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Some people act despite knowing their actions are wrong. Others know and do the right thing. This paper focuses on people who rightly believe that gaining specific knowledge would be enough to motivate moral action but remain strategically ignorant due to self-interest. This paper argues that such individuals have a moral obligation to acquire the salient knowledge given the following applies: first, such individuals are aware of the morally efficacious knowledge; and second, the efficacious knowledge is accessible to them. Then, we examine similarities and differences between morally mandatory knowledge and culpable ignorance. Finally, morally mandatory knowledge shows that ignorance can result from deficient moral character.
Several malaria control measures aim to reduce infection levels in mosquitoes, and evaluation of these measures usually relies on experimental infections of mosquitoes or evaluation in field populations. Both require robust statistical tools to account for multiple variables and non-normal distributions of parasites in the vector host. We argue that a well-chosen generalized linear or mixed model is the most appropriate statistical tool for analysing and interpreting these biological data. We suggest specific methods to overcome datasets where some groups have zero/close to zero prevalence, or many zero counts of parasite numbers (as would be seen with an effective transmission blocking intervention). These methods are more broadly applicable across many parasitic infections with similar patterns of parasite numbers across hosts.
As hybrid work arrangements have become more prevalent in the wake of the COVID-19 pandemic, the alignment between jobs and workers has also evolved, arguably in ways that research has yet to fully capture. We build on the theoretical foundation of person-environment fit – and person-job fit specifically – to investigate how employees’ work arrangements and their perceived fit with their work arrangements influence important personal (e.g., work-life balance, stress) and work-related (e.g., organizational commitment, engagement) outcomes. Quantitative evidence from a survey of 427 hybrid workers supports the idea that the extent to which an individual’s desires, needs, and values align with their work arrangement plays an important role in their personal and work-related well-being. We advocate for expanding the conceptualization of person-job and person-environment fit models to incorporate work arrangements and provide recommendations for research and practice.
Global discussions around the risks, benefits and governance of solar radiation modification (SRM) in the climate change response portfolio are accelerating, but the topic remains nascent in Latin America and the Caribbean (LAC). In 2023, a US start-up (Make Sunsets) performed a small-scale, non-research deployment of SRM in Baja California, Mexico, without prior permission or community engagement. Their actions prompted Mexico to announce its intention to ban SRM experimentation, underscoring the need for governance to prevent irresponsible practices that could discredit legitimate research. We perform an empirical and ethical analysis of the landscape of academic discussions and media coverage on SRM in the LAC region, focusing on the Make Sunset case. Our analysis leads us to three conclusions: first, a lack of regulations in LAC that fosters mistrust, fuels perceptions of neo-colonialism and restricts potentially valuable and responsible research; second, we argue that the theatrical Make Sunsets case is not ethically justified in light of the diversity of risks associated with it; third, we offer foundational, participatory recommendations to promote effective, transparent and sustainable governance of SRM, including LAC in global conversations.
Compensation schemes are certainly not a new phenomenon in England and Wales, and they are increasingly being used, and called for, to compensate victims in the field of occupational and public health. Despite their long existence, compensation schemes have always been thought to develop on ad hoc basis, without any real discernible logic behind them. This paper suggests that, contrary to this idea, compensation schemes emerging in the field of occupational and public health are generally following an identifiable, if covert, pattern that is deeply rooted in their relationship with the tort system. This relationship, the paper contends, is crucial not only to explain the creation and operation of compensation schemes but also to shed some light on the place and limits of the tort system in this legal system. More than that, this paper demonstrates that the relationship between these two sources of compensation could be the key to offer the beginning of a categorisation of compensation schemes that could help identify which schemes are in need of reform.
Despite prior research on political capabilities and their relationships with meaningful outcomes at work, it remains unclear why certain employees are incapable of successfully navigating workplace politics. To clarify this, our research develops and validates a measure of political self-efficacy at work (PSEW) across seven independent and varying samples. Evidence from faculty members and subject-matter experts in Study 1 provides initial support for the content validity of the new PSEW scale. Then, in Studies 2 and 3, we employ two separate samples to confirm the scale’s convergent and discriminant validity and factor structure. We repeat this process, in Study 4, on several new nomological neighbors (e.g., the Dark Triad traits, general political behavior, impression management, and political will). In Studies 5 and 6, using multi-wave and multi-source data, we assess the criterion-related and predictive validity of the PSEW scale, and in Study 7, we test our full theoretical model. Altogether, these findings verify the nomological network and validity of the new PSEW measure and provide theoretical and practical developments surrounding organizational politics.
