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Depression affects over 280 million people worldwide. Long-chain n-3 fatty acids may relate to depression, but observational evidence is inconsistent. This cross-sectional analysis of the National Health and Nutrition Examination Survey 2021–2023 examined the association between dietary long-chain n-3 intake and depression severity in USA adults ≥ 18 years with complete dietary, Patient Health Questionnaire-9 (PHQ-9) and covariate data (n 3608). PHQ-9 severity categories (0–4 to 20–27) served as the main outcome. Total n-3 (α-linolenic acid (ALA), EPA, DPA and DHA) from 24-h recalls (Food and Nutrient Database for Dietary Studies 2021–2023) served as the exposure; supplements were excluded, and supplement use was a binary covariate. Survey-weighted ordinal logistic regression (svyolr) was used with all continuous variables centred/scaled (OR per 1 sd). Covariates included age, sex, race/ethnicity (collapsed for sparse cells), income:poverty ratio, BMI, smoking, alcohol, physical activity and n-3 supplement use. Higher total n-3 intake was inversely associated with depression severity (OR 0·865 per 1 sd, 95 % CI 0·761, 0·983, P = 0·026). EPA showed a significant inverse association (OR 0·907, 95 % CI 0·824, 0·998, P = 0·045); ALA, DPA and DHA were NS. No interaction by sex (P = 0·656) or race/ethnicity (P = 0·155). Sensitivity analyses: excluding supplement users (n 3093) OR 0·872 (95 % CI 0·773, 0·984, P = 0·026); two recalls only (n 3229) OR 0·847 (95 % CI 0·751, 0·955, P = 0·007). Dietary n-3 intake, particularly EPA, was modestly and inversely associated with depression severity. Residual confounding and reverse causation remain possible; longitudinal studies with biomarkers are needed.
Debates concerning the roles of sensory perceptions and responses in past societies are increasingly gaining traction in the archaeological discipline, but European medieval archaeology has only recently begun to engage with them. Moving beyond previous approaches in medieval studies that focused on the five physical senses, this article investigates material culture through the conceptual lens of sensory regimes. Drawing on case studies from the sixth to seventeenth centuries and examining diverse archaeological evidence—including artefacts, burial practices and urban environments—the author argues that material culture can facilitate or oppose social, political and religious regimes through sensory practices.
Direct numerical simulations with two-way coupled Lagrangian tracking are carried out to study the bubble preferential concentration and the flow field modification. Simulations are conducted in an upward vertical turbulent channel driven by a constant pressure gradient, corresponding to a friction Reynolds number $Re_{\tau 0}=180$. Micro-sized bubbles with diameters ranging from 0.72 to 1.43 wall units are considered. Competition between lift force and wall-lift force in the wall-normal direction leads to significant near-wall bubble accumulation and directly results in distinct preferential concentration patterns across the channel. Below (above) the peak concentration height, the wall-lift (lift) force dominates, driving bubbles to accumulate in regions of high-speed sweep (low-speed ejection) events. In the vicinity of the wall, the wall-normal lift force exhibits a strong correlation with the local streamwise flow velocity, further reinforcing the preferential concentration of bubbles in high-speed regions. Additionally, bubbles show a strong preference for the low-enstrophy and high-dissipation nodal topologies. Furthermore, small bubbles primarily accumulate in the vicinity of the wall, reducing the work done on the flow and leading to a decrease in bulk velocity and turbulence statistics. In contrast, the turbulence statistics of large bubbles are nearly identical to those of the unladen flow. The impact of large bubbles on the flow field primarily manifests as an effective increase in the mean pressure gradient. These findings demonstrate that bubbles in the upward vertical channel flow exhibit strong preferential concentration behaviours, whereas their ability to modulate turbulence remains limited.
