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Semantic extensibility captures the semantic side of productivity. It is the likelihood that a given sense of a linguistic expression will support extension to new senses. Even though linguistic expressions are naturally polysemous, semantic extensibility is constrained. In previous literature, it has been argued that semantic extensions are motivated by mostly one-directional conceptual operations such as metaphor and metonymy, and that in any polysemous expression only one or a few so-called ‘sanctioning’ senses have privileged status in supporting new extensions. One factor believed to determine sanctioning status is high frequency. Drawing on three case studies from the history of English, involving change in the adjective awful, the preposition and adverb about and the multifunctional item so, this article provides diachronic evidence from semantic loss to support this view. On the one hand, it is shown that when old sanctioning senses go into decline, this also impacts the senses derived from them, underscoring the motivational relations that tie extended senses to sanctioning senses. On the other hand, what typically initiates a decline in a sanctioning sense is a frequency increase elsewhere in the polysemy network coincident with the emergence of a new sanctioning sense, underscoring the role of frequency in determining sanctioning status and the directionality of sanctioning relations.
The COVID-19 pandemic has impacted various aspects of daily life, leading to increased psychological symptoms and changes in alcohol use, yet little is known about their specific interactions, particularly early stages during the pandemic. We examined the relationship between psychological symptoms and alcohol-related behaviors associated with COVID-19, and determined whether associations shifted already early during the pandemic and whether changes in psychological symptoms from the pre- to during COVID-19 impacted changes in alcohol consumption.
Methods
Participants were young adults from a longitudinal cohort (N=435, age: 22–25) from two time points. We applied paired samples t-tests, correlation analyses, SHapley Additive exPlanations, and classification models to examine the multiple associations between psychological symptoms and alcohol use directly pre- and early during COVID-19.
Results
We found significant associations between psychological symptoms and alcohol use pre- compared to during COVID-19. Anxiety was the strongest factor influencing alcohol use pre-pandemic, depression had the greatest impact during COVID-19. Changes in anxiety from pre- to during COVID-19 were the main factor associated with an increase in alcohol use, while changes in depression appeared to be most predictive for a decrease/persistence in alcohol use.
Conclusion
These findings suggest a shift in the association between psychological symptoms and alcohol use following COVID-19, as well as a differential impact of psychological symptoms, depending on their changes related to the pandemic. Changes in anxiety may contribute to riskier alcohol use behaviors following the pandemic, while depression appears to be one of the most critical factors influencing alcohol use during such crisis situations.
This article explores how multilateral negotiations for technology trade accelerated the fall of the Cold War economic divide in East Asia. Drawing on archival sources in Japan, the United States, China, Britain, and France, it focuses on computer trade between China and capitalist countries from 1968 to 1980. The computer, a dual-use technology essential to China’s industrial and military modernisation, was at the centre of debate among capitalist countries. While competing to export advanced technologies to the China market, they needed to relax export controls through the Coordinating Committee for Multilateral Export Controls, an international regime to oversee export restrictions on communist countries during the Cold War. This combination of competition and cooperation weakened the restrictive trade regime dating back to before the Korean War, enabling capitalist countries with diverse economic and security interests to find common ground to sell to Chinese customers. By examining this process, this article reveals that dual-use technologies, often viewed in global history as a source of division among states, could in fact promote economic and political interactions across the East-West divide.
Despite an early surge in copper-ore mining during the sixth and fifth millennia BC (the ‘boom’), evidence for metal production in the Balkans dwindles in the fourth millennium (the ‘bust’). Here, the authors present new evidence for copper mining at Curak in south-west Serbia, c. 3800 cal BC, during this apparent downturn. By integrating field surveys, excavations and provenance analyses, they explore activity at the site, challenging the visibility bias in the archaeological record of this region for this key period. Rather than a societal collapse, the authors argue, fewer artefacts may instead reflect a widening Balkan sphere of influence.
In this paper, we investigate the relation between head movement and the synthesis-periphrasis distinction in the verbal domain. We use the term synthesis to refer to verbal expressions in which the lexical verb bears all the verbal inflection in a clause (e.g. rode in English). In contrast, a periphrastic verbal expression additionally contains an auxiliary verb (specifically, be or have), and verbal inflection is distributed between the lexical verb and the auxiliary (e.g. had ridden). We argue for two crosslinguistic generalizations: AfTonomy and *V-Aux. According to AfTonomy, affixal Ts vary as to whether they are in a head movement relation with a verb. *V-Aux states that in periphrasis, the lexical verb and the auxiliary cannot be related by head movement. Existing analyses of periphrasis can account for one or the other generalization, but not for both. We further argue that this tension between the two generalizations is resolved if we adopt the hypothesis that both head movement and periphrasis are tied to selection. More specifically, we propose that head movement is parasitic on a selectional relation (following Svenonius 1994, Julien 2002, Matushansky 2006, Pietraszko 2017, Preminger 2019) and that auxiliaries are merged as specifiers selected by functional heads such as T (Pietraszko 2017, 2023).
