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Designing complex products increasingly requires integrative methodologies that address the rising challenges of multi-disciplinary complexity and functional inter-dependencies. This article proposes a conceptual design framework that combines the abstractional design method (ADM) with a novel inter-coupling index (ICX) to model and manage inter-component dependencies within cyber-physical vehicle (CPV) systems. The ADM provides a unified object-based representation of system components through functional and attribute abstraction, facilitating shared understanding across disciplines. The ICX quantitatively captures the degree of inter-dependency among system elements, offering a new metric for evaluating design complexity. A case study of a CPV acceleration module demonstrates how indirect coupling and cascading failure risks can be identified and mitigated in the early design process. The methodology supports the decomposition and synthesis of design architectures while preserving functional intent and reducing system vulnerability. This research contributes a transferable and scalable approach to conceptual system design in multi-disciplinary domains.
Do voters want representatives who share their race, ethnicity, or partisanship? We examine this question with a focus on Asian Americans who face trade-offs between descriptive (that is, Asian American or ‘pan-ethnic’) and partisan representation, as well as trade-offs involving ‘co-ethnic’ (for example, Korean for Korean) and ‘cross-ethnic’ (for example, Indian for Korean) descriptive representation. Across two experiments, we find that when Asian Americans are asked about collective representation in Congress, they prioritize more co-ethnic and pan-ethnic legislators over co-partisan legislators. However, in a competitive electoral setting, they often trade off race/ethnicity for partisanship. Asian Americans are only willing to cross party lines to vote for a co-ethnic candidate, but never for a cross- or pan-ethnic candidate. These findings shed light on the importance of considering heterogeneous preferences along ethnicities within the same racial ‘in-group’, such as Asian Americans, a heavily understudied and heterogeneous group in American politics.
Seeking to clarify the parent-offspring transmission of Major Depression (MD) and type I Bipolar Disorder (BD), we examined offspring MD and BD risk in five informative parental pairs: Unaffected x MD, Unaffected x BD, MDxMD, MDxBD and BDxBD.
Methods
We identified 289,637 individuals born in Sweden 1970-1990, followed through 2018, from parents with MD and/or BD identified from Swedish medical registers. We quantified the MD→MD, BD→BD, MD→BD and BD→MD parent-offspring transmission and explored effects of parental illness on MD→BD conversions.
Results
The risk for MD was modestly and similarly increased in offspring of Unaffected x MD (HR=1.64) and Unaffected x BD parents (HR=1.53), higher in MDxMD and MDxBD pairings (HRs=2.39 and 2.47) and slightly lower in BDxBD matings (HR=2.29). By contrast, risk for BD was much higher in Unaffected x BD versus Unaffected x MD matings (HRs = 5.59 vs. 1.70), further elevated modestly in MDxBD matings (HR=6.26) and very high in BDxBD matings (HR=13.61). The rate of offspring MD→BD conversions was substantially increased by parental BD but not parental MD. Offspring BD was equally predicted by paternal and maternal affective illness while offspring MD was more strongly predicted by maternal than paternal affective illness.
Conclusions
Examining risk for MD and BD in offspring of different parental mating types of MD and BD is an informative strategy for further clarifying the cross-generational transmission of these two partially related and partially distinct mood disorders.
The Task Force on Environment, Sustainability and Climate (TFESC) of Academia Europaea investigates ways of enhancing global science policy communication on the topic of food security and sustainability. This Focus reports the initial outcome of this investigation in the form of three articles. First, given the complexity of the link between food security and sustainability, and in particular the two-way relation between the impact of food production on sustainability, on the one side, and of ecological degradation on food security, on the other, we explored the ways in which new Integrated Assessment Models (IAMs) can provide more comprehensive knowledge on the question. Second, even though knowledge and awareness of the link between food security and sustainability have grown, this has by and large not yet translated into significant transformations of attitudes and actions by consumers. In this light, we analysed the implications for communication strategies. Acknowledging the necessity of global coordinated action, third, we analysed the experience of the Intergovernmental Panel on Climate Change, which is often hailed as a model for a global science–policy interface that provides the necessary link between producers of relevant scholarly knowledge and office-holding policymakers. This introduction explains the background to the TFESC investigation and outlines the reasoning in the three following articles.
