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We investigate the notion of a semi-retraction between two first-order structures (in typically different signatures) that was introduced by the second author as a link between the Ramsey property and generalized indiscernible sequences. We look at semi-retractions through a new lens establishing transfers of the Ramsey property and finite Ramsey degrees under quite general conditions that are optimal as demonstrated by counterexamples. Finally, we compare semi-retractions to the category theoretic notion of a pre-adjunction.
The article deals with food profiteering in the Bohemian Lands after the declaration of Czechoslovakia in 1918. The new state faced a disintegrated society in which various units continued to fight each other for an advantage in the food market. While food shortages persisted, the Czechoslovak authorities had to deal with a situation in which food rationing laws had lost some of their power to distinguish between the legal and the criminal. Moreover, collective ideas about what was right and wrong, about the victims and perpetrators of food profiteering, and of whom to punish and how, varied according to the different social and ethnic affiliations of the population. Political instrumentalization of such ideas jeopardized the postwar consolidation based on the promise of a better future. Thus, the introduction of food profiteering courts with lay judges was an attempt to institutionalize conflicts over food profiteering and to reduce the impacts of the atomization of society until the economic situation improved.
Cardiac hypertrophy, acting as a pathologic process of chronic hypertension and coronary disease, and its underlying mechanisms still need to be explored. Long non-coding RNA (LncRNA) potassium voltage-gated channel subfamily Q member 1 Transcript 1 (KCNQ1OT1) has been implicated in myocardial infarction. However, its role in cardiac hypertrophy remains reported.
Method:
To explore the regulated effect of lncRNAKCNQ1OT1 and miR-301b in cardiac hypertrophy, gain-and-lose function assays were tested. The expression of lncRNAKCNQ1OT1 and miR-301b were tested by quantitative real time polymerase chain reaction (qRT-PCR). The levels of transcription factor 7 (Tcf7), Proto-oncogene c-myc (c-myc), Brainnatriureticpeptide (BNP) and β-myosin heavy chain (β-MHC) were detected by Western blot. Additionally, luciferase analysis revealed interaction between lncRNAKCNQ1OT1, BNPβ-MHCmiR-301b, and Tcf7.
Result:
LncRNAKCNQ1OT1 overexpression significantly induced cardiac hypertrophy. Furthermore, lncRNAKCNQ1OT1 acts as a sponge for microRNA-301b, which exhibited lower expression in cardiac hypertrophy model, indicating an anti-hypertrophic role. Furthermore, the BNP and β-MHC expression increased, as well as cardiomyocyte surface area, with Ang II treatment, while the effect was repealed by miR-301b. Moreover, the protein expression of Tcf7 was inversely regulated by miR-301b and Antisense miRNA oligonucleotides (AMO)-301b.
Conclusion:
Our study has shown that overexpression of lncRNAKCNQ1OT1 could promote the development of cardiac hypertrophy by regulating miR-301b and Tcf7. Therefore, inhibition of lncRNAKCNQ1OT1 might be a potential therapeutic strategy for cardiac hypertrophy.
An original, empirically rich, and analytically multilayered and provocative statement by Tomila Lankina, The Estate Origins of Democracy in Russia (2022) is a meticulous work of sociology focused on the exploration and elaboration of social mechanisms of resilience in a transforming polity and society. It is also an attempt to link the past, the 19th-century reform of the estate system in Russia, to the present, Russia’s failed democratization, by arguing that the social basis for democracy in postcommunist Russia was associated with the thin stratum of the more privileged, educated, and politically engaged members of the middle class who were able to build on the intergenerational capital and became “the silent custodian of institutions and values that nurtured the democratic promise of post-communism” (391). As such, it is a passionate statement against Soviet historiography that has been influential in shaping the mainstream Western understanding about the socially transformative nature of communism. The book goes against the received wisdom about the degree to which the Soviet society has been modernized and transformed through communist experience: “the narratives of grand revolutionary rupture,” as Lankina phrases it (394). Excavating specific family histories, Lankina shines light “on the ‘tectonic’ layers of skills, values, and occupational complexity” that underlay wealth-supporting strategies along with the pursuit of better education and the acquisition of better-paid jobs in the Soviet Union. The already privileged social groups—the urban and rural meshchane—were better “connected, networked and engaged” and therefore better-equipped “with the skills, tools, and capital” (393). The Soviet regime reincorporated these privileged professional groups into an elite layer (prosloyka) of the Soviet society, commonly known as Soviet intelligentsia.