Adam Neumann surely ranks among the most disgraced corporate leaders of our time. The former WeWork founder and CEO, who was ousted from the company in 2019, became emblematic of the corporate excesses and hollow boosterism of post-dotcom Silicon Valley. In the public imagination his name is synonymous with failure and fraud. But to the outrage of many he is back on the scene, securing unprecedented backing from venture capital titan Andreessen Horowitz for his new real estate venture Flow. This essay unpacks the non-death of Adam Neumann, interrogating why someone seemingly so untouchable is being funded at the highest level by one of Silicon Valley’s most infamous VCs. I argue that, through his atypical ‘exiting’ of WeWork, whereby he extracted billions from the company without initial public offering or acquisition, Neumann attained a level of wealth and power that made him ripe for reinvestment. The case challenges the liberal ‘fake-it-till-you-make-it’ myth of Silicon Valley meritocracy. US tech today increasingly takes the form of billionaire VCs funding already-powerful, deceptive and ruthless repeat founders. It is this increasingly consolidated and cynical system that enables Adam Neumann to ‘fail up’; rewarded rather than punished for his extreme misdemeanors.
This paper studies the stabilization properties of time-varying capital requirements in an environment dominated by an oligopolistic banking sector, where banks accumulate capital subject to a leverage adequacy cost. The results indicate that macroprudential policy can stabilize fluctuations in business and credit cycles by controlling the loan rate, thereby influencing the spread within the banking system. A welfare analysis shows that the welfare gains from macroprudential policy depend on the type of shock hitting the economy, and that higher banking competition can amplify these benefits. The findings also highlight that time-varying capital requirements should not substitute for monetary policy, but rather complement it in addressing financial imbalances and adverse sectoral shocks.
This study addressed the prevalence of resilience within specific domains (domain-specific resilience) and across multiple domains (multidomain resilience), as well as the predictive value of resilience for long-term outcomes. Using data from 244 parentally bereaved youth ages 8 – 16 who completed multiple assessments over 15 years in a randomized preventive intervention trial, we examined resilience trajectories across 10 outcomes in five domains on which bereaved youth are at risk, assessed over 14 months. Resilience was defined as low, stable problems or high, stable competencies across assessments; and multidomain resilience as the number of outcomes on which there were resilient trajectories. Results showed that resilience was generally common within specific domains, though its prevalence varied across multiple domains. Multidomain resilience followed a near-normal distribution, with few people having no domain on which they are resilient or being resilient across all domains. Several domain-specific resilience trajectories and multidomain resilience predicted multiple outcomes 15 years after baseline.
In this study, we engage in a deep dive into Black Americans views of the Congressional Black Caucus. We argue that given the goals of the organization, Black people should be the CBC’s strongest supporters. We also anticipate that age will be a major cleavage in support for the CBC among Black people. We test our hypotheses using the 2020 Collaborative Multiracial Post-Election Survey (CMPS). We find that Black people, and older Black people in particular, are the most supportive of the CBC. Moreover, we find that disparities in support among the youngest and oldest Black respondents are greater than the differences between Black and White people in our analysis. We empirically explore the causes of this intergenerational rift and show that younger Black Americans’ lower levels of support for the organization are in part tied to their lower levels of linked fate and their perception that elected officials do not work to advance their interest in government.
Describe the first healthcare-associated outbreak of Candida auris in Maricopa County, Arizona. Also, outline the Maricopa County Department of Public Health (MCDPH) response activities to halt transmission and identify affected healthcare facilities (HCFs) and contacts colonized with C. auris.
Methods:
At HCFs with confirmed C. auris cases (i.e., exposed HCFs), MCDPH provided virtual infection control assessment and response activities, including contact investigations among hospitalized patients and point prevalence surveys (PPSs) to identify ongoing transmission. Confirmed C. auris cases included C. auris detected by cultures or polymerase chain reaction (PCR) in a hospitalized patient. Clinical cases had C. auris from cultures obtained during routine care in a hospitalized patient. Colonized cases included C. auris detected by PCR obtained from hospitalized patients for screening purposes.
