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This article explains why the Netherlands, uniquely among major European states, issued a sovereign apology for its role in transatlantic slavery in December 2022 while comparable states, notably the United Kingdom, have not. Using process tracing and an analytically eclectic framework, the apology activation model, or AAM, identifies three interlocking conditions that activate sovereign apologies: institutional openness that admits minoritized voices into competitive politics; influential domestic allies who translate transnational pressure into parliamentary and executive action; and a cohesive, domestically represented victim constituency able to sustain claims and shape framing. The Dutch case shows how forward-looking framing and strategic localization converted CARICOM and EU pressure into parliamentary commitment, a policy package, and a durable reparative agenda despite mixed public opinion; the UK comparison demonstrates that international advocacy alone is insufficient. The article advances theory by integrating normative and material explanations, foregrounding elite interest convergence and domestic opportunity structures, and offering a practical template for analyzing reparations politics across diverse political systems.
As usually conceived and practiced, education – sustainability, environmental and beyond – is embedded in an overarching narrative of progress: increasing human knowledge leading us to make wiser decisions about our behaviour, as individuals and societies. This article outlines an alternative story that draws on the work of two Indigenous scholars, E. Richard Atleo (Nuu-chah-nulth) and Leanne Simpson (Nishnaabeg), who approach living well as a quest to co-exist in harmony and balance with all our relations (that is, the living world of which we are an integral part). Among the core principles they identify are self-determination, consent and sacred respect, understood both as operative in the functioning of healthy ecosystems and as guides to human development and relationships. We show how these principles are grounded in a quest for the mutual beneficial flourishing of free beings and trace some of their implications for environmental education. While stories of this kind are at odds with the current dominant conception of schooling, there are many ways in which they could begin to influence how we move beyond the metacrisis and further, how wethink about and practice education for eco-social –cultural change and the future world/s to come.
Adolescents, particularly today’s Generation Alpha, face uncertainty about whether, when and how their autonomy will be respected, especially in mental health contexts. Existing consent and confidentiality practices may not reflect adolescents’ preferences, potentially deterring help-seeking. This Feature examines the tension between adolescent autonomy and parental authority in mental healthcare. We synthesise interdisciplinary perspectives from the developmental sciences, medical ethics and law. We present data from 20 844 students (aged 11–18 years) in the 2023 OxWell Student Survey regarding barriers to accessing mental health support. Among those who wanted but had not accessed additional support (n = 2792), 72.3% reported privacy/confidentiality concerns, with half (50.3%) specifically citing that they did not want their parents to know. These concerns were particularly common among students reporting self-harm, gender-diverse adolescents and those in less stable home environments. We argue that respecting adolescent autonomy must be central to healthcare planning, not only as an ethical and legal imperative, but also to enable timely support. A capacity-based, adolescent-centred approach – grounded in greater transparency, clearer explanations of when and how information may be shared (including the option to involve a trusted adult) and consistent, aligned policies across institutions, especially around parental involvement, could help address a key barrier to care.
We consider a family $b_{s,\tau }$ of free multiplicative Brownian motions labeled by a real variance parameter s and a complex covariance parameter $\tau $. We then consider the element $xb_{s,\tau }$, where x is non-negative and freely independent of $b_{s,\tau }$. Our goal is to identify the support of the Brown measure of $xb_{s,\tau }$. In the case $\tau =s$, we identify a region $\Sigma _s$ such that the Brown measure is vanishing outside of $\overline {\Sigma }_s$ except possibly at the origin. For general values of $\tau $, we construct a map $f_{s-\tau }$ and define $D_{s,\tau }$ as the complement of $f_{s-\tau }(\overline {\Sigma }_s^c)$. Then, the Brown measure is zero outside $D_{s,\tau }$ except possibly at the origin. The proof of these results is based on a two-stage PDE analysis, using one PDE (following the work of Driver, Hall, and Kemp) for the case $\tau =s$ and a different PDE (following the work of Hall and Ho) to deform the $\tau =s$ case to general values of $\tau $.
Negative neuropsychiatric symptoms, such as apathy, are a core feature of Alzheimer’s disease. Previous studies have shown that levels of fasting plasma proline and differential activity of the catechol-O-methyltransferase (COMT) enzyme, which metabolises dopamine, influence negative symptoms in patients with severe psychiatric illness and those at risk for psychosis. For patients with the COMT high activity enzyme (as assessed via the COMT Val158Met polymorphism), high plasma proline was associated with less severe negative symptoms. Conversely, high proline was associated with more severe negative symptoms in patients with the low activity COMT enzyme.