After the collapse of the Habsburg monarchy, Czechoslovak leaders sought ways to strengthen the state's position in Europe and considered the republic's good reputation as essential to stabilizing the state and securing food supplies. This article analyzes how the Czechoslovak authorities portrayed their country's image and the postwar food shortage, and who participated in its construction. Hunger and scarcity were interpreted as the result of years of deliberate exploitation by Austria-Hungary, and requests for aid were justified on the grounds that a democratic and moral state deserved aid as a matter of priority. Czechoslovak leaders sought to secure a favorable position among the victorious powers by establishing a consistent historical narrative, an elaborate system of publicity, lobbying networks, and personal relationships with Entente officials. They were able to present their country's situation in a positive manner, even in terms of scarcity, and to promise their citizens a better future. This article examines the ways the Czechoslovak state communicated its need for humanitarian aid, particularly from the United States. It argues that the Czechoslovak effort to capitalize on its self-proclaimed moral reputation was partially successful in attracting a circle of supporters, even promoters, and in creating and cultivating its international image as “an island of democracy in Central Europe.”
Studies have shown that genetic factors play an important role in CHD’s development. The mutations in GATA4 and CITED2 genes result in the failure of the heart to develop normally, thereby leading to septal defects. The present study investigated the underlying molecular aetiology of patients with cardiac septation defects from Xinjiang. We investigated variants of the GATA4 and CITED2 gene coding regions in 172 patients with cardiac septation defects by sequencing. Healthy controls (n = 200) were included. Three heterozygous variations (p.V380M, p.P394T, and p.P407Q) of the GATA4 gene were identified in three patients. p.V380M was discovered in a patient with atrial septal defect. p.P394T was noted in a patient with atrial septal defect. p.V380M and p.P407Q of the GATA4 gene were detected in one patient with ventricular septal defect. A novel homozygous variation (p. Sl92G) of the CITED2 gene was found in one patient with ventricular septal defect. Other patients and healthy individuals were normal. The limited prevalence of genetic variations observed in individuals with cardiac septal defects from Xinjiang provides evidence in favour of the hypothesis that CHD is a polygenic hereditary disorder. It is plausible that mutations in the GATA4 and CITED2 genes could potentially underlie the occurrence of idiopathic CHD in affected patients.
In this study, we investigated the conceptual approaches to disability and ageing in two leading social scientific journals (Ageing & Society [AS] and Disability & Society [DS]) of the research fields that form the bases of policies on disability and ageing. This study aimed to identify the journals’ trajectories of conceptual development and their differences, and through that, find possible pathways for further interaction between the yet largely separate policy frameworks for disability and ageing. Our analysis showed considerable differences between the conceptual approaches of the two journals, with the dominant approach in DS being sociomaterial and individual-functional in AS. We conclude this paper by identifying the conceptual gaps in the respective journals, suggesting a further collaboration between the approaches in research as well as policies. These gaps could be potentially narrowed, leading to a constructive dialogue on older disabled people.
There is increasing recognition that Indigenous knowledges have considerable potential to enhance collective understandings of and improve responses to complex ecological threats, such as those to cultural heritage from climate change. At the same time, it appears that Indigenous peoples face structural barriers to participation in international organisations that advance knowledge about those problems. Using the conceptual framework of boundary organisations (BOs) theory and case studies of the Intergovernmental Panel on Climate Change (IPCC) and UNESCO, I argue that the lack of meaningful Indigenous engagement in international knowledge institutions is not just an ethical problem; it also undermines the effectiveness of their assessments. The future success of their boundary work partly depends on further engagement with Indigenous stakeholders. At least at the heritage–climate change nexus, the salience, legitimacy, and credibility of IPCC and UNESCO assessments require substantive Indigenous representation alongside other state/non-state parties. Successful experiences in biodiversity governance indicate that incorporating the principles of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) would enhance Indigenous engagement in UNESCO and the IPCC.
Georgia lies to the northeast of Türkiye, having a western border on the Black Sea. With a population of some 3·73 million, Georgia has a tradition of gastronomic excellence dating back millennia. However, changing lifestyles and external influences have, as elsewhere, led to problems of suboptimal nutrition, and lifestyle-related diseases and disorders prevail. There is considerable scope for improving the focus on public health (PH) and nutrition in Georgia. With this in mind, the Georgian Nutrition Society teamed up with The Nutrition Society of the UK and Ireland and the Sabri Ülker Foundation, a PH charity based in Istanbul, Türkiye, to host a conference and workshops in Tbilisi, Georgia. The primary purpose was to review the current status of PH and nutrition in Georgia with reference to the situation elsewhere, to share examples of best practice and to identify opportunities for improvement. A particular highlight was the presentation of a programme of nutrition education for family physicians recently implemented in Türkiye. This summary of the proceedings is intended as a blueprint for action in Georgia and also to inspire others to consider how PH might be improved via a focus on balanced nutrition.
