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This article explores the concept of partnerships in public humanities as both a process and a vital outcome. Drawing from experiences within a classroom environment, where university students and community members learned and engaged together, we identify three key precepts for sustaining effective community-university partnerships: centering human relationships, leveraging institutionalization, and redistributing risk. These strategies do not aim to avoid the challenges inherent in collaboration but rather use complexities as opportunities for deeper engagement. We argue that community-university partnerships should themselves be viewed as a valuable and meaningful form of public humanities.
Outbreaks of Pseudomonas aeruginosa infections have been linked to water-related sources. We describe the investigation of a suspected outbreak of five P. aeruginosa infections in pediatric oncology patients in 2021 that triggered a retrospective review and prospective monitoring of additional cases, environmental sampling, and bacterial genomic analysis.
Setting and patients:
Pediatric oncology center.
Methods:
Medical records of patients with P. aeruginosa were reviewed and staff were interviewed to identify common exposures. Environmental samples were cultured for P. aeruginosa. Patient and environmental isolates underwent whole genome sequencing and core genome multi-locus sequence typing (cgMLST) and sequences were added to a previously existing library of P. aeruginosa clinical isolates collected in 2017 and onwards to determine strain relatedness.
Findings:
During 2019–2022, 82 patients with 110 episodes of P. aeruginosa infections were identified and 132 isolates of P. aeruginosa were sequenced. Twenty-three environmental samples were collected, of which two grew P. aeruginosa in culture. CgMLST demonstrated four multi-patient isolate clusters but no genetic relatedness among the isolates from the patients in the suspected outbreak. Two sink-derived isolates from 2021 were genetically related to patient-derived isolates from 2018 and 2017.
Conclusions:
Sequencing revealed there is no common source or linkage between the isolates of the suspected P. aeruginosa outbreak in 2021. However, it revealed genetic relatedness of previous patient strains to later strains collected from hospital sinks, suggesting persistent colonization of a reservoir with P. aeruginosa.
Low-inertia pulsatile flows in highly distensible viscoelastic vessels exist in many biological and engineering systems. However, many existing works focus on inertial pulsatile flows in vessels with small deformations. As such, here we study the dynamics of a viscoelastic tube at large deformation conveying low-Reynolds-number oscillatory flow using a fully coupled fluid–structure interaction computational model. We focus on a detailed study of the effect of wall (solid) viscosity and oscillation frequency on tube deformation, flow rate, phase shift and hysteresis, as well as the underlying flow physics. We find that the general behaviour is dominated by an elastic flow surge during inflation and a squeezing effect during deflation. When increasing the oscillation frequency, the maximum inlet flow rate increases and tube distention decreases, whereas increasing solid viscosity causes both to decrease. As the oscillation frequency approaches either $0$ (quasi-steady inflation cycle) or $\infty$ (steady flow), the behaviours of tubes with different solid viscosities converge. Our results suggest that deformation and flow rate are most affected in the intermediate range of solid viscosity and oscillation frequency. Phase shifts of deformation and flow rate with respect to the imposed pressure are analysed. We predict that the phase shifts vary throughout the oscillation; while the deformation always lags the imposed pressure, the flow rate may either lead or lag depending on the parameter values. As such, the flow rate shows hysteresis behaviour that traces either a clockwise or counterclockwise curve, or a mix of both, in the pressure–flow rate space. This directional change in hysteresis is fully characterised here in the appropriate parameter space. Furthermore, the hysteresis direction is shown to be predicted by the signs of the flow rate phase shifts at the crest and trough of the oscillation. A distinct change in the tube dynamics is also observed at high solid viscosity which leads to global or ‘whole-tube’ motion that is absent in purely elastic tubes.
There are few studies on what diet mothers following a vegan diet (VD; or strict plant-based diet) choose for their children and how the child’s diet is implemented in everyday life. The present study aimed to explore choices that mothers following a VD make regarding their child’s diet and feeding practices, and what determines these choices. Mothers on a VD whose youngest child was <4 years old were recruited via social media or newsletters about a VD. Participants (N=28) were between 27 and 45 years old and had been adhering to a VD between 0.5 and 23 years. Online semi-structured interviews based on the Theory of Planned Behaviour were audio-recorded and transcribed verbatim. A hybrid thematic analysis approach was used to identify themes that emerged from the data. Mainly driven by ethical considerations of eating animal products, 21 (75%) women chose a VD for their child(ren). When the participant’s partner followed a vegetarian diet (VEGD) or omnivorous diet (OMD), most women chose a VEGD (N=4) or OMD (N=3) for their child as well. Overall, women indicated to make well-considered choices regarding children’s diet and related feeding practices. Determinants for the dietary choice for their children involved various motivations, attitudes, norms, facilitating/hindering factors and knowledge. In conclusion, driven mainly by ethical motivations, most women on a VD chose this diet for their children as well. Despite experiencing several hindering factors and acknowledging the potential negative effects of a VD, mothers seemed to make well-considered choices concerning their child’s diet.
The use of compulsory community treatment (CCT) in Australia is some of the highest worldwide despite limited evidence of effectiveness. Even within Australia, use varies widely across jurisdictions despite general similarities in legislation and health services. However, there is much less information on whether variation occurs within the same jurisdiction.
Aims
To measure variations in the use of CCT in a standardised way across the following four Australian jurisdictions: Queensland, South Australia, New South Wales (NSW) and Victoria. We also investigated associated sociodemographic variables.
Methods
We used aggregated administrative data from the Australian Institute of Health and Welfare.
Results
There were data on 402 060 individuals who were in contact with specialist mental health services, of whom 51 351 (12.8%) were receiving CCT. Percentages varied from 8% in NSW to 17.6% in South Australia. There were also wide variations within jurisdictions. In NSW, prevalence ranged from 2% to 13%, in Victoria from 6% to 24%, in Queensland from 11% to 25% and in South Australia from 6% to 36%. People in contact with services who were male, single and aged between 25 and 44 years old were significantly more likely to be subject to CCT, as were people living in metropolitan areas or those born outside Oceania.
Conclusions
There are marked variations in the use of CCT both within and between Australian jurisdictions. It is unclear how much of this variation is determined by clinical need and these findings may be of relevance to jurisdictions with similar clinician-initiated orders.
To examine if the current taught undergraduate psychiatry syllabus at an Irish University relates to what doctors in psychiatry consider to be clinically relevant and important.
Methods:
Doctors of different clinical grades were invited to rate their views on 216 items on a 10-point Likert scale ranging from ‘0 = not relevant’ to ‘10 = very relevant’. Participants were invited to comment on topics that should be excluded or included in a new syllabus. Thematic analysis was conducted on this free-text to identify particular themes.
Results:
The doctors surveyed rated that knowledge of diagnostic criteria was important for medical students. This knowledge attained high scores across all disorders with particularly high scores for a number of disorders including major depressive disorder (mean = 9.64 (SD = 0.86)), schizophrenia (mean = 9.55 (SD = 0.95)) and attention deficit hyperactivity disorder (Attention Deficit Hyperactivity Disorder (ADHD); mean = 9.26 (SD = 1.40)). Lower scores were noted for less frequently utilised management strategies (transcranial magnetic stimulation (mean = 4.97 (SD = 2.60)), an awareness of the difference in criteria for use disorder and dependence from psychoactive substances (mean = 5.56 (SD = 2.26)), and some theories pertaining to psychotherapy (i.e. Freud’s drive theory (mean = 4.59 (SD = 2.42)).
Conclusions:
This study highlights the importance of an undergraduate programme that is broad based, practical and relevant to student’s future medical practice. An emphasis on diagnosis and management of major psychiatry disorders, and knowledge of the interface between mental health services, other medical specialities and support services was also deemed important.
Cover crops are an important management tool for organic vegetable farmers, but selection of individual cover crop species can lead to a tradeoff between agroecosystem services provisioned. In contrast, cover crop mixtures may provide multiple ecosystem services simultaneously, known as multifunctionality. This study evaluated the performance of browntop millet (Urochloa ramosa; BTM), buckwheat (Fagopyrum esculentum; BW), cowpea (Vigna unguiculata; CP), and sunnhemp (Crotalaria juncea; SH) in monocultures, two three-way mixtures (3-CP = browntop millet, buckwheat, and cowpea; 3-SH = browntop millet, buckwheat, and sunnhemp), and a four-way mixture containing all evaluated cover crop species (4-W). An autumn cabbage vegetable crop (Brassica oleracea var. Caraflex) was grown following cover crop termination. To evaluate the cover crop treatments and explore the applicability of some tenets of biodiversity theory to cover crop mixtures, we monitored the ecosystem services of weed suppression, inorganic nitrogen provisioning, vegetable yield, and habitat for microorganisms. Overall, the cover crop mixtures evaluated were able to combine the benefits of the individual species in the mixture and provision the sought ecosystem services, although they did not exceed the performance of the best monocultures. Weed suppression was similar between mixtures and the top performing monoculture, BTM in 2022 and BW in 2023. The high productivity of browntop millet in mixtures, accounting for on average 74% of 3-CP biomass and 56% of 4-W biomass, when seeded at 20% and 25% its full rate, respectively, likely drove weed suppression in mixtures. In 2022, cabbage yield following 3-SH and 4-W was similar to the legume monocultures. Due to the suppression of cowpea in 3-CP from interspecific competition, 3-CP plots had a lower cabbage yield than the legume monocultures and were similar to BTM and Control. Soil microbial biomass, used to measure habitat for microorganisms, was 18% higher following mixtures compared to monocultures in the first year, although no differences were found in the second year. The seeding rate proportions used in the three-way mixtures, 60% of the legume full rate and 20% of the full rate of both browntop millet and buckwheat, achieved the target of a C:N ratio ≤30:1 and can be recommended when based on appropriate seeding rates for a given area. Tailoring future cover crop mixture research to questions of seeding rate thresholds and interspecific competition will improve complementarity and the provisioning of multiple ecosystem services in mixtures, offering valuable, practical guidance to growers.
We present an agent-based model to study how the structure of a scientific network could affect the public uptake of science and how this impact is influenced by scientific uncertainty and affinity bias. For unbiased agents, a highly connected scientific network decreases the probability that the public favors the correct theory. For biased agents, however, a moderately connected scientific network causes the public to favor the correct theory more often. This results from the competition between the scarcity of information (for poorly connected agents) and the spread of misleading information (for highly connected agents). Adding more scientists strengthens both effects.
This article defends informed preference satisfaction theories of welfare against the most influential objections put forward in the economic and philosophy of science literatures. The article explicates and addresses in turn: the objection from inner rational agents; the objection from unfeasible preference reconstruction; the objection from dubious normative commitments; the objection from conceptual ambiguity; and the objection from conceptual replacement. My defence does not exclude that preference satisfaction theories of welfare face significant conceptual and practical challenges. Still, if correct, it demonstrates that philosophers/welfare economists are justified in relying on specific versions of such theories, namely informed preference satisfaction theories.
Is gender violence considered a part of advancing Indigenous self-determination in Alaska? What are the key jurisdictional, institutional, infrastructural, and community level challenges in combating violence against Alaska Native women? Few studies have considered the relationship between gender violence and Alaska Native sovereignty. I address this gap by employing the theory of relational Indigenous self-determination and drawing on research interviews with Indigenous women in Alaska and analyzing the data in light of two recent legislative changes: the 2022 reauthorization of the Violence Against Women Act, and the legislation that formally recognizes Alaska Native tribes in the state of Alaska. The findings demonstrate that persistent questions about Alaska Native jurisdiction stemming from the 1971 Alaska Native Claims Settlement Act (ANCSA) limit considering violence against Indigenous women and Indigenous self-determination as issues that need to be addressed in tandem.
We use recent advances in polynomial diffusion processes to develop a continuous-time joint mortality model for the actuarial valuation and risk analysis of life insurance liabilities. The model considers the stochastic nature of future mortality improvements and introduces a common subordinator for the marginal survival processes, resulting in a nontrivial dependence structure between the survival of pairs of individuals. Polynomial diffusion processes can be used to derive closed-form formulae for standard actuarial quantities. The model fits well with a classic dataset provided by a Canadian insurer and can be used to evaluate products issued to multiple lives, as shown through numerical applications.
