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To address limited data on whole grain (WG) consumption in the UK, we investigated trends and socio-demographic patterns of WG consumption from the National Diet and Nutrition Survey from 2008/2012 to 2016/2019 and examined the relationship between WG and dietary intakes. We analysed 15 655 individuals aged ≥ 1·5 years who completed a 4-day food diary. WG consumption was quantified by estimating the WG content of individual foods using publicly available ingredient information. Survey-weighted mean WG consumption over time and by population sub-group was calculated. Survey-weighted trend tests and Wald tests were used. Total WG intake in the general population did not change from 2008/2012 to 2016/2019. WG from high-fibre cereals and bread declined by 16·2 % (11·1–9·3 g/d) and 19·4 % (12·4–10 g/d), respectively, while other cereals (e.g. rice/pasta) increased by 72·5 % (4·0–6·9 g/d), but contributed considerably less than other categories. In the most recent data (2016–2019), older adults (65+ years) had the highest energy-adjusted WG consumption, followed by children 1·5–3 years. Individuals with lower incomes, adolescents and current smokers consumed the least WG. Whole grain intake was associated with generally higher quality diets, specifically consuming more fibre, potassium, Ca, Fe, Mg, fruits/vegetables, pulses/nuts and oily fish and consuming less free sugars, total fat, saturated fat, Na and red/processed meat (Ptrend < 0·001 for all). Despite some dietary improvements in the UK, WG intake appears unchanged from 2008/2012 to 2016/2019.
This manuscript presents a novel three-series-only topology P-insulator-N (PIN) diode single-pole-double-through (SPDT) switch designed to address the challenges of high power handling and low insertion loss in Q-band and V-band communication systems. The manuscript provides a detailed theoretical analysis of series-connected PIN diodes, offering insights into their behavior under both small- and large-signal conditions. Based on GaAs PIN diode technology, the switch operates across a frequency range of 37.7 to 61 GHz, achieving a low insertion loss of 0.707 dB and providing an isolation of 24.6 dB. The proposed SPDT switch demonstrates a high $\text{IP}_{\text{0.1~dB}}$ of 37.6 dBm at 38 GHz. With a compact chip size of $0.905\times 0.885 \text{mm}^2$, including all pads, this work offers excellent power handling capability, making it highly suitable for advanced communication systems in Q-band and V-band applications.
This article investigates the boundaries of the chronological-cultural unit of ‘Early Greece’, a phrase widely used in scholarship but which has little taxonomic meaning. I argue that the phrase, and the values that it encodes, continues to exist in a traditional evolutionary framework of cultural development within the Greek world. Through a bibliographical case study, I further demonstrate that there are different chronological understandings of ‘Early Greece’ within different subdisciplines, with material-based scholarship applying it predominantly to the Early Iron Age and text-based scholarship predominantly to the Archaic period. Following this, the article connects ‘Early Greece’ with protohistory, particularly through the lens of Homer references, and explores the ways in which the positionality of ‘Early Greece’ emphasizes the authority of textual sources over material ones and continues to articulate an under-defined vision of Greece centred on the fifth century BCE.
Predicting particle segregation has remained challenging due to the lack of a general model for the segregation velocity that is applicable across a range of granular flow geometries. Here, a segregation-velocity model for dense granular flows is developed by exploiting force balance and recent advances in particle-scale modelling of the segregation driving and drag forces over the entire particle concentration range, size ratios up to 3 and inertial numbers as large as 0.4. This model is shown to correctly predict particle segregation velocity in a diverse set of idealised and natural granular flow geometries simulated using the discrete element method. When incorporated in the well-established advection–diffusion–segregation formulation, the model has the potential to accurately capture segregation phenomena in many relevant industrial applications and geophysical settings.
What was the relationship between national character, government, and civilization for James Mill? This article answers this question by focusing on Indian and British national characters. For Mill, Indian national character was unsuited to trigger the progress of civilization. He questioned how a society with a flawed character could be led toward improvement. This article underlines the importance of human agency for the progress of civilization in Mill’s thought. In order to cause progress, individuals had to voluntarily guide society toward improvement by embracing the principle of utility. Governmental action should create the conditions necessary to bring about individuals of suitable character. Members of the middle class could foster progress better than those of any other class. They could oppose the despotism of the aristocracy and be the driving force of civilization by voluntarily shaping their ideas in accordance with the public good.
Proper nutrition enhances athletes’ performance and recovery during sports activities. This review aims to investigate the effects of nutrition education interventions on dietary intake, nutrition knowledge, and body composition of female athletes. From a comprehensive search, we identified 20 single-arm and 8 double arm studies that met the inclusion criteria. The interventions in these studies ranged from personalized consultations to group workshops. The mode of delivery was mainly face-to-face. Most of these interventions consisted of group sessions with variable duration and frequency. From the studies finally included, nutrition education intervention significantly increased the nutrition knowledge of female athletes in 76% and improved their dietary intake in 67%. However, only 44% of the studies that measured changes in body composition reported significant changes. Moreover, only a minority of studies (14%) maintained follow-up assessments to measure the lasting impact of the interventions. Sixty percent of interventions were delivered by professional nutritionists or dietitians, ensuring high-quality education. There is a need for standardized methodologies and more robust study designs to better assess the effectiveness of nutrition education interventions. Knowing athletes’ preferences when planning education may improve engagement and intervention efficacy. Also, longer-term follow-up of athletes would allow for a more accurate evaluation of the consolidation of acquired knowledge. Including coaches in nutrition education interventions would probably amplify the impact on athletes’ dietary behaviours. Nutrition education can positively influence the knowledge and eating habits of female athletes, but its effect on body composition represents an area where much remains to be explored.
Mirroring the general population, the number of medical students, doctors and, indeed, psychiatrists disclosing being neurodivergent is rising. These individuals commonly have a variety of strengths that can enhance their work, but these strengths may go unrecognised. All too often such individuals have been labelled ‘doctors in difficulty’. We begin this article with a review of contemporary thinking regarding neurodiversity, before considering specific issues facing neurodivergent doctors, specifically psychiatrists. We explore neurodivergent strengths and the evidence regarding career outcomes and mental health. We discuss the stigma that many neurodivergent psychiatrists face in the medical sphere and how difficulties may be reframed as unmet needs. We highlight initiatives that aim to change workplace culture, before discussing the concept of reasonable adjustments, alongside a wide range of practical suggestions of adjustments to consider, using the Autistic SPACE framework and the Royal College of Psychiatrists’ reasonable adjustments guidance. Finally, we consider how those in senior leadership roles can contribute to this field and provide role modelling and signposting to further information and support for neurodivergent doctors and their supervisors and line managers.
In this commentary on Itamar Mann’s rich re-reading of Regina v Dudley and Stephens (1884), I want to draw attention to two issues. First, the salience of the distinction between abstraction and idealization for his argument. Second, the question of political form in relation to each of the three models of the lifeboat that Mann explore – the providential, the catastrophic, and the commonist. I do so in order to explore the implications of Mann’s proposal for the politics of global governance.
The historiography of bankruptcy and insolvency in the early modern era focusses on merchants and banks. The position of landowning noble elites in insolvency procedures has less often been explored. The Lower Austrian Lamberg seigneurial archive contains rich documentation on the insolvency procedures against the counts of Lamberg-Sprinzenstein – one of the largest landowning families in Lower Austria – between 1735 and 1768. Based on this source material, this article presents a case study treating the question of how political and judicial authorities in the Habsburg Empire dealt with insolvent aristocrats. The analysis is contextualized by a detailed reconstruction of the debt and asset structure of the Lamberg-Sprinzenstein estate. The most important policy enacted to regulate the debt crisis of the noble landowners was ‘judicial administrations’ during which a judicial official took over the administration of the landed patrimony and other assets. Compared to official norms regarding insolvency procedures, creditors had little say in how the debtors’ property was managed, and measures were taken to partially preserve the debtors’ wealth and social status. The majority of creditors were nobles. Non-noble creditors also acquired bonds on less favourable legal terms and ended up as losers in the debt crisis.
Individuals with 22q11 deletion syndrome have a mutation in the TBX1 gene. This is associated with reduced left pulmonary artery/right pulmonary artery ratio in animal models and in humans with structurally normal hearts.
Method:
A retrospective analysis was undertaken of patients who underwent surgical repair of Tetralogy of Fallot, truncus arteriosus, and interrupted aortic arch between 01/2007 and 12/2022. The left pulmonary artery/right pulmonary artery ratio on initial and most recent echocardiogram and initial and subsequent intervention on the left pulmonary artery were compared between patients with and without 22q11 deletion.
Results:
There were 134 included patients; 19 patients had the deletion (22q11 positive), and 115 patients did not have the deletion (22q11 negative). Tetralogy of Fallot was present in 8/19 and 101/115 patients, truncus arteriosus in 7/19 and 7/115 patients, and interrupted aortic arch in 4/19 and 7/115 patients. Patients who were 22q11 positive had a reduced left pulmonary artery/right pulmonary artery ratio on both the initial echocardiogram [0.88 (interquartile range 0.71, 0.97) versus 1.02 (interquartile range 0.92, 1.12); p < 0.001] and most recent echocardiogram [0.66 (interquartile range 0.62, 0.91) versus 1.01 (interquartile range 0.89, 1.16); p < 0.001] and were more likely to have intervention on the left pulmonary artery at their initial surgery (36% versus 8.7%; p = 0.003).
Conclusion:
Patients who were 22q11 positive trended towards reduced left pulmonary artery/right pulmonary artery ratios and need for early surgical intervention on the left pulmonary artery in comparison to patients without 22q11 deletion negative patients.
The limestone and marlstone succession of the Pliensbachian Vale das Fontes and Lemede formations at the Global Boundary Stratotype Section and Point (GSSP) at Peniche (Portugal) received much attention in numerous studies. It contains abundant pyritic and limonitic aggregates, which are herein described and interpreted as remarkably preserved soft-bodied organisms (worms) for the first time. The slender to compact bodies with a cylindrical or dorsoventrally flattened cross-section are several centimetres long and have a diametre/width of 0.5–8 mm. They occur on bedding planes or are partly preserved within their burrows. Although their taphonomic history did not favour the preservation of many details, key features such as body shape, size and composition, as well as occasionally preserved segmentation and body appendages, allow a rough assignment to the phyla Nemertea, Annelida and Nematoda. Favourable circumstances such as intermittent dysoxic to anoxic bottom conditions, microbial activity and sudden burial have probably contributed to a reduced decay of the soft bodies. Comparison with similar successions globally shows that such a preservation of worms is not a unique process but occurs in several thick, fine-grained units throughout the Phanerozoic. Such inadequately preserved soft-bodied animals are still often overlooked but have the potential to add to our knowledge of the distribution and evolution of major clades of non-skeletal organisms.
The glacial history of northeast Siberia is poorly understood compared with other high-latitude regions. Using 10Be and 26Al exposure dating together with remote sensing, we have investigated the glacial history of a remote, formerly glaciated valley in the Tas-Kystabyt Range of the Chersky Mountains in central northeast Siberia. Based on measurements from moraine boulders and bedrock samples, we find evidence for deglaciation of the valley 45.6 ± 3.4 ka ago, that is during the peak of Marine Isotope Stage 3. Satellite imagery of the range reveals at least two generations of moraines in other nearby valleys, indicating that multiple stages of glaciation took place across the Tas-Kystabyt Range. Based on calculated equilibrium-line altitudes, we speculate that the outer set of moraines is linked to the 45.6 ± 3.4 ka deglaciation event identified by our dating, while the inner generation of moraines is associated with a younger glaciation event, possibly the last glacial maximum (LGM). Thus, our results reaffirm current impressions that the maximum ice extent during the last glacial cycle was reached before the global LGM in northeast Siberia.