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This paper presents a novel machine learning framework for reconstructing low-order gust-encounter flow field and lift coefficients from sparse, noisy surface pressure measurements. Our study thoroughly investigates the time-varying response of sensors to gust–airfoil interactions, uncovering valuable insights into optimal sensor placement. To address uncertainties in deep learning predictions, we implement probabilistic regression strategies to model both epistemic and aleatoric uncertainties. Epistemic uncertainty, reflecting the model’s confidence in its predictions, is modelled using Monte Carlo dropout – as an approximation to the variational inference in the Bayesian framework – treating the neural network as a stochastic entity. On the other hand, aleatoric uncertainty, arising from noisy input measurements, is captured via learned statistical parameters, and propagate measurement noise through the network into the final predictions. Our results showcase the efficacy of this dual uncertainty quantification strategy in accurately predicting aerodynamic behaviour under extreme conditions while maintaining computational efficiency, underscoring its potential to improve online sensor-based flow estimation in real-world applications.
Study coding is an essential component of the research synthesis process. Data extracted during study coding serve as a direct link between the included studies and the synthesis results, allowing reviewers to justify claims about the findings from a set of related studies. The purpose of this tutorial is to provide authors, particularly those new to research synthesis, with recommendations to develop study coding manuals and forms that result in efficient, high-quality data extraction. Each of the 10 easy-to-follow practices is supported with additional resources, examples, or non-examples to help authors develop high-quality study coding materials. With the increase in publication of meta-analyses in recent years across many disciplines, a primary goal of this article is to enhance the quality of study coding materials that authors develop.
Ultraintense laser–plasma experiments generate a variety of high-energy radiations, including nonlinear inverse Compton scattered (NCS) X-rays, which are expected to be a key experimental observable as we transition into the quantum electrodynamic plasma regime. However, there is also a high bremsstrahlung X-ray background that reduces our ability to observe NCS X-rays. Previous numerical studies comparing NCS and bremsstrahlung emissions fail to capture the full temporal emission of both processes. We present for the first time two-dimensional particle-in-cell (PIC) and three-dimensional hybrid-PIC EPOCH simulations that capture up to 150 ps of the laser–plasma interaction and directly compare the NCS and bremsstrahlung emissions for a plastic target for intensities of ${10}^{20}{-}{10}^{23}$ W/cm2. We present angular distribution plots where the NCS emission is seen to dominate at intensities greater than 5$\times {10}^{21}$ W/cm2 and the target design is seen to successfully divert the bremsstrahlung signal away from the NCS lobe regions, making the experimental observation of nonlinear inverse Compton scattering at lower intensities more likely.
Nonnative earthworm species are invading the boreal forest in North America. Oribatid mites are key detritivores in boreal forest soils, initiating litter decomposition and maintaining forest floor structure. Earthworms are also detritivores and are considered ecosystem engineers. When introduced into nonendemic environments, earthworms may alter soil biogeochemical cycling and adversely affect oribatid mite communities. However, to our knowledge, no field studies in boreal forests have investigated invasive earthworms and their impacts on oribatid mites. The present study was conducted in a boreal trembling aspen, Populus tremuloides Michaux (Salicaceae), stand near Wolf Lake, Alberta, Canada. After assessing the current state of earthworm invasion, we identified an area with a lower density of earthworms that was invaded by one species, Dendrobaena octaedra Savigny (Crassiclitellata: Lumbricidae), and an area with a higher density of earthworms that was invaded by multiple species, D. octaedra (Crassiclitellata: Lumbricidae) and Aporrectodea spp. (Crassiclitellata: Lumbricidae). The higher-density area was associated with lower understorey vegetation species richness and with thinner forest floors characterised by higher bulk density but lower total organic carbon and nitrogen stocks. Oribatid mite community composition differed between the two areas, and their richness significantly decreased with higher earthworm density. Our findings suggest that earthworm invasion is substantially disrupting habitat for oribatid mites and might affect the overall boreal ecosystem equilibrium in the long term.
We examine the convergence of lean hog futures and cash prices, focusing on the thinning of negotiated cash markets. Using daily Livestock Mandatory Reporting data from 2001 to 2024, we confirm significant non-convergence between negotiated and futures prices over the past two decades. Regression results show that as the share of negotiated transactions declines, the absolute basis increases, emphasizing the critical role of negotiated markets in ensuring convergence. These findings highlight concerns about the reliability of negotiated prices as a benchmark for contracts and offer valuable insights for price risk management in the hog industry.
The antibiotic spectrum index (ASI) outcome quantifies antibiotic exposure based on spectrum of activity. Our objective was to examine ASI as an exploratory outcome in the context of a recent stewardship-focused, clinical trial in childhood pneumonia that originally used a binary guideline-concordant outcome.
Design:
Secondary analysis of a randomized clinical trial.
Setting:
Two tertiary pediatric hospitals.
Methods:
Encounters were randomly assigned to clinical decision support (CDS) or usual care treatment arm. The ASI was calculated by summing daily ASI scores for each unique antibiotic administered. It was evaluated as a continuous and ordinal measure: No Antibiotics (ASI = 0), Narrow (1-2), Intermediate (3-4), Broad (5-7), and Very Broad (≥8). Proportional odds regression modeled the ordinal ASI outcome in the first 24 hours by treatment arm and compared to the guideline-concordance outcome. Results were stratified by emergency department (ED) disposition. We also conducted a longitudinal, descriptive analysis of day-to-day ASI for those with in-hospital dispositions.
Results:
We included 1027 encounters, 549 (53%) were randomized to CDS and 478 (47%) usual care respectively. ASI Category did not differ by treatment arm overall (Odds Ratio: 0.88[95% Confidence Interval: 0.70,1.09]), which mirrored binary guideline-concordance. Mean ASI was lower for concordant encounters (2.1 vs 8.4, P < 0.001) and across all ED dispositions. In the longitudinal analysis, there were 1137 day-to-day ASI comparisons, with only 7% representing spectrum escalations.
Conclusions:
The ASI outcome yielded similar results to a dichotomous concordance outcome. However, ASI provided more granular insights into antibiotic prescribing, suggesting ASI may be a useful outcome measure in future stewardship-focused trials.
A wideband harmonic rejection (HR) voltage-domain mixer using resistive scaling is presented featuring excellent linearity and high intermediate frequency (IF) bandwidth. Thin-oxide devices with constant gate-to-source voltages (VGS) are utilized to maximize the switching linearity. A novel switching core topology providing low-impedance IF outputs is proposed to support wideband in-phase (I) and quadrature (Q) mixer outputs when capacitively loaded by an analog-to-digital converter (ADC). Eight LO clock phases, each with a 25% duty cycle, are on-chip generated for quadrature down-conversion and HR. By cleverly activating and organizing the mixer branches, the mixer's input impedance at radio frequency (RF) can be kept perfectly constant throughout all eight clock phases, enhancing the mixer’s linearity. The TSMC 40 nm-CMOS realized mixer reaches 20.9 dBm OIP3 at an IF of 50 MHz with a conversion loss of 22.5 dB. It offers an 800 MHz 3-dB IF bandwidth when connected to a differential capacitive loading of 0.15 pF, with a total power consumption of 40.7 mW drawn from a 1.1 V supply. The mixer targets linear wideband base station observation receiver applications.
In this article, I present a modified reliabilist theory of knowledge which purports to solve many of the problems currently facing standard reliabilism. With the help of a dispositionally construed reliabilist theory of knowledge and justification (DRK and DRJ), tentative responses to the following problems for reliabilism are offered: The New Evil Demon Problem, The Clairvoyance Problem, The Mr. Truetemp Problem, The Gettier Problem, Barn Cases (Brandom’s and Goldman’s), and The Lottery Problem. Lastly, I argue that, despite diverging from the letter of standard reliabilism, DRK and DRJ remain within the spirit of reliabilist epistemology
Academic freedom is founded on two fundamental principles: professional autonomy and the public good. These dual foundations are necessarily in tension with each other. Academic freedom is not a civil right, as is freedom of speech, nor is it an individual employment benefit provided to those in a restricted number of academic appointments. It is, instead, a freedom belonging to the academic profession collectively to pursue inquiry and teach freely, limited and guided by the principles of that profession and of a scholar’s respective disciplines. Academic freedom guarantees both faculty members and students the right to engage in intellectual inquiry and debate without fear of censorship or retaliation. It grants considerable scope to the consciences of individual teachers and researchers, but functions ultimately as the collective freedom of the scholarly community to govern itself in the interest of serving the common good in a democratic society. Academic freedom must protect not only independent research and classroom teaching, but a scholar’s expression as a citizen of both the university and the broader polity. Hence, to thrive, academic freedom depends on a democratic and constitutional system that guarantees the rule of law. Academic freedom has always been contested and vulnerable, to be sure, but in recent years it has faced a series of escalating challenges almost everywhere, amounting to a major crisis. In this context, calls for ‘institutional neutrality’ must be critically examined.
We explored the dynamics of Taylor–Couette flows within square enclosures, focusing primarily on the turbulence regime and vortex behaviour at varying Reynolds numbers. Laboratory experiments were conducted using particle image velocimetry for Reynolds numbers $Re_{\varDelta }\in [0.23, 4.6]\times 10^3$ based on the minimum gap $\varDelta /d = 1/16$, $1/8$ and $1/4$, where $d$ is the cylinder diameter, or $Re\in [1.8, 9.8]\times 10^3$ based on $d/2$. At lower $Re$, the flow was dominated by well-defined Taylor and Görtler vortices, while higher $Re$ led to a turbulent state with distinct motions. Space–time radial velocity analysis revealed persistent Taylor vortices at lower $Re$, with larger gaps but increased turbulence, and irregular motions at higher $Re$, with smaller gaps. Velocity spectra reveal that the energy distribution is maintained at frequencies lower than the integral-type frequency $f_I$ across varying $\varDelta$ due to the dominance of large vortices. However, there is a monotonic increase in energy at higher frequencies beyond $f_I$. The reduced characteristic frequency $f_I\varDelta /\omega _ir_i \sim 1/10$ indicates that these motions scale linearly with angular velocity, and inversely with the gap. Proper orthogonal decomposition (POD) and spectral POD were used to distinguish between Taylor and Görtler vortices, showing the effects of gap size and the associated energy cascade. Linear stability analysis included as complementary support revealed primary instability of the Taylor vortex, which is similar to the circular enclosure, along with multiple corner modes that are unique to the geometry.
In the late 1740s and the 1750s the Jacobite exile James Steuart began to compose the work that became his Principles of Political Oeconomy. This article shows how the political principles of this work were shaped in two contexts neglected by earlier scholars: the networks that shaped Steuart’s formation as a Jacobite, and the debates about absolute monarchy that he encountered in France early during his exile starting in 1746. It demonstrates that Steuart’s vision of an economically active, interventionist state chiefly developed not from German debates about administration, as is often assumed, but from long-running Scottish currents of opposition to British government policy and radical French ideas about how monarchical reform can secure equal rights for all. This article thus uncovers the Jacobite and French origins of Steuart’s variety of interventionism, which troubled Adam Smith, inspired French revolutionaries, and influenced Hegel, Marx, and the broader history of political economy.
