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This article considers three “unanswered questions” raised by R. (McConnell) v Registrar General for England and Wales (AIRE Centre Intervening) [2020] EWCA Civ. 559, which held that a trans man (with a Gender Recognition Certificate) who gave birth must be registered as “mother” on his child’s birth certificate. This article considers these questions to clearly situate McConnell within the context of the UK’s legal regimes concerning access to fertility treatment, gender recognition and legal parenthood in cases involving assisted reproduction. The article argues that clearly establishing the current legal position will provide the proper context to facilitate any subsequent legal reforms.
Sustainability is becoming a major strategic driver within the aviation industry, which has moved from providing primarily economic benefits to delivering the ‘triple bottom line’, including social and environmental impact as well as financial performance. Sustainable aviation is also being tracked by the International Civil Aviation Organisation (ICAO) Global Collation for Sustainable Aviation. Operations and Infrastructure is an important near-term opportunity to deliver sustainability benefits. Digital Technologies, Integrated Vehicle Health Management (IVHM) and Maintenance Repair and Overhaul (MRO) play a prominent role in implementing these benefits, with a particular focus on operational efficiencies. As part of this, the sustainable smart hangar of the future is a concept that is becoming more and more important in forming the future of the aviation industry. The Hangar of the Future is an excellent opportunity for innovation, combining the progress in manufacturing, materials, robotics and artificial intelligence technologies. Succeeding in developing a hangar with these characteristics will provide us with potential benefits ranging from reduced downtime and costs to improved safety and environmental impact. This work explores some of the key features related to the sustainable smart hangar of the future by discussing research that takes place in DARTeC’s (Digital Aviation Research and Technology Centre) hangar led by the IVHM Centre in Cranfield. Additionally, the paper touches on some longer-term aspirations.
The proto-Milky Way epoch forms the earliest stars in our galaxy and sets the initial conditions for the subsequent disk formation. Recent observations showed that the [$\alpha$/Fe] ratio among in situ metal-poor stars declined between [Fe/H] $=-3$ and $-1.3$ until it reached the lowest value ($\sim$0.25) and rose to the traditional value associated with the high-[$\alpha$/Fe] thick disk ($\sim$0.3) at [Fe/H] $\approx$ -1.0. It was suggested that the rise in [$\alpha$/Fe] could be caused by an increase in the star formation efficiency (SFE), known as the ‘simmering’ phase scenario. However, gas inflow also plays a vital role in shaping the star formation history and chemical evolution of galaxies, especially during the earliest epoch of the universe. We investigate this unexpected [$\alpha$/Fe]-rise with an experiment involving a galactic chemical evolution model. Our model has five free parameters: the mass of the initial reservoir of the cold interstellar medium (ISM) at birth, the frequency of Type Ia supernovae (SNe Ia), the cooling timescale of the warm ISM, the SFE, and the inflow rate of fresh gas. The last two free parameters were allowed to change after [$\alpha$/Fe] reached its lowest value, dividing the proto-Galaxy epoch into two phases. The models that reproduced the observed [Fe/H]-[$\alpha$/Fe]-track provided estimates for these fundamental parameters of the proto-Milky Way. We find that the rise in [$\alpha$/Fe] could also be caused by a large inflow of high-[$\alpha$/Fe] gas and conclude that the [$\alpha$/Fe]-rise could be a signature of the gas accretion that fuelled the formation of the Milky Way disk.
The interaction between deformable surfaces and oscillatory driving is known to produce complex secondary time-averaged flows due to inertial and elastic nonlinearities. Here, we revisit the problem of oscillatory flow in a cylindrical tube with a deformable wall, and analyse it under a long-wave theory for small deformations, but for arbitrary Womersley numbers. We find that the oscillatory pressure does not vary linearly along the length of a deformable channel, but instead decays exponentially with spatial oscillations. We show that this decay occurs over an elasto-visco-inertial length scale that depends on the material properties of the fluid and the elastic walls, the geometry of the system, and the frequency of the oscillatory flow, but is independent of the amplitude of deformation. Inertial and geometric nonlinearities associated with the elastic deformation of the channel drive a time-averaged secondary flow. We quantify the flow using numerical solutions of the perturbation theory, and gain insight by developing analytic approximations. The theory identifies a complex non-monotonic dependence of the time-averaged flux on the elastic compliance and inertia, including a reversal of the flow. Finally, we show that our analytic theory is in excellent quantitative agreement with the three-dimensional direct numerical simulations of Pande et al. (Phys. Rev. Fluids, vol. 8, no. 12, 2023, 124102).