Indonesia is located within the Asia-Pacific Ring of Fire, so natural disasters such as earthquakes, tsunamis, volcanic eruptions, floods, and landslides are common. Preparedness is essential to prevent many casualties due to various disasters.
Problem:
The Aceh, Indonesia earthquake and tsunami in 2004 was one of the most devastating disasters since the 1990s. Some of the victims were children. This is because there was no pattern of preparedness in dealing with disasters when the incident took place; even the word tsunami was not familiar in Indonesia at that time. Thus, the preparation of a disaster preparedness and safety curriculum began to be implemented in Indonesia after the Aceh earthquake and tsunami.
Conclusion:
The disaster preparedness and safety curriculum in early childhood education is developed in accordance with the potential and characteristics of the school area. Basic disaster material provided concepts, characteristics and threats, maps, ways of overcoming, and disaster preparedness and security. Facilities and infrastructure supporting disaster preparedness learning used disaster puzzles, disaster posters, songs about disasters, and prayers asking God for help to be protected from disasters.
Behavioural treatments are recommended first-line for insomnia, but long-term benzodiazepine receptor agonist (BZRA) use remains common and engaging patients in a deprescribing consultation is challenging. Few deprescribing interventions directly target patients. Prescribers’ support of patient-targeted interventions may facilitate their uptake. Recently assessed in the Your Answers When Needing Sleep in New Brunswick (YAWNS NB) study, Sleepwell (mysleepwell.ca) was developed as a direct-to-patient behaviour change intervention promoting BZRA deprescribing and non-pharmacological insomnia management. BZRA prescribers of YAWNS NB participants were invited to complete an online survey assessing the acceptability of Sleepwell as a direct-to-patient intervention. The survey was developed using the seven construct components of the theoretical framework of acceptability (TFA) framework. Respondents (40/250, 17.2%) indicated high acceptability, with positive responses per TFA construct averaging 32.3/40 (80.7%). Perceived as an ethical, credible, and useful tool, Sleepwell also promoted prescriber–patient BZRA deprescribing engagements (11/19, 58%). Prescribers were accepting of Sleepwell and supported its application as a direct-to-patient intervention.
Contrast-induced encephalopathy (CIE) is an adverse event associated with diagnostic and therapeutic endovascular procedures. Decades of animal and human research support a mechanistic role for pathological blood-brain barrier dysfunction (BBBd). Here, we describe an institutional case series and review the literature supporting a mechanistic role for BBBd in CIE.
Methods:
A literature review was conducted by searching MEDLINE, Web of Science, Embase, CINAHL and Cochrane databases from inception to January 31, 2022. We searched our institutional neurovascular database for cases of CIE following endovascular treatment of cerebrovascular disease during a 6-month period. Informed consent was obtained in all cases.
Results:
Review of the literature revealed risk factors for BBBd and CIE, including microvascular disease, pathological neuroinflammation, severe procedural hypertension, iodinated contrast load and altered cerebral blood flow dynamics. In our institutional series, 6 of 52 (11.5%) of patients undergoing therapeutic neuroendovascular procedures developed CIE during the study period. Four patients were treated for ischemic stroke and two patients for recurrent cerebral aneurysms. Mechanical stenting or thrombectomy were utilized in all cases.
Conclusion:
In this institutional case series and literature review of animal and human data, we identified numerous shared risk factors for CIE and BBBd, including microvascular disease, increased procedure length, large contrast volumes, severe intraoperative hypertension and use of mechanical devices that may induce iatrogenic endothelial injury.
On January 17, 2023, the Grand Chamber of the Court of Justice of the European Union (CJEU) delivered its judgments in case C-632/20, P Spain v. Commission (Kosovo), ruling that notwithstanding the European Union's non-recognition of Kosovo as a state, Kosovo may participate in an EU agency, namely the Body of European Regulators for Electronic Communications (BEREC). The judgment is significant for several reasons: (1) for the European Union's growing engagement with non-recognized territorial entities since it clarifies the meaning of the concept of “third country” and confirms that such entities may participate in EU agencies; (2) for the European Union's engagement with Kosovo—particularly in the light of Kosovo's 2022 bid for EU membership; and (3) more broadly, in the context of the burgeoning debate regarding the CJEU's approach to international law.
