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This article revisits the concept of the instrument’s inherent score, exploring how musical instruments can embody a form of notation that both shapes and inspires performance. Building on earlier research (Tomás 2016; Tomás and Kaltenbrunner 2014), the study examines the historical and theoretical foundations of this idea, tracing its roots to experimental music practices of the 1960s and 1970s, particularly within the Sonic Arts Union collective. Composers such as Alvin Lucier, Gordon Mumma and Nicolas Collins have described how electronic instruments embody compositional elements, effectively functioning as scores. The paper argues that the instrument’s score emerges from the material and symbolic affordances of the instrument, mediating the performer’s engagement with its sonic and physical properties. This concept has influenced contemporary digital instrument design, where the boundary between composition and instrument becomes blurred. The study also engages with theoretical frameworks from Vilém Flusser and Friedrich Kittler, situating the instrument’s score within broader discourses on technology and embodiment. Finally, the paper explores the challenges of notating such scores, drawing parallels with choreographic practices, and concludes by emphasising the body’s central role in interpreting and enacting these inscriptions during performance.
Extensive evidence links air pollution exposure to cognitive decline; however, it remains unclear whether cognitive reserve and brain reserve modify this association. We examined the moderating roles of cognitive reserve contributors and brain reserve in the association between air pollution and cognitive function in dementia-free adults.
Methods
Cross-sectional data were obtained from 650 participants who underwent 3T brain magnetic resonance imaging and completed the Montreal Cognitive Assessment (MoCA). Cognitive reserve contributors were assessed based on education, occupation, and social engagement. Brain reserve was quantified using the ventricle-to-brain ratio derived from brain scans. Five-year average concentrations of particulate matter with diameters ≤10 and ≤2.5 μm and nitrogen dioxide were estimated based on residential addresses. Partial least squares structural equation modeling was applied to construct latent variables representing the air pollution mixture and composite cognitive reserve (contributors). Analyses examined whether cognitive reserve contributors and brain reserve modified associations of air pollution with MoCA scores and suspected mild cognitive impairment.
Results
In individuals with an average level of cognitive reserve, a 1–standard deviation increase in air pollution mixture was associated with a 0.24-point decrease in MoCA scores (95% confidence interval [CI]: −0.31 to −0.16). This association was attenuated in individuals with higher cognitive reserve (β = −0.12; 95% CI: −0.25 to 0.02) and intensified in those with lower cognitive reserve (β = −0.36; 95% CI: −0.37 to −0.35). The moderating effect of brain reserve was not significant.
Conclusions
Higher cognitive reserve may mitigate the effects of air pollution on cognitive function.
Within resource-limited health care, it is important to demonstrate the value and impact of neuropsychological assessment (NPA) services. However, the most suitable methods for capturing these outcomes are yet to be established. We aimed to identify key potential outcomes of NPA, existing measures of these outcomes, and issues and challenges associated with outcome measurement.
Method:
Focus groups of experienced Australian neuropsychologists discussed possible NPA outcomes, existing measures, and challenges of outcome measurement, analyzed using thematic analysis. The Delphi method of expert consensus was then used to identify the most important set of NPA outcomes, using iterative survey rounds with expert panelists. Panelists also rated the top three outcomes most likely to demonstrate the impact of NPA in trials.
Results:
There were 50 potential NPA outcomes generated by the focus groups, spanning proximal and distal patient, caregiver, health service, and societal domains. Numerous issues and challenges were identified associated with meaningfully measuring NPA outcomes. After three Delphi survey rounds (n = 46), a total of 16 outcomes achieved consensus agreement. Few existing validated measures were identified. The top three rated outcomes were 1) better patient and/or caregiver understanding of presenting problems, 2) better patient and/or caregiver understanding of how to manage and cope with cognitive symptoms, and 3) diagnostic clarification.
Conclusions:
Psychoeducational benefits of NPA were considered by Australian experts as key outcomes relevant across contexts; however, there are no existing measures of these outcomes. Future research should develop valid outcome measures to be used in clinical trials evaluating NPA impacts.
We evaluate the systematic position of Shundeagrion cheni Huang, Lia, and Nel, 2024 and transfer it to the odonate suborder Cephalozygoptera and family Dysagrionidae.
Golden Dawn (GD), Greece’s most prominent far-right political organization, strategically utilized antisemitism as its core ideological principle rather than a marginal prejudice or rhetorical device. This article argues that antisemitism served primarily as an epistemological conspiratorial framework central to GD’s ideological worldview, providing a coherent interpretive lens through which all political, economic, and social phenomena were explained as elements of a singular Jewish-orchestrated plot. Drawing on qualitative discourse analysis of over 10,300 GD publications spanning 1993 to 2020, the study illustrates how this epistemological master frame enabled the party to unify diverse domestic and international issues, from foreign policy tensions and immigration debates to economic crises, under a consistent antisemitic narrative. Additionally, by explicitly employing Holocaust denial, endorsing Nazi symbolism, and openly propagating antisemitic conspiracies, GD deliberately violated post-Holocaust European norms. This normative transgression was integral to the party’s identity, positioning it in overt defiance of mainstream moral and political boundaries. The article thus demonstrates how GD’s antisemitism functioned not merely as a rhetorical provocation but as the foundation of a comprehensive ideological system that consciously challenged established European taboos. These findings also suggest broader implications for understanding the role and adaptability of conspiratorial antisemitism and normative transgression in other extremist ideologies beyond the Greek context.