Patients with advanced cancer present various symptoms as their disease progresses. Among these, fatigue is a frequent symptom in patients with advanced cancer and is associated with decreased quality of life (QOL). However, there are few reports regarding its association with thiamine deficiency (TD).
Methods
We report a case in which we found TD in a patient with advanced lung cancer who presented with weight loss, significant fatigue, and appeared to have a worsening general condition, for whom symptoms were dramatically improved within a short period of time by intravenous administration of thiamine.
Results
The patient was a 76-year-old woman who had been diagnosed with lung cancer and liver metastases 6 months earlier. Due to interstitial pneumonia, she was not a candidate for chemotherapy and so palliative care was started. At 8 months after initial diagnosis, the patient complained of fatigue during a medical examination, so a blood sample was taken. A week later, she visited the hospital with a cane. She felt extremely fatigued and was unable to stand, but results from the previous blood test revealed that a TD. The fatigue disappeared 15 minutes after intravenous administration of thiamine and she was able to return home without the cane.
Significance of results
Fatigue is a frequent symptom in advanced cancer patients, and TD may be the underlying cause. Inclusion of TD in the differential diagnosis may contribute to improving patient QOL.
Medications with anticholinergic properties are associated with a range of adverse effects that tend to be worse in older people.
Aims
To investigate medication regimens with high anticholinergic burden, prescribed for older adults under the care of mental health services.
Method
Clinical audit of prescribing practice, using a standardised data collection tool.
Results
Fifty-seven trusts/healthcare organisations submitted data on medicines prescribed for 7915 patients: two-thirds (66%) were prescribed medication with anticholinergic properties, while just under a quarter (23%) had a medication regimen with high anticholinergic burden (total score ≥3 on the anticholinergic effect on cognition (AEC) scale). Some 16% of patients with a diagnosis of dementia or mild cognitive impairment were prescribed medication regimens with a high anticholinergic burden, compared with 35% of those without such diagnoses. A high anticholinergic burden was mostly because of combinations of commonly prescribed psychotropic medications, principally antidepressant and antipsychotic medications with individual AEC scores of 1 or 2.
Conclusions
Adults under the care of older people's mental health services are commonly prescribed multiple medications for psychiatric and physical disorders; these medication regimens can have a high anticholinergic burden, often an inadvertent consequence of the co-prescription of medications with modest anticholinergic activity. Prescribers for older adults should assess the anticholinergic burden of medication regimens, assiduously check for adverse anticholinergic effects and consider alternative medications with less anticholinergic effect where indicated. The use of a scale, such as the AEC, which identifies the level of central anticholinergic activity of relevant medications, can be a helpful clinical guide.
Microplastics pollution is a widely recognized issue, although significant analytical challenges remain to be overcome in order to achieve a more comprehensive ecological understanding. The complex nature of this pollutant, with its variable physical and chemical properties, presents considerable challenges when it comes to establishing standardized methods for studying it. One crucial factor that influences its toxicity is particle size, yet even this parameter lacks a well-established framework, especially in the case of nanoplastics. Although the size range limits are already proposed in the literature, where the most acceptable values for microplastics are from 1 to 5,000 μm and for nanoplastics are from 1 to 1,000 nm, we propose narrowing these limits to 0.1–1,000 μm and 10–100 nm, respectively. We based our discussion on conceptual terminology, polymer structure and toxicity, highlighting the significance of accurately defining their size range. The standardization of these limits will allow the development of more efficient approaches to studying this pollutant, enabling a comprehensive understanding of its ecological consequences and potential risks.
Literature emphasises the importance of identifying and intervening in the adoption of unhealthy lifestyle behaviours (ULBs) during adolescence at an early stage, to mitigate their long-term detrimental effects. Among the possible associated factors contributing to ULBs, attention-deficit hyperactivity disorder (ADHD) has been shown to play an important role. However, little is known about ADHD subclinical manifestations.
