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Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aimed to determine whether depressive symptoms and post-psychotic depressive episodes can be predicted from baseline clinical data, quality of life, and blood-based biomarkers, and to assess the geographical generalizability of these models.
Methods
Two FEP trials were analyzed: European First-Episode Schizophrenia Trial (EUFEST) (n = 498; 2002–2006) and Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) (n = 404; 2010–2012). Participants included those aged 15–40 years, meeting Diagnostic and Statistical Manual of Mental Disorders IV criteria for schizophrenia spectrum disorders. We developed support vector regressors and classifiers to predict changes in depressive symptoms at 6 and 12 months and depressive episodes within the first 6 months. These models were trained in one sample and externally validated in another for geographical generalizability.
Results
A total of 320 EUFEST and 234 RAISE-ETP participants were included (mean [SD] age: 25.93 [5.60] years, 56.56% male; 23.90 [5.27] years, 73.50% male). Models predicted changes in depressive symptoms at 6 months with balanced accuracy (BAC) of 66.26% (RAISE-ETP) and 75.09% (EUFEST), and at 12 months with BAC of 67.88% (RAISE-ETP) and 77.61% (EUFEST). Depressive episodes were predicted with BAC of 66.67% (RAISE-ETP) and 69.01% (EUFEST), showing fair external predictive performance.
Conclusions
Predictive models using clinical data, quality of life, and biomarkers accurately forecast depressive events in FEP, demonstrating generalization across populations.
The radical right is now able to impose its personnel and its agenda as the ‘new normal’ for a different European Union (EU). Nevertheless, there is still a lack of research into how this normalization is circulated by radical-right members of the European Parliament (MEPs), eager to be part of the social world of the liberal democratic European parliamentarians. This process of normalization is investigated in this article by carrying out a critical discourse analysis of the argumentation used by radical-right MEPs to reject an EU regulation supposed to preserve press freedom, currently threatened by the radical right in many EU member states: the European Media Freedom Act (EMFA). The analysis shows that these MEPs have been keen to use a series of topoi to claim their embeddedness in liberal democracies, while mobilizing symbols and meanings revealing their autocratic roots and their willingness to redefine media freedom.
Our family album is often the first medium through which we encounter war: nestled in the heart of home life and revisited throughout childhood, its pages intertwine peacetime photos of vacations and gatherings with wartime images featuring smiling soldiers and pastoral landscapes from missions abroad, blending these contrasting realities into one familiar story. This article introduces, for the first time, this overlooked heritage, tracing its roots to WWI – the first conflict photographed by the public. With the outbreak of war, the amateur photography industry, focused on leisure and holidays, came to a halt. Kodak found an unexpected solution: rebranding the camera as a tool to transform harsh realities into peaceful moments by capturing images that portrayed war as joyfully as a summer vacation. It marketed the zoom as a way to avoid violence by keeping it out of the frame while promoting one-click shooting as a means to preserve fleeting moments of beauty amid chaos. The flash was positioned as a source of optimism in dark times, and the family album was framed as a nostalgic object creating a view of the ongoing war as if it had already ended. Capitalizing on witnesses’ longing for peace, this campaign achieved unprecedented success, establishing norms for amateur war photography. This article defines this model that shapes how we see, capture, and share the experience of war, acquiring renewed significance as amateur war photography expands from family albums to the global reach of social media.
Recent functional magnetic resonance imaging (fMRI) studies have shown that interpersonal synchronization of brain activity can be measured between people sharing similar emotional, narrative, or attentional states. There is evidence that odors can modulate the activity of brain regions involved in memory, emotion and social cognition, suggesting a link between shared olfactory experiences and synchronized brain activity in social contexts.
Method:
We used fMRI to investigate the effects of a positively-valenced odor on inter-subject correlation (ISC) of brain activity in healthy volunteers watching movies. While being inside an MRI scanner, participants (N = 20) watched short movie clips to induce either positive (happiness, tenderness) or negative (sadness, fear) emotions. Two movie clips were presented for each emotional category. Participants were scanned in two separate randomized sessions, once while watching the movie clips in the presence of an odor, and once without.