New developments in neuro-navigation and machine learning have allowed for personalised approaches to repetitive transcranial magnetic stimulation (rTMS) to treat various neuropsychiatric disorders. One specific approach, known as the cingulum framework, identifies individualised brain parcellations from resting state fMRI based on a machine-learning algorithm. Theta burst stimulation, a more rapid form of rTMS, is then delivered for 25 sessions, 5 per day, over 5 days consecutively or spaced out over 10 days. Preliminary studies have documented this approach for various neurological and psychiatric ailments. However, the safety and tolerability of this approach are unclear.
Methods:
We performed a retrospective study on 165 unique patients (202 target sets) treated with this personalised approach between January 2020 and December 2023.
Results:
Common side effects included fatigue (102/202, 50%), local muscle twitching (89/202, 43%), headaches (49/202, 23%), and discomfort (31/202, 17%), all transient. The top 10 unique parcellations commonly found in the target sets included L8av (52%), LPGs (28%), LTe1m (21%), RTe1m (18%), LPFM (17%), Ls6–8 (13%), Rs6–8 (9%), L46 (7%), L1 (6%), and L6v (6%). Fatigue was most common in target sets that contained R6v (6/6, 100%) and L8c (5/5, 100%). Muscle twitches were most common in target sets that contained RTGv (5/5, 100%) and LTGv (4/4, 100%).
Conclusion:
These side effects were all transient and well-tolerated. No serious side effects were recorded. Results suggested that individualised, connectome-guided rTMS is safe and contain side-effect profiles similar to other TMS approaches reported in the literature.
To examine the potential indirect effect of meal frequency on mortality via obesity indices.
Design:
Prospective cohort study
Setting:
Korean Genome and Epidemiology Study.
Participants:
This cohort study involved 148 438 South Korean adults aged 40 years and older.
Results:
Meal frequency at the baseline survey was assessed using a validated FFQ. Outcomes included all-cause mortality, cancer mortality and CVD mortality. Cox proportional hazards regression models were employed to examine the relationship between meal frequency and the risk of mortality. Mediation analyses were performed with changes in obesity indices (BMI and weight circumference (WC)) as mediators. In comparison to the three-time group, the once-per-day and four-times-per-day groups had a higher risk for all-cause mortality. The irregular frequency group had a higher risk for CVD mortality. Both once-per-day and four-times-per-day groups exhibited higher risks for cancer mortality. The effect of meal frequency on all-cause mortality was partially mediated by WC. For specific-cause mortality, similar mediation effects were found.
Conclusions:
The data suggests that three meals per day have a lower mortality and longer life expectancy compared with other meal frequencies. Increased waist circumference partially mediates this effect. These findings support the implementation of a strategy that addresses meal frequency and weight reduction together.
Anosognosia, commonly understood as a lack of insight, renders individuals with schizophrenia and schizoaffective disorder unable to understand that they are living with a disease, often resulting in a refusal to accept treatment. Typically, to impose involuntary commitment in an effort to obtain treatment, an individual must be a danger to others or themselves. Even if involuntary commitment is imposed, however, an individual may remain competent to refuse medication—despite symptoms of anosognosia and an inability to understand that they are ill. This article examines the existing legal theories of competency and informed consent and proposes a statutory definition of competency that encompasses the specific needs of people with anosognosia, while considering the significant interests at stake when taking away an individual’s right to choose or refuse treatment.
This article provides an overview of individuals with schizophrenia who become unhoused and explores current approaches to managing this severe illness in those who often do not want care or believe they need it. Individuals with schizophrenia and who are unhoused face numerous adverse consequences including premature mortality and increased rates of suicide. There is a dearth of research evidence demonstrating efficacy of the Housing First (HF) model and harm reduction approach in decreasing psychotic symptoms in individuals with schizophrenia. Ensuring medication adherence in individuals with psychosis, both housed and unhoused, is important to prevent delays in untreated psychosis and chronic deterioration.