Aims
The present study aimed to bridge the gap in the literature and shed light on the relationship between subclinical ADHD and early adoption of ULBs during adolescence. Through a clinimetric approach, prevalence of ULBs, severity of ADHD symptoms and psychosocial factors (i.e. allostatic overload, abnormal illness behaviour, quality of life, psychological well-being) were investigated among adolescents. The associations between different degrees of ADHD, ULBs and psychosocial factors were also explored.
Method
This multicentre cross-sectional study involved 440 adolescents (54.5% females; mean age 14.21 years) from six upper secondary schools. Participants completed self-report questionnaires on sociodemographic characteristics, ULBs, ADHD symptoms and psychosocial factors.
Results
The most common ULBs were energy drinks/alcohol consumption and problematic smartphone use. Of the sample, 22% showed subclinical ADHD and 20.2% showed clinical ADHD. The subclinical ADHD group showed several ULBs (i.e. altered mindful eating, impaired quality of sleep, problematic technology use) and psychosocial factors, akin to those of ADHD group and different from peers without ADHD symptoms.
Conclusions
Since subclinical ADHD manifestation is associated with ULBs, similarly to clinical ADHD, identifying subthreshold symptoms during adolescence is crucial, as it could improve health-related outcomes in adulthood across different domains.
To bring linguistic theory back in touch with commonplace observations concerning the resilience of language in use to language change, language acquisition and ungrammaticality, Pullum and colleagues have argued for a ‘model-theoretic’ theory of syntax. The present paper examines the implications for linguists working in standard formal frameworks and argues that, to the extent that such theories embrace monotonicity in syntactic operations, they qualify as model-theoretic under some minor modifications to allow for the possibility of unknown words.
This study aimed to explore the experiences and support requirements of psychiatrists undergoing investigations within their mental health organisation. An anonymous online survey was distributed to all non-training psychiatrists registered as members of the Royal College of Psychiatrists.
Results
Of the 815 psychiatrists who responded to the survey, 287 (35%) had been investigated. The majority (76%) were unaware of the concerns before being notified, 36% lacked understanding and 62% experienced timeline deviations. Furthermore, 34% had concerns over conflicts of interest, with 52% perceiving the investigation as unfair, 62% were not informed of their rights. Many respondents reported feeling isolated and lacking support and experienced significant psychological distress, such as symptoms of post-traumatic stress disorder. Suggestions for improvement included better communication, transparency, impartiality, adherence to timelines, proactive support and oversight, and opportunities for learning and reparation post-investigation.
Clinical implications
Mental health service providers should recognise the multifaceted nature of complaints and provide comprehensive support and guidance to psychiatrists undergoing investigations.
Bioethics as a philosophical discipline deals with matters of life and death. How it deals with them, however, depends on the kind of life particular bioethicists focus on and the kind of value they assign to it. Natural-law ethicists and conservative Kantians emphasize biological human life regardless of its developmental stage. Integrative bioethicists also embrace nonhuman life if it can be protected without harming humans. Liberal and utilitarian moralists concentrate on life that is sentient and aware of itself, to the exclusion of biological existence devoid of these. Extinctionist and antinatalist philosophers believe that life’s value is negative and that its misery should be alleviated and terminated by not bringing new individuals into existence. As the last-mentioned approach reverses the idea of life’s positive value, it could be called oibethics.
This paper presents geomorphological and historical records of the surge-type behaviour of Hansbreen, one of the most studied tidewater glaciers in Svalbard. The surge-type behaviour of the glacier has not been considered before due to the lack of evidence of this phenomenon. We integrate geomorphological mapping of the terrestrial and submarine forefields with historical data from the 19th and 20th centuries to reconstruct the glacier dynamics and identify the possible timing of surging. Landform assemblages are representative of the surging glacier landsystem, including crevasse-squeeze ridges (CSRs) and submarine streamlined glacial lineations. Abundant CSRs in the outer part of the terrestrial forefield were also documented in the 1980s, but most have been obliterated since then. We suggest the identified surge landsystem was produced during a surge of Hansbreen detected from photographs taken during the Austro-Hungarian expedition in 1872. Historical photogrammetric photos from the Norwegian expedition in 1918 revealed surge-diagnostic features in the glacier surface, including a folded medial moraine and a dense, complex network of crevasses. A potential next surge remains questionable in the following decades due to the low-lying accumulation area of the main stream hindering the mass build-up, but potential surges of the tributary glaciers should not be excluded.