One of the most pressing regulatory issues of our time is whether, when, and how short selling should be regulated. Short selling facilitates the dissemination of negative information that is otherwise not available to the marketplace, thereby improving market efficiency. However, it may also disrupt market stability, particularly during times of stress. Therefore, regulators seek to regulate this market practice in a balanced manner. This paper examines the Korean short selling regime, the world’s longest ban, instituted following the COVID-19 pandemic. It argues that the regulatory system is run on archaic methods. In particular, our analysis demonstrates that the rules are overly restrictive and complex compared to those in other major jurisdictions. Also, critical decisions are entirely at the government’s discretion, rendering it vulnerable to political interference. Stressing the need for a revamp of the current short selling system, we call for a thorough revision of law and regulations. Market authorities must set out clear standards for regulatory intervention to avoid arbitrary and capricious decisions. In doing so, they can enhance transparency and accountability in law enforcement. Regulators should be aware that it is the most effective way to protect themselves from undue political influences and to restore regulatory trust.
This article examines the emigration of impoverished Azoreans and Madeirans to Rio de Janeiro (Brazil) and the British West Indies (BWI), especially British Guiana, in the nineteenth century, driven by the demand for labour following the prohibition of the slave trade in Brazil and emancipation in the BWI. It explores the shared causes of these migratory flows, migrants’ living and working conditions, and the efforts of Portuguese authorities to distinguish their labourers from other colonized peoples. Drawing on Brazilian and Portuguese archives, as well as secondary sources on the Portuguese in the British West Indies, this transnational study situates Portuguese islanders within the broader labour experiments of the nineteenth century.
Eudaimonism is a richly complex ethical tradition. To distinguish eudaimonism from other ethical approaches and to demonstrate the diversity of eudaimonistic accounts, I outline five key distinctions: (i) form vs. content, (ii) weak vs. strong eudaimonism, (iii) perfectionism vs. non-perfectionism, (iv) intellectualism vs. materialism, and (v) dogmatism vs. non-dogmatism. This analysis escapes the traditional focus on eudaimonism through a predominantly Aristotelian lens. It also offers a rich conceptual framework for understanding the historical development of eudaimonism and the dialogue between ancient, early modern, and modern eudaimonists.
A recently discovered site in southern Mississippi considered early Arikareean based on identified mammals represents the first of this age from the Gulf Coastal Plain outside of Florida. The Jones Branch Local Fauna was recovered from deltaic/estuarine deposits low in the Catahoula Formation resting unconformably on marl/clay beds of the subjacent, upper Rupelian (lower Oligocene), marine Paynes Hammock Formation. In addition to well-preserved plant material plus reptiles, amphibians, and fishes, the mammals are represented primarily by species previously known almost exclusively from the Great Plains, the northern Rocky Mountains (Montana), and/or John Day region, Oregon, with only a few apparently endemic to the Gulf Coastal Plain. Genera representative of the former include the proscalopid Mesoscalops, the sciurid Hesperopetes, the aplodontiid Downsimus, the putative early castoroid Eutypomys, the castorid Microtheriomys, the eomyids Apeomys and Leptodontomys, the florentiamyid Kirkomys, the mustelids Corumictis and Promartes, the tapir Protapirus, the leptochoerid Leptochoerus, the anthracothere Elomeryx, and the hornless ruminants Hypertragulus and ?Leptomeryx. Mesoscalops, Downsimus, and Apeomys are represented by new species. Additionally, a new genus and species of lagomorph is described, Oligolagus welleri, as is a new genus and new species of eomyid, Paraktioeomys palmeri. Known from both regions is the marsupial Herpetotherium, an apatemyid provisionally referred to Sinclairella, and the borophagine Phlaocyon. Gulf Coastal Plain endemics include the protoceratid Prosynthetoceras orthrionanus and apparently Oligolagus n. gen. and Paraktioeomys n. gen. The geographically broadly distributed horse Miohippus, rhinoceros Diceratherium, and giant entelodont Daeodon are also present. Marine mammals are represented by the dugong Crenatosiren olseni and the odontocete Agorophius pygmaeus. Additionally noted are two taxa from stratigraphically lower formations that are not part of the Jones Branch LF. These include a large species of the entelodont Archaeotherium and the anthracothere Elomeryx armatus, both of which were previously unknown along the Gulf Coastal Plain. The long recognized biotic disparity between the Midcontinent and Gulf Coastal Plain by the early Miocene was not yet strongly apparent during the early to middle Oligocene.
