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Few studies have examined how differing diagnostic criteria for mild cognitive impairment (MCI) relate to neuroimaging markers of cerebrovascular disease and neurodegeneration in Veterans. We compared three MCI diagnostic schemes on their associations with white matter hyperintensity (WMH) burden, hippocampal volume, and cortical thickness in nondemented Vietnam-era Veterans.
Methods:
228 Veterans (mean age = 69.65) were classified using: (1) Alzheimer’s Disease Neuroimaging Initiative (ADNI) criteria (subjective memory concerns, impaired Logical Memory, global Clinical Dementia Rating = 0.5); (2) neuropsychological criteria (>1 standard deviation [SD] below norms on two tests within a domain or one test across three domains); and (3) typical criteria (subjective memory concerns and >1.5 SD below norms on one test). Regression models predicting WMH burden adjusted for age and intracranial volume and included MCI status and hippocampal volume; ADNI-based models also included posttraumatic stress disorder symptom severity.
Results:
Neuropsychological criteria were associated with greater WMH burden (β = 0.45, p = .024), whereas typical and ADNI criteria were not. Sensitivity analyses found that meeting neuropsychological criteria for amnestic MCI interacted with lower hippocampal volume to predict greater WMH burden (β = −0.001, p = .028). No criteria were associated with cortical thickness.
Conclusions:
Neuropsychological criteria more sensitively identified Veterans with greater WMH burden and demonstrated a small, hippocampal volume-dependent effect in amnestic MCI. These findings support the clinical utility of multi-test neuropsychological approaches for detecting complex brain changes in high-comorbidity populations, with implications for risk stratification and targeted intervention in aging Veterans.
The olive weevil Pimelocerus perforatus (Roelofs, 1873) is a destructive wood-boring pest of Oleaceae plants, which has caused serious damage to Fraxinus pennsylvanica Marshall and Olea europaea L. in China and Japan. This study evaluated the feeding preference, nutritional indices, and oviposition performance of olive weevil adults feeding on five Oleaceae plants, F. pennsylvanica, O. europaea, Osmanthus fragrans Lour., Syringa oblata Lindl., and Ligustrum × vicaryi Rehder. The results showed that adult olive weevils preferred to feed on O. fragrans, with a selection rate of 56.25 ± 6.91%, followed by F. pennsylvanica and O. europaea. No feeding preference was observed on L. × vicaryi. The nutritional index F values for female adult weevils feeding on F. pennsylvanica and S. oblata were the highest, 0.37 ± 0.02 g and 0.37 ± 0.01 g, respectively. For both female and male adults, F values were lowest on O. europaea for both sexes, while ECD, ECI, and GR were highest on this host. Although adult olive weevils preferred O. fragrans, the female adults did not exhibit oviposition behaviour after feeding on O. fragrans. After feeding on F. pennsylvanica and S. oblata, the maximum number of eggs laid by female adults was 19.20 ± 3.90 and 18.80 ± 3.11, respectively. Therefore, we believe that F. pennsylvanica and S. oblata may be the plants with the most serious harm caused by adult olive weevils, while O. fragrans could be used as a trap plant to attract female adult olive weevils.
Inaugurated in 1948 with initially 23 signatories, the General Agreement on Tariffs and Trade (GATT) constituted a vital part of the post-war economic architecture. While traditionally the founding of the GATT has been strongly identified with the role of US hegemonic power and free trade enthusiasm, this article reframes the GATT’s origins by highlighting how (anti-)imperial dynamics shaped negotiations over its basic elements, including participation, membership, and permissible exceptions to most-favoured nation principles. Drawing on sources from the GATT archives and government documents from the United Kingdom and the United States, it highlights how empires sought to preserve key elements of imperial economic relations, including by incorporating imperial authority structures, preserving colonial preference systems, and creating other exceptions to trade liberalization. It also shows how developing countries leveraged the trade negotiations to loosen the grip of empires, expand participation, and promote regional and developmental cooperation. Consequently, the final GATT outcome represents a hybrid and transitionary organization, with the organization preserving key elements of imperial economic relations even as it incorporated some demands for the equality of states and economic justice.