Subject pronoun interpretation in native Spanish has generally been approached under the Position of Antecedent Strategy, a parsing strategy which claims that null pronouns bias toward subject antecedents and overt pronouns toward object antecedents. While some studies align with the predicted patterns, others present mixed evidence. To further clarify this, our study tests the offline interpretation of null and overt subject pronouns in 55 native Peninsular Spanish speakers. We additionally tested the role played by different temporal subordinating conjunctions (mientras “while” vs. cuando “when”) in modulating subject pronoun interpretation preferences. Our findings reveal that overt pronouns bias toward object antecedents independently from the subordinating conjunction. Conversely, null pronouns bias toward subject antecedents, but their interpretation is influenced by the type of subordinating conjunction, with higher rates of subject interpretations in the mientras “while” condition. These results lend support to theoretical accounts such as the Form-Specific Multiple-Constraints approach, which asserts that referring expressions are subject to different constraints and to varying degrees. These findings thus extend beyond purely structural accounts and underscore the complexity of subject pronoun interpretation in Spanish.
In Hong Kong, the basic joint enterprise principle is recognised as an independent basis for attributing criminal liability. Although the principle has been recognised by the highest courts of the United Kingdom, Australia, and Hong Kong at different times, this article suggests that it does not have a historical foundation in common law. This article further argues that the basic joint enterprise principle (i) has no practical utility as it completely overlaps with traditional accessorial liability and the inchoate offence of conspiracy; (ii) necessarily requires the court to engage in circular reasoning; (iii) is unable to deal with situations of evidential uncertainty; and (iv) unjustifiably disrupts the principal-accessory distinction under common law. It is therefore recommended that the basic joint enterprise principle be abolished.
Growing evidence suggests that psychedelic-assisted therapies can alleviate depression, anxiety, posttraumatic stress, and substance use disorder, offering relatively safe profiles, enhanced efficacy, and lasting effects after a few applications. Athletes often experience high levels of stress and pressure, making them susceptible to these psychiatric conditions. However, the effects of psychedelic substances on athletic performance remain largely unknown. Before potential acceptance, evaluating their impact on physical and physiological measures beyond mental health outcomes is crucial. Here, we aim to explore this topic and highlight research directions to advance our understanding. Preclinical studies suggest that psilocybin/psilocin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), and ayahuasca possess anti-inflammatory and anti-nociceptive properties. Studies investigating the effects of classical psychedelics or 3,4-methylenedioxymethamphetamine (MDMA) on factors such as muscle strength, motor coordination, locomotion, endurance, fluid and electrolyte balance, hormonal regulation, and metabolism are still scarce. While adhering to regulatory frameworks, further research in animal models, athletes, and non-athletes is needed to address these gaps, compare psychedelics with commonly used psychoactive drugs, and explore the potential prophylactic and regenerative benefits of specific interventions.
In 1946, the United Nations Educational, Scientific, and Cultural Organization (UNESCO) was formed to promote peace through education and cross-cultural understanding. In the postwar atomic age, American leaders saw UNESCO and education for world citizenship as critical to the prevention of future war, the promotion of a new pluralistic vision, and the development of a well-informed society. A hyper-local case study, this article follows the story of Milton S. Eisenhower, leading UNESCO delegate and president of Kansas State College, and the series of progressive reforms he pursued to promote democracy, citizenship, and global peacebuilding at a rural land-grant college in the center of the former “isolationist belt” of America. This article traces the impact of these curricular reforms, the UNESCO campus-community partnership they inspired, and the subsequent peacebuilding movement that agitated for humanitarian action, civic participation, and desegregation from 1947 to 1950.
In recent decades, ethicists have engaged with new developments in human reproductive technologies from a variety of angles. Yet there has been relatively little effort to problematize the concept of reproduction itself. In this paper, we examine the question of what reproduction is and its relationship with biology. We show that reproduction is commonly assumed to entail biological parenthood—an assumption that we term “the biological reproduction paradigm.” Drawing on Sally Haslanger’s analysis of the biological/social division between sex and gender, we suggest that the concept of reproduction is socially constructed, despite its apparently biological nature. In turn, we argue that the supposed necessity of the relationship between reproduction and biological parenthood leads to a situation in which access to a variety of medical, legal, and social goods is constrained on the basis of spurious, inconsistent, and undertheorized assumptions. Finally, we note that, given the socially constructed nature of reproduction, we cannot take it for granted that the term “reproduction” signifies the same thing among different interlocutors and in different contexts.