Results:
When all emotional categories were combined, the odor condition showed significantly higher ISC compared to the control condition in bilateral superior temporal gyri (STG), right middle temporal gyrus, left calcarine, and lingual gyrus. When splitting the movies according to valence, odor-induced increases in ISC were stronger for the negative movies. For the negative movies, ISC in the supramarginal gyrus and STG was larger in the second compared to first movie clips, indicating a time-by odor interaction.
Conclusion:
These findings show that odor increases ISC and that its effects depend on emotional valence. Our results further emphasize the critical role of the STG in odor-based social communication.
Respite for individuals caring for family living with dementia is a common way to take personal time away from caregiving. Other than respite, there is little indication that caregivers receive adequate support from community and healthcare services. As a result, caregivers tend to experience a decline in well-being, due, in part, to a reduction in meaningful leisure experiences. The purpose of this article is to share findings from research aimed at discovering ways to enhance caregiver participation in meaningful leisure. Findings highlight how participants sacrificed their leisure time in favour of caregiving responsibilities and experienced a diminished sense of social connection. Findings also highlight how participants can have their own care needs met through leisure programming that lets them know they matter. We draw from these findings to suggest ways to direct more attention and resources to meeting caregiver needs.
We study a family of variants of Jensen’s subcomplete forcing axiom, $\mathsf {SCFA,}$ and subproper forcing axiom, $\mathsf {SubPFA}$. Using these, we develop a general technique for proving nonimplications of $\mathsf {SCFA}$, $\mathsf {SubPFA}$ and their relatives and give several applications. For instance, we show that $\mathsf {SCFA}$ does not imply $\mathsf {MA}^+(\sigma $-closed) and $\mathsf {SubPFA}$ does not imply Martin’s Maximum.
The breakup dynamics of viscous liquid bridges on solid surfaces is studied experimentally. It is found that the dynamics bears similarities to the breakup of free liquid bridges in the viscous regime. Nevertheless, the dynamics is significantly influenced by the wettability of the solid substrate. Therefore, it is essential to take into account the interaction between the solid and the liquid, especially at the three-phase contact line. It is shown that when the breakup velocity is low and the solid surface is hydrophobic, the dominant channel of energy dissipation is likely due to thermally activated jumping of molecules, as described by the molecular kinetic theory. Nevertheless, the viscous dissipation in the bulk due to axial flow along the bridge can be of importance for long bridges. In view of this, a scaling relation for the time dependence of the minimum width of the liquid bridge is derived. For high viscosities, the scaling relation captures the time evolution of the minimum width very well. Furthermore, it is found that external geometrical constraints alter the dynamic behaviour of low and high viscosity liquid bridges in a different fashion. This discrepancy is explained by considering the dominant forces in each regime. Lastly, the morphology of the satellite droplets deposited on the surface is qualitatively compared with that of free liquid bridges.
In the late nineteenth century, the orally transmitted Armenian legend about the folk hero David of Sassoun seemed doomed to oblivion when Ottoman Armenian clergyman Karekin Srvandzdiants published a tiny booklet containing the story that he had learned by chance. Srvandzdiants noted that he would be happy if the story could reach twenty people. Decades later, this hitherto little-known folk legend would be read, and its main heroes celebrated by tens of millions of citizens of the Soviet Union. Scores of variants of the epic were collected from all over the newly established Soviet Armenia; some of the most revered Soviet poets and linguists produced a collated text of the epic and translated it into dozens of languages. More importantly, David of Sassoun and other heroes of the epic cycle came to symbolize the newly forged Soviet Armenian national character in a vast totalitarian empire whose guiding ideology was inimical to various aspects of Armenian traditions. In this article, I examine the underlying messages of the epic, discuss how Soviet policies helped the epic captivate a large audience in a short period, and analyze the political calculations and ideological justifications behind the promotion of the epic.