We consider a generalization of the forest fire model on $\mathbb{Z}_+$ with ignition at zero only, studied by Volkov (2009 ALEA6, 399–414). Unlike that model, we allow delays in the spread of the fires and the non-zero burning time of individual ‘trees’. We obtain some general properties for this model, which cover, among others, the phenomenon of an ‘infinite fire’, not present in the original model.
Under a natural assumption on the dynamical degrees, we prove that the Green currents associated to any Hénon-like map in any dimension have Hölder continuous super-potentials, i.e., give Hölder continuous linear functionals on suitable spaces of forms and currents. As a consequence, the unique measure of maximal entropy is the Monge-Ampère of a Hölder continuous plurisubharmonic function and has strictly positive Hausdorff dimension. Under the same assumptions, we also prove that the Green currents are woven. When they are of bidegree $(1,1)$, they are laminar. In particular, our results generalize results known until now only in algebraic settings, or in dimension 2.
The urban authorities of early modern Dutch cities employed a broad variety of public servants to manage the urban administration and provide public services relating to health, security, education, and entertainment. Neither part of the governing elite nor members of the guilds, these urban officials are of interest to historians of both work and governance. This article demonstrates that studying these public servants might yield valuable insights into premodern attitudes to work, especially public work. Using applications for employment in public office as well as petitions for improved remuneration, we analyse the value public servants of early modern Dutch cities attached to their professional activities. The town of Zwolle (c.1550–1700) serves as a case study, shedding light on the conditions under which people decided to work in urban public services. In their competition for the town’s salaried offices, candidates demonstrated considerable individual initiative, ranging from unsolicited applications to proposals concerning their personal value for the civic community. Similarly, officeholders demanded proper remuneration befitting the value of their work and their services for the town’s common good.
Investment facilitation is an increasingly important policy tool to promote foreign investment. However, we know very little about its prevalence. This paper introduces a new dataset for measuring the adoption of investment facilitation measures at country level. The Investment Facilitation Index (IFI) covers 101 measures, grouped into six policy areas, and maps adoption across 142 economies. The paper outlines the conceptual and methodological framework of the IFI, analyses the current levels of adoption, and demonstrates the index’s robustness. The data show that economies with lower adoption rates typically belong to the low-income or lower-middle-income groups, often located in Sub-Saharan Africa, Latin America and the Caribbean. This dataset serves as a benchmark for assessing the design and impact of international agreements, such as the Investment Facilitation for Development Agreement (IFDA). It can also support the IFDA implementation by guiding domestic assessments of technical assistance needs and capacity development.
This study aimed to investigate the abundance distribution of Quinella in yak rumen, a dominant microbe associated with low methane emissions and high propionate yield, and its modulation of microbial carbohydrate metabolism. A high-quality genomic database for rumen Quinella was constructed through the screening of 12 717 published metagenome-assembled genomes from 12 ruminant species. Genomic annotation indicated that Quinella possessed two distinct gene clusters for converting fumarate to propionate. The 16S rRNA sequencing data revealed that the ruminal Quinella abundance is host-dependent, with a markedly higher prevalence in yaks (56.3%) than in cattle (3.01%). In yaks, higher rumen Quinella abundance was accompanied by the lower abundances of enoyl-CoA hydratase and acetate CoA transferase, encoding two butyrate synthetases but higher abundances of key genes involved in propionate synthesis. In vivo analyses found that yaks carrying more Quinella abundance (high or low groups, n = 9 per group) exhibited higher total volatile fatty acids and lower butyrate percentage in their ruminal contents. Additionally, comparative metagenomic analysis indicated that microbial genes from yaks with higher Quinella were enriched in critical metabolic pathways, including glycolysis, the reductive Krebs cycle, and the conversion of acetyl-CoA to acetate. However, no significant differences in methane production (prediction based) were observed between yaks with higher or lower Quinella (n = 9 per group). In summary, this study provided a valuable genomic resource for further research on Quinella and partially verified its potential in microbial carbohydrate metabolism, specifically enhancing volatile fatty acid production. However, its role in yak methane emission requires further validation.
School refusal among neurodivergent students underscores systemic failures in traditional educational systems. This qualitative study, informed by the neurodiversity paradigm, examines how Flexible Learning Options (FLOs) in South Australia address drivers of disengagement, such as sensory overload, punitive discipline, and identity erasure, while fostering reengagement through autonomy, relational safety, and identity empowerment. Drawing on interviews conducted with a subsample of 18 students aged 13–19, reflexive thematic analysis resulted in the development of three themes: (1) autonomy and its limits, (2) relational safety as harm reduction, and (3) identity empowerment through neuroaffirmation. The findings reported in this paper advocate for educational models that transform flexibility from a temporary solution into a blueprint for equity, ensuring schools become spaces of support rather than harm for neurodivergent learners.
