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Community structure in networks naturally arises in various applications. But while the topic has received significant attention for static networks, the literature on community structure in temporally evolving networks is more scarce. In particular, there are currently no statistical methods available to test for the presence of community structure in a sequence of networks evolving over time. In this work, we propose a simple yet powerful test using e-values, an alternative to p-values that is more flexible in certain ways. Specifically, an e-value framework retains valid testing properties even after combining dependent information, a relevant feature in the context of testing temporal networks. We apply the proposed test to synthetic and real-world networks, demonstrating various features inherited from the e-value formulation and exposing some of the inherent difficulties of testing on temporal networks.
RUCAI is an AI-based open-source software platform designed for humanities and social sciences educational workflows that require traceability to assigned course materials. RUCAI has a teacher-only workspace in which teachers can curate class exercises grounded in curriculum documents (articles, book chapters, and notes). From here, the teacher can set up workspaces grounded explicitly in curriculum materials, learning outcomes, and course requirements for students to use throughout the course. The system is set up to run on institution-controlled infrastructure using FastAPI, PostgreSQL, and a local LLM model serving via Ollama, and is intended to be deployable on a GPU-enabled virtual machine. RUCAI’s primary contributions are practical: (1) it presents a software architecture for local-first, source-grounded educational AI that treats the course as the primary software object; (2) it documents concrete implementation choices for reliable ingestion and retrieval across heterogeneous course materials, including a three-tier extraction pipeline, word-based chunking, and intent-aware retrieval; and (3) it describes a publish-to-student mechanism that lets teachers freeze course context and prompt constraints into student-facing instances. The paper also reports pilot observations, current limitations, and future development directions.
We aimed to describe the development and evaluation of the Brazilian Dietary Guidelines Adherence Score (BraScore).
Design:
The process comprised multiple steps: defining guiding principles, identifying food components, setting scoring cut-off points and assessing validity and reliability.
Setting:
Nationally representative sample of the Brazilian population.
Participants:
46 164 Brazilians aged ≥ 10 years.
Results:
The BraScore has ten components: to be consumed (legumes; fruits; vegetables and diversity), to be limited (red meat; other animal-based foods; processed foods; table sugar and cooking salt) and to be avoided (ultra-processed foods). Scores range from 0 to 100, with higher values indicating greater adherence to the Dietary Guidelines. Analyses showed a weak correlation with energy intake (coefficient: –0·12) and substantial variability among individuals (1st percentile: 20·5; 99th: 77·7). Scree plot analysis revealed multidimensionality, indicating four distinct patterns. The scores differentiated population groups (older adults and rural residents had higher scores) and were high for diets developed by nutritionists (84·6–97·6 points). The reliability analysis yielded a coefficient of 0·6, suggesting acceptable internal consistency.
Conclusions:
The BraScore is a valid and reliable tool to assess adherence to the Dietary Guidelines for the Brazilian Population.
Developing the next generation of leaders in congenital cardiology is critical to advancing the field. Increasingly, it is recognised that earlier opportunities to establish professional networks, gain unique skills, and disseminate scientific work can be highly beneficial. While cross-institutional collaboration has been successful in supporting quality improvement, it has not been widely used in other areas. We describe our initial experience with a multi-centre congenital heart early-career exchange programme.
Methods:
Faculty (<10 years from training) among five participating congenital heart centres were eligible to apply. Applications were reviewed and matched with host sites. Visits (typically 3–5 days) included topics spanning research and collaboration, unique clinical programmes/skills, networking, and presenting a formal lecture. All participants were invited to complete an anonymous post-visit survey, with descriptive results reported.
Results:
Overall, 20/28 (71%) applicants over the initial two years of the programme were selected for participation. The majority were assistant professors; 75% were <5 years from training. There was an equal distribution of males and females and a diverse range of clinical specialties/areas of interest. Post-visit survey responses (75% response rate) were highly favourable, with 92% indicating “strongly agree” regarding the value of the programme across domains and highlighting valuable exposure to unique clinical and research opportunities, networking, and mentorship.
Conclusions:
Initial results from the congenital heart early-career exchange programme highlight the feasibility and positive impact of a collaborative approach to career development. Further efforts should be prioritised to foster broader engagement and impact.
Post-traumatic stress disorder (PTSD) is a growing health problem whose neurobiology remains incompletely understood. Neuroimaging is useful in probing PTSD-related brain dysfunction, and techniques continue to evolve. Structural–functional coupling (SFC) offers a novel integrated perspective on PTSD neurobiology. We sought to define unique SFC alterations in PTSD and explore their associations with clinical symptoms, brain molecular architecture, and gene expression.
Methods
We studied 61 PTSD patients and 62 trauma-exposed non-PTSD controls (TENC) recruited from earthquake survivors. We compared SFC constructed from multimodal MRI data by an eigendecomposition method between the two groups. We explored the spatial correlation of SFC with molecular maps, used partial least squares (PLS) regression to associate them with Allen Human Brain Atlas gene data, and conducted enrichment analysis on the identified genes.