Aims
In this proof-of-concept cross-sectional study, we tested the hypothesis that proline and COMT Val158Met interact to modify negative symptom severity across neuropsychiatric disease, specifically now investigating patients with Alzheimer’s disease dementia.
Method
Least Absolute Shrinkage and Selection Operator regression was employed to model the interaction between proline and COMT on negative symptoms in n = 50 patients with probable Alzheimer’s disease or mild cognitive impairment with underlying Alzheimer’s disease biomarkers.
Results
The proline × COMT interaction significantly predicted symptoms as assessed via the negative items of the Positive and Negative Symptom Scale, interaction coefficient 0.025, p = 0.031, with a trend toward significance when assessed via the Scale for Assessment of Negative Symptoms in Alzheimer’s disease, interaction coefficient 0.075, p = 0.055. Higher proline was beneficial for both Val/Val and Val/Met dementia patients, but detrimental to patients with the low activity Met/Met COMT enzyme.
Conclusions
Higher proline also has opposing effects on negative symptoms by COMT genotype in patients with dementia and further supports the development of therapeutics aimed at modulating this interaction pathway across neuropsychiatric disorders.
Cognitive impairment in major depressive disorder (MDD) may be driven by neuro-inflammatory processes involving pro-inflammatory cytokines.
Aims
This study aimed to examine the relationship between serum tumour necrosis factor-alpha (TNF-α) levels and cognitive performance across different domains in individuals with MDD.
Method
Sixty patients with MDD and 60 healthy controls were recruited. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum TNF-α levels were measured via flow cytometry.
Results
After adjusting for covariates, RBANS total and subscale scores were significantly lower in MDD patients compared with controls (P < 0.001), while log10-transformed TNF-α levels were significantly higher in the MDD group (P = 0.006). In MDD patients, log10TNF-α levels were inversely correlated with immediate memory scores after adjusting for confounding factors (r = −0.35, P = 0.009); however, this relationship was not observed in healthy controls (r = −0.02, P = 0.90). Stepwise multivariate regression analysis further confirmed the negative association of log10TNF-α with immediate memory scores in MDD patients (β = −14.58, t = −4.14, P < 0.001), but not in healthy controls (β = −0.02, t = −0.14, P = 0.89).
Conclusions
These findings suggest that elevated serum TNF-α may contribute to the pathophysiology of MDD and is specifically associated with deficits in immediate memory.
Two fourth-order difference approximations for fractional derivatives based on Lubich-type second-order approximation with different shifts are derived. These approximations are applied to the space fractional diffusion equation with the Crank–Nicolson scheme. Here, we analyse the stability and convergence of these schemes and prove that they are unconditionally stable and convergent for a fractional order $\alpha $ ranging from $1$ to $2$. Numerical examples are presented to show that both schemes converge, and we obtain the correct convergence rates and unconditional stability.
A burning droplet in normal gravity inevitably encounters buoyant convection set up by the flame, which can significantly impact its shrinkage kinetics traditionally described by the D2-law. However, the detailed mechanism governing droplet vapourisation under such self-generated flame-driven buoyant convection remains elusive. Here, we present both experimental and theoretical evidence highlighting the critical role of buoyant convection in droplet combustion. Experimentally, we precisely measure the values of the shrinkage exponent n for various liquid fuels, revealing a significant departure from the D2-law. While the measured n values consistently fall within the narrow range 2.6–2.7, they exhibit a slight increase with the fuel’s boiling point. A more general and in-depth theory is also developed to explain such small but systematic variations, revealing that differences in flow and thermal boundary layer structures – arising from varying combustion intensities – may account for the observed trends. Our theory predicts three distinct values of n, namely 2.6, 8/3 ≈ 2.67 and 35/13 ≈ 2.69, successfully capturing slight differences in n among various fuels. This is the first study demonstrating that the shrinkage kinetics in droplet vapourisation driven by flame-induced buoyant convection is nearly universal, determined solely by the underlying transport mechanisms, although these can be significantly altered due to their high susceptibility to detailed fuel chemistry and combustion kinetics. The present theoretical framework not only enables accurate prediction and control of burning droplet behaviour, but also is extendable to analyse more complex combustion processes involving a broader range of fuel types and flow conditions.
This paper examines the evolution and implications of ‘must-carry’ obligations in the regulation of online platforms, with a focus on Europe. These obligations, which restrict platforms’ discretion to remove or deprioritise certain content, represent a novel regulatory response to the growing power of platforms in shaping public discourse. The analysis traces developments at EU and national levels. At the EU level, it considers rejected must-carry proposals during the drafting of the Digital Services Act (DSA) and the adoption of Article 18 of the European Media Freedom Act (EMFA), which grants privileges to recognised media service providers. At the national level, it examines Germany’s prohibition on content discrimination, the UK’s Online Safety Act, and Poland’s abandoned legislative proposal on freedom of expression online. Case law from courts in the Netherlands, Germany, Italy, and Poland further illustrates the emergence of judicially crafted duties resembling must-carry obligations. The paper argues that these measures are best understood as special treatment rules that privilege particular speakers, notably media organisations and politicians, by limiting platform autonomy in content moderation. While intended to safeguard pluralism and access to trustworthy information, such rules risk creating a two-tier system of expression in which established voices receive disproportionate protection while ordinary users remain vulnerable. Protections for politicians raise concerns about shielding powerful actors from justified moderation, whereas media privileges, though more defensible, remain limited in scope and potentially counterproductive, especially when exploited by outlets disseminating disinformation. The conclusion is that compelled inclusion and preferential treatment are unlikely to offer sustainable solutions to the structural imbalances between platforms, media providers, and politicians. More durable approaches should focus on strengthening journalism through financial and structural support, fostering innovation and local media, and prioritising user empowerment measures. Only systemic safeguards of this kind can effectively promote pluralism, accountability, and resilience in the digital public sphere.
The COVID-19 pandemic sent shockwaves throughout the world. Even though the Czech Republic has less stable state structures and a less consolidated party system than its West European counterparts, during the first wave, the country actually performed better than most West European countries in terms of infection rates, death rates, and economic growth. During the second wave, however, the country’s position radically dropped. Despite its increasing health problems, its social policies still performed rather well and managed to keep unemployment at comparatively low levels. How can we explain these differences between erratic performance on the health side and comparatively solid performance on the social policy side? Our study explains why traditional social policies basically remained path dependent, while epidemiological policies dealing directly with fighting the spread of COVID-19 did not. Our explanation combines sociological and rational choice institutionalism and links them with the concepts of repeated games and bounded rationality.
Government representation is an essential part of the functioning of international organizations (IOs). As IOs are mostly composed of states, government representatives bring them life: member state officials negotiate and vote in their organs, and they participate on behalf of their state in institutional dispute settlement. However, the constituent instruments of IOs typically do not prescribe explicit rules on government representation. Therefore, IOs use their so-called credentials procedures to ascertain who speaks for a particular member state.1 While the recognition of credentials is a straightforward process, it becomes politicized when the exercise of governmental authority is contested. After giving an overview of the rules on credentials, this essay discusses the fragmented practice in which different organs and organizations within the United Nations (UN) system address situations of contested government representation. This practice shows that IOs are often torn between, on the one hand, idealist considerations, such as condemning an illegitimate change in government, and, on the other hand, the practical necessity of ensuring the effective fulfillment of their mandates.
The finding of an incorrect non-Antarctic locality assigned to a specimen of Trematomus loennbergii at the Natural History Museum, London, led to the discovery of two (of three) syntype specimens, previously considered missing, of this species. The third syntype, a larger specimen in better condition, is designated as the lectotype of T. loennbergii; the two newly discovered specimens, re-identified as Trematomus pennellii, become paralectotypes.
Particles in compressible shear flows experience lifting effects due to asymmetric pressure and viscous forces across the particle surface, rotation induced by asymmetric viscous forces (Magnus effect), and asymmetric compression and viscous effects if near a wall (wall effect). This work focuses on the lifting force on a solid spherical particle due to asymmetric pressure and shear stress distributions driven by density and velocity gradients. We show via direct numerical simulation and verify using scaling arguments that the lifting force in unbounded laminar compressible shear flows is a function of dynamic pressure gradient. We show that steady flow regimes demonstrate predictable lifting forces. Unsteady flow regimes demonstrate asymmetric vortex shedding which creates lift in directions not readily predictable. Thus, predicting lift requires the ability to predict wake structure. We develop approximate delineations between wake types at Reynolds numbers up to 20 000. We use the non-dimensional dynamic pressure gradient, Mach number, Reynolds number and predicted wake structure to develop a shear-induced lift model. The proposed model can be used in conjunction with a drag model to simulate particle motion in compressible shear flow.