Archaeological knowledge of Indigenous human–plant relationships within the Canadian northern plains is comparatively limited to more southern areas of the Great Plains. This is partly due to a lack of standardized requirements and methodologies for paleoethnobotanical research in Canadian cultural resource management; in addition, often such research is only routinely practiced by paleoethnobotanists, of which there are few in the study region. However, deep-rooted traditions of Eurocentric Western ontologies have also shaped archaeological knowledge of precolonial Indigenous human–plant relationships. This article illuminates how archaeological knowledge of precolonial Indigenous Ways-of-Being has been highly influenced by early historical, anthropological, and settler-colonial logics. We then collate and reevaluate archaeological evidence of Indigenous plant management from the Canadian northern plains (e.g., paleoethnobotanical evidence) and problematize contemporary archaeological approaches to past Indigenous human–plant relationships in the study area. To conclude, we suggest pathways for expanding archaeological knowledge of Indigenous human–plant relationships in the Canadian northern plains through engaging with Indigenous Knowledge, dismantling remnant colonial foundations in archaeological practices, and expanding archaeological science approaches.
I analyze the main characteristics of the hierarchy of levels of selection as manifestors of adaptation (i.e., hierarchy of levels of evolutionary organization) and show that, while ranked, this hierarchy is nonnested. Secondly, I consider a potential objection to my approach derived from Eronen and Ramsey’s (2025) claim that levels of organization should be teased apart from levels of selection. I argue that their approach rests on a failure to distinguish between interactors and manifestors of adaptation, for while a hierarchy of interactors does not correspond to a hierarchy of levels of organization, a hierarchy of manifestors does.
This article argues that at Od. 16.305 καί κ’ ἐτεοδμώων is to be preferred to the medieval vulgate καί κέ τεο δμώων. The latter is metrically anomalous and semantically obscure, and its awkwardness prompted secondary variants and conflicting interpretations. By contrast, the reading associated with Ptolemy of Ascalon is metrically sound and semantically apt, meaning ‘true slaves’. The evidence further suggests that ἐτεοδμώων was already regarded in antiquity as an authentic manuscript reading. Since both readings derive from the same unaccented sequence (ΚΕΤΕΟΔΜΩΩΝ), the issue is not one of conjectural intervention but of correct division and interpretation. Future editions should therefore adopt καί κ’ ἐτεοδμώων.
Fungal contamination of healthcare environments is increasingly recognized as a potential contributor to healthcare-associated infections, yet standardized environmental surveillance strategies remain poorly defined. Culture-based methods are widely used but have limitations including low sensitivity and prolonged turnaround time. Molecular approaches such as quantitative PCR (qPCR) may improve detection but have not been extensively evaluated in real-world hospital environments.
Methods:
We conducted a longitudinal observational study across three inpatient units at a tertiary academic medical center from September 2023 through June 2024. Environmental samples were collected monthly from patient rooms and shared unit areas, including air, bathroom floors, HVAC components, patient bedrails, and linen storage areas. Samples were analyzed using direct-from-sample 18S qPCR and culture-based detection followed by 18S or ITS sequencing.
Results:
Among 742 samples collected, 474 (64%) were positive for fungi by qPCR compared with 213 (29%) by culture (P < .01). qPCR showed higher detection rates across most sample types, including air (35% vs 3%), bathroom floors (86% vs 42%), HVAC exhaust vents (72% vs 41%), and patient bedrails (78% vs 10%). Culture methods identified a broader diversity of fungi, including Talaromyces, Candida, and Penicillium, while qPCR detections were dominated by Malassezia.
Conclusions:
Molecular and culture-based methods provide complementary insights into hospital fungal contamination. qPCR demonstrated greater sensitivity, while culture identified a broader range of viable fungi. Future surveillance strategies may benefit from leveraging qPCR sensitivity using targeted primers for clinically important fungi, reducing the need for broad sequencing and bioinformatic analysis.
Knut Wicksell’s contributions to economic theory were of central importance for Mauro Boianovsky’s personal development and achievements in the history of economic thought. This paper describes the distinctly archiv(e)ological approach that Mauro developed in the research for his dissertation and his long 1995 article on “Wicksell’s Business Cycle,” an approach that he also adopted in most of his articles in later years. The account is based on the author’s personal experience of collaboration with Mauro in a number of studies on monetary theory, business cycle theory, unemployment, and modern macroeconomics.