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This study was conducted to investigate the effects of blended oils with a balanced n-6/n-3 PUFA ratio of 6:1 and unsaturated fatty acid/SFA (UFA/SFA) ratio of 2·5:1 on growth performance and intestinal health in lipopolysaccharide (LPS)-challenged piglets. One hundred and twenty piglets were selected and randomly assigned to two treatments (2 % soybean oil or 2 % blended oils). On day 28, the experiment was conducted as a 2 × 2 factorial arrangement of treatments, including dietary treatment (2 % soybean oil v. 2 % blended oil) and LPS challenge (saline v. LPS). The results showed that the blended oils supplementation increased average daily gain and average daily feed intake during 1–14 d (P < 0·05), and reduced feed to gain ratio in the whole experimental period (P < 0·05). In addition, the blended oils supplementation improved intestinal morphology, increased maltase and sucrase activities and alleviated inflammation response in the intestine. Moreover, the blended oils supplementation increased proliferating cell nuclear antigen mRNA expression in jejunum and Ki67 mRNA expression in ileum (P < 0·05) in both saline-treated piglets and LPS-challenged piglets. The blended oils reduced C-myc and caspase-3 mRNA expressions and increased Axin2 and Cyclin d1 mRNA expressions after LPS challenge (P < 0·05). In conclusion, the blended oils can improve growth performance and promote intestinal health in piglets.
La guerre d’Algérie est entrée dans l’ère des réparations. Face à la pression de groupes mémoriels (appelés, rapatriés, harkis), l’État a pris des mesures compensatrices ciblées avant de nommer cette guerre en 1999. Mais cette histoire partielle marginalise les familles des 4 000 tués et 10 000 blessés qui, sans s’être constituées en groupes, n’ont pas moins œuvré à bas bruit dès le début de la guerre pour une reconnaissance de leur expérience : une guerre en métropole faite d’affrontements fratricides entre Algériens, de répressions policières et de menées OAS. À partir de questions écrites à l’Assemblée nationale, de textes réglementaires, de milliers de dossiers de successions montés par des familles algériennes et de centaines de demandes d’indemnisations adressées aux autorités, cet article propose une ethnographie historique de l’État pris dans les transactions réparatrices d’une guerre non déclarée. Il redéfinit alors la chronologie, les modalités et les stratégies déployées par les victimes civiles de la guerre d’Algérie pour obtenir réparation. Il remarque d’abord que la fiction d’une guerre sans nom n’a pas été simplement imposée par l’État, mais a été renforcée par en bas, à travers les négociations engagées sous la forme d’accidents de travail ou de trajet. Il souligne ensuite que la lutte menée par les victimes collatérales françaises a suscité un élan de solidarité nationale à l’origine d’une des premières lois d’indemnisation pour les victimes du terrorisme en France, rejetant les « inexcusables » algériens. Il démontre enfin que les amnisties, les frontières nationales, la définition rétroactive du maintien de l’ordre et la reconnaissance progressive par l’État de la guerre en Algérie ont achevé de créer une nouvelle guerre sans nom, la guerre en métropole, avec son lot d’exclus des réparations.
Social connections might be protective against depressive and anxious symptoms and dementia in later life. The extent to which social connections are heritable versus modifiable in older age remains unknown.
Aims
We aimed to investigate the heritability of social connections and their influence on mental and cognitive health over time among older adults in a longitudinal cohort.
Method
We analysed data from the Older Australian Twins Study (333 monozygotic, 266 dizygotic twins; 65+ years) at three time-points over 6 years. We examined the factor structure and heritability of baseline social connections and their associations with mental and cognitive health longitudinally.
Results
We found three weakly heritable social connections factors: (a) interacting with friends/neighbours/community (h2 = 0.09, 95% CI: 0.00, 0.44); (b) family interactions/childcare (h2 = 0.13, 95% CI: 0.00, 0.43); (c) involvement in religious groups/caregiving (h2 = 0.00, 95% CI: 0.00, 0.19). Strong genetic correlations were observed between depressive symptoms and factors a (r = −0.96) and b (r = −0.60). More frequent baseline interactions with friends/neighbours/community were associated with fewer depressive symptoms cross-sectionally (B = −0.14, p = .004) and longitudinally (B = −0.09, p = 0.006), but the associations between social connections and cognitive health were not significant.
Conclusions
Social connections were weakly heritable, suggesting large environmental determination. Connections with friends/neighbours/community were associated with better mental health cross-sectionally and over time.
A number of recent monographs testify to the dynamism of transimperial analyses of the Russian and Ottoman Empires in the late modern period. In particular, the study of prisoners of war, refugees, and pilgrims has enabled three young scholars, Will Smiley, Vladimir Hamed-Troyansky, and Lâle Can, to offer fresh perspectives on the history of institutions central to political modernity. By exploiting new sources, focusing on interactions between state and non-state actors, exploring ordinary practices of government, and decentering perspectives, these volumes contribute to shaping a powerful historiographical renewal. Reading them together, this article considers the dynamics of the co-construction of imperial orders based on shared conceptions of sovereignty, subjecthood, and protection. It underlines the systemic entanglement of the two empires’ colonization projects, the centrality of borderland actors, and the complex redefinition of affiliations and belonging that took place in the course of these often violent processes of modernization.