Effective mental health primary prevention and early detection strategies targeting perinatal mental healthcare settings are vital. Poor maternal mental health places the developing foetus at risk of lasting cognitive, developmental, behavioural, physical, and mental health problems. Indigenous women endure unacceptably poor mental health compared to all other Australians and disproportionately poorer maternal and infant health outcomes. Mounting evidence demonstrates that screening practices with Indigenous women are neither effective nor acceptable. Improved understanding of their perinatal experiences is necessary for optimizing successful screening and early intervention. Achieving this depends on adopting culturally safe research methodologies.
Methodology:
Decolonizing translational research methodologies are described. Perspectives of Australian Indigenous peoples were centred on leadership in decision-making throughout the study. This included designing the research structure, actively participating throughout implementation, and devising solutions. Methods included community participatory action research, codesign, and yarning with data analysis applied through the cultural lenses of Indigenous investigators to inform culturally meaningful outcomes.
Discussion:
The Indigenous community leadership and control, maintained throughout this research, have been critical. Allowing time for extensive community collaboration, fostering mutual trust, establishing strong engagement with all stakeholders and genuine power sharing has been integral to successfully translating research outcomes into practice. The codesign process ensured that innovative strengths-based solutions addressed the identified screening barriers. This process resulted in culturally sound web-based perinatal mental health and well-being assessment with embedded potential for widespread cultural adaptability.
A model is proposed for the one-dimensional spectrum and streamwise Reynolds stress in pipe flow for arbitrarily large Reynolds numbers. Constructed in wavenumber space, the model comprises four principal contributions to the spectrum: streaks, large-scale motions, very-large-scale motions and incoherent turbulence. It accounts for the broad and overlapping spectral content of these contributions from different eddy types. The model reproduces well the broad structure of the premultiplied one-dimensional spectrum of the streamwise velocity, although the bimodal shape that has been observed at certain wall-normal locations, and the $-5/3$ slope of the inertial subrange, are not captured effectively because of the simplifications made within the model. Regardless, the Reynolds stress distribution is well reproduced, even within the near-wall region, including key features of wall-bounded flows such as the Reynolds number dependence of the inner peak, the formation of a logarithmic region, and the formation of an outer peak. These findings suggest that many of these features arise from the overlap of energy content produced by both inner- and outer-scaled eddy structures combined with the viscous-scaled influence of the wall. The model is also used to compare with canonical turbulent boundary layer and channel flows, and despite some differences being apparent, we speculate that with only minor modifications to its coefficients, the model can be adapted to these flows as well.
The article addresses the question of the distinction between voluntary and involuntary immobility under emigration restrictions. Based on semi-structured in-depth interviews with people whose family members intended to emigrate from the Polish People’s Republic and the Russian Soviet Federative Socialist Republic but who have not fulfilled their intentions, it examines the role of the would-be migrant’s agency in driving the immobility outcome under the narrow opportunity structure for international mobility. The analysis of reasons for the emigration intentions of formerly aspiring migrants having remained unfulfilled demonstrates that the boundary between voluntary and involuntary immobility – similar to that of voluntary versus forced migration – is often blurred. The studied cases suggest it is more justified to view immobility through the lens of a continuum of (in)voluntariness rather than as a voluntary-involuntary binary. Moreover, the study shows how the blurriness of the boundary between voluntary and involuntary immobility may be understood through changes over time in the reasons for the non-realization of one’s migration intentions.
Many young people feel distressed about climate change, and pessimistic about what the future holds. Gaps in education about climate change contribute to limited understanding of opportunities for climate mitigation and adaptation, and to a pervasive “discourse of doom.” Here we describe a “game for change” co-designed by climate and education researchers and young people, that aims to shift narratives about climate changed futures toward an active, adaptation-oriented focus.
The Heat Is On is designed to be played by high school classes. Set in 2050, the game takes place on a fictional island called “Adaptania.” Teams of students play the role of town councillors in communities facing the same challenges that Australian towns are experiencing as the climate heats up, including flooding, heatwaves, bushfires, inequality, health issues and economic challenges. By focussing on decision-making for adaptation and resilience, The Heat Is On enables participants to envision climate-changed futures in which communities can thrive. Students learn how to plan and collaborate to prepare for diverse and cascading impacts of climate hazards. We explore the potential for games in climate education, focussing on The Heat Is On as a case study, and share initial learnings from its development and implementation in schools.
Coccidiosis, caused by Eimeria spp., leads to substantial economic losses in the poultry industry globally. These protozoan parasites invade the intestinal epithelium of birds, impairing nutrient absorption, causing diarrhoea and potentially leading to mortality. The complex endogenous life cycle of Eimeria spp., particularly the gametogony phase, presents significant challenges for in vitro cultivation. This study aimed to develop mature chicken intestinal organoids as an in vitro model capable of supporting the complete endogenous life cycle of Eimeria tenella. Two commercially available culture media, 3dGRO L-WRN conditioned medium (L-WRN) and IntestiCult™ Organoid Growth Medium (OGM), were evaluated for their ability to support chicken intestinal organoid development. The results demonstrated that basolateral-out organoids embedded in Matrigel and cultured in the L-WRN medium expanded more rapidly. In contrast, those apical-out organoids in the OGM developed more microvilli structures on enterocytes. Apical-out organoids, initially cultured in L-WRN medium and subsequently matured in OGM, were selected as the optimal host for the Eimeria infection model. Sporozoites of E. tenella successfully invaded the organoids and progressed through both the schizogony and gametogony phases. Moreover, the parasites produced a new generation of oocysts in this study. The presence of schizonts, gametocytes, and sporulated oocysts confirmed that the model can support the full endogenous life cycle of the parasite in vitro. This organoid-based infection model serves as a promising platform for studying host–pathogen interactions and developing novel interventions to control avian coccidiosis.
This paper explores the transformative potential of artificial intelligence (AI), particularly generative AI (GenAI), in supporting the teaching, learning, and assessment of second language (L2) listening and speaking. It examines how AI technologies, such as spoken dialogue systems and intelligent personal assistants, can refine existing practices, offer innovative solutions, and address challenges related to spoken language competencies, as well as drawbacks they present. It highlights the role of GenAI, explores its capabilities and limitations, and offers insights into the evolving role of GenAI in language education. This paper discusses actionable insights for educators and researchers, outlining practical considerations and future research directions for optimizing GenAI integration in the learning and assessment of listening and speaking.
Rosai–Dorfman disease is a rare histiocytic disorder typically presenting with cervical lymphadenopathy. Sinonasal involvement is uncommon and presents diagnostic and therapeutic challenges. This scoping review synthesises literature on the clinical presentation, diagnosis, management and outcomes of sinonasal Rosai–Dorfman disease.
Method
We systematically searched PubMed, Scopus and Embase. Articles were screened using Endnote. Studies reporting sinonasal Rosai–Dorfman disease were included. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses-ScR (Scoping Review) guidelines.
Results
Thirty studies comprising 36 patients were included. Common symptoms were nasal obstruction (80.6 per cent) and epistaxis (41.7 per cent). Computed tomography (75 per cent) and magnetic resonance imaging (36.1 per cent) were primary imaging modalities. Histopathology showed emperipolesis (66.7 per cent), S-100 (69.4 per cent) and CD68 (47.2 per cent) positivity. Management was mainly surgical (72.2 per cent), with corticosteroids (44.4 per cent), radiotherapy (5.6 per cent) and chemotherapy (5.6 per cent) used less frequently. Outcomes included complete resolution (38.9 per cent), stable disease (38.9 per cent) and recurrence (16.7 per cent).
Conclusion
Diagnosis relies on histopathology and imaging. Surgical procedures, often with corticosteroids, remain the primary treatment. Future research should guide diagnostic and treatment protocols.
Past research alerts to the increasingly unpleasant climate surrounding public debate on social media. Female politicians, in particular, are reporting serious attacks targeted at them. Yet, research offers inconclusive insights regarding the gender gap in online incivility. This paper aims to address this gap by comparing politicians with varying levels of prominence and public status in different institutional contexts. Using a machine learning approach for analyzing over 23 million tweets addressed to politicians in Germany, Spain, the United Kingdom, and the United States, we find little consistent evidence of a gender gap in the proportion of incivility. However, more prominent politicians are considerably and consistently more likely than others to receive uncivil attacks. While prominence influences US male and female politicians’ probability to receive uncivil tweets the same way, women in our European sample receive incivility regardless of their status. Most importantly, the incivility varies in quality and across contexts, with women, especially in more plurality contexts, receiving more identity-based attacks than other politicians.
Take two positions, both of which we take to be popular ways of thinking about law. First, some norm N is part of the law only if, and in virtue of, N being ultimately recognized or validated by the rule of recognition. Call this Hartian Orthodoxy. Second, statements about legal rights are best understood as claims about the existence of moral rights according to law. Call this legal perspectivalism. Here we show that the two are incompatible. Our argument is that, to account for certain arguments that mix legal and factual claims, perspectivalism must close the legal perspective according to some inference rule. As it happens, however, the only defensible candidates render perspectivalism incompatible with Hartian Orthodoxy.
Necrotising otitis externa is a serious infective condition with significant risk of complications and a profound impact on patients’ quality of life.
Methods
A quantitative descriptive study was undertaken using epidemiological data from the National Health Service Hospital Episode Statistics database and other national databases. Data correlating with reported cases 2002-2024 were compiled and analysed.
Results
The national incidence of necrotising otitis externa has demonstrated a sustained increase 2002-2024. The 30 per cent incidence drop during the coronavirus disease 2019 pandemic may be attributable to reduced exposure to risk factors, reduced contact between susceptible patients and health professionals and pandemic-related deaths of at-risk populations. There remains a strong correlation between growths in necrotising otitis externa incidence, the ageing population and national incidence of diabetes mellitus. These are all projected to continue to rise. Antibiotic resistance is not a significant contributing factor.
Conclusion
This study demonstrates several significant trends, offering a strong foundation for deeper exploration in future studies.
Only months after starting as KPFA’s music director, Charles Amirkhanian launched the radio show Ode to Gravity in March 1970. The evocative name referred to his 1968 experimental theatre piece that involved dropping objects such as a marble and car fender into a circle of spectators. The radio programme similarly released a range of avant-garde music and sound objects over the airwaves, reflecting Amirkhanian’s preferred title as KPFA’s ‘Sound Sensitivity Information Director’. Informed by analyses of archival broadcasts and other primary sources, this article frames Ode to Gravity as a conceptual extension of the 1968 piece and long-running ‘sound sensitivity’ experiment that sought to make sense of the contemporary musical landscape by collecting and propagating sonic data. Ode to Gravity’s consciousness-raising mission broadly, and the changes in content and presentation style over its twenty-five-year history specifically, add further texture to our understanding of post-war avant-garde impulses in music and sound.
Why and how does Russia engage in the arms trade? Scholars have largely focused on why Russia participates in the arms trade, often neglecting the equally crucial question of how it conducts this trade. Yet understanding the mechanisms by which Russia promotes arms sales provides deeper insights into why it does so. While many portray Russia’s arms trade as driven by economic or strategic motivations, few examine the specific tools it employs, particularly defence counter-trade, which includes non-monetary barter, counter-purchase obligations, and industrial or technological investments (offsets). This paper fills that gap by offering an eight-decade perspective on Russian arms trade practices, drawing on data and case studies to uncover a more nuanced set of motives. Russia integrates economic and political objectives in its arms trade, seeking not only to out-compete Western suppliers but also to expand or regain influence in various regions, circumvent Western-imposed sanctions, secure access to valuable resources, and sustain its military capabilities. Although barter and technological cooperation have long been part of its trade practices, Russia has only recently adopted offset practices in a systematic way. By leveraging defence counter-trade, Moscow aims to stabilise, and potentially grow, its arms exports as global conditions shift.