Vision impairment disproportionately affects individuals from low-income and African American communities, yet underutilization of preventive eye care persists. We conducted a community-based participatory research (CBPR) study to explore perceptions, values, and barriers related to vision care in an underserved urban neighborhood.
Methods:
In partnership with University Settlement, a trusted community center in Cleveland, Ohio, and a study-specific Community Advisory Board (CAB), we conducted semi-structured interviews with 60 adult residents of the Broadway-Slavic Village neighborhood. Thematic analysis identified key facilitators and barriers to accessing vision care.
Results:
Participants across racial groups described vision as highly important and often endorsed more frequent preventive eye care than they reported receiving. Barriers to eye care utilization included cost, inadequate insurance coverage, transportation challenges, fear of diagnosis, and limited awareness of preventive benefits. Distinct differences emerged in insurance type and visit frequency between African American and White participants despite comparable socioeconomic status. Participants identified community-specific solutions such as free or low-cost exams, mobile clinics, transportation support, and increased education.
Conclusions:
Our findings demonstrate that underutilization of eye care reflects structural and systemic barriers rather than lack of motivation. System-level interventions that integrate screenings into clinical and community settings, streamline referral pathways, and reduce logistical burdens are needed to facilitate equitable access to vision care. Embedding data collection in a trusted community setting surfaced perspectives from individuals who may be absent from clinic-based or online research and provides a model for translational research addressing health disparities.
Organized, competitive wholesale power markets emerged in the U.S. during the 1990s, driven by technological change and regulatory restructuring. Regional Transmission Organizations (RTOs) manage these markets while governing a congestible transmission network whose physical coupling creates ill-defined property rights and persistent coordination problems. The growth of new generations, storage, and digital technologies further strains RTO governance by increasing heterogeneity in participants and business models. Integrating Elinor Ostrom’s common-pool resource (CPR) framework with James Buchanan’s theory of clubs, this paper analyses how RTOs govern reliability through rule-defined exclusion. The analysis argues that reliability is a CPR, but that RTOs formalize a scalable, club-like exclusion regime as a governance institution. Because transmission systems are non-replicable, governance institutions and polycentric oversight must substitute for competitive discipline. Institutional reforms that make boundary rules adaptive and participation more inclusive are essential to preserve reliability while enabling innovation and long-run efficiency.
The South American tomato pinworm, Phthorimaea absoluta, is a major global tomato pest, and its control relies on insecticides. However, P. absoluta has developed resistance to most insecticides, leading to control failure under field conditions. Chlorantraniliprole, a diamide insecticide, has been widely employed in spraying programs. Nevertheless, the current status of chlorantraniliprole resistance in P. absoluta has not been well examined in Türkiye. This study investigated chlorantraniliprole resistance and the associated mechanisms in field populations of P. absoluta. Toxicity assays revealed that P. absoluta developed moderate to high levels of resistance (13.8- to 97.7-fold) to chlorantraniliprole. Biochemical assays showed a significant correlation between cytochrome P450 monooxygenase activity and resistance (R2 = 0.677, P < 0.05). Although no significant association was found between ryanodine receptor (RyR) expression levels and resistance (R2 = 0.145, P < 0.05), several known target-site mutations (I4746M/K and G4903E/V) were identified. Lastly, the P. absoluta RyR (PaRyR) gene sequence was characterised, revealing a 15,633-bp open reading frame encoding 5,121 amino acid residues, with 78% sequence identity to RyR isoforms from other insects. PaRyR was predicted to embrace all the hallmarks of RyR, including a well-conserved C-terminal domain, six transmembrane domains, and a large N-terminal domain. These findings provide insights into chlorantraniliprole resistance mechanisms and will inform future resistance management strategies in P. absoluta.