This study aims to evaluate differences in healthcare utilization among patients with ischemic stroke in metropolitan versus non-metropolitan Manitoba.
Methods:
This study is a population-level analysis using the Discharge Abstract Database from Manitoba. The database includes all patients who received care in a Manitoba facility for ischemic stroke between April 2019 and March 2023. Data were collected on patient demographics, comorbidities and geographical location of stroke presentation (metropolitan Winnipeg vs non-metropolitan). Outcomes included length of stay (LOS), treatment, discharge disposition and mortality. Regression analysis was performed to analyze outcomes, adjusting for age, sex and comorbidities.
Results:
3704 (71.6%) patients were admitted in Winnipeg, and 1471 (28.4%) patients were admitted in non-metropolitan Manitoba. Patients presenting to Winnipeg were younger (mean age 72.3 vs 74.3 years) and had higher rates of atrial fibrillation, hypertension, diabetes, chronic kidney disease and heart failure. Patients presenting to Winnipeg had a shorter LOS (16.1 days vs 18.4 days, coefficient 0.05, 95% CI −4.54 to −1.27), had higher rates of intravenous thrombolysis (adjOR 5.13, 95% CI 3.85–6.84), were less likely to be discharged home (39.8% vs 57.5%, adjOR 0.47, 95% CI 0.41–0.53) and were more likely to be transferred for inpatient stroke rehabilitation (adjOR 3.46, 95% CI 2.64–4.54). There were no differences in in-hospital mortality. There was a higher incidence of stroke in Winnipeg compared to non-metropolitan Manitoba (F-statistic 23.84, p = 0.0028).
Conclusions:
This study illustrates differences in healthcare utilization outcomes between patients living in metropolitan Winnipeg versus non-metropolitan Manitoba presenting with ischemic stroke.
This study presents the integrated results of stable carbon (δ13C) and nitrogen (δ15N) isotope and aDNA analyses, conducted to examine dietary and mobility practices in two mid- to late Byzantine communities in western Anatolia: the coastal cosmopolitan site of Kadıkalesi Anaia and the rural inland settlement of Barcın Höyük. Isotopic data from thirty-eight individuals indicate that both populations primarily consumed terrestrial C₃-based resources. At Kadıkalesi, δ15N values show greater variability, suggesting more differentiated access to animal protein sources, whereas the rural community at Barcın Höyük exhibits isotopic homogeneity, consistent with more uniform dietary practices and an equitable access to food. Kadıkalesi also shows intra-site dietary variation by age and sex, while Barcın is again more homogeneous. At Barcın, aDNA results indicate a predominant local genetic continuity, suggesting a stable population; a single instance of external ancestry is attested by a male individual with affinities to western populations, particularly from eastern Europe, in line with historical military resettlement patterns (stratiotika ktemata). By integrating isotopic and genomic evidence, this study demonstrates how ancestry and mobility shaped dietary habits, offering insights into the interplay of urbanism, mobility, and social organization in the Byzantine period.
The Supreme Court is less constrained than political science has recognized. Motivated justices can dramatically alter politics without deferring to actors in the other branches. Subverting constraints, justices can aggrandize power and impose their irreducible preferences. Using Reconstruction as an example, this article brings new evidence to support the claim that an autonomous Court precipitated the end of Reconstruction. I make three essential arguments: First, the Republican commitment to federal civil rights protection extended longer than is traditionally supposed. Second, the architect of postbellum constitutionalism, Justice Bradley, harbored long-standing fear of Black equality and enfeebled the Reconstruction amendments when neither legal nor political imperatives compelled him to do so. Last, Bradley’s interventions substantially hindered Reconstruction by facilitating the “redemption” of southern state governments. This article employs mixed-methodology, using a difference-in-differences analysis and novel archival data. Contrary to scholarship arguing that the Court simply followed a Republican retreat, the Court dramatically reshaped the political-social development of Reconstruction.
Le 8 juin 2023, le Canada et les Pays-Bas ont saisi la Cour internationale de justice (CIJ) pour des violations de la 1984 Convention contre la torture et autres peines ou traitements cruels, inhumains ou dégradants attribuées à l’État syrien. À cette situation étatique, souvent décrite comme une zone où le droit et la justice n’avaient pas leur place, se superposent ainsi de premiers efforts pour que l’État rende des comptes. Au-delà de la possibilité dont dispose la Cour internationale de Justice (CIJ), en tant que visage institutionnel de la responsabilité étatique, de réduire ici le “fossé d’impunité,” cette affaire met également en lumière la tension existante entre deux visions opposées du droit international (“universaliste” et “souverainiste”) qui sont appelées à coexister dans le cadre de la lutte contre l’impunité. Bien que cette affaire, s’inscrivant dans une lignée jurisprudentielle favorable à l’élargissement de la fonction judiciaire de la CIJ, confirme la proximité avec le modèle “universaliste” eu égard à l’extension du locus standi devant son prétoire et à l’évolution de son mandat pour embrasser les contextes gouvernés par des violations massives des droits de la personne, il ne faudrait pas en déduire que le paradigme “souverainiste” a été effacé et remplacé.