The fiduciary conception of political power that the republican tradition adopted in its struggle against absolutism was dissolving during the late eighteenth century and the nineteenth. However, in the mid-nineteenth century, some attempts appeared that represent a reemergence of the fiduciary democratic (or proto-democratic) scheme. One of them was the case of Spanish federalism and its greatest exponent, Francisco Pi y Margall. This article shows that the core of Pimargalian federal republican thought is based on a fiduciary conception of sovereignty, which is grounded in a recovery of the language of revolutionary natural law. By arguing that the fiduciary principle applied not only to his concept of public authority, but also to his comprehensive proposal for the federal reorganization of the state, this article contributes to a better understanding of the specific contribution of Pi’s work and to contemporary discussions on the foundations and scope of republicanism, federalism, and fiduciary relationships.
This study explores early domestic life at the historic Yoruba site of Orile-Owu. Excavations and ethnography reveal insights into diet and food processing, medicinal practices and the daily routines of occupants during the mid-fifteenth to mid-seventeenth centuries AD.
Cultural Property Agreements (CPAs) between the United States and foreign governments help to stop criminal activity at US borders by keeping looted and stolen art and artifacts out of American markets. Under US and international law, the United States can join CPAs to prevent looted and stolen antiquities and artifacts from entering the US art market, thereby fighting the illicit trade while allowing the legal trade to continue and even thrive. Moreover, bilateral agreements aim to lessen global demand for illicitly obtained or looted objects—especially because the United States makes up 42% of the legal global art market—while increasing responsible cultural exchange. The United States has signed CPAs with a growing number of countries around the world—generating mutual respect, strengthening global law enforcement, and protecting archaeological heritage in situ. From its inception, a key priority for the Antiquities Coalition (AC) has been shutting down markets to illicit antiquities, while increasing responsible cultural exchange. This article discusses the importance of barring antiquities traffickers from the multibillion US art market through legislation, international agreements, and executive orders—protecting both American consumers and our world heritage.
Toxoplasmosis, caused by the obligate intracellular parasite Toxoplasma gondii, is one of the most prevalent zoonotic parasitic infections worldwide. When acquired during pregnancy, T. gondii can be transmitted to the fetus, with clinical outcomes influenced by gestational age at time of infection and the parasite’s genotype. Prenatal screening enables the detection of maternal seroconversion and offers a critical window for intervention. In Uruguay, despite mandatory serological screening during pregnancy, national data on T. gondii seroprevalence and maternal seroconversion have not been updated in two decades. In addition, the genetic diversity of local strains remains poorly characterized. In this study, we analysed publicly available serological data from pregnant individuals attending Uruguay’s largest public maternity hospital between 2019 and 2023. We found that seroprevalence has modestly declined from 50% (reported in 1998) to 45.5%, with a congenital transmission rate of 0.58%. Clinical analysis of affected newborns revealed chorioretinitis as the predominant manifestation. To investigate parasite diversity, we performed genotyping of T. gondii strains using in silico PCR-RFLP following molecular detection. Our findings revealed substantial genetic diversity, including novel allele combinations not previously described in the region. These results highlight both the continued public health burden and the evolving genetic landscape of T. gondii in Uruguay. Our findings underscore the need to strengthen surveillance and prevention strategies for congenital toxoplasmosis in South America.
In 2022, a project was initiated to investigate the cemetery at Nowy Chorów, northern Poland, with Orzeszkowo-type (rectangular) burial mounds. During the excavations, both inhumation and cremation graves were uncovered, along with elements of elite grave goods and evidence of the reopening of the graves.
Ceramic smoking pipes are among the most distinctive artifacts recovered from Iroquoian sites dating from AD 1350 to 1650 in what is today New York, Ontario, and Quebec. In this study, we conduct network analyses of pipe forms to examine assemblages of relations among the ancestral and colonial-era Huron-Wendat during a period of coalescence, conflict, and confederacy formation. We bring these networks based on pipe form together with previous network analysis of collar decoration on ceramic vessels to develop insights about the social networks that each artifact type comprises. Our findings indicate that, unlike pottery collar decorations (which are primarily associated with women and reflect highly cohesive social networks), Huron-Wendat smoking pipes (which are more closely associated with men) were less cohesive and reflect the formation of coalitional networks. We interpret these patterns in the context of defensive alliances that formed to provide mutual aid among communities and nations. These differences highlight the distinct social and material domains in which these artifacts operated, offering complementary perspectives on the complex social dynamics that shaped the social and political landscapes of precolonial and early colonial northeastern North America.
