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The US major-party presidential nominating conventions are an essential platform for a political party’s branding and messaging for upcoming presidential and congressional elections. The conventions also can provide revenue and media attention to their host cities and, consequently, convention fundraising has grown substantially in recent decades. Convention fundraising rules were changed in 2014, tripling the limit for contributions to a party’s campaign funds and removing limits on contributions to host-city committees. Although we do not expect these changes to affect individual donors, we expect corporations, banks, and labor unions to have taken advantage of these new rules. Elections since 2014, however, have been unusual in many ways—for instance, in the relationship between the nominees and their parties and, in 2020, the public health precautions required to hold conventions. This study examines developments in political-party convention fundraising since 2014, focusing on the relationships among candidates, their parties, and the cities where conventions have been held. To make this determination, funding reports were collected for the 2000–2024 election cycles. The article explores changes in the characteristics of convention donors—their other contributions and their relationships to candidates, party committees, and host cities—and notes variations that might be attributable to the nominees or the host cities. It considers whether the new convention-funding rules have matured sufficiently that it is possible to make broad claims about the effects of the rules themselves.
Biochar, when used as soil amendment, could enhance soil health, plant growth, and farm profitability while offsetting adverse effects of environmental pollution. Yet the adoption rate of biochar among agricultural producers remains extremely low. Message framing has been shown to play an important role in forming positive attitudes and generating desirable outcomes. To understand the effect of message framing in promoting biochar, we conducted a randomized experiment through an online survey of crop producers located in Eastern South Dakota. The results showed that participants who read a message about the benefits of adopting biochar from an economic perspective expressed higher interest in learning about biochar; no such effect was observed among participants who read a message about the benefits of adopting biochar from a stewardship perspective. Compared with the control group, economic and stewardship frames increased farmers’ likelihood of adopting biochar in the next 5 years, by 10.6% and 10.8%, respectively. Our findings illustrate the importance of message framing in encouraging farmers to adopt conservation practices that are rarely used. To promote future adoption of conservation practices such as biochar, it is important to highlight both economic and stewardship benefits when conveying information to farmers.
The objective of this study was to develop and validate an educational comic book designed to promote healthy eating among caregivers of young children. The study was conducted in four phases: (1) literature review and script development; (2) creation of the initial version of the comic book, including illustrations, layout and design, and calculation of the Flesch Readability Index (FI); (3) expert validation of the initial version and calculation of the Content Validity Index (CVI); and (4) adaptation of the comic book based on expert suggestions, recalculation of the FI, and pilot testing (CVI) with a lay population. A total of 64 volunteers participated in the validation process, including 14 expert judges and 50 caregivers responsible for feeding children aged 0 to 5 years. