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This article examines Conor Cruise O’Brien’s ideas about historical objectivity and the craft of the historian. Drawing on a mix of published material and unpublished manuscript sources, it charts the evolution of the thinking of a key Irish public intellectual about how historians should write history and how their work should relate to their contemporary world. It identifies several unacknowledged intellectual debts O’Brien owed to influential twentieth-century thinkers — namely, the philosophers Michael Oakeshott and Maurice Merleau-Ponty and the sociologist C. Wright Mills. The article challenges the claim that O’Brien’s view of historiography underwent significant changes in response to the outbreak of violence in Northern Ireland during the late 1960s. On the contrary, it is argued that O’Brien’s thinking on these themes remained fundamentally unchanged from the mid 1950s until the end of his long career as a public intellectual.
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant public health concern, disproportionately affecting socioeconomically disadvantaged populations, including individuals experiencing poverty, homelessness, incarceration, and injection drug use. This scoping review synthesizes existing literature on factors influencing CA-MRSA occurrence and community transmission in these populations. A comprehensive search of PubMed, MEDLINE, and Scopus for studies published between January 2000 and February 2024 identified 3,223 articles, of which 40 met the inclusion criteria. Findings indicate that the CA-MRSA burden remains high, with community transmission influenced by factors, such as limited access to hygiene resources, structural barriers to care, and social network dynamics. Surveillance and intervention strategies remain largely healthcare-focused, with limited data on community-level transmission and risk. This review highlights the urgent need for targeted public health interventions and the adoption of expanded, innovative surveillance methods, such as genomic epidemiology, to better track and mitigate CA-MRSA transmission in vulnerable populations. As antibiotic resistance continues to rise, future research should prioritize longitudinal studies and community-based surveillance to develop effective, population-specific infection prevention, and control strategies.
To evaluate the impact of implementation of a conditional reflex urine culturing strategy on urine culture rates, antimicrobial use, and clinical outcomes in hospitalized adults.
Design:
Pre-post quasi-experimental study.
Setting:
Emergency departments and inpatient units within a large, integrated healthcare system in Northeast Ohio, comprising 10 medical centers.
Patients:
Adult patients with a urine culture ordered from June 1, 2018, to May 31, 2023.
Methods:
A system-wide intervention was implemented on June 1, 2020, requiring urinalysis (UA) with pyuria findings to trigger a urine culture order. We compared urine culture rates, antimicrobial use (measured by days of therapy [DOT] and days of antimicrobial spectrum coverage [DASC]), and clinical outcomes between pre-and post-intervention periods.
Results:
The intervention resulted in an 85.4% reduction in urine culture rates (0.54 vs 3.71 per 100 patient days). Antimicrobial use decreased, with DOT per 100 patient days dropping by 11.5% and DASC/DOT by 16.1%. No significant differences were observed in Clostridioides difficile infection rate, subsequent bloodstream infections with urinary pathogens, or mortality between pre- and post-intervention groups.
Conclusions:
A conditional reflex urine culturing strategy implemented as part of a diagnostic stewardship framework reduced urine culture and antimicrobial use without adverse clinical outcomes. This highlights the potential of diagnostic stewardship to optimize antimicrobial use in hospitalized adults.
Quarries are information-rich anthropic landscapes, but their unique characteristics often limit the effectiveness of traditional archaeological documentation strategies. Here, the authors present a novel interdisciplinary method for the documentation and analysis of these landscapes, focusing on two ancient marble quarries on the Mediterranean island of Naxos. The workflow, combining lidar, photogrammetry, sculptural and architectural study, geoscience, ecological study and archaeological survey, provides a means for the systematic documentation of quarry landscapes in the Mediterranean and beyond, and aims to promote an understanding of premodern extractive activities not as isolated occurrences but as important aspects of interconnected, evolving landscapes.
This study aims to assess the knowledge and determine the level of compliance with human immunodeficiency virus (HIV) post exposure management (PEM) among dentists.
Design:
A descriptive cross-sectional study was done among 114 dentists.
Setting:
Study was done among dentists in two Nigerian tertiary hospitals.
Participants:
All dentists available, who consented to the study during the period of data collection were included in the sample. Three cadres of dentists; house officers, residents and consultants, were involved in the study.
Methods:
Using self-administered questionnaires, information was sought on knowledge of managing exposures-first aid and prophylaxis as well as compliance when exposed. Data was analyzed using the SPSS statistical software.
Results:
Nearly all respondents, 111(97.4%), reported having heard about HIV PEM. Exposure incidents most frequently identified by respondents were needlestick injuries, 111(97.4%). Majority of the dentists recognized practices such as flushing exposed mucous membranes with water, 97(85.1%), and washing skin injuries with soap and water, 75(65.8%), as first aid for exposure incidents, while 20(17.5%) endorsed inappropriate measures like applying bleach to the wound. Seventy-one (62.3%) reported awareness of a HIV PEM protocol in their institution while 39(33.3%) were uncertain, with only 25(21.9%) reporting routine practice of the protocol. Fifty-six (49.1%) of the respondents had experienced an exposure of which only 30(53.6 %) reported and 32(57.1%) requested blood tests for the source patient(s).
Conclusion:
The level of compliance with post exposure management is inadequate, therefore there is a need to update the knowledge and device methods of encouraging compliance with HIV PEM protocol among dentists.
An I.R.B. supreme council member and the I.R.A. 2nd Northern Division commandant, Charlie Daly was executed at Drumboe on 14 March 1923. Daly’s case shows how, through I.R.B. auspices, Free State G.H.Q. planned a joint northern offensive with republicans to avert civil war, while deploying the resources of the new state (and false promises) to engineer the support or at least neutrality of the Northern I.R.A. Eoin O’Duffy and Richard Mulcahy connived to remove Daly from his command because of his opposition to the Treaty, with events coming to a head at the ‘Beggar’s Bush inquiry’ on 2 March 1922. In due course, the Free State elite killed every senior republican brother party to the northern intrigue, including Joe McKelvey and Daly, the latter of whom was shot alongside Seán Larkin from Derry — a witness to GHQ ‘crookedness’ the previous March.
We identify a parsimonious set of factors from a large pool of candidates for explaining hedge fund returns, ranging from equity market, anomaly, and trend-following factors to macroeconomic factors. The resulting 9-factor model, including five anomaly factors, outperforms existing hedge fund models both in sample and out of sample, with a significant reduction in alphas while showing substantial cross sectional performance heterogeneity. Further analysis based on fund holdings confirms the model’s ability to capture returns from arbitrage trading. Overall, the anomaly factors help quantify hedge fund strategies and risk exposures and improve fund performance evaluation.
Vibration control in structures is essential to mitigate undesired dynamic responses, thereby enhancing stability, safety, and performance under varying loading conditions. Mechanical metamaterials have emerged as effective solutions, enabling tailored dynamic properties for vibration attenuation. This study introduces a convolutional autoencoder framework for the inverse design of local resonators embedded in mechanical metamaterials. The model learns from the dynamic behaviour of primary structures coupled with ideal absorbers to predict the geometric parameters of resonators that achieve desired vibration control performance. Unlike conventional approaches requiring full numerical models, the proposed method operates as a data-driven tool, where the target frequency to be mitigated is provided as input, and the model directly outputs the resonator geometry. A large dataset, generated through physics-informed simulations of ideal absorber dynamics, supports training while incorporating both spectral and geometric variability. Within the architecture, the encoder maps input receptance spectra to resonator geometries, while the decoder reconstructs the target receptance response, ensuring dynamic consistency. Once trained, the framework predicts resonator configurations that satisfy predefined frequency targets with high accuracy, enabling efficient design of passive controllers of the syntonized mass type. This study specifically demonstrates the application of the methodology to resonators embedded in wind turbine metastructures, a critical context for mitigating structural vibrations and improving operational efficiency. Results confirm strong agreement between predicted and target responses, underscoring the potential of deep learning techniques to support on-demand inverse design of mechanical metamaterials for smart vibration control in wind energy and related engineering applications.
This forum contribution explores the strengths and limits of Noam Yuran’s innovative call for a new political economy of sex and desire. It has three prongs. First, I discuss Yuran’s compelling focus on the curious durability of monogamy as an institution. Second, I examine his analysis of thinkers such as Mandeville and Weber. Finally, I turn to the question of love. I suggest that Yuran’s approach opens a pathway to a more loving and more realistic political economy of intimacy and familial love, one that I suggest is missing in much critical theory today, particularly in the rhetoric of family abolitionists.
The Great Depression era provides a natural experiment to study the effects of employee stock ownership on productivity due to the unexpected nature of the stock market crash in 1929 and the predetermined expiration of employee stock offerings staggered throughout the 1930s. I collect information on employee stock ownership from reports by the National Industrial Conference Board, annual company reports and other primary sources, and then merge them with the US Census of Manufactures to form the main establishment-level dataset. The results indicate that companies with active programs had significantly lower establishment-level output growth and fewer hours worked per employee than firms with inactive ESOPs post-crash. These negative effects, however, can be mitigated in smaller firms where employees feel their effort level has non-negligible effects. To my knowledge, this is the first study to empirically investigate these early ESOPs as well as address how continuing an employee stock ownership program during a financial crisis affects productivity.
The Parsi Sanskrit Yasna, attributed to Nēryōsangh, presupposes a sophisticated philological system that features historical, religious, and cultural elements. This philological system, developed in a multicultural environment, reflects both the Zoroastrian tradition and contemporary Indian society. Centuries later, Eugène Burnouf effectively utilised the same system to make significant advances in comparative Indo-Iranian studies. This article examines Burnouf’s philological approach and his rediscovery and revival of the original philological system of the Sanskrit Yasna, thanks to a multilingual and multicultural scope that allowed him to understand the text and draw important comparative patterns from it. The article emphasises the importance of multidisciplinary studies to fully explore the historical implications of the philological system, urging us to revisit its methodology in light of current knowledge and technology.
Joseph Raz’s service conception of legitimacy says citizens must obey the state when its directives allow them to comply with reason better than they would by deciding independently. Yet citizens’ capacity to decide for themselves is endogenous to state authority: the more they defer, the less competent they might become. Consequently, a state might secure its legitimacy through a self-fulfilling dynamic whereby citizens need state authority only because they have grown dependent upon it. This article diagnoses the problem and explains how the service conception can guard against it. Besides Raz's account, its argument applies to any theory of legitimacy with a “service” component.
This article explores the theme of the alchemical interpretations of medieval iconography through the life and the writings of Esprit Gobineau de Montluisant (c.1590–between 1652 and 1665). This French alchemist and poet indeed composed a dissertation on some of the ornaments on the main facade of Notre-Dame de Paris, in which he asserted that the sculptures that adorn it conceal alchemical allusions. This curious thesis, written by a practitioner who was in contact with leading political figures of his time, such as the diplomat Léon Bouthilier (1608–52) or the marshal Abraham Fabert d’Esternay (1599–1662), did not emerge from nothing. It is part of an exegetical literature that combines alchemical theories, scriptural allegories, and a sense of heritage for Gothic monuments that were often in disrepair at the time. Far from being anecdotal, Gobineau’s treatise continued to be studied and read over the following centuries by alchemists, writers, art critics and even archaeologists. This influence, albeit discreet, justifies rediscovering his life and his dissertation. It also reminds us of the need to consider works linked to Western esotericism in the study of European cultural and scientific history.
Mass dispersion in oscillatory flows is closely tied to various environmental and biological processes, differing markedly from dispersion in steady flows due to the periodic expansion and contraction of particle patches. In this study, we investigate the Taylor–Aris dispersion of active particles in laminar oscillatory flows between parallel plates. Two complementary approaches are employed: a two-time-variable expansion of the Smoluchowski equation is used to facilitate Aris’ method of moments for the pre-asymptotic dispersion, while the generalised Taylor dispersion theory is extended to capture phase-dependent periodic drift and dispersivity in the long-time asymptotic limit. Applying both frameworks, we find that spherical non-gyrotactic swimmers can exhibit greater or lesser diffusivity than passive solutes in purely oscillatory flows, depending on the oscillation frequency. This behaviour arises primarily from the disruption of cross-streamline migration governed by Jeffery orbits. When a steady component is superimposed, oscillation induces a non-monotonic dual effect on diffusivity. We further examine two well-studied shear-related accumulation mechanisms, arising from gyrotaxis and elongation. Although these accumulation effects are less pronounced than in steady flows due to flow unsteadiness, gyrotactic swimmers respond more strongly to the unsteady shear profile, significantly modifying their drift and dispersivity. This work offers new insights into the dispersion of active particles in oscillatory flows, and also provides a foundation for studying periodic active dispersion beyond the oscillatory flow, such as periodic variations in shape and swimming speed.
Morphological characters are central to phylogenetic inference, especially for fossil taxa for which genomic data are unavailable. While Bayesian methods have gained popularity in recent years, they typically assume characters evolve independently, despite known correlations among characters. Here, we assess the impact of character correlation and evolutionary rate heterogeneity on Bayesian phylogenetic inference using extensive simulations of binary characters evolving under independent and correlated models. We find that Bayesian inference assuming character independence accurately recovers tree topologies even when characters are strongly correlated or evolve under heterogeneous rates. However, branch lengths or clock rates tend to be underestimated, particularly under extreme rate heterogeneity. These biases are partially corrected using models that integrate over character-state heterogeneity. Our results demonstrate that Bayesian methods are robust to violations of character independence in topological inference, supporting their continued use in morphological phylogenetics.
How do citizens evaluate the judiciary in the wake of politically salient rulings? I argue that judicial checks on the government shape citizens’ attitudes about judicial institutions at large, but these effects are driven by instrumental considerations, namely partisanship. In particular, my account suggests that judicial checks – as specific instances of interbranch conflict – provide citizens with instrumental information that shapes their beliefs about the broader judiciary. Thus, I hypothesize that court rulings limiting the government’s power will undermine support for the judiciary among individuals aligned with the incumbent, but increase support among opposition sympathizers. I test these expectations by exploiting the timing of two judicial decisions in Argentina (enacted by a lower court and the Supreme Court) that invalidated a highly salient judicial reform promoted by the government in 2013. Using data from a survey fielded before and after the court rulings, I show that the decisions significantly decreased government supporters’ trust in the judiciary, while opposition supporters increased their trust only following the Supreme Court ruling. Moreover, suggestive evidence provides support for the mechanism proposed by my account – that judicial checks expose citizens to information that is primarily instrumental. This article contributes to our knowledge of the determinants of public support for judicial institutions involved in interbranch conflicts.
After World War II, many countries, including Nigeria, embraced Keynesian “welfarist” policies to stimulate economic growth and enhance the well-being of their citizens. However, in the late 1960s and early 1970s, a global economic crisis prompted a shift towards neoliberalism, leading to the commodification of social institutions and the implementation of policies such as privatization, trade liberalization and deregulation in Nigeria. This shift had a significant impact on Nigeria’s socio-legal economy, particularly in terms of property rights in company ownership. The article raises concerns about the structural injustice and growing inequality resulting from these neoliberal policies. It advocates for a legal framework that addresses these issues and proposes reconceptualizing private property rights in company ownership in Nigeria. This proposed framework aims to counter the dominance and power of property-owning elites and mitigate the structural injustice induced by neoliberal policies in Nigeria.