length, observing the system at the beginning of each period and using cash on hand plus cash obtained from a reinsurance payoff (if any) during the previous period to decide how much cash to retain and how much reinsurance to purchase for the current period. The study relies on expected utility to determine indifference premiums and compare the premiums and loss probabilities for the three strategies.