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I argue for a hybrid analysis of English numeratives that (i) treats the extended basic numeratives (0–99) as lexemes but (ii) analyzes larger expressions as syntactic phrases or coordinations with magnitudes (hundred, thousand, million, …) as heads and factors (two hundred, forty-two million, …) as (obligatory) modifiers. A number of independent diagnostics – including ordinal/fractional morphology, prosodic phrasing and ellipsis/coordination – converge on the existence of a constituent containing all preceding material up to the rightmost base; this directly contradicts the cascading NumP + NP-deletion architecture of Ionin & Matushansky (2006, 2018) when applied to English. The analysis preserves the category assignments of The Cambridge Grammar of the English Language – cardinals as determinatives and nouns, ordinals as adjectives, fractionals as nouns – and refines the functional picture: (i) multiplicative factors (one hundred) function as modifiers, never as determiners or complements, and (ii) additions (one hundred and two) are coordinates in a coordination. The resulting determinative category is a small closed list, not an open-ended stock of ‘numeral lexemes’. Cardinal nouns split in two: proper when they name, common when they count – a division borne out by distributional diagnostics. The result is a more complete, empirically tighter, morphosyntax-sensitive account of English numeratives that explains why English is lexical below 100 but demands overt syntax above it.
We report an experimental study on the effects of polymer additives in the dissipative-scale flow field properties in turbulent Rayleigh–Bénard convection. The experiments were conducted in a cylindrical convection cell with a minute amount of polyacrylamide long-chain polymer. The local velocity gradient tensor was measured using an integrated home-made measurement system (J. Fluid Mech., 2024, vol. 984, p. A8). Although the single-roll large-scale circulation persists (owing to the slight tilt of the convection cell), polymers induce an anisotropic suppression of the dissipative-scale flow properties. The normal velocity gradient components are suppressed more than the shear components. The mean energy dissipation rate in both centre and side regions decreases, then levels off with increasing polymer concentration and the final reduction ratio exceeds 50 % in each region. In the side region, adding polymers has a stronger stabilising effect on the strain rate than the rotation. The anisotropic suppression of the velocity gradient tensor affects dissipation-rotation co-occurrence probability, velocity gradient triple decomposition and local streamline topology. Adding polymers also induces a deceleration effect and increases the contribution of local buoyancy in driving the flow. These results reveal that the addition of polymers can non-trivially manipulate dissipative-scale turbulence fields and energy cascades.
This research presents the design and development of a microwave sensor capable of detecting and distinguishing hydroxylated organic compounds (HOCs), namely water, methanol, ethanol, and propanol. The work analyzes the physical mechanisms that govern the sensitivity and detectability of these liquids in the microwave range. Differences in sensor response are linked to variations in molecular characteristics such as dipole moment, microwave absorption, and refractive index. Unlike approaches that rely solely on experimentation, this study connects microwave behavior to fundamental molecular properties, enabling a predictive, physics-based understanding of HOC detection. Molecular polarization and relaxation models were combined with experimental observations to explain how these compounds interact with microwave fields. A metamaterial-based sensing cell was designed, simulated, and experimentally validated. Results demonstrate that the sensor effectively identifies hydroxyl compounds with high sensitivity. Water produced the highest resonance-frequency shift (0.76 GHz), followed by methanol (0.7 GHz), while ethanol and propanol showed similar shifts around 0.35–0.37 GHz. Propanol achieved a quality factor of 10.82 in the 12–17 GHz range. The sensor also reached a frequency detection resolution of 6.75 MHz and showed strong amplitude sensitivity, highest for water at 10.66 dB.
Predicting unsteady loads on plate-like objects during unsteady motion is important in many applications, such as ship manoeuvring, flight and biological propulsion. The drag force on a starting plate that moves normal to its surface can be severely underestimated during the acceleration phase when conventional methods are used to incorporate the effects of acceleration. These methods often introduce an inviscid added mass force that has its origin in potential flow. However, the flow field around a starting plate quickly diverges from potential flow after the start of the motion due to the continuous creation of vorticity at the plate surface. Following the concept of drag by Burgers (1921 Proc. K. Ned. Akad. Wet. 23, 774–782), we propose a model to predict the creation of vorticity on the plate surface and its advection into the vortex loop at the plate edges, based on Stokes’ first problem. This model shows that the acceleration drag force is a history force, in contrast to the inviscid added mass force that is proportional to the instantaneous acceleration of the plate. We perform experiments on starting plates over a large range of accelerations, velocities, fluid viscosities and plate geometries for which the model gives accurate predictions for the drag force during acceleration and during the relaxation phase immediately after the acceleration ceases. This model is extended to also predict the drag forces on accelerating plates during a starting motion with a non-constant acceleration.