Heartwater is a tick-borne disease (TBD) of wild and livestock ruminants that threatens food security and the economy throughout much of Africa. Furthermore, the geographic range of heartwater is expanding and is predicted to continue doing so. Despite this, our understanding of heartwater dynamics lags far behind that of many other TBDs. We are therefore limited in our ability to design effective disease control strategies. In this study, we derive and analyse a mathematical model of heartwater dynamics. We analyse our model to predict the most influential parameters for disease risk, both in terms of new outbreaks and in heartwater-endemic regions. We show that the host-finding efficiency of ticks is the most influential parameter affecting outbreak risk. Also, outbreak risk is highly sensitive to the impact of the heartwater pathogen on tick fitness – a previously unexplored concept for any TBD system. In areas where heartwater is established, we show that disease can be controlled via enzootic stability (prolonged host immunity attained via frequent pathogen exposure). However, the maintenance of enzootic stability was dependent on several ecological and physiological parameters. Regarding practical output, we suggest prioritizing tick control measures during periods when ticks are most active in terms of dispersing towards hosts, so as to mitigate heightened outbreak risk. In addition, given the specificity of conditions required for enzootic stability, we caution against relying solely on enzootic stability for long-term heartwater protection. More broadly, our study highlights important tick life history parameters that have been neglected by previous TBD models.
This is a radiobiological modelling study aimed at comparing stereotactic ablative body radiotherapy (SABR) with conventional palliative radiotherapy (CPRT) and curative-dose volumetric-modulated arc therapy (CD-VMAT) in the palliation of patients with previously untreated head and neck cancer.
Methods:
Three radiotherapy plans were generated for 8 patients with head and neck cancer: SABR, prescribed to 45 Gy in 5 fractions; CPRT, prescribed to 30 Gy in 5 fractions and CD-VMAT, prescribed to 70 Gy in 35 fractions. The tumour control probability (TCP) and normal tissue complication probability for salivary and swallowing function (NTCPsaliva and NTCPswallow, respectively) were determined. From those values, the therapeutic ratio, as measured by the uncomplicated tumour control probability (UTCP), was determined.
Results:
Dosimetric objectives were achieved in all treatment plans. SABR had a higher mean TCP compared to CPRT and CD-VMAT (100% vs 81% vs 93%, p = 0·003). There were no statistically significant differences in the mean NTCPs for salivary or swallowing function (mean NTCPsaliva 27% vs 41% vs 36%, p = 0·093 and mean NTCPswallow 9% vs 12% vs 23%, p = 0·093). This resulted in the mean UTCP being statistically significantly higher for SABR plans compared to CPRT and CD-VMAT (66% vs 42% vs 49%, p = 0·004).
Conclusion:
It is feasible to create SABR plans that satisfy the dosimetric objectives in this study. Based on radiobiological modelling, SABR has superior TCP and similar NTCP, leading to a better therapeutic ratio than CPRT and CD-VMAT.
The impact of CHD on safe driving for adolescents is currently unknown. A prospective, qualitative descriptive study was conducted among adolescents with CHD to describe perceived barriers, facilitators, and impacts of CHD on safe, independent driving among adolescents.
Study design:
Twenty-eight adolescents aged 15–19 years with CHD participated in virtual, semi-structured interviews in 2023. Adolescent interview data were analysed with conventional content analysis refined by Theoretical Domains Framework in NVivo software.
Results:
Mean participant age was 16.4 ± 0.23 years (57% male). Single ventricle physiology (25%) and septal defects (32%) were prevalent diagnoses among the study population. Most participants (92%) did not have driving restrictions.
Two themes emerged from the data:
Driving as a normal rite of passage for adolescents with CHD; and confident—but curious—about the impacts of CHD on driving. Adolescents felt confident that driving is not impacted by CHD. They were curious about the likelihood of cardiovascular emergencies and related symptoms while driving. Perceived barriers and facilitators to safe, independent driving were like what has been described in published literature among adolescents without CHD.
Conclusion:
These findings celebrate the normalcy of driving during adolescence and reveal curiosities about the impacts of stress, anxiety, fatigue, and risks of heart attack and stroke on driving. Adolescents may look to CHD healthcare providers to help them learn about driving. These findings may inform the development of tools to facilitate meaningful conversations with adolescents regarding driving safety as part of the transition to adult CHD care.
Sponge-Sticks (SS) and ESwabs are frequently utilized for detection of multidrug-resistant organisms (MDROs) in the environment. Head-to-head comparisons of SS and ESwabs across recovery endpoints are limited.
Design:
We compared MDRO culture and non-culture-based recovery from (1) ESwabs, (2) cellulose-containing SS (CS), and (3) polyurethane-containing SS (PCS).