Results
PTSD patients showed significant regional SFC alterations in multiple regions: lower SFC in PTSD versus TENC in the default mode network (DMN), frontoparietal network (FPN), dorsal attention network, sensorimotor network, visual network, and thalamus, and higher SFC in PTSD versus TENC in the DMN, FPN, and ventral attention network. Some changes were correlated with clinical symptom severity. In both groups, the spatial distribution of SFC was similarly correlated with molecular architectures. The second component of the PLS regression genes were linked to PTSD-specific SFC variations, enriched mainly in molecular functions and pathways related to synapses and neurotransmitter signaling.
Conclusions
This study yields new insights into PTSD pathophysiology by connecting macroscale SFC changes with their microscale molecular and transcriptional basis.
The rising incidence of antimicrobial resistance (AMR) underscores the urgent need for effective antimicrobial stewardship (AMS). This study assessed the impact of a tailored AMS initiative in Indian hospitals.
Methods:
An AMS surveillance program was implemented across 11 Indian hospitals (January 2022–June 2023). The intervention (July 2022–June 2023) included hospital-specific antibiograms, antibiotic policy design and implementation, monitoring antibiotic consumption, and tracking multidrug-resistant organisms (MDROs). Hospital staff were trained, and compliance audits with feedback were conducted. Implementation followed the Model for Improvement methodology over 18 months.
Results:
AMS surveillance revealed significant improvement in AMS knowledge and practices from the baseline to the postintervention phase. Antibiotic compliance increased from a baseline of 10% to 71% across hospitals, reaching 73%–91% in the subsequent period. Surgical prophylaxis compliance improved substantially, particularly in hospitals with initially low adherence. Optimizations in antibiotic selection, dosing, duration, intravenous-to-oral switching, and de-escalation were also observed, resulting in significant compliance gains across all domains. Use of antibiotics classified by the World Health Organization as safer first-line options with a narrow spectrum increased, while use of second- and third-line antibiotics, including those with broader spectra and higher resistance risks, decreased, reflecting a shift toward safer prescribing practices. However, MDRO incidence rates remained variable across sites, showing room for improvement.
Conclusion:
Locally tailored AMS interventions within a structured quality improvement framework can establish sustainable practices to mitigate AMR. These findings demonstrate effective strategies for optimizing antibiotic use and provide valuable insights for broader implementation of AMS.
Many social welfare measures will sometimes rank a large population of very well-faring people below a very large population of barely well-faring people. Thus, they entail the repugnant conclusion. If such rankings are indeed repugnant, there must be some mistake behind measures that imply them. This paper discusses what that mistake might be. After rejecting other proposals, I suggest that the mistaken assumption is that welfare values that are insignificant for individuals, due to being small, could have significant impact on social welfare. To avoid this mistake, two new measures are introduced that aggregate significant and insignificant welfare values differently.
The Outlook argues that whatever the participant or mediatory statuses of machines may be in future research with large and complex datasets, understanding their uses and impacts at the granularity of human interaction and social accountability will be essential for attempts to integrate human and machine learning from data. It highlights the uses of the two notions of accountability addressed in this book, identifies a spectrum of natural scientists’ social inquiries that hints at their normative orientations, and argues for the use of ethnography as a reminder of human agency and responsibility.
This paper overviews an overlapping generations financial cash flow valuation model that evaluates the financial sustainability of English NHS Trusts. It quantifies the financial sustainability constraints related to societal demographic shifts that affect their ability to maintain service delivery quality. The financial model computes a new long-term financial sustainability performance metric based on the notion of the Social Return on Investment (“SROI”). The measure evaluates the financial sustainability of two English acute care hospital foundation Trusts. Significant generational imbalances are identified for both sample NHS Trusts, both within different cohorts of existing generations, and between existing and future generational cohorts. Suggestions are provided for implementing these ideas and expanding actuaries’ expertise and skill sets.
The integration of generative AI into humanities research presents both new opportunities and significant methodological challenges. While generative AI enables more sophisticated textual, visual, and historical analysis than ever before, it also introduces novel methodological risks. Prompts now function as measurement instruments, construct validity is entangled with model fluency, the increasing abstraction and subjectivity of tasks challenge single-answer evaluations, small changes in prompt or model configuration can materially alter substantive conclusions, and model training encodes strong theoretical assumptions prior to human interaction. This article advances a theory-first framework for generative-AI-assisted humanities research that traces how theoretical commitments intervene across the research lifecycle. Drawing on examples from the computational humanities and social sciences, it argues that theory operates as methodological infrastructure that constrains degrees of freedom, supports reproducibility, and enables principled iteration. By reframing generative AI as a site of theoretical inscription, the article outlines practical strategies for building robust and theoretically grounded humanities research in the era of generative AI.