Studies have linked lower birth weight to development of radiographic osteoarthritis (OA). We examined early life factors in relation to subsequent knee pain among individuals with radiographic OA. 143 participants from the UK Hertfordshire Cohort study were included. Birth weight and weight at one year (WA1) were ascertained from health ledgers and used to derive conditional infant weight gain (CIWG). At baseline and follow-up, heath questionnaires (including knee pain) and knee radiographs were collected. Only those with radiographic knee OA at baseline were analysed. Logistic regression was used to examine early life factors in relation to pain. Pain at follow-up was common (men 41.3%, women 50%). Greater WA1 and greater CIWG were related to reduced risk of knee pain at follow-up after adjustment for sex and follow-up time. CIWG was protective against knee pain at follow-up, with this association attenuated after adjustment for follow-up osteophyte score. Validation in larger studies is required.
Late-phase graft incompatibility and subsequent yield reduction pose significant threats to sustainable nutmeg (Myristica fragrans) production in India, primarily due to the widespread use of wild Myristica species as rootstocks. Accurate rootstock authentication at the seedling stage is critical to prevent these long-term losses, but current methodologies are insufficient. This study develops novel chloroplast DNA (cpDNA)-based markers for species authentication and phylogenetic analysis in Myristica. Utilizing a comparative chloroplast genomics approach, we identified hypervariable regions to create robust sequence length polymorphism markers. Marker validation across 33 diverse Myristica accessions, including all major Indian cultivated germplasm, revealed a unique 25 bp deletion in the ycf4-cemA region. This deletion serves as a highly reliable diagnostic marker to differentiate cultivated nutmeg from wild rootstock species. The validated markers were successfully used to authenticate rootstocks in both commercial nurseries and established plantations, offering a critical tool to prevent long-term graft incompatibility. Intraspecific variation within M. fragrans cultivars was observed in the rpoB_trnC-GCA, trnS-UGA_psbZ and trnR-ACG_rrn5S intergenic spacer regions. UPGMA clustering distinctly separated the Myristica accessions into three discrete phylogenetic groups. Beyond rootstock management, the identified M. fragrans-specific marker can reliably authenticate nutmeg in commercial products, distinguishing it from potential adulterants like M. magnifica and M. andamanica. Furthermore, we report a species-specific marker for the endemic and IUCN red-listed vulnerable species, M. andamanica, which will be invaluable for its precise identification and conservation efforts. Our research provides an invaluable, easy-to-use toolkit for Myristica germplasm management, breeding programs and quality control of nutmeg products.
Dynamics of spheroidal particle migration within the elasto-inertial square duct flow of Giesekus viscoelastic fluids were studied by using the direct forcing/fictitious domain method. The results show rich migration behaviours, a spheroidal particle gradually transitions from the corner (CO), channel centreline (CC), inertial rotational (IR), diagonal line and cross-section midline equilibrium positions with a decrease in the elastic number, depending on the initial particle position, initial particle orientation and fluid elasticity. From the effect of secondary flow, the IR equilibrium position is reported when the fluid inertia is relatively strong. Six (five) kinds of rotational behaviours are observed for the elasto-inertial migration of prolate (oblate) spheroids. Moreover, the critical elastic number is determined for the migration of spheroidal particles in Giesekus fluids. Near the critical elastic number, oblate and prolate spheroids can simultaneously maintain the CC, CO and IR equilibrium positions, and the initial orientation of particles affects their final rotational modes and equilibrium positions. Through comprehensive analysis, empirical formulas governing the ability of oblate and prolate spheroids to maintain the CC equilibrium position are proposed as $\textit{Wi} = 0.055\,\textit{Re}{-0.1}$ and Wi = 0.045 Re−0.35 when n = 0.5, 0.01 ≤ Wi ≤ 1. Due to the different directions of the pressure forces acting on the particles and the forces from the first normal stress difference and the second normal stress difference, the equilibrium position in Giesekus fluids is rapidly increased by increasing the secondary flow at higher elastic numbers, which is contrary to the phenomenon observed in the Oldroyd-B fluid.