Methods:
Known quantities of each MDRO were pipetted on a stainless-steel surface and swabbed by each method. Samples were processed, cultured, and underwent colony counting. DNA was extracted from sample eluates, quantified, and underwent metagenomic next-generation sequencing (mNGS). MDROs underwent whole genome sequencing (WGS). MDRO recovery from paired patient perirectal and PCS-collected environmental samples from clinical studies was determined.
Setting:
Laboratory experiment, tertiary medical center, and long-term acute care facility.
Results:
Culture-based recovery varied across MDRO taxa, it was highest for vancomycin-resistant Enterococcus and lowest for carbapenem-resistant Pseudomonas aeruginosa (CRPA). Culture-based recovery was significantly higher for SS compared to ESwabs except for CRPA, where all methods performed poorly. Nucleic acid recovery varied across methods and MDRO taxa. Integrated WGS and mNGS analysis resulted in successful detection of antimicrobial resistance genes, construction of high-quality metagenome-assembled genomes, and detection of MDRO genomes in environmental metagenomes across methods. In paired patient and environmental samples, multidrug-resistant Pseudomonas aeruginosa (MDRP) environmental recovery was notably poor (0/123), despite detection of MDRP in patient samples (20/123).
Conclusions:
Our findings support the use of SS for the recovery of MDROs. Pitfalls of each method should be noted. Method selection should be driven by MDRO target and desired endpoint.
To examine the relationship between children’s adaptive functioning and neighborhood resources – such as school quality, access to healthy food, green spaces, and housing quality – using a large, diverse clinical outpatient sample.
Method:
Pediatric outpatients (N = 6,942; age M = 10.44 years; 67.0% male; 50.3% White; 33.9% Medicaid), aged 1-18, who underwent neuropsychological or psychological evaluation were included if their caregiver completed the Adaptive Behavior Assessment System, 3rd Edition (ABAS-3) and had a nationally normed Child Opportunity Index (COI) score, a composite measure of 29 geo-coded neighborhood characteristics.
Results:
Children from higher-opportunity neighborhoods demonstrated significantly stronger adaptive functioning across conceptual, social, and practical domains. Those in the top 40% of neighborhood advantage exhibited stronger adaptive skills than those in the bottom 60%. Neighborhood resources and family financial resources were associated with greater adaptive skills beyond child age, sex, and racial/ethnic background.
Conclusion:
Neighborhood resources are linked to children’s adaptive functioning, possibly due to increased opportunities to practice these skills in safer, more supportive environments. These findings emphasize the importance of considering environmental factors in assessing adaptive skills and highlight the need for public health investments and legislation related to community resources.
The concept of provisional possession in Kant presents a significant interpretative challenge. Scholars agree that prior empirical possession must be rationalized but have struggled to identify a form of omnilaterality within the state of nature. I propose understanding provisionality through the Pure Concept of Understanding of Possession (PUP) – a unilateral yet normative framework that rationalizes empirical possession based on temporal priority. Possession understood through PUP serves as a precursor to intelligible possession within the state of nature. To support this account, I first demonstrate that intelligible possession starts from empirical possession, thereby requiring an explanation of the transition from the latter to the former. I then argue that provisional possession unfolds in two distinct steps: first, prior empirical possession acquires an empirical title through the postulate of practical reason, which confers normative significance on temporal priority; second, PUP abstracts from empirical conditions, facilitating the progression towards a rational title.
The endosymbiotic association between the diatom Hemiaulus and the cyanobacterium Richelia was first observed in the Sea of Marmara in July 2021. The spatial distribution of the host diatom Hemiaulus spp. and the endosymbiont cyanobacterium Richelia intracellularis was investigated along with available physicochemical parameters. Three species of the Hemiaulus genus (H. hauckii, H. membranaceus, and H. sinensis) were morphologically identified in the study area. Hemiaulus hauckii and H. sinensis reached up to 128 × 103 cells L−1 and 38 × 103 cells L−1, respectively, while H. membranaceus was rarely observed. Each Hemiaulus cell contained one Richelia trichome, which had heterocysts at both ends. The surface water temperatures and salinity varied between 23.2°C and 28.5°C, 21.4 and 23.5, respectively. Dissolved oxygen levels ranged from 6.2 to 7.6 mg L−1, while chlorophyll-a concentrations were between 0.3 and 6.8 µg L−1. Nutrient concentrations varied between 0.05 and 0.18 μM for NO3 + NO2–N, 0.04–0.24 μM for NH4–N, 0.02–0.39 μM for PO4–P, and 0.18–1.42 μM for SiO2–Si. This study reveals that the Hemiaulus–Richelia symbiosis may promote the proliferation of diatom populations and may play an important role in nutrient dynamics in nitrogen-limiting environments and in the overall functioning of the marine ecosystem.