We show how a complete mathematical model of a physical process can be learned directly from data via a hybrid approach combining three simple and general ingredients: physical assumptions of smoothness, locality and symmetry, a weak formulation of differential equations and sparse regression. To illustrate this, we extract a complete system of governing equations of fluid dynamics – the Navier–Stokes equation, the continuity equation and the boundary conditions – as well as the pressure-Poisson and energy equations, from numerical data describing a highly turbulent channel flow in three dimensions. Whether they represent known or unknown physics, relations discovered using this approach take the familiar form of partial differential equations, which are easily interpretable and readily provide information about the relative importance of different physical effects. The proposed approach offers insight into the quality of the data, serving as a useful diagnostic tool. It is also remarkably robust, yielding accurate results for very high noise levels, and should thus be well suited for analysis of experimental data.
Domestic fruit and vegetable producers contend that rising imports during seasonal harvesting windows have negatively impacted domestic prices and revenue. This study simulates producers’ revenue with the removal of above-average imports as defined by the U.S. International Trade Commission. Results indicate significant additional revenues to domestic producers in the simulated scenario. Also, additional revenues to producers by state and season show substantial heterogeneity with robustness checks revealing similar patterns. Options such as risk management and technological improvements are needed to enhance the competitiveness of U.S. fresh produce industries instead of limiting imports in the absence of illegal dumping.
The dewetting of thin nanofilms is significantly affected by thermal fluctuations, liquid–solid slip and disjoining pressure, which can be described by lubrication equations augmented by appropriately scaled noise terms, known as stochastic lubrication equations. Here molecular dynamics simulations along with a newly proposed slip-generating method are adopted to study the instability of nanofilms with arbitrary slip. These simulations show that strong-slip dewetting is distinct from weak-slip dewetting by faster growth of perturbations and fewer droplets after dewetting, which cannot be predicted by the existing stochastic lubrication equation. A new stochastic lubrication equation considering the strong-slip boundary condition is thus derived using a long-wave approximation to the equations of fluctuating hydrodynamics. The linear stability analysis of this equation, i.e. surface spectrum, agrees well with molecular simulations. Interestingly, strong slip can break down the usual Stokes limits adopted in weak-slip dewetting and bring the inertia into effect. The evolution of the standard deviation of the film height $W^2(t)={\overline {h^2}-{\bar {h}}^2}$ at the initial stage of the strong-slip dewetting is found to be $W\sim t^{1/4}$ in contrast to $W\sim t^{1/8}$ for the weak-slip dewetting.
The overall system of interest is an infinite half-space in which a compressible ocean is the top layer and an elastic seafloor (together with the crust beneath) forms a semi-infinite bottom layer. Whereas water-column compression waves and seafloor waves individually have received considerable attention, not much is known about their propagation as groups. This work utilizes the group behaviour of these waves to derive energy balance relations for wavenumber spectra for wave groups propagating through a mildly non-uniform water-column–seafloor system. Dispersion relations for the coupled system are derived using known kinematic and kinetic conditions at the interface, and free and forced wave solutions for the wavenumber spectra are obtained, with particular attention to the case when certain frequency–wavenumber combinations in the forcing excite the two-media system into resonance. Wavenumber spectra predicted using the theory for mildly non-uniform media are found to be close to those predicted assuming uniform media, though the effect of non-uniformity becomes more noticeable as the groups propagate farther from the generation area. Here, nonlinear interactions among stationary, random multi-directional surface-wave fields provide the forcing for groups of compression waves in the water and surface waves on the seafloor. The formulation includes the cumulative effect of multiple generation areas along the group propagation direction. Comparisons with observational data from a sensor array in the Atlantic Ocean indicate that the theory can be applied to reconstruct plausible combinations of generation areas and interaction times that are consistent with the measured data, for deriving approximate predictions at down-wave distances along the group propagation directions. Implications of this and other findings are discussed for (i) the potential for energy conversion from water-column compression waves on the seafloor, (ii) tracking of tropical cyclones from the seafloor, and (iii) quantification and comparative assessment of low-frequency mid-ocean ambient noise and microseism activity.