Exercise capacity (VO2peak) predicts mortality in adult patients with CHD. There is a lack of paediatric exercise capacity data based on specific CHD lesions, limiting the ability to contextualise interpretation based on expected performance during testing. The primary aim of this study was to establish VO2peak percentiles for paediatric patients with repaired CHD undergoing treadmill-based cardiopulmonary exercise testing (CPET).
Methods:
Retrospective analysis of CPET data from 2004 to 2022. CPETs were analysed for patients with CHD aged 6–18 years. Patients with repaired CHD were categorised based on their most haemodynamically significant CHD lesion. Percentiles and age-based trends were plotted for each group.
Results:
A total of 887 patients were included. CHD patients were divided into ten diagnostic subgroups. The mean percent expected VO2peak for each of the subgroups were as follows: Atrial and ventricular septal defect (94.5 ± 25.1%), pulmonary valve repair (88.1 ± 18.4%), aortic valve repair (92.7 ± 16.4%), tricuspid and mitral valve repair (81.3 ± 20.4%), coarctation of the aorta (93.6 ± 18.8%), transposition of the great arteries (90.5 ± 19.4%), double outlet right ventricle and truncus arteriosus (80.5 ± 16.2%), tetralogy of Fallot (85.6 ± 20.9%), left ventricle dominant Fontan (74.7 ± 18.3%), and right ventricle dominant Fontan (75.7 ± 16.7%).
Conclusion:
There is a varying degree of reduced exercise capacity in paediatric patients with repaired CHD. Univentricular hearts and tricuspid and mitral valve repair have the lowest VO2peak. These CHD-specific percentiles may help providers risk-stratify and counsel patients with CHD.
Switching is one of three primary executive functions alongside inhibitory control and updating but remains relatively understudied in childhood attention-deficit/hyperactivity disorder (ADHD) compared to investigations into working memory and inhibitory control deficits. Where extant literature in adults suggests that switch costs are due to a combination of task set inertia and task set reconfiguration costs, it is not clear which of these is most relevant to explaining ADHD-related atypicalities in performance.
Methods:
Children with (N = 34) and without ADHD (N = 28) aged 8–12 (average age = 9.45) completed a 192-trial computerized cued switching paradigm. Diffusion model decomposition of the data was performed to identify cognitive subprocesses responsible for the switch.
Results:
Consistent with the switching literature in adults, switch costs for children were due to a combination of both task set inertia (reduced drift rate) as well as slower task set reconfiguration (Ter) on switch versus repeat trials. Children with ADHD were less accurate than non-ADHD controls, but the ADHD × Switch interactions were not significant for any variable, indicating that the deficit was general and not switch-specific. Lower accuracy was in turn attributed to slower general drift rate among children with ADHD.
Conclusions:
This study contributes to a growing literature finding that the performance deficits in children with ADHD across executive and non-executive function tasks are related to lower-level perceptual decision-making weaknesses that have downstream effects on higher-order processing.
Digital technologies provide a convenient and scalable approach to dietary assessment and personalised feedback, facilitating behaviour change. This is essential for reducing the prevalence of non-communicable diseases at a population level. However, the evaluation of the acceptability and feasibility of dietary feedback delivered via online platforms has not been thoroughly investigated. By utilising the term ‘system architecture’ to describe the essential components of the digital approach to capturing dietary feedback, this systematic review outlines the platform, dietary assessment methodology, reference values for assessing dietary intake and elements of personalised dietary feedback. When reported, the acceptability and feasibility of personalised feedback were captured. OVID Medline, OVID Embase, Scopus via Elsevier and Cinahl Plus via EBSCO identified 5839 studies. Search terms included dietary assessment, feedback and digital technologies. In total, twenty-eight studies involving 301 271 participants were included. Food frequency questionnaires were the most commonly used dietary assessment method, accessed via web-based platforms. Dietary intake was commonly assessed using a diet quality index, and feedback was provided on food groups, often combined with a diet quality score or macronutrient analysis. While participant acceptance of personalised dietary feedback was generally high, the overall completion rates for acceptability questionnaires were low, and feasibility was seldom reported. Methods used to measure acceptability and feasibility varied, preventing comparisons across studies. Study quality was high; however, future research would benefit from the involvement of stakeholders and end-users in designing feedback messages.