Charmarite, Mn4Al2(OH)12CO3⋅3H2O, is a hydrotalcite supergroup member (or layered double hydroxide, LDH) with a previously unknown crystal structure and a Mn2+-analogue of quintinite (commonly erroneously reported as ‘2:1 hydrotalcite’). The single-crystal X-ray diffraction (XRD) data were obtained from the specimen from Mont Saint-Hilaire, Québec, Canada and are best processed in the space group P$\bar{3}$, a = 10.9630(4), c = 15.0732(5) Å and V = 1568.89(12) Å3. The crystal structure has been solved by direct methods and refined to R1 = 0.0750 for 3801 unique reflections with Fo > 2σ(Fo). The charmarite structure has long-range periodicity in the xy plane due to $2\sqrt 3$a’ × $2\sqrt 3$a’ scheme (or 11 × 11 Å) determined for LDHs for the first time (where a’ is a subcell parameter ≈ 3.2 Å). This periodicity is produced by the combination of two superstructures formed by: (1) Mn2+ and Al3+ ordering in the metal-hydroxide layers [Mn4Al2(OH)12]2+ according to the $\sqrt 3$a’ × $\sqrt 3$a’ pattern and (2) the (CO3)2– ordering according to the 2a’ × 2a’ pattern in the [CO3(H2O)3]2– interlayer sheet in order to avoid close contacts between adjacent carbonate groups. The $2\sqrt 3$a’ × $2\sqrt 3$a’ superstructure is an example of the adaptability of the components of the interlayer space to the charge distribution of the metal-hydroxyl layers. The Mn2+ and Al3+ cations have a large difference in size, which apparently leads to the considerable degree of their order as di- and trivalent cations resulting in a higher degree of statistical order of the interlayer components. Both powder and single-crystal XRD data show that the samples studied belong to the hexagonal branch of two-layer polytypes (2T or 2H) with d00n ≈ 7.57 Å. The chemical composition of the samples studied is close to the ideal formula. The Raman spectrum of charmarite is reported and the band assignment is provided.
The descriptions of two co-occurring cardioid crustaceans from the Ballagan Formation (Tournaisian, Lower Carboniferous) of Chirnside, Scottish Borders, help to resolve the taxonomy of the genus Tealliocaris. Tealliocaris robusta Peach, 1908 is assigned to Schramocaris to form S. robusta (Peach, 1908) comb. nov. on the basis of morphological characters such as the rugosity and position of the branchial carinae as well as the nature of the pleon, and becomes the earliest representative of this genus in Scotland. A new species of Tealliocaris is also recognised from this locality and is described as T. briggsi sp. nov., based on the smooth carapace, lack of pleonic grooves and the number of spines on the scaphocerite and lateral margin of the anterior carapace. The systematic position of the Pendleian specimens identified by Peach (1908) as ‘Tealliocaris robusta var.’ is finally resolved and described as T. weegie sp. nov.
In this note, we establish a boundary maximum principle for a class of stationary pairs of varifolds satisfying a fixed contact angle condition in any compact Riemannian manifold with smooth boundary.
To examine the prospective association between purpose in life measured at three points across middle and older adulthood and cognitive outcomes assessed 8–28 years later.
Design:
Prospective Study.
Setting:
Wisconsin Longitudinal Study of Aging (WLS).
Participants:
WLS participants who reported on their purpose in life at Round 4 (1992–1994; Mage = 52.58), Round 5 (2003–2007; Mage = 63.74), and/or Round 6 (2010–2012; Mage = 70.25) and were administered a cognitive battery at Round 7 (2020; Mage = 79.94) were included in the analysis (N = 4,632).
Measurements:
Participants completed the Ryff measure of purpose in life and were administered the telephone interview for cognitive status and measures of verbal fluency, digit ordering, and numeric reasoning.
Results:
Purpose in life measured at age 52 was related to better global cognitive function and verbal fluency but unrelated to dementia at age 80. In contrast, purpose in life at ages 63–70 was associated with lower likelihood of dementia, as well as better global cognitive function and verbal fluency at age 80. The effect sizes were modest (median Beta coefficient = .05; median odds ratio = .85). A slightly steeper decline in purpose in life between ages 52 and 70 was found for individuals with dementia at age 80.
Conclusions:
Purpose in life is associated with healthier cognitive function measured up to 28 years later. Individuals with lower purpose, especially in their 60s or older, and with steeper declines in purpose, are more likely to have dementia at age 80.
This essay employs the anthropological notion of female social agency to analyse a selection of case studies in the art history of the late Byzantine Empire. They concern three women – Nicoletta Grioni, Isabelle de Lusignan, and Maria d'Enghien-Brienne – who lived between the mid- to late fourteenth century and the first half of the fifteenth. All three were part of a Greek-Latin Mediterranean socio-cultural context. While their stories are not fully represented in textual primary sources, the present essay examines a selection of heterogeneous visual and cultural materials that help to reinstate their role in history and overcome the male-logocentric nature of the written evidence related to them.