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Sub-threshold depression (SD) affects around 11% of adolescents and can be as impairing as conditions reaching the full diagnostic criteria of Major Depressive Disorder (MDD). However, limited research has been conducted on how affective disturbances manifest in SD during adolescence, a period of affective vulnerability. We compared three groups of adolescents along the spectrum of depression on their positive affective (PA) and negative affective (NA) levels and dynamics, including variability, inertia, and reactivity to event-related stress and pleasure in daily life.
Method
One hundred and ninety eight adolescents (age 12–18), grouped by psychiatric diagnosis (MDD = 66; SD = 35; healthy controls, HC = 88), completed a 14-day experience sampling on their smartphone, clinical ratings, and questionnaires. They were recruited from multiple sources, including an epidemiologic study and specialist clinics.
Results
The level of NA was the highest in MDD, followed by SD and HC; vice versa for PA. MDD and SD displayed greater NA variability than HC. NA inertia was greater in MDD than SD and HC. NA reactivity (to event-related pleasure and stress) and PA reactivity (to event-related pleasure) were greater in MDD and SD than HC. SD showed greater PA reactivity to event-related stress than MDD.
Conclusions
Adolescents with SD were as reactive and expansive in their NA experience as the MDD group, but they did not stay in that negative state for as long. The SD group was more reactive than HC to event-related pleasure and stress, suggesting heightened sensitivity. Clinical implications of emotional sensitivity and flexibility on early intervention for depression are discussed.
The article examines the 1941 Ventotene Manifesto, one of the most celebrated—yet widely misunderstood—documents in the history of federalist Europeanism. Written by Ernesto Rossi and Altiero Spinelli while confined on the island of Ventotene for antifascist activity, the text diagnosed Europe’s collapse as the consequence of sovereign nation-states operating in an anarchic international order and called for the creation of a supranational government imposed by a revolutionary elite. This article situates the manifesto within interwar and wartime socialist, liberal–socialist, and antifascist debates, showing how Rossi and Spinelli elevated federalism as the primary criterion of political progress, displacing class struggle and national liberation. I argue that the manifesto’s revolutionary aims have been obscured by postwar narratives of European integration, which retrospectively recast it as a program for the gradual development of what became the present-day EU. Rather than being a blueprint for incremental unification, the manifesto advocated for a revolutionary federalism that fused socialism with a Jacobin conception of political power. This study challenges teleological readings of Europeanism, offering a historicist account of wartime federalist ideas as shaped by crisis, exile, and revolutionary expectations.
In established democracies, governing parties are expected to govern effectively. Government terminations that result from breaking the rule of law, policy blunders, or disastrous policy performances have the potential to damage voters’ perceptions of how well democracy functions in their countries. Yet, current research on coalition politics has not examined the specific consequences of scandal-based government terminations on voters’ attitudes toward politics and the quality of democracy. We analyze the attitudinal impacts of scandal-based government terminations and argue that this type of termination reduces citizens’ satisfaction with the way democracy functions in their countries and their propensity to vote for the party responsible for the scandal. We also examine whether scandal-based coalition terminations negatively impact voter perceptions of the government’s performance. We test our arguments by relying on a recent scandal that took place in Austria: the so-called Ibiza scandal, which caused the early termination of the coalition between the Austrian People’s Party (ÖVP) and the Austrian Freedom Party (FPÖ). At the time the scandal broke, the Austrian National Election Study was in the field. We utilize an Unexpected Event during Survey Design to test if the scandal had consequences for voters’ perceptions of the parties and their collaboration. The supporting evidence for our argument calls for the need to revive research on government termination and to initiate a new line of research on how government breakdowns affect citizens’ democratic attitudes.
While the legislative text of the Digital Fairness Act (DFA) has not yet been published, it is already clear that its effectiveness will depend as much on its enforcement design as on the content of its substantive provisions. Experience with recent instruments – including the Digital Services Act, the Digital Markets Act, the Artificial Intelligence Act and the Data Act – reveals persistent difficulties in ensuring consistent and timely enforcement across Member States. Building on the findings of the Commission’s Fitness Check of EU Consumer Law on Digital Fairness, this article examines how the enforcement design developed in these legal acts can inform the institutional and procedural design of the DFA. It argues that the challenges identified by the Digital Fitness Check reflect deeper patterns of procedural, institutional and epistemic fragmentation in EU enforcement. By analysing how different enforcement designs address these tensions through mechanisms of centralisation, coordination and capacity-building, the article identifies key design choices that may shape the emerging enforcement framework of the DFA.
This paper proposes a Palm-based framework for component importance measures conditioned on system failure events, uniformly applicable to nonrepairable, repairable, and phase-mission systems. The formulation does not require renewal, stationary, or Markovian assumptions. We classify measures into transition- and state-based importance. The former captures component failure transitions, recovering Birnbaum and Barlow–Proschan importance, while the latter provides an event-based interpretation of Fussell–Vesely importance. This framework yields well-defined finite-time and phase-conditioned measures for nonstationary systems, establishing a rigorous probabilistic foundation for failure-event-based analysis.
Dietary diversity is associated with health benefits. However, food biodiversity has been understudied. Therefore, we aim to evaluate the associations between dietary species richness (DSR), i.e. the number of species consumed by individuals, and dietary sustainability dimensions, including environmental pressures, diet quality and monetary cost.
Setting:
The study was carried out among the NutriNet-Santé cohort.
Participants:
29 173 volunteers were included.
Design:
Participants completed a 264-item FFQ. Food items were linked to the corresponding species. ANCOVA models were fitted to evaluate the associations between total, plant, animal DSR and dietary sustainability dimensions. The dietary share of organic food was computed.
Results:
Higher DSR was associated with lower overall environment impact, captured by the pRecipe, an indicator including greenhouse gases emissions, land occupation and cumulative energy demand (pRecipe, Q5 v. Q1, −8·5 %), better diet quality, reflected by the level of adherence to the French dietary guidelines (sPNNS-GS2, Q5 v. Q1: +44·8 %) and stable dietary cost. Higher plant DSR was related to lower environmental impacts, better diet quality and higher monetary cost. Higher animal DSR was associated with higher environmental pressures, lower diet quality and monetary cost. The amount of organic food consumed was positively associated with plant DSR and negatively associated with animal DSR.
Conclusions:
Overall, more biodiverse diets were related to better diet quality and lower environmental pressures. The associations seemed to be driven by plant biodiversity. Further studies are warranted to better understand the relationship between food biodiversity and sustainability dimensions across settings.
Obesity is a growing global public-health concern, particularly among immigrants to high-income countries. This umbrella literature review synthesises evidence from systematic reviews to explore the multifactorial cultural, socio-economic and environmental determinants of obesity and weight gain among immigrants to high-income countries.
Design:
A systematic search of PubMed, Web of Science and Scopus was conducted from January 2015 to November 2025 to identify systematic reviews and meta-analyses examining the impact of cultural, socio-economic and environmental factors on obesity among adult immigrants (i.e. economic, students and refugees) to high-income countries.
Setting:
Thirty-three reviews were included and thematically synthesised under four domains: physical climate and physiological changes, socio-economic stressors and psychological mediators, cultural factors and methodological quality – rated using the A Measurement Tool to Assess Systematic Reviews tool.
Results:
The review found consistent evidence linking longer duration of residence and higher levels of acculturation with increased obesity risk. Socio-economic disadvantage, food insecurity and psychological stress – particularly acculturation stress – were key mediators of weight gain. Less sunny colder climates impacted on weight gain indirectly through limiting physical activity and accessibility to traditional-healthy diet outlets. Cultural dietary transitions and intergenerational differences further influenced obesity trajectories. Methodological quality varied, with only six reviews providing meta-analysis pooled estimates of obesity and being rated as high to moderate quality.
Conclusions:
Obesity among immigrants is shaped by intersecting cultural, socio-economic, environmental and physiological factors. Public-health strategies must adopt culturally sensitive approaches that address structural barriers and support healthy transitions post-migration. Future research should emphasise longitudinal, intersectional and climate-tailored studies to inform targeted interventions.
Maternal mental health strongly influences child development and depression risk. This study investigated how positive and negative dimensions of prenatal maternal mental health differentially shape childhood depressive symptoms through cognitive mediators.
Methods
Participants were drawn from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort. Of the 1198 mother–child dyads enrolled, 523 (52.6% boys) had sufficient data for the mediation analysis. Maternal mental health at 26 weeks’ gestation was assessed using a bifactor model derived from the Beck Depression Inventory-II, State–Trait Anxiety Inventory, and Edinburgh Postnatal Depression Scale. Child language ability was measured at age 2 years with the Bayley Scales of Infant Development, executive function at age 7 years with the Behaviour Rating Inventory of Executive Function, and depressive symptoms at age 9 years with the Children’s Depression Inventory-2. Serial mediation models tested hypothesized pathways.
Results
Distinct mediation pathways emerged. Positive maternal mental health was associated with enhanced early language ability, which in turn was associated with fewer depressive symptoms in later childhood (β = −0.017, 95% CI: −0.042, −0.003). Conversely, negative maternal mental health was associated with poorer executive functioning, which in turn was associated with more depressive symptoms (β = 0.040, 95% CI: 0.016–0.077).
Conclusions
Positive and negative maternal mental health are linked to childhood depressive symptoms through distinct neurocognitive pathways. By identifying language and executive function as specific developmental mediators, our findings point to targeted and developmentally sensitive intervention opportunities to disrupt intergenerational pathways of depression.
This real-world study aimed to characterize patients with schizophrenia who achieve sustained good functional outcomes after antipsychotic discontinuation and to develop the Functional Remission in Schizophrenia after Antipsychotic Discontinuation (FURSAD) predictive model.
Methods
We retrospectively identified individuals aged 18–65 years with schizophrenia (ICD-10) from the Shanghai Mental Health Center discharge database. Patients who discontinued antipsychotics for ≥1 year were classified as functional remission (FR) or functional non-remission (FNR) based on functioning assessments. Sociodemographic, clinical, and treatment-related data were extracted blindly from hospital records and structured interviews.
Results
Among 4,166 discharged patients screened, 180 met the inclusion criteria (FR: 116; FNR: 64). Six independent predictors were identified: total disease course, Clinical Global Impression-Severity (CGI-S) score, Positive and Negative Syndrome Scale (PANSS) emotional distress subscale score, use of first-generation antipsychotics, discontinuation due to treatment benefits, and discontinuation due to lack of insight. The logistic regression model showed strong predictive performance (AUC = 0.867, 95% CI 0.813–0.921), with 82.8% sensitivity and 81.9% specificity. Internal validation was performed via 10-fold cross-validation.
Conclusion
Discontinuation motives and illness trajectory are relevant in predicting long-term functional outcomes. A limitation is that a substantial number of patients could not be recontacted or declined participation, which may introduce selection bias. The FURSAD nomogram may help clinicians estimate the probability of FR 4.5 years post-antipsychotic discontinuation in patients previously on antipsychotics for ≥3 years.
We have used a modern, medium-sized hovercraft to further explore air cushion transport in Antarctica. Hovercraft travel over hard-blown snow at safe cruising speeds of 40–60 km/h requires about 50% of the fuel consumption for hovercraft travel over a flat ocean surface. The Griffon 2000TD craft used here has an endurance of >1000 km with a 1-tonne payload (personnel and equipment). However, this standard craft, designed for operations at sea level, is limited to altitudes below about 700 m elevation by the decrease in air density. The hovercraft provides accommodation, communication and first aid facilities for its crew in the event of any weather or operational issues. Two safety features of air cushion travel in Antarctica stand out: (1) low ground pressure per unit area (15% of a human), and (2) the ability to freely cross open ice cracks of dimensions of a metre or more. The total considerations of fuel economy, safety and environmental impact suggest the surface of hard-blown snow in Antarctica provides the optimum conditions for air cushion travel on planet Earth.
Robert Colls was Professor of English History at the University of Leicester before moving to the International Centre for Sports History and Culture at De Montfort University, also in Leicester, where he is Professor Emeritus. He is the author of many highly regarded works examining English identity, culture and class. His most recent book is George Orwell: Life and Legacy (Oxford, 2026). Colls’s writing has consistently stood out for being both scholarly and accessible, engaging general audiences as well as professional historians. The Editors of Transactions asked him to reflect on the craft of historical research and – especially – writing, and this piece is the end result. Further reflections on this theme would be very welcome. Colleagues interested in contributing to the Common Room should contact the Editors in advance.