This study aimed (1) to characterise the use and prevalence of nutrition and health claims (NHC) and (2) to examine the association between NHC and the potential presence of Health Canada’s front-of-pack (FOP) nutrition symbol indicating high saturated fats, sugars and/or Na on a sample of Canadian prepackaged food products.
Design:
A cross-sectional analysis was conducted on five categories of prepackaged food products. Label components were classified using the International Network for Food and Obesity/non-communicable diseases Research, Monitoring and Action Support (INFORMAS) labelling taxonomy. Products’ nutritional profile was evaluated using Health Canada’s FOP symbol nutrient thresholds for saturated fats, sugars and Na.
Setting:
Data were obtained from the Food Quality Observatory database, collected between 2018 and 2022 from food retailers in Québec City and the Greater Montreal Area or online.
Participants:
A total of 2937 food products were evaluated from five food categories: breakfast cereals (n 392), cookies and granola bars (n 983), flavoured milks and plant-based alternative beverages (n 202), salty snacks and crackers (n 1063) and yogurts and plant-based yogurt alternatives (n 297).
Results:
Overall, 74·2 % of food products had an NHC and 28·9 % had an NHC and would require to display the FOP symbol. Food products that would require the FOP symbol were less likely to carry an NHC.
Conclusions:
The results demonstrate substantial use of marketing techniques highlighting positive product attributes. Given the potential for inconsistent messaging on food products carrying NHC and the FOP symbol, these results highlight an opportunity to improve Canadian labelling regulations by restricting the use of NHC on products high in saturated fats, sugars and/or Na.
This article deals with the domestic politics of Estonia and Latvia after the Russian invasion of Ukraine on 24 February 2022. It studies the cases of the Estonian Conservative People’s Party (EKRE) and Latvia’s National Alliance (NA). This piece concentrates on the cases of EKRE and NA with an interest in these parties’ formation processes, outlooks on identity politics, their stances vis-à-vis the EU and developments in international politics, and their relations with other political actors in Estonia and Latvia.
EKRE and NA anchor their ideological prerogatives in the longer trajectories of ethno-nationalism in Estonia and Latvia. However, whereas NA transformed into a party of the national conservative right, open to cooperation with centrist and centre-right partners, EKRE has remained a party of the radical right with a staunchly anti-systemic rhetoric and agenda. This particularity is largely to account for NA’s convergence with Latvia’s major parties on the increased securitisation of relations with Russia and EKRE’s divergence towards a rhetoric that urges a prioritisation of the national interest and a “pro-peace” stance vis-à-vis the war in Ukraine.
Healthcare personnel (HCP) are at risk for occupational exposure to tuberculosis. Current guidelines for managing exposed HCP are broad and resource intensive. Based on review of our internal data, we propose a risk-based stratification approach to streamline exposure follow-up testing and optimize resource utilization.
Childhood undernutrition is a global public health challenge, affecting children unevenly within the same household. This study assessed the behavioural and genetic correlates of malnutrition among children aged 1–3 years in a district of the Greater Accra Region, Ghana. A cross-sectional study involving 262 child-caregiver pairs was conducted. Children were classified as wasted, stunted or healthy based on anthropometric indices. Feeding behaviours – including appetite, food refusal, force feeding and maternal feeding anxiety, were assessed using the International Complementary Feeding Evaluation Tool. Saliva samples were used to genotype nine SNP associated with appetite and energy regulation and a polygenic risk score (PGRS) was generated. Wasted children had significantly lower appetite z-scores (mean difference MD (CI): –0·37 (–0·65, –0·09) and higher z-scores for food refusal (0·30 (0·03, 0·58)) and caregiver feeding anxiety (0·67 (0·39, 0·94)) compared with healthy children. Maternal feeding anxiety attenuated the association between appetite and weight for height z-score while remaining a strong independent predictor. No associations were found between feeding behaviour and stunting. Although force feeding was common (33 % of children), it did not differ by nutritional status. The SNP rs2274333 showed a higher frequency of homozygosity for the AA genotype in wasted children. The PGRS was significantly associated with low appetite (p = 0·046) but not with food refusal or nutritional status. Children with wasting had a lower appetite and a higher food refusal. This is associated with high levels of maternal feeding anxiety, but does not seem to have a strong genetic basis.
Infectious diseases result from multiple interactions among microbes and hosts, but community ecology approaches are rarely applied. Manipulation of vector populations provides a unique opportunity to test the importance of vectors in infection cycles while also observing changes in pathogen community diversity and species interactions. Yet for many vector-borne infections in wildlife, a biological vector has not been experimentally verified, and few manipulative studies have been performed. Using a captive colony of fruit bats in Ghana, we conducted the first study to experimentally test the role of bat flies as vectors of Bartonella species. We observed changes in the Bartonella bacteria community over time following the decline of bat flies and again after their subsequent restocking. Reduced transmission rates led to microbial community changes attributed to ecological drift and potential species sorting through interspecific competition mediated by host immunity. We demonstrate that forces maintaining diversity in communities of free-living macroorganisms act in similar ways in communities of symbiotic microorganisms, both within and among hosts.