This article investigates how Central and Eastern European (CEE) cities construct notions of Europeanness and articulate localized European identities through their participation in the European Capital of Culture (ECOC) programme. Focusing on the 17 CEE cities awarded the ECOC title between 2007 and 2028, the article argues that these cities use the ECOC platform not only to reframe their cultural narratives but also to reconcile and strategically re-narrate their communist pasts within a European framework. Employing a post-structuralist discourse analysis, the study identifies two interrelated discursive strategies – unity and diversity – through which cities position themselves in relation to a broader European identity. The findings highlight spatial and temporal variation in how Europeanness is mobilized. This analysis contributes to debates on cultural policy, memory politics, and identity-making in contemporary Europe.
Growing evidence supports early eating to control appetite and energy balance but there are few controlled studies to assess the amount and/or type of breakfast meal. This randomised, within-participant, diet intervention examined the effects of higher-fibre (HF) and higher-protein (HP) breakfasts in adults with overweight/obesity. Nineteen healthy adults consumed two randomised 28-d weight loss (WL) diets, as higher-fibre (HFWL) or higher protein (HPWL), with all food provided. Both WL diets were designed as 45 %, 35 % and 20 % of calories to be consumed in the morning, afternoon and evening, respectively. The primary outcome was energy balance, analysed by body weight changes. The secondary outcomes were gut health (assessed by changes in faecal microbiota composition and microbial metabolite concentrations) and subjective appetite assessed with visual analogue scales. There was a diet effect on WL, with mean loss of −4·87 kg and −3·87 kg for the HFWL and HPWL diets, respectively (P = 0·002). The HPWL diet was superior to the HFWL diet for suppressing subjective appetite (P = 0·003). The faecal microbiota analysis showed beneficial groups of bacteria, including bifidobacteria, and the butyrate producers Faecalibacterium and Roseburia, were significantly increased in proportional abundance on the HFWL diet. Breakfast composition has an important role in influencing subjective appetite with the HP diet promoting greater feelings of satiety. The proportional abundance of putatively beneficial groups of gut microbiota was markedly higher on the fibre-enriched diet, which may be preferable for gut health.
In this study, direct numerical simulation of a turbulent flame–wall interaction (FWI) has been done for premixed H$_2/$air and NH$_3/$H$_2/$air flames in a fully developed channel flow at Re$_\tau$$\approx$ 300. Both isothermal and adiabatic walls are considered. The results contribute to further clarification of the underlying mechanisms of FWIs. First, the underlying mechanism for the rapid increase of chemical flame thickness near the wall is found to be the zero-flux boundary condition for diffusion. Effects of wall heat loss and wall turbulence are minor. Then, a ridge-based flame surface identification method is proposed to track the flame front, which is found to be more accurate than an isosurface of $C$ (the progress variable), especially during FWIs. Using this technique, the near-wall flame geometry and orientation are correctly captured. It is found that the flames are laminarised near the wall and almost parallel to the isothermal wall shortly before quenching. Flame–vortex interactions lead to entrained flame pockets for H$_2$ as a fuel and to a distributed reaction zone for the case of NH$_3/$H$_2$. Finally, the turbulent combustion regime is investigated by checking wall-distance-dependent Reynolds number and Karlovitz number. It is found that the flames enter the laminar flame regime shortly before wall quenching, instead of the broken reaction regime suggested in previous studies. To support the analysis, the turbulent flame dynamics, including turbulent burning rate, turbulent flame surface area, flame stretch factor, local displacement speed, flame dilatation, flame strain rate (both tangential and normal) and flame alignment with the principal strain rate are quantified, providing a full picture of near-wall turbulent flames for the considered conditions.