Previous research has shown that US Spanish heritage speakers produce the tap-trill contrast with varying manners of articulation and a non-canonical number of occlusions, while using duration as a more robust cue to the contrast. This contrast is present in Spanish, the heritage language, and absent in English, the majority language. In this paper, we examine the development of duration as an acoustic correlate of the tap-trill contrast by analyzing semi-spontaneous productions from child and adult heritage speakers as well as age-matched Spanish speakers from a monolingual environment. The durations of phonetic taps and trills were fitted to Bayesian hierarchical models to examine how these speaker groups differ with respect to their use of duration as an acoustic correlate. The results of our analysis show that the average child heritage speaker produces a smaller durational contrast with increased variability, and that some child heritage speakers show near-complete overlap in the duration of the two segments. Adult heritage speakers demonstrate a reduced difference in the tap-trill contrast when compared to Spanish speakers raised in a monolingual environment, but maintain a contrast between the two sounds. Developmental analyses within the child groups do not show significant differences in trill duration by age, but child Spanish monolinguals show a non-linear reduction in tap duration by age that does not occur for heritage children. Overall, our results support a scenario of protracted development in heritage children for the tap-trill contrast, as well as a potential sound change in progress for US Spanish.
Dr. Anthony Harris is Professor of Epidemiology and Public Health and Internal Medicine, and Head of the Division Genomic Epidemiology and Clinical Outcomes of Health Care Outcomes Research. He is an infectious disease physician and epidemiologist whose research interests include emerging pathogens, antimicrobial-resistant bacteria, hospital epidemiology/infection control, epidemiologic methods in infectious diseases, and medical informatics. He has published over 360 papers. He has current or has had funding from the NIH, CDC, VA, and AHRQ to study antibiotic resistance and hospital epidemiology. He is extremely proud of his mentoring track record.
We advocate for a change in the way individuals with cognitive impairment are enrolled in minimal risk clinical research. We do so in the hope that such a change will lead to more cognitively impaired individuals being enrolled in research. Our proposal applies only to cases where would-be participants retain some interest in decision-making as well as the ability to express a decision. In these cases, we argue that the common practice whereby researchers either obtain consent from the individual or consent from a surrogate and assent from the individual, is ethically unnecessary. Instead, a process of facilitated decision-making based on SDM (supported decision-making) should be employed. Although it is possible that this process of facilitation will enable some individuals to make a capacitated choice who would not otherwise have done so, this should not be a requirement of getting to choose. In those cases where a would-be participant, despite support, fails to make a capacitated choice, the individual should still have the final say about participation. In this respect, our proposal deviates from standard practice. However, we argue that our proposal offers participants as much ethical protection as the more common procedures involving surrogates.
We assume that some monetary assets are unobserved and that the demand for them affects the demand for observed assets. We develop a model of the demand for both observed and unobserved assets based on the normalized quadratic flexible functional form and augment the Divisia monetary aggregates with unobserved assets. We construct a new set of Divisia aggregates and argue that they are more accurate measures of money in terms of capturing the relationship between velocity and the opportunity cost of holding money, a relationship that has been a major concern in monetary economics for more than half a century.
Analyses of online social interactions on major platforms have become central to evaluating the ideological leanings of users. Social scientists often represent individuals’ policy preferences as ideal points in a low-dimensional space. We first demonstrate that standard ideal-point estimation approaches can be temporally inconsistent by examining the evolution of ideological positions for political elites and non-elite Twitter users from 2017 to 2022. To address this instability and to improve overall measurement quality, we augment the social-network data conventionally used for ideal-point estimation with unstructured text data widely available on social media. Our results indicate that this data-augmented approach improves identification at the extreme ends of the ideological spectrum and yields robust estimates consistent with those from more complex word-embedding techniques, while offering greater computational efficiency and interpretability. This framework can enhance future studies that measure political ideology using behavioral data and inform broader discussions about integrating textual and network information.