In Danish, the distribution of stød exhibits a pattern related to the position of the stressed syllable. Some phonological theories of stød, e.g. Basbøll (2005), consider stød on the antepenultimate or ultimate syllable, and non-stød on the penultimate syllable, to be the default. This article reports on a production study with nonce words, investigating the distributional pattern of stød in relation to the position of the stressed syllable in monomorphemic nonce words. Ten speakers were asked to pronounce 336 nonce words with stress on either the ultimate, penultimate, or antepenultimate syllable. The results showed that stød on ultimate stressed syllables and non-stød on penultimate stressed syllables replicates in nonce words, but stød on antepenultimate stressed syllables does not. This suggests that stød in antepenultimate stressed words is not the default, but lexical.
Supraglacial lakes on Antarctic ice shelves can have far-reaching implications for ice-sheet stability, highlighting the need to understand their dynamics, controls and role in the ice-sheet mass budget. We combine a detailed satellite-based record of seasonal lake evolution in Dronning Maud Land with a high-resolution simulation from the regional climate model Modèle Atmosphérique Régional to identify drivers of lake variability between 2014 and 2021. Correlations between summer lake extents and climate parameters reveal complex relationships that vary both in space and time. Shortwave radiation contributes positively to the energy budget during summer melt seasons, but summers with enhanced longwave radiation are more prone to surface melting and ponding, which is further enhanced by advected heat from summer precipitation. In contrast, previous winter precipitation has a negative effect on summer lake extents, presumably by increasing albedo and pore space, delaying the accumulation of meltwater. Downslope katabatic or föhn winds promote ponding around the grounding zones of some ice shelves. At a larger scale, we find that summers during periods of negative southern annular mode are associated with increased ponding in Dronning Maud Land. The high variability in seasonal lake extents indicates that these ice shelves are highly sensitive to future warming or intensified extreme events.
This article serves as a commentary on Michael Hallsworth’s 2023 piece, ‘A manifesto for applying behavioural science,’ featured in Nature Human Behaviour. The manifesto was prompted by methodological, practical and normative critiques directed at behavioural science and its role in public policy. In this commentary, I argue that the manifesto presents numerous insightful and constructive reform proposals regarding the scope, methods and values in behavioural science, which can help advance the field of behavioural public policy. While there is much to agree with, I contend in this commentary that applied behavioural science can and should delve deeper into the study of socially and culturally embedded processes of goal formation. Additionally, it should explore the institutional conditions necessary for individuals to formulate their goals competently and in a self-determined manner.
This study explores the application of a wall-attached ferrofluid film to decrease skin-friction drag in turbulent channel flow. We conduct experiments using water as a working fluid in a turbulent channel flow set-up, where one wall is coated with a ferrofluid layer held in place by external permanent magnets. Depending on the flow conditions, the interface between the two fluids is observed to form unstable travelling waves. While ferrofluid coating has been previously employed in laminar and moderately turbulent flows (Reynolds number $Re<4000$) to reduce drag by creating a slip condition at the fluid interface, its effectiveness in fully developed turbulent conditions, particularly when the interface exhibits instability, remains uncertain. Our primary objective is to assess the effectiveness of ferrofluid coating in reducing turbulent drag with particular focus on scenarios when the ferrofluid layer forms unstable waves. To achieve this, we measure flow velocity using two-dimensional particle tracking velocimetry (2D-PTV), and the interface contour between the fluids is determined using an interface tracking algorithm. Our results reveal the significant potential of ferrofluid coating for drag reduction, even in scenarios where the interface between the surrounding fluid and ferrofluid exhibits instability, with observed drag reduction rates up to 95 %. In particular, waves with an amplitude significantly smaller than a viscous length scale positively contribute to drag reduction, while larger waves are detrimental, because of induced turbulent fluctuations. However, for the latter case, slip outcompetes the extra turbulence so that drag is still reduced.