The freshwater fish fauna of southern Africa is highly diverse; however, the magnitude of parasitic species they host is unevenly known. The region’s documented adult trematode fish fauna is sparse, while the opposite is evident for intermediate trematode stages. Perceived difficulty in identification of underdeveloped stages lead to the exclusion of reporting metacercariae or lack either morphological or molecular data resulting in a depauperate comparative molecular data repository for species of the region and Africa as a whole. In an effort to address the morphological and molecular data void of the parasite fauna of southern African freshwater fishes, we sought to comprehensively investigate and characterise this fauna. Here we report on three metacercarial forms of Clinostomum (Clinostomidae) from three fish families (Clariidae, Mochokidae, and Mormyridae), provide the first report of a species of the Cryptogonimidae from a cyprinid host in South Africa, and include molecular data for the partial 28S rDNA, ITS1–2 and COI mtDNA regions of these metacercarial forms. Our clinostomid specimens morphologically and genetically corresponded with Clinostomum brieni (e.g., Clarias gariepinus) and Clinostomum ‘morphotype 2’ and ‘morphotype 3’ per Caffara et al. (2017) from the mormyrid Marcusenius pongolensis and the mochokid catfish Chiloglanis sp., respectively. Our cryptogonimid metacercariae did not correspond with any known species or available molecular sequence data; however, the presence of robust circumoral spines on the oral sucker indicated that they are either a species of Acanthostomum or Proctocaecum. The molecular data we provide are the first for an Acanthostomum/Proctocaecum-type cryptogonimid from Africa.
The value-creation opportunities enabled by the ubiquitous availability of data indisputably lead to the necessity of restructuring innovation processes. Moreover, the variety of stakeholders potentially involved in innovation processes and the apparent heterogeneity of scenarios and contexts imply much less established practices and routines and not yet constituted reference frameworks to lead the transition to data-driven product innovation. In this context, the paper attempts, from the analysis of the data-driven innovation processes of 36 Italian companies, to recognise the emerging innovation opportunities offered by the rich network of the resulting data flows. However, these opportunities also imply new tasks, which in turn raise further concerns. Building on data-driven design literature and on industrial practices in the field of innovation management, the authors discuss the role that research achievements in the field of engineering design can play in addressing such concerns.
This article investigates how British textile traders navigated Cuban markets when Spain, Britain, and the United States competed to maintain or gain access to Cuba’s commercial activity. Cuba was one of the largest textile consumers in the Americas and a loyal market for British textiles, a significance hitherto overlooked by existing scholarship on Anglo-Hispanic trading relations. The article fills this gap by examining the interplay between local dynamics and imperial rivalry through the case of the Manchester-based textile commission merchant, Stavert, Zigomala, & Co. Through the cross-examination of the company’s business records, visual, material, and other archival and primary printed sources this article contends that a successful engagement with the Cuban market required a nuanced approach transcending formal trading structures, challenging traditional assumptions about commercial predominance based on forms of imperialism. The article’s argument is divided into three parts: 1) it locates Stavert, Zigomala within Cuban consumer culture; 2) it examines how traders responded to Cuban demand; and 3) it situates the role of British textile merchants in the context of Cuba’s international relations between approximately 1860 until1914.
Speaking is often challenging for language learners to develop due to factors such as anxiety and limited practice opportunities. Dialogue-based computer-assisted language learning (CALL) systems have the potential to address these challenges. While there is evidence of their usefulness in second language (L2) learning, the effectiveness of these systems on speaking development remains unclear. The present meta-analysis attempts to provide a comprehensive overview of the effect of dialogue-based CALL in facilitating L2 speaking development. After an extensive literature search, we identified 16 studies encompassing 89 effect sizes. Through a three-level meta-analysis, we calculated the overall effect size and investigated the potential moderating effect of 13 variables spanning study context, study design and treatment, and measures. Results indicated a moderate overall effect size (g = .61) of dialogue systems on L2 learners’ speaking development. Notably, three moderators were found to have significant effects: type of system, system meaning constraint, and system modality. No significant moderating effect was identified for education stage, L2 proficiency, learning location, corrective feedback, length of intervention, type of interaction, measure, and key assessment component. These findings suggest directions for future research, including the role of corrective feedback in dialogue-based CALL, the effectiveness of such systems across proficiency levels, and their potential in diverse learning contexts with the integration of generative artificial intelligence.
We define the Schur–Agler class in infinite variables to consist of functions whose restrictions to finite-dimensional polydisks belong to the Schur–Agler class. We show that a natural generalization of an Agler decomposition holds and the functions possess transfer function realizations that allow us to extend the functions to the unit ball of $\ell ^\infty $. We also give a Pick interpolation type theorem which displays a subtle difference with finitely many variables. Finally, we make a brief connection to Dirichlet series derived from the Schur–Agler class in infinite variables via the Bohr correspondence.