The Introduction sets out from an ethnographic vignette to specify the book’s anthropological approach to data-rich science. It briefly reviews the literature on the social practices of data use in the sciences. It then argues for setting out from the tenet that humans are fundamentally evaluative and attending to social interactions and accountabilities by means of ethnography. Doing so helps making sense of data-centric socialities: forms of social coordination unfolding in the making, use, and publication of data. Adopting this view, readers discover a view of ethics that is mindful of all participants and see how researchers learn from technicians about data production, instruct new data users, use diagrams to cultivate data, engage mundane reasoning to resolve disjunctive findings, organize collaborative work, manage issues of normativity in “open science,” and seek to encode their knowledge in datasets. The Introduction concludes with a description of ethnographic fieldwork and a discussion of its representativeness and generalizability.
The tail behavior of aggregates of heavy-tailed random vectors is known to be determined by the so-called principle of ‘one large jump’, be it for finite sums, random sums, or Lévy processes. We establish that, in fact, a more general principle is at play. Assuming that the random vectors are multivariate regularly varying on various subcones of the positive orthant $[0,\infty)^d$, first we show that their aggregates are also multivariate regularly varying on these subcones. This allows us to approximate certain tail probabilities rendered asymptotically negligible under classical regular variation. Second, we discover that depending on the structure of a particular tail event, the tail behavior of the aggregates may be characterized by more than a single large jump. Finally, we illustrate a similar phenomenon for regularly varying multivariate Lévy processes, establishing as well a relationship between regular variation of a multivariate Lévy process and multivariate regular variation of its Lévy measure on different subcones. The applicability of these results in financial and insurance risk management is discussed.
Trichuris muris infections in laboratory mice underpin current understanding of host-parasite interactions, yet the extent to which these insights apply to natural systems remains largely untested. In this study, we experimentally infected wild-caught Mastomys natalensis with Trichuris mastomysi under controlled conditions. Mice were assigned to either a single high-dose infection or repeated low-dose exposure. Larval infection success and intensity were assessed 21 days post-infection. Infection success was high in both exposure groups, and infection dose strongly influenced parasite burden, with high-dose animals carrying significantly more larvae than low-dose animals. These results demonstrate that T. mastomysi readily establishes in wild-caught M. natalensis and that exposure dose primarily affects early larval burden rather than infection success. By experimentally infecting a natural rodent host under controlled conditions, this study links mechanistic laboratory approaches with ecologically relevant host-parasite dynamics in the wild.
Diagrams are essential for interpreting complex datasets and making discoveries. This chapter examines how diagrams in use make private thoughts, models, and phenomena accessible intersubjectively and complex datasets surveyable. When designed and used conventionally, diagrams are bearers of tradition and culture. This chapter shows that they can also be resources for scientific understanding, pruning and cultivating datasets, and achieving social accountability. Diagrams are the ground on which scientists can play and experiment with data: researchers suspend sequential courses of action for explorations in which they gain insights into possible interpretations and their work’s robustness as they decide which action among alternatives to make consequential. This chapter describes this play in the making of a discovery. As diagrams are standardized and used at many places, the resistance that their users experience can be ascribed to their efforts to be accountable to researchers elsewhere.
This chapter focuses on evaluations of persons as a lens into scientific data production and its ethics. That humans are fundamentally evaluative is a basic tenet of social interaction and social life. People are concerned that others understand their intentions adequately, knowing that their actions are being evaluated, and they examine others’ actions and intentions likewise. In many sciences, data production has become a service, with technicians generating data in the absence of researchers. Such new arrangements of data production come with numerical and social accountabilities as well as ethical evaluations. Focusing on data production in astronomy, this chapter traces these through several contexts. Joining data-producing technicians and data-using scientists as an ethnographer reveals that both are themselves exploring the epistemic and social accountabilities they face. Their way of “doing ethnography” is an ordinary social competence. The chapter argues that such ethnographic practices support and enable scientific data production as a service while also revealing its ethical tensions.
As artificial intelligence (AI) systems rapidly develop in biomedical research, bioethical frameworks focused on human subjects research are often limited in their capacity to address ethical concerns related to data-driven and black-boxed AI algorithms. Calls to embed Ethical, Legal and Social Implications research into large research consortia focused on AI seek to address the challenges of applying models developed in the context of genomics research to AI projects. Foundational questions related to the conduct of such embedded ethics work include: what are the goals of this work, what counts as “ethics,” who qualifies as an ethics expert and what mechanisms, including organizational structures, can ensure success in achieving ethics goals alongside scientific goals by multidisciplinary research teams? We draw on empirical case studies (including semi-structured interviews and document analysis) of large, federally funded AI research projects in the US that required embedded ethics. Notable findings include the lack of consensus among key players regarding the definition of AI ethics and conflict over the scope of ethics work, which impedes the implementation of ethics-related goals in research practices. These conflicts highlight the differences in disciplinary cultures, contentious boundaries between technical and ethical expertise and the lack of power and impact of the ethics team. Our findings underscore that effective ethics integration depends on trust and respect for ethics scholarship through leadership and relationship-building. We argue that building long-lasting, equitable relationships requires institutional commitment through organizational frameworks and funding mechanisms that prioritize deliberation about ethical concerns, shared values and shared power, as well as co-developing ethics goals alongside science goals. A horizontal approach is needed to nurture joint relationships for fostering ethical and just biomedical AI research and development.