Results:
On April 21, 2022, the first clinical case was identified, resulting in an outbreak with C. auris screening at 28 exposed HCFs. In total, 39 clinical C. auris cases were reported. Among 1,994 contacts identified, 899 (45.0%) were screened, 8 (0.4%) declined screening, and 1,087 (54.5%) were ineligible for screening (i.e., no longer hospitalized in Maricopa County). Among screened patients, 158 (17.6%) were colonized with C. auris; 15 (9.5%) colonized contacts later acquired clinical infections. This outbreak concluded on February 23, 2023, after 2 consecutive PPSs yielded no C. auris detection at exposed HCFs.
Conclusions:
The first C. auris outbreak in Maricopa County highlights the coordinated efforts between HCFs, laboratories, and public health to identify exposed HCFs, screen contacts, and halt C. auris transmission.
This paper traces enslaved people’s attempts at staking out liberty in Hamburg and attendant reactions by Hamburg inhabitants and authorities. It argues that in the decades before Hamburg’s anti-slavery laws were passed in 1837, treatment of people of African and Asian descent intersected strongly with ever-stricter alien laws. Based on extensive research in archival sources as well as newspapers and other printed material, the article contains two parts: First, it examines Hamburg’s few existent traces of attempted flights from slavery, pointing to conditions of escape and recapture. Second, the paper links these findings to Hamburg’s legal history leading up to its 1837 anti-slave-trade law, examining alien legislation, poor relief regulations, and domestic workers’ legislation. It also highlights how these policies affected individual lives. In combining legal historical and micro-historical/prosopographical approaches, the paper contributes to studies of Black German history, free soil policies, and questions around the policing of aliens.
Scholars trained in disciplines like anthropology, history, law, political science, and sociology helped to give rise to the field of law and society over the past two generations. What theories does law and society offer those disciplines in return, and are scholars in those fields looking back to law and society? To answer these questions, this article, which introduces a symposium celebrating the 60th anniversary of the Law & Society Review, brings together scholarship across disciplines to share the possible future influence of law and society on the disciplines. This theoretical and forward-looking inquiry invites us all to reflect upon law and society’s contributions over the past two generations and to consider what law and society will contribute to the next generation of interdisciplinary – and disciplinary – scholarship.
Bribery by the pharmaceutical industry is one common manifestation of corruption that can be found in a pharmaceutical system. This study analyzes patterns of bribery in the global pharmaceutical industry through a systematic review of Organisation for Economic Co-operation and Development (OECD) Working Group on Bribery Phase Reports published between 1999 and February 2025. These reports document investigations and enforcement actions related to bribery across jurisdictions. An inductive thematic analysis was used to identify key patterns in cases implicating pharmaceutical firms. We found patterns across many of the cases we studied. For example, bribery was often approved by high-ranking managers. Also, the use of intermediaries and complicated corporate structures to obscure bribes. Multiple cases revealed the involvement of subsidiaries, third-party vendors, or shell companies that processed payments disguised as legitimate transaction. Reported bribes amounted to about US$12.6 million, with sanctions exceeding US$1.1 billion. Government officials, regulatory authorities, and healthcare providers were bribed through cash, gifts, luxury travel, and fraudulent research to gain market access, increase sales, or influence prescribing. These findings underscore the systemic nature of bribery in the pharmaceutical sector and call for stronger oversight and accountability to protect public trust and equitable medicine access.
Community engagement that emphasizes shared leadership is essential in clinical and translational science, and language, naming, and framing have the potential to shape power dynamics. This study explored how renaming and restructuring a Community Advisory Board (CAB) into a Community Leadership Board (CLB) could strengthen a trauma-informed network of care (TINoC) by elevating community power, cultural responsiveness, and equitable participation.
Methods:
Guided by the Trauma and Resilience Informed Research Principles and Practice(TRIRPP) framework, we established a paid CLB in Yolo County, California, composed of six individuals who identified as members of groups underrepresented in science. We reviewed timesheets and TINoC products and conducted an inductive thematic analysis of meeting minutes to determine the CLB’s main areas of influence.
Results:
The CLB met 25 times over two years, provided iterative feedback on more than a dozen educational materials, clinical workflows, trauma-informed trainings, and communication strategies, and co-presented at community meetings. Eight recurring areas of influence were identified: trauma-informed ACE screening, accessibility, workflow feasibility, community- and patient-centered feedback, health communication, participant compensation, engagement, and post-screening navigation. CLB members highlighted gaps not identified by the academic and community members of the TINoC, including translation accuracy, time allowed for ACE screening, and ensuring voluntary patient participation.
Conclusions:
Renaming the CLB as a “leadership” body signaled a shift in accountability, deepened engagement, and underscored how naming practices can drive more equitable translational research. Virtual-only meetings potentially limited the representativeness of the CLB; however, results suggest naming is a critical component of trauma-informed community-engaged research(CEnR).
New challenges and opportunities are emerging to support young people to learn about socio-ecological risk. While experiences with risk are a daily occurrence, a new phase of history defined by global environmental change will transform lives in complex ways. All young people need to be provided with the knowledge and skills to critique the failings of modernity and learn to manage risk. For that reason, environmental pedagogies need to be balanced with critical understandings of risk across different societies. Forest research in Australia, Nepal and Switzerland highlights that understanding local perceptions of value and risk generates vital knowledge to inform conceptions of sustainable forest management, while providing critical knowledge and processes to support active learning. There are opportunities to guide education systems to help people develop understandings of how beautiful, biodiverse, forested landscapes can be managed sustainably within local socio-cultural contexts. Educators can utilise constructivist pedagogies to identify the values and risks of forests with walks, rides, explorations, monitoring, and analysis of different conceptions of sustainable management. In such a manner, learning about socio-ecological risk develops knowledge and skills, but also supports young people to become advocates and actors for positive change in the forest and beyond.
Erroneously labeled penicillin allergies can lead to prolonged hospitalization, increased adverse effects and infection rates with alternative antibiotics. Although elderly patients are more vulnerable to these negative outcomes, penicillin allergy assessments and de-labeling remain underutilized in this population.
Objective:
To assess the efficacy and challenges of implementing penicillin allergy de-labeling in hospitalized elderly patients.
Methods:
Between March 2024 and April 2025, we conducted a quality improvement study on patients who were 65 years and older, had a penicillin allergy, and were admitted to Burnaby Hospital Acute Care for Elderly (ACE) Unit. Patients were proactively screened, interviewed, and assessed for eligibility in allergy de-labeling based on PEN-FAST score ≤1, predefined criteria, clinical judgment, and patient consent. If penicillin challenge was given, patients received pharmacist follow-up and 4-week outcomes were documented. A post-implementation survey was distributed to ward healthcare staff to identify barriers to implementation.
Results:
Out of 105 patients screened, 87 patients met study inclusion criteria. Among 34 patients deemed eligible for de-labeling, 24 patients (71%) were de-labeled from either oral amoxicillin challenge or information gathering alone. Within four weeks after de-labeling, 10 patients (42%) received beta-lactam antibiotics, and no patients received guideline-discordant broad-spectrum antibiotics. Only 1 patient experienced a delayed reaction to amoxicillin-clavulanate. From surveying ACE unit nursing, physician, and pharmacy staff, frequently reported barriers to allergy assessment and de-labeling included time and staffing constraints, and patient complexity.
Conclusions:
Our pharmacy-driven interdisciplinary penicillin allergy de-labeling initiative is effective and safe for eligible hospitalized older adults with low PEN-FAST scores (≤1).
Sexual-identity disparities in substance use among U.S. veterans, and whether mental-health treatment mitigates risk for those with depression, remain under-examined. Using data on veterans from the 2021–2023 National Survey on Drug Use and Health (NSDUH; N = 7,212), disparities were estimated in past-30-day nicotine, marijuana, binge drinking, and polysubstance use, as well as severe psychological distress (K6≥13) and past-year suicidal ideation. Guided by a biosocial/minority-stress framework, multiple imputation was applied (m = 20) and survey-weighted logistic regression adjusting for age, year, race/ethnicity, sex, education, metro status, insurance, marital status, employment, and income; among veterans with a past-year major depressive episode (MDE), interactions were tested between sexual identity and (a) depression-related clinical contact (DRC) and (b) prescription medication for depressive feelings. Bisexual veterans showed the highest prevalence of marijuana (33.5%) and polysubstance use (30.6%), exceeding that of heterosexual (11.8%, 14.9%) and gay/lesbian veterans (24.0%, 18.8%). Models restricted to veterans with MDE, past-year DRC (DRC defined as any visit or conversation with a health professional about depressive feelings) moderated risk for gay/lesbian veterans, with DRC associated with lower odds of binge drinking and polysubstance use; prescription medication showed a similar moderating pattern for nicotine and polysubstance outcomes. Findings for severe psychological distress and suicidal ideation were mixed and consistent with confounding by indication. Results should be interpreted cautiously given the cross-sectional data, self-report, small sexual-minority subgroups, and non-aligned recall windows (past-year mental health/treatment vs past-30-day substance use). Overall, sexual-identity disparities in substance use are evident, with bisexual veterans bearing the greatest burden, and engagement in DRC and medication among veterans with MDE, particularly gay/lesbian veterans, showing associations consistent with a buffering effect of affirming care. Longitudinal and qualitative studies are needed to test causal pathways and to illuminate lived experiences, and policy/clinical efforts should expand culturally competent, integrated services and routine SOGI data collection to monitor and reduce inequities.
This study aimed to investigate leptin (LEP) (G-2548A) and leptin receptor (LEPR) (668A>G) gene polymorphisms in schizophrenia patients with and without suicide attempts, compared to controls.
Methods:
The study included 120 patients with schizophrenia and 130 healthy volunteers. Sociodemographic characteristics, suicidal behavior, and symptom severity were assessed using data collection forms. Gene polymorphisms were analyzed from DNA samples using the polymerase chain reaction–restriction fragment length polymorphism.
Results:
The LEP genotype distribution in schizophrenia patients differed significantly from controls, with the heterozygous GA genotype more frequent in controls (p = 0.026). Within schizophrenia, LEPR genotype distribution differed by suicide attempt history; the heterozygous AG genotype was more frequent in non-attempters (p = 0.048). Logistic regression showed that the LEPR polymorphism (p = 0.023), number of hospitalizations (p = 0.036), and Positive and Negative Syndrome Scale-psychopathology score (p = 0.023) predict suicide attempt history in schizophrenia.
Conclusion:
Our findings suggest that LEP polymorphism may contribute to schizophrenia susceptibility, while LEPR polymorphism may be linked to suicide attempts in schizophrenia.
Exact mathematical expressions are derived to predict the exponent $p$ observed in non-equilibrium turbulence, where the classical dissipation law is replaced by a new dissipation scaling law $C_{\varepsilon } \sim \textit{Re}_{\lambda }^p$. Here, $ \textit{Re}_{\lambda }$ is the Taylor-based Reynolds number and $C_{\varepsilon } = \varepsilon L_{11} / u^{\prime 3}$ is the non-dimensional dissipation rate, defined by the viscous dissipation rate, $\varepsilon$, longitudinal integral scale, $L_{11}$, and root-mean-square of the velocity fluctuations $u^{\prime} = \sqrt {\overline {u^{\prime 2}}}$ (Vassilicos, Annu. Rev. Fluid Mech., vol. 47, 2015, pp. 95–114). Assuming homogeneous and isotropic turbulence, it is shown that the exact value of $p$ involves only first-order derivatives of these variables; however, at very high Reynolds numbers, and under particularly strong changes in the power input of the external forcing (without changing the shape of the forcing spectrum), the exact expression simplifies to $p = 3\pi / 4\alpha L_{110} - 5 / 2$, where $L_{110}$ is the initial value of the longitudinal integral scale and $\alpha$ represents an effective forcing wavenumber. Thus, the main finding is that only large-scale effects are involved in the imposition of the non-equilibrium dissipation scaling law. The results are compared with direct numerical simulation (DNS) results of isotropic turbulence under abruptly changing forcing conditions and with experimental data of non-equilibrium decaying isotropic turbulence, showing consistent results.