Rough walls are commonly encountered in engineering applications. However, existing understanding of combustion in the turbulent boundary layer over rough walls is lacking. This study investigates turbulent boundary layer premixed flame flashback over rough walls using direct numerical simulations for the first time. The features of boundary layer flashback over walls with various roughness are explored in terms of flame morphology and flashback speed. It is found that the flame in rough-wall cases is more wrinkled compared with the smooth-wall case, particularly in the near-wall region, due to the presence of more small-scale vortical structures. Wall roughness reduces the flame flashback speed, which is attributed to the higher flow velocity at the leading edge of the flame front in rough-wall cases. The effects of wall roughness and combustion on boundary layer turbulence are revealed through two-point correlations of fluctuating velocity and wall resistance. The results show that, under non-reacting conditions, wall roughness reduces the streamwise and wall-normal extents of near-wall hairpin packets of boundary layer turbulence while increasing their inclination angles. Under reacting conditions, combustion further increases the inclination angle, with a more pronounced effect in rough-wall cases. Wall roughness influences wall resistance, primarily through its pressure component. Flame/wall interactions are also scrutinised, revealing higher wall heat loss in rough-wall cases, which is is mainly attributed to the increased wall surface area. A negative correlation between the quenching distance and the alignment of flame normal and wall normal is observed in rough-wall cases, which is weaker in smooth-wall cases.
This paper examines how public health promotion in colonial Australia figures the maternal body as an instrument for the production of whiteness for the perpetuation of the colonial state. In the context of a paradox between the institutional valuing of motherhood and institutional practices of systemic child removal and violence against women and mothers, I argue that public health promotion should be understood as a mechanism for the production of the white maternal body. I first establish the coloniality of public health promotion, arguing that its purpose is the production of bodies for the sake of colonial futurity, and that it so functions as a racializing code. Next, I offer a genealogical account in which the emergence of maternal subjectivity is shown to be the product of the colonial struggle for power; the white maternal body is thus produced through a schema of colonial mechanisms, among them the naturalization of sex, the feminization of the domestic sphere, the institutional establishment of the nuclear, heteroromantic family, and the British colonial notion of private property. I finally analyze how the white maternal body is subsequently materialized through the body’s own existential-temporal capacity for habituation.
Capacity assessments under the Mental Capacity Act 2005 (MCA) are a routine part of daily clinical practice in England and Wales. One element of these is the role of insight within the MCA’s capacity criteria. This article focuses on the issue of insight and capacity in a recent Court of Protection judgment, discussing how to assess insight in clinical practice and elucidating key issues regarding the role and assessment of insight within capacity assessments. The article includes a 10-point checklist for capacity assessments that was presented in the judgment, and a discussion of insight assessments that can guide documentation and be implemented in clinical practice.
This randomised controlled trial examined the effect of a 4-week, high-dose (Lf-High, 600 mg/d) or low-dose (Lf-Low, 200 mg/d) oral lactoferrin (Lf) intervention v. placebo on immune cell responses to respiratory virus, immune cell subsets and systemic inflammation. In healthy older adults (n 103, ≥50 years old), ex vivo cytokine release of interferon (IFN)-α2, IFN-γ, IL-6 and TNF-α from rhinovirus A-16 (RV-16) or influenza A virus (H1N1) stimulated peripheral blood mononuclear cells, circulating immune cell subsets, and plasma IL-6, C-reactive protein (CRP) and TNF-α were assessed. Ninety-seven participants completed the 4-week intervention (Lf-High n 32, Lf-Low n 31, placebo n 34, withdrawals n 6). There was no difference in RV-16 or H1N1-induced IFN-γ release between groups. RV-16-induced IL-6 was lower in Lf-High v. placebo (P = 0·001), and RV-16-induced IFN-α2 was higher in Lf-High v. Lf-Low (P = 0·04). Lf-High increased total T cells (P = 0·03) and CD4+ T cells (P = 0·03) v. placebo. Lf-Low reduced neutrophil (P = 0·04), natural killer cell (P = 0·045), activated CD8+ T cell (P = 0·03) and γδ T cell (P = 0·03) frequency v. placebo. Plasma IL-6 (P = 0·004) and CRP (P = 0·03) were lower following Lf-High v. Lf-Low, but not placebo. Both high- and low-dose Lf altered ex vivo immune cell responses after 4 weeks. High-dose increased T-cell subsets, promoting adaptive immunity, and reduced systemic inflammation, while low-dose reduced proinflammatory and cytotoxic immune cells. High- and low-dose Lf supplements may have immunoceutical benefits in older adults.