Twin fetuses show a physiologically slower growth rate in the third trimester compared to singletons. Therefore, it has been suggested that the anthropometric evaluation of twins at birth should be performed using twin-specific charts. To be reliable, anthropometric charts need to fulfil certain methodological criteria to systematically review studies that have developed neonatal twin-specific anthropometric charts and assess their methodological quality. A comprehensive search was conducted across Cinahl, Embase, Global Index Medicus, PubMed, Scopus, Web of Science, Google Scholar, and relevant preprint repositories, followed by a predefined snowballing search. Two reviewers independently screened studies for eligibility, selecting those that have developed cross-sectional anthropometric charts for twins at birth, published since January 1990. Articles were excluded if they did not use anthropometric measurements at birth to construct charts. Two reviewers independently extracted data and performed quality assessment with a 16-item grading system. Sixty-eight studies were included, with all but one constructed reference, not standard, charts. Most studies did not meet the quality criteria: only 9% were prospectively designed, 34% reliably estimated gestational age, 19% reported standardized instruments, 28% described measurement techniques, and 26% did not stratify centiles by sex. This review reveals considerable methodological limitations in existing twin-specific neonatal anthropometric charts.
The optically stimulated luminescence (OSL) sensitivity of quartz ranges across five orders of magnitude. Previous studies suggested that quartz OSL sensitivity is enhanced by solar exposure–burial irradiation cycles. Spatially resolved luminescence measurements and laboratory illumination–irradiation experiments were used to investigate the OSL sensitivity of quartz crystals from a granodiorite cobble and quartz grains from a fluvial sand. Quartz from the granodiorite cobble has low OSL sensitivity, showing an approximately linear sensitization path that resulted from laboratory illumination–irradiation cycles. The mean OSL sensitivity of quartz sand grains (100 grains) increased from ∼40 to 80 counts after 1260 illumination–irradiation cycles. Each grain has a specific sensitization trajectory due to illumination–irradiation cycles, suggesting that quartz crystal composition heterogeneities drive the OSL sensitization of their daughter sediment grains. Maximum OSL sensitivity of quartz sand grains is reached after illumination–irradiation cycles representing an accumulated dose of around 4000 Gy. This dose corresponds to sediment burial time of 2–4 Ma, which is unlikely to occur during a single sediment transport route. This study suggests that illumination–irradiation cycles are unable to produce quartz sand grains with OSL sensitivity up to five orders of magnitude higher than the sensitivity of parent crystals in igneous or metamorphic rocks.
This paper studies efficiency in the housing market in the presence of search frictions and endogenous entry of buyers and sellers. These two features are essential to explain the housing market stylized facts and to generate an upward-sloping Beveridge Curve in the housing market. Search frictions and endogenous entry create two externalities in the market. First, there is a congestion externality common to markets with search frictions. Sellers do not internalize the effect of listing a house for sale on other sellers’ probability of finding a buyer. Second, the endogenous entry of buyers leads to a participation externality, as new entrants in the market raise search costs for all buyers. The equilibrium is inefficient even when the Hosios-Mortensen-Pissarides condition holds. Using a calibration to the US housing market, we quantify the size of these externalities and how far the housing market is from the optimal allocation. The optimal vacancy rate and time-to-sell are about half their equilibrium counterparts, whereas the optimal number of buyers and homeowners are above their decentralized equilibrium values. Finally, we investigate how housing market policies restore efficiency in the housing market.
Digital health services in Kenya comprise mobile health applications (mHealth apps), electronic health records, telehealth and telemedicine, which form part of an expanding digital health assemblage. These are shaped by transnational development agendas and donor-driven public health interventions. This paper discusses the for-profit turn in the digitalisation of health care – what I term the ‘appisation’ of health – as a site of intensified commodification where users are reconfigured as digitised health consumers. While other scholars have argued that digitalisation functions as extractive in deepening market penetration into spheres of life we rely on, I extend these arguments by claiming that, far from enhancing access, these technologies exploit vulnerabilities through opaque governance mechanisms and algorithmic decision-making, while transferring responsibility for health from the state to the individual, thus creating new dependencies on market-mediated platforms. Using discursive interface analysis of two health apps in Kenya, I examine how consumer health apps embed vulnerabilities while consumer law remains structurally limited in confronting the collective harms they generate.
Blood culture contamination (BCC) leads to increased costs and patient harms. We reviewed 525 BCC cases and found 71.2% of BCC cases were ordered for indications with low risk for bacteremia and most received unnecessary tests and antibiotics. Diagnostic stewardship of blood cultures may reduce BCC and its associated costs.