Answers to the question 'what is medical progress?' have always been contested, and any one response is always bound up with contextual ideas of personhood, society, and health. However, the widely held enthusiasm for medical progress escapes more general critiques of progress as a conceptual category. From the intersection of intellectual history, philosophy, and the medical humanities, Vanessa Rampton sheds light on the politics of medical progress and how they have downplayed the tensions between individual and social goods. She examines how a shared consensus about its value gives medical progress vast political and economic capital, revealing who benefits, who is left out, and who is harmed by this narrative. From ancient Greece to artificial intelligence, exploring the origins and ethics of different visions of progress offers valuable insight into how we can make them more meaningful in future. This title is also available as open access on Cambridge Core.
This volume shows how remote work is regulated by a holistic set of arrangements that govern all forms of employment, weaving together labor institutions in complex ways that the book presents and explains. The scholarship assembled here examines the handling of remote work through institutional analysis cutting across national cases and focusing on both fundamental rights and regulatory challenges. The rights that are examined – by analyzing their nteraction with employer powers – include privacy, equality and non-discrimination as well as collective rights and the distribution of responsibilities in the workplace. The book shows how the location of work interacts with new technologies redefining the universe of labor relations and the institutional system governing employment. This title is also available as open access on Cambridge Core.
Early modern English people were obsessed with making babies. In this fascinating new history, Leah Astbury traces this preoccupation through manuscript letters, diaries, recipe books and almanacs, revealing its centrality to family life. Information was plentiful in guides on the burgeoning fields of domestic conduct and midwifery, as well as in the many satirical ballads focused on sex, marriage and family. Astbury utilises this broad source base to explore all aspects of early modern childbearing, from conception to the months after delivery. She demonstrates that, while religious and cultural ideals dictated that women carry out all of this work, men were engaged in its practice through directing medical decisions. With the entire household including servants, wetnurses and other unexpected actors included in the project, childbearing can be situated within the histories of gender, medicine, social status, family and record-keeping. This title is also available as open access on Cambridge Core.
The setting in which patients face the end of life (EOL) is shaped by complex, individualized needs beyond physical care. Mr. X, a man in his mid-50s with glioblastoma, endured treatment complications and progressive decline. Supportive care was engaged to manage symptoms and support his wife, Mrs. X, who was simultaneously the family’s financial provider and caregiver for both her husband and their autistic adult son. As his condition worsened, she resisted hospice and code status changes, citing emotional, logistical, and financial barriers, while fiercely advocating for his wish to die in the hospital. Counseling and empathic validation helped her share her burdens and reframe her advocacy as rooted in love and grief. She ultimately consented to comfort-focused care, and Mr. X died peacefully in the hospital after a 31-day stay. This case underscores the need to integrate psychosocial factors into individualized EOL planning and to strengthen person-centered care.
Unsteady aerodynamic forces in flapping wings arise from complex, nonlinear flow structures that challenge predictive modelling. In this work, we introduce a data-driven framework that links experimentally observed flow structures to sectional pressure loads on physical grounds. The methodology combines proper orthogonal decomposition and quadratic stochastic estimation (QSE) to model and interpret these forces using phase-resolved velocity fields from particle image velocimetry measurements. The velocity data are decomposed in a wing-fixed frame to isolate dominant flow features, and pressure fields are reconstructed by solving the Poisson equation for incompressible flows. The relationship between velocity and pressure modes is captured through QSE, which accounts for nonlinear interactions and higher-order dynamics. We introduce an uncertainty-based convergence criterion to ensure model robustness. Applied to a flapping airfoil, the method predicts normal and axial forces with less than 6 % average error using only two velocity modes. The resulting model reveals an interpretable underlying mechanism: linear terms in the QSE model the circulatory force linked to the formation of vortices on the wing, while quadratic terms capture the nonlinear component due to added-mass effects and flow–vorticity interactions. This data-driven yet physically grounded approach offers a compact tool for modelling the unsteady aerodynamics in flapping systems with potential to generalise to other problems.