Protest event analysis (PEA) is the core method to understand spatial patterns and temporal dynamics of protest. We show how Large Language Models (LLM) can be used to automate the classification of protest events and of political event data more broadly with levels of accuracy comparable to humans, while reducing necessary annotation time by several orders of magnitude. We propose a modular pipeline for the automation of PEA (PAPEA) based on fine-tuned LLMs and provide publicly available models and tools which can be easily adapted and extended. PAPEA enables getting from newspaper articles to PEA datasets with high levels of precision without human intervention. A use case based on a large German news-corpus illustrates the potential of PAPEA.
Psychosocial wellbeing is increasingly recognised as a key outcome in dementia research and care, reflecting a shift towards person-centred care and patient-reported outcome measures. However, progress is hindered by a lack of a clear and consistent definition. The present systematic review aimed to establish how previous dementia research has defined the term and how existing definitions may be unified.
Methods:
A systematic literature review was conducted in PubMed, Embase, and Web of Science using only the term ‘psychosocial’ as well as terms related to dementia in the search string. Two blinded reviewers independently conducted the abstract screening and full-text screening. Definitions used in included records were extracted and their content grouped into categories and domains. For papers presenting empirical findings, quality screening was performed using Critical Appraisal Skills Programme (CASP) checklists and findings were narratively summarised.
Results:
A total of n = 36 records were identified that provided a definition for psychosocial wellbeing. Conceptualizations most commonly (86 %) included emotional wellbeing, social health (64%), behavioural symptoms (44%), and subjective lived wellbeing (42%). A total of n = 23 records also contained empirical data, which indicated that psychosocial wellbeing may be improved by several interventions such as tailored activities and validation group therapies, among others.
Discussion:
The construct of ‘psychosocial wellbeing’ as currently used in dementia research predominantly incorporates emotional and subjective lived wellbeing, social health, and behavioural symptoms. This indicates an emerging consensus. To progress dementia research and care practice, it is essential that future studies use a common operationalisation.
Vitamin A deficiency (VAD) poses significant health risks and is prevalent in children and adolescents in India. This study aimed to determine the effect of seasonal variation and availability of vitamin A-rich (VA-rich) foods on serum retinol in adolescents. Data on serum retinol levels from adolescents (n 2297, mean age 14 years) from the Comprehensive National Nutrition Survey (2016–2018) in India were analysed, with VAD defined as serum retinol < 0·7 µmol/L. Five states were selected based on a comparable under-five mortality rate and the seasonal spread of the data collection period. Dietary data from adolescents and children ≤ 4 years old were used to assess VA-rich food consumption. A linear mixed model framework was employed to analyse the relationship between serum retinol, month of the year and VA-rich food consumption, with a priori ranking to control for multiple hypothesis testing. Consumption of VA-rich foods, particularly fruits and vegetables/roots and tubers, showed seasonal patterns, with higher consumption during summer and monsoon months. Significant associations were found between serum retinol concentrations and age, month of sampling, consumption of VA-rich foods and fish. VAD prevalence was lowest in August, coinciding with higher consumption of VA-rich fruits and foods. Findings highlight the importance of considering seasonality in assessing VAD prevalence and careful interpretation of survey findings. Intentional design, analysis and reporting of surveys to capture seasonal variation is crucial for accurate assessment and interpretation of VAD prevalence, including during monitoring and evaluation of programmes, and to ensure that public health strategies are appropriately informed.