We introduce the implied value premium (IVP), the difference between the implied costs of capital of value and growth stocks, to predict time variation in the ex post value premium. During 1977–2023, IVP is the strongest predictor of the ex post value premium. It also predicts the investment premium, consistent with the Investment CAPM. However, IVP’s ability to predict the difference in cumulative abnormal returns around quarterly earnings announcements of value and growth stocks suggests that mispricing may also play a role. Overall, our results suggest that recent value underperformance reflects cyclical variation rather than a permanent shift.
This paper presents an actively controllable nonreciprocal metasurface based on a ferrite–patch structure with PIN diodes for dynamic control. Two activation methods are investigated: (a) phase control, which enables a 30° transmission-phase shift while maintaining nonreciprocal behavior, and (b) ON–OFF control, which switches the response by altering the propagation path. The phase-control metasurface is analyzed using transmission-line theory, full-wave simulation, and experiments, showing good agreement across methods. The ON–OFF design is optimized to suppress bidirectional transmission when ON. Experimental results confirm strong nonreciprocity, though slight frequency shifts arise from FR4 variability, and a back-fitted simulation improves consistency. The proposed dual-control framework provides a compact and low-cost approach to reconfigurable nonreciprocal surfaces that retain the use of permanent magnets for ferrite bias and are applicable to microwave wireless systems, including adaptive isolation, interference control, and tunable shielding. The results demonstrate the feasibility of compact, reconfigurable nonreciprocal metasurfaces using simple biasing circuits and offer design insights for frequency-stable implementations.
The current study was designed to examine the association between a composite healthy lifestyle score (HLS) and thyroid function biomarkers among American adults. This cross-sectional study utilised data from 5693 adults aged ≥ 18 years in the National Health and Nutrition Examination Survey 2007–2012 cycles. A HLS (range 0–6) was constructed based on six modifiable factors: non-smoking, no heavy alcohol intake, normal BMI (18·5–24·9 kg/m2), high physical activity (upper tertile of metabolic equivalent-min/week), adequate sleep (7–9 h/night) and appropriate energy intake. Serum concentrations of thyroid-stimulating hormone, free and total thyroxine (FT4, TT4), free and total triiodothyronine (FT3, TT3), thyroglobulin (Tg) and thyroid antibodies (TPOAb, TgAb) were measured. Multivariable linear regression adjusted for sociodemographic factors was used to assess associations. In fully adjusted models, each one-point increase in HLS was associated with lower serum FT4 (β = –0·07 ng/dl; 95 % CI: –0·10, –0·03; P < 0·001) and TT4 (β = –0·11 µg/dl; 95 % CI: –0·15, –0·06; P < 0·001). Compared with participants with an HLS of 0–1, those with HLS 4–6 had lower FT4 (β = –0·20; 95 % CI: –0·30, –0·09; P < 0·001) and TT4 (β = –0·36; 95 % CI: –0·49, –0·22; P < 0·001). Associations for other thyroid markers were not statistically significant after correction for multiple comparisons (P > 0·05). A healthier lifestyle is inversely associated with serum FT4 and TT4 levels, highlighting potential links between modifiable behaviours and thyroid physiology.
Assisted dying debates overlook the powerful unconscious forces that shape end-of-life decision-making. These dynamics influence personal, clinical and societal judgements and may be contributing to the rapid international expansion of assisted dying practices. Strengthening safeguards requires acknowledging these forces and integrating structured psychological assessment, clinician support and reflective practice to reduce unconscious bias and enhance the reliability, transparency and ethical integrity of decisions.