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A finite wall-mounted cylinder (FWMC) refers to a cylinder mounted to a flat wall, characterised by flow over its free end and at the wall junction. In the present study, finite wall-mounted harbour seal vibrissal cylinders with different spanwise aspect ratios ($\textit{AR} = L/D$, where $L$ is the length of the cylinder and $D$ is its diameter) are examined at a Reynolds number of $\textit{Re} = 12\,000$ based on the cylinder diameter, with an incoming turbulent boundary layer thickness of $\delta /D = 0.16$. The far-field acoustic spectra of the harbour seal vibrissal FWMCs are broadband for all aspect ratios and effectively suppress the tonal peaks observed in the spectra of circular FWMCs. However, the effectiveness of the suppression mechanism diminishes with decreasing aspect ratio. For the shortest harbour seal vibrissal FWMC ($\textit{AR}= 3.2$), the overall sound pressure level exceeds that of its circular counterpart, and the tonal peak is replaced by broadband noise of comparable magnitude. Spanwise-intermittent recirculation zones and cellular vortex shedding are identified in the near wake of the harbour seal vibrissal FWMCs. For all harbour seal vibrissal FWMCs, as well as for circular FWMCs with $\textit{AR}$ = 6.5, hairpin vortex shedding is observed rather than classical von Kármán vortex shedding. This corresponds to the absence of tonal peaks in the far-field acoustic spectra. Wavy separation lines play a crucial role in the formation of hairpin vortices and in inducing phase differences in vortex shedding in the spanwise direction. Concentrated quadrupole streamwise vortical structures periodically appear along the span in the wake of the longest harbour seal vibrissal FWMC, which diminish with $\textit{AR}$ decreasing to $\textit{AR}$ = 6.5. This concentrated quadrupole arrangement of positive–negative streamwise vortices suppresses the vortex shedding observed along the span of circular FWMCs by disrupting the acoustic-coherent structures into smaller, spanwise-wavy organised elements. It also stabilises the flow and balances transverse ($y$) forces.
Successful surgery for Cushing’s disease (CD) leads to an abrupt change in cortisol levels, and patients often experience symptoms that can adversely affect their quality of life (QOL). The goal of this study was to provide a detailed characterization of the changes in QOL before and after successful surgery.
Methods:
The QOL-CD, a CD-specific questionnaire, was administered at routine clinical visits during active disease prior to surgery and during the early postoperative phase following successful surgery. Descriptive statistics and nonparametric tests characterized clinical, endocrinological, and ophthalmological attributes at both phases. Euclidean hierarchical clustering of the 34 patients who completed both pre- and postoperative questionnaires identified latent subgroups of QOL change.
Results:
In the cohort as a whole, hypertension (OR = 0.31, p = .003), emotional health (p = .026) and physical health (p < .001) improved following treatment. Changes in emotional health were correlated with changes in mental status (r = 0.66, p < .001) and social well-being (r = 0.53, p = .001). The cluster analysis revealed five distinct patterns of pre- to postoperative changes in QOL domains, grouped into three categories based on severity. Group 1 (n = 5) patients showed worsening in most domains of QOL, Group 2 (n = 20) showed marginal changes in QOL and Group 3 (n = 9) demonstrated improvements across all QOL domains.
Conclusions:
Our results highlight the need to educate and support patients before and after surgery for CD. Long-term follow-up studies are needed to better understand the trajectory of QOL recovery and to identify predictors of treatment response.
The Ornaments Rubric of 1549 directs that graduate clergy should wear academic hoods for choir offices, and by the Canons of 1604, the practice was extended to Holy Communion. The Tractarian and Ritualist movements of the nineteenth century led to the publication of ritual books, often noting the influence of Roman Catholicism on liturgical dress and praxis. The Vesture of Ministers Measure of 1964 removed any doctrinal significance in relation to vesture, and the hood effectively became optional. The wearing of the academic hood in church services is discussed in relation to rubrics and canon law from 1549 to the present, with emphasis placed on Anglo-Catholic practice and current societal trends.