This paper has been prepared by the IFoA’s Collective Defined Contribution (CDC) working party. The purpose is to raise awareness within the actuarial community and pensions industry on the wide range of design options and considerations for CDC solutions, together with a set of principles for the design work, which we believe should apply in most cases. This should also aid understanding of why different designs are better in different circumstances, and why some designs might have certain features that others would avoid.
In the recent case of Ezuame Mannan v Attorney General and Speaker of Parliament,1the Ghanaian Supreme Court in a 5-4 decision struck down the Narcotics Control Commission Act, 2020 (Act 1019), on grounds that the parliamentary processes leading to its enactment were unconstitutional. In arriving at this decision, the court strived to define the limits of Parliament’s legislative powers. While some clarity was achieved, difficult contradictions emerged. Prominent among these was the extent to which the constitutional power of judicial review over legislative actions should interfere with the autonomy of Parliament. In this article, I propose that a proper understanding and application of the purposive approach to interpretation offers an effective tool for reconciling these seemingly conflicting constitutional values.
The aerodynamic performance of an ultra-high aspect ratio strut-braced wing design is assessed for flight at cruise. The sensitivity of a selected airframe design from a recent CleanSky2 project to operating conditions around the design point is quantified using the adaptive-cut high-dimensional model representation (HDMR) method, which allows for the decomposition of the parameter space into smaller subdomains to isolate the parameter interactions and influence on the aerodynamic forces. A comparative analysis with a cantilever wing configuration is performed to identify the role of the strut on the sensitivity of the design. Insight into the transonic performance is gained by characterisation of buffet limits and drag rise. Results show that, for the selected optimised airframe configuration, small changes in freestream parameters can lead to significant reduction in performance due to drag divergence triggered by the shock wave generated at the strut-wing junction and at the fuselage-strut intersection. Cruise conditions can be achieved without buffet onset throughout much of the parameter space. Safety margins associated with buffeting are satisfied, but sensible limits are imposed on the flight envelope for this configuration.
Plant invader genotype determines much about how the plant establishes, spreads, and impacts receiving habitat and the types of management required to achieve its control. We investigated phenology, vegetative spread, growth and biomass allocation, and response to herbicides of four flowering rush (Butomus umbellatus L.) amplified fragment length polymorphism (AFLP) genotypes (triploid: GT1; diploid: GT3, GT4, GT5) in a multiyear mesocosm experiment. Monthly observations were made over 31 mo to determine whether there were differences in timing of peak plant growth and flowering. We also applied herbicides during years 2 and 3 using imazamox or triclopyr at rates previously determined to be efficacious against B. umbellatus. By the end of year 1, all genotypes spread vegetatively within their containers. From a single sprouted axillary bud (i.e., bulbil), GT4 plants spread to cover nearly 2,000 cm2 in 6 mo. Flowering occurred May through October for all genotypes, but was reduced in years 2 and 3, including almost no flowering in triploid plants after year 1. Maximum leaf abundance occurred in August or September for all genotypes. After one season of growth, biomass was greatest for diploid genotypes, allocated primarily to leaves. However, by year 3, triploid plant biomass was greater than diploid GT4 and GT5, but not GT3. Bulbil production occurred only in diploid genotypes. At the study conclusion, GT4 and GT5 produced nearly 15,000 and 20,000 bulbils each, whereas GT3 plants produced fewer than 5,000 bulbils. Herbicides were effective in reducing biomass, but triploid plants were far more susceptible than diploid plants. Propagule production was generally reduced by herbicides, but rhizome bud production increased 240% in triploid plants treated with imazamox. These results demonstrate (1) the significant capacity for reproduction and spread of B. umbellatus and (2) the importance of investigating differences between lineages of B. umbellatus to inform management and risk assessments.
Refugees and forced migrants are particularly susceptible to trauma-related disorders, due exposure to traumatic events before, during or after displacement. In trauma therapy, the concept of psychological stabilization refers to the improvement of a patient’s capacity to manage symptoms and emotions associated with traumatic experiences. While exposure-based therapies are widely recommended for treating posttraumatic stress disorder (PTSD), stabilizing interventions may offer a valuable alternative, particularly given the unique challenges in refugee care. This scoping review aims to provide a comprehensive overview of stabilizing, non exposure-based interventions for traumatized refugees A systematic search identified 31 relevant studies featuring diverse interventions, settings, and outcomes. Most studies showed a significant reduction in PTSD symptoms compared to waitlist (six studies), treatment as usual (three studies) and pre-post analyses (nine studies), though nine studies found no difference between intervention and comparison group. Notably, two studies found the stabilizing approach less effective than the comparison group, and two reported no symptom reduction in pre-post analysis. Heterogenity among the examined interventions as well as living conditions was high and limited the generizability of the results. Further studies should take these environmental factors into consideration.
Research on mortality and admissions for physical health problems across eating disorder diagnoses in representative settings is scarce. Inequalities in these outcomes across a range of sociodemographic characteristics have rarely been investigated.
Aims
We investigated whether people with eating disorders had greater all-cause mortality and physical health-related in-patient admissions compared with those without eating disorders, and whether associations varied by sex, ethnicity, deprivation, age and calendar year at diagnosis.
Method
Using primary care Clinical Research Practice Datalink linked to Hospital Episode Statistics, we matched people with an incident eating disorder diagnosis (any, anorexia nervosa, bulimia nervosa, eating disorders not otherwise specified, generic eating disorder or a referral code) from primary care Read codes to four people without eating disorders (1:4 matching) on year of birth, sex, primary care practice, year of registration and index date. We used univariable and multivariable Cox (mortality) and Poisson (admissions) models, and fitted interactions to investigate whether associations varied by sociodemographic characteristics.
Results
We included 58 735 people (90.1% female, 91.6% White). People with any eating disorders had higher all-cause mortality (hazard ratio: 2.15, 95% CI: 1.73–2.67). Anorexia nervosa had the highest mortality (hazard ratio: 3.49, 95% CI: 2.43–5.01). People with any eating disorders had higher rates of planned (incidence rate ratio (IRR): 1.80, 95% CI: 1.4–1.87) and emergency admissions for physical health problems (IRR: 2.35. 95% CI: 2.35–2.46) and emergency admissions for injuries, accidents and substance misuse (IRR: 5.26, 95% CI: 5.24–5.29). Mortality and admission rate ratios were greater in males.
Conclusions
People with eating disorders have high rates of mortality and physical health-related admissions. Observed inequalities call for an understanding of why such inequalities exist. These findings highlight the need for prompt and effective treatment for eating disorders, and for improved guidance on primary care management of people with eating disorders.
To identify changes in emergency department (ED) use in Houston, TX during the mid-summer Hurricane Beryl-induced power outage to inform future targeted public health interventions.
Methods
Syndromic surveillance system ED visit daily counts for total visits, heat-related illness, carbon monoxide poisoning, acute cardiac condition, stroke, dialysis, and medication refills post-hurricane were statistically compared to the 2 weeks prior and plotted alongside the percentage of the population with power outage.
Results
Daily ED visits post-storm were statistically higher (P< 0.05) than the 2 weeks prior for total visits and acute cardiac events (Day 1, 2); heat-related illness (Day 1-3); dialysis (Day 0-3); and carbon monoxide poisoning and medication refill (Day 1-9).
Conclusions
While 50% of the city experienced power outages from high winds, total ED visits, acute cardiac events, and heat-related illness were statistically higher in the first 3 days after Beryl than expected. Houston developed targeted messaging to mitigate these events in future disasters.
Female genital schistosomiasis (FGS) is a chronic disease manifestation of the waterborne parasitic infection Schistosoma haematobium that affects up to 56 million women and girls, predominantly in sub-Saharan Africa. Starting from early childhood, this stigmatizing gynaecological condition is caused by the presence of Schistosoma eggs and associated toxins within the genital tract. Schistosoma haematobium typically causes debilitating urogenital symptoms, mostly as a consequence of inflammation, which includes bleeding, discharge and lower abdominal pelvic pain. Chronic complications of FGS include adverse sexual and reproductive health and rights outcomes such as infertility, ectopic pregnancy and miscarriage. FGS is associated with prevalent human immunodeficiency virus and may increase the susceptibility of women to high-risk human papillomavirus infection. Across SSA, and even in clinics outside endemic areas, the lack of awareness and available resources among both healthcare professionals and the public means FGS is underreported, misdiagnosed and inadequately treated. Several studies have highlighted research needs and priorities in FGS, including better training, accessible and accurate diagnostic tools, and treatment guidelines. On 6 September, 2024, LifeArc, the Global Schistosomiasis Alliance and partners from the BILGENSA Research Network (Genital Bilharzia in Southern Africa) convened a consultative, collaborative and translational workshop: ‘Female Genital Schistosomiasis: Translational Challenges and Opportunities’. Its ambition was to identify practical solutions that could address these research needs and drive appropriate actions towards progress in tackling FGS. Here, we present the outcomes of that workshop – a series of discrete translational actions to better galvanize the community and research funders.
We live in a time of significant global risk. Some research has focused on understanding systemic sources of this risk, while other research has focused on possible worst-case outcomes. In this article, we bring together these two areas of research and provide a simple conceptual framework that shows how emergent features of the global system contribute to the risk of global catastrophe.
Technical summary
Humanity faces a complex and dangerous global risk landscape, and many different terms and concepts have been used to make sense of it. One broad strand of research characterises how risk emerges within the complex global system, using concepts like systemic risk, Anthropocene risk, synchronous failure, negative social tipping points, and polycrisis. Another focuses on possible worst-case outcomes, using concepts like global catastrophic risk (GCR), existential risk, and extinction risk. Despite their clear relevance to each other, connections between these two strands remain limited. Here, we provide a simple conceptual framework that synthesises these research strands and shows how emergent properties of the global system contribute to the risk of global catastrophic outcomes. In particular, we show that much of GCR stems from the interaction of hazards and vulnerabilities that arise endogenously within the global system, and how ‘systems thinking’ and complex adaptive systems theory can help illuminate this. We also highlight some unique challenges that systemic sources of GCR pose for risk assessment and mitigation, discuss insights for policy, and outline potential paths forward.
Social media summary
The global system is generating global catastrophic risk.
This study examined the variability of language profiles in Spanish–English bilingual children with and without developmental language disorder (DLD). The data included 529 children between the ages of 5 and 10 years. Eighty-eight of these children were identified as having DLD. A latent profile analysis was conducted based on children’s morphosyntax and semantics performance in Spanish and English. The optimal model identified five different profiles, illustrating the heterogeneity in bilingual development. Children with DLD were observed across all profiles, but most were classified in the only two profiles where lower morphosyntax than semantic performance was observed across languages. These results show the variability in both bilingual children with and without DLD. Additionally, the hallmark deficit of DLD in morphosyntax was confirmed, with the morphological weakness being observed in each of the bilingual children’s languages. Children’s background factors (age, maternal education and language exposure) were associated with profile characteristics.
To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults.
Design:
Prospective observational study.
Setting:
611-bed, quaternary care academic medical center in the United States.
Patients:
126 critically ill adults (mean age 68.1 ± 15.6 yr, 51.6% male, median APACHE II score 20.5 [IQR 15–25]); 71.4% met sepsis criteria.
Methods:
Secondary infection was defined as ≥3 consecutive antibiotic days within a year after the index sepsis admission. Multivariate analyses adjusted for age, APACHE II score, BMI, and glucocorticosteroid dose. Time-to-event analysis employed Cox proportional hazards modeling; cumulative infection burden was assessed via nonparametric tests using normalized antibiotic exposure (AD as a proportion of days alive).
Results:
Within 30 days, longer AD correlated with increased hospital stay; each additional antibiotic day added ∼0.93 hospital days (P < 0.001) in adjusted linear regression. AD did not predict one-year mortality (OR 1.01, P = 0.739) or readmission (OR 1.01, P = 0.771). Normalized antibiotic exposure significantly differed by cumulative secondary infection episodes (P = 0.0033), with higher exposure among patients experiencing two or more secondary infections (P = 0.026 and P = 0.036, respectively). Cox regression showed a significant association between AD and time to first secondary infection (HR 1.10, 95% CI: 1.04–1.15, P = 0.001), indicating that longer AD predisposed to secondary infection or recurrent antibiotic use.
Conclusions:
Extended AD, in critically ill patients, prolongs hospitalization without reducing mortality or readmission rates. These findings highlight the importance of robust antibiotic stewardship practices, where shorter, targeted regimens may minimize unintended complications.
This article analyzes structures of feeling among the generation of trauma carriers who grew up under Pinochet’s dictatorship. Drawing on interviews with thirty-seven cultural producers (including filmmakers, novelists, visual artists, and memory activists), we shed light on the generational memory work involved in processing cultural trauma, emphasizing the emotional force behind memory transmission in postconflict societies dealing with legacies of terror. Drawing on Raymond Williams’s notion of structures of feeling, we explore how the generational memory of children during Pinochet’s dictatorship is shaped by melancholic intergenerational identification with past struggles. This intergenerational bond is characterized by melancholic affect in representing the previous generation, which is rooted in experiences of state violence and resistance and plays a key role in processing historical trauma and shaping contemporary social critique in postconflict Chile.