Dialectical behavior therapy skills training (DBT-ST) has received empirical evidence for treating non-suicidal self-injury (NSSI). However, its effectiveness in Chinese contexts remains understudied. This study aims to explore the effectiveness of DBT-ST for NSSI in a clinical sample of individuals with NSSI.
Methods
We conducted a multicenter, randomized clinical trial in China to evaluate the effectiveness of a 13-week DBT-ST compared with social support group therapy (SSGT). A total of 196 individuals with mental disorders and NSSI were recruited. The primary outcome was the frequency of NSSI thoughts and behaviors, assessed using the Ottawa Self-Injury Inventory.
Results
Participants were randomized to the DBT-ST group (n = 97) or the SSGT group (n = 99). DBT-ST was significantly more effective than SSGT in reducing the frequency of NSSI behaviors. It also showed superior effects on borderline symptoms and multiple domains of psychological functioning, including emotion dysregulation, impulsivity, alexithymia, mindfulness, psychological resilience, and emotional intelligence. Both groups exhibited significant reductions in the frequency of NSSI thoughts, suicidal ideation and attempts, and depression, with no significant between-group differences in these outcomes.
Conclusions
These findings confirm that the 13-week DBT-ST intervention is an effective treatment for Chinese patients with NSSI in clinical settings.
Current bipolar disorder (BD) therapies suffer from limited efficacy and adverse effects, necessitating mechanistically grounded targets.
Methods
We integrated BD genome-wide association study data (158,036 cases; 2,796,499 controls) with brain proteomics (ROSMAP and Banner dorsolateral prefrontal cortex, n = 376 and 152) to perform proteome-wide association studies (PWAS). Bayesian colocalization and summary-data-based Mendelian randomization (SMR) prioritized causal genes. Cell-type-specific transcriptomics validated dysregulation in iPSC-derived neurons, astrocytes, and postmortem hippocampus/prefrontal cortex. Weighted gene co-expression networks (WGCNAs), functional enrichment, and molecular docking assessed functional pathways and druggability.
Results
PWAS identified eight BD-associated genes (false discovery rate < 0.05), with DOC2A emerging as the top candidate. Colocalization (H4 > 0.8) and SMR supported a causal association of DOC2A with BD, with no pleiotropy (heterogeneity in dependent instruments P > 0.01); DOC2A expression decreased in BD across neurons (P = 4.26 × 10−2), astrocytes (P = 2.09 × 10−2), hippocampus (P = 9.80 × 10−3, t = −2.738), and prefrontal cortex (P = 1.44 × 10−2, t = −2.580); WGCNA positioned DOC2A as a key regulator (module membership/gene significance P < 0.05) of co-expression networks enriched for BD-associated processes including neurotransmitter secretion and postsynaptic actin cytoskeleton organization (P < 0.05); molecular docking revealed favorable-affinity binding (ΔG < −4 kcal/mol) between DOC2A and BD-related drugs and neuroprotective compounds.
Conclusions
Our convergent multi-omics framework highlights DOC2A dysregulation as a key contributor to synaptic dysfunction in BD and nominates it as a promising therapeutic target. The demonstrated interaction with existing neuroactive compounds provides immediate translational avenues.
Humanitarianism is imagined to be a short-term response to a temporary emergency. However, in reality, both crisis and aid often become protracted. This article examines a glaring consequence of protracted humanitarian presence in the eastern Democratic Republic of the Congo: the formation of a local humanitarian class, for whom the sector becomes a site of social mobility and identity construction. Incorporation into the humanitarian political economy, however, has been vastly unequal, exacerbating processes of social stratification. There has been a groundswell of public discontent with global humanitarianism. Framing these tensions as a story of local resistance versus international intervenors overlooks the fact that most employees working for global aid agencies in the Global South are locally hired. This article illustrates how protracted humanitarian action also generates localised tensions around access to resources and employment, and questions of material inequality and class stratification produced by humanitarian permanence itself. A focus on local class transformation and stratification challenges neat assumptions about local empowerment in the global politics of humanitarianism. Instead, the humanitarian class is at the centre of contemporary debates about the future of international humanitarianism: a lightning rod for mounting public frustration at the paradoxical consequences of protracted emergency operations.