Starting from the accounts by the first Jesuit missionaries to arrive in Japan, this article documents their culture shock at witnessing the sexual habits of the country’s upper classes, in particular the clergy and warrior class. It shows how these sexual customs were part and parcel of the samurai construction of virility and of organising their hierarchy. Therefore the missionaries came to face an impossible choice: either accept these customs or fight them on the ground. The result was an instance of ideological warfare that resulted in the departure of the missionaries or their persecution and eventual execution.
If a rectangular object is dipped into a liquid, the contact line normally rises up the surface and dips near the corner, often an undesirable outcome in an industrial dip-coating context. Is it possible to round the corners of the object in such a way that the contact line curve becomes horizontal? We find that just rounding the corner is not sufficient to accomplish this, but by additionally roughening the surface in a prescribed way, one can indeed achieve the desired horizontal contact line.
The Twins Early Development Study (TEDS) is a longitudinal population study of over 10,000 twin pairs born in England and Wales between 1994 and 1996. As the twins enter their thirties, a primary focus of TEDS is to better understand the development of common physical and mental health problems and the relationship with the different social milestones of adulthood (e.g., employment, partnerships, and/or parenthood). With over 30 years of prospectively collected questionnaire and genetic data, the study is uniquely placed to answer questions about the health challenges facing young adults today. Incorporating linked medical records with the existing research data will provide a different data perspective on our twin’s health status and outcomes and support more equitable research by helping to address both response and attrition bias. This article provides an overview of the protocol to link TEDS participants to electronic health records collected by the UK National Health Service (NHS). It will outline the linkage process, characterize the available linked study sample and NHS datasets, and describe the legal basis for this work.
We study the collective behaviour of clusters of cylinders placed in the wake of a fixed cylinder and free to move in a direction perpendicular to that of the incoming flow, with no structural damping or stiffness. We keep the Reynolds number, defined based on the cylinder diameter, at 100 and consider five different configurations for the initial positions of the cluster cylinders: linear, rectangular, V-shaped, triangular and circular. In each configuration, we consider progressively increasing numbers of cylinders in the cluster. We show that overall, the cylinders tend to form final linear configurations, in which, after their transition, the cylinders form one or more lines. Some free-to-move cylinders might take the lead position in some of these linear formations depending on the initial configuration. These steady-state positions are achieved when the mean value of lift that acts on the cylinders becomes negligible. As a byproduct of these reconfigurations, the overall drag force that acts on the collection of cylinders reduces at their final steady-state locations in comparison with their original configurations. The complicated wakes that are observed in the fixed counterparts of these configurations are replaced by a series of vortex rows in the wake of separate lines of cylinders. Reducing the mass ratio allows the cylinders to oscillate about their mean displacement paths, but their transient paths and their final steady-state positions are not affected significantly by the decrease in the mass ratio.
Evaluate the utility of comprehensive neuromonitoring to allow for early identification of arterial ischaemic strokes in high-risk critically ill infants with CHD.
Methods:
Design: Single-center, retrospective review of Pediatric Cardiac Critical Care Consortium registry data, internal cardiac ICU database, and electronic health records. Setting: Tertiary care children’s hospital cardiac ICU. Patients: Patients <6 months old who underwent surgical and/or catheter intervention from 01/01/2016 to 12/31/2022.
Results:
Of 362 patients, 25 were diagnosed with arterial ischaemic strokes. The latter had more complex CHD and underwent higher risk operations: 60% (n = 15) had single ventricle CHD versus 15% (n = 50) of controls (P < 0.001); 88% (n = 22) underwent STAT* 4 or 5 operations versus 32% (n = 108) of controls (P < 0.001). Strokes were identified in 13 patients (52%) because of acute post-procedure neuromonitoring, including head ultrasound (n = 5) and continuous video electroencephalography (n = 8). Strokes manifested clinically in less than half of the episodes (11 of 25), and focal neurologic signs were noted in 20% (5 of 25). A head ultrasound first diagnosed 60% of arterial ischaemic strokes (15/25); 36% (9/25) were diagnosed by head CT, and 4% (1/25) were diagnosed by MRI.
Conclusions:
Comprehensive neuromonitoring in high-risk critically ill CHD patients leads to identification of arterial ischaemic strokes even in the context of significant haemodynamic lability and limited neurological examination secondary to sedation and neuromuscular blockade. Head ultrasound is useful as an initial screening modality, with advanced imaging used to confirm an injury or in cases of high clinical suspicion.
In this paper, we introduce and study a new kind of generalized Hilbert matrix operators, induced by a positive finite Borel measure on $(0,1)$, acting on weighted sequence spaces. We establish a sufficient and necessary condition for the boundedness of these operators. These results extend some related ones obtained recently in [Bull. Lond. Math. Soc. 55(6) (2023), 2598–2610].
The central claim of constitutivism is that there is an inescapable, constitutive aim (or feature) of action that generates and grounds normativity in general, and moral normativity in particular. However, constitutivist accounts often face two significant challenges: the specificity challenge, which argues that any norm-generating aim is too specific to be genuinely inescapable (giving rise to so-called ‘shmagency’ objections), and the vagueness challenge, which contends that any sufficiently general aim fails to generate specific norms. This paper argues that a version of constitutivism that draws on a Hegelian account of willing can overcome both challenges, thereby enabling constitutivism to maintain its viability as a metaethical theory.
Motivated by the understanding of fluid mechanics behind dry eye syndrome during the winter season, we perform the linear and nonlinear stability analysis of the tear film. To reflect the biological structure of the tear film, we model it as a viscoelastic film on a substrate with an insoluble surfactant at the air–film interface, destabilisation by van der Waals forces, variation of viscosity and elasticity along the film height, and impose a substrate-normal temperature gradient. The air–film interface tension is assumed to decrease linearly with temperature and surfactant concentration. To conduct general linear stability analysis (GLSA), we employ the pseudo-spectral method. The GLSA predicts the existence of a longwave thermocapillary-induced instability, which overcomes the stabilisation by the solutocapillary effect due to the surfactant. The elasticity of the film, van der Waals forces and slip at the film–substrate interface contribute to further destabilisation, while a decrease in viscosity along the film height stabilises the film. The longwave instability is the dominant mode of instability. Thus, we derive longwave evolution equations whose linear stability analysis confirms the predictions of GLSA. The nonlinear analysis of the derived evolution equations, carried out using COMSOL 6.2, demonstrates tear-film rupture due to pure thermocapillary instability for sufficiently high thermal Marangoni numbers. In contrast, diseased eyes suffering from lipid layer dysfunction can undergo tear-film rupture at a much lower temperature difference between the ambient air and the cornea. Consideration of a viscosity decrease with increasing film height delays tear film rupture, while van der Waals forces decrease tear film rupture time. The rupture time range predicted by our model is in good agreement with clinical observations, thereby confirming the impact of the winter season on tear film dynamics.
We investigate Taylor–Couette flow with realistic no-slip boundary conditions at all surfaces through direct numerical simulation (DNS) and theoretical analysis. Imposing physically consistent end-wall conditions at the top and bottom lids significantly alters the flow dynamics compared with that for periodic boundary conditions. We extend the classical angular-momentum-flux framework to account for axial transport, thereby extending the Eckhardt–Grossmann–Lohse model (Eckhardt et al. J. Fluid Mech. vol. 581, 2007, pp. 221–250) to no-slip boundary conditions. A systematic exploration of the parameter space $(\textit{Re}, n)$ uncovers multiple long-lived states with different roll number $n$ configurations at identical Reynolds numbers $\textit{Re}$, giving rise to pronounced hysteresis loops occurring under realistic boundary conditions. Our DNS for no-slip axial endcaps reveals a sequence of structural transitions: as the inner-cylinder Reynolds number increases, the flow evolves from Taylor vortex flow through chaotic wavy vortex flow and turbulent wavy vortex flow to an axisymmetric turbulent Taylor vortex flow. Using modal energy budgets, we identify transition mechanisms and quantify how the accessible phase-space volume and associated roll-specific angular momentum flux depend on control parameters and the specific flow state. Our findings demonstrate the impact of realistic boundary conditions on the dynamics in Taylor–Couette flow and how they change the stability landscape of multiple states. The coexistence of distinct flow patterns and their stability analysis offers promising insights into transition dynamics between laminar and turbulent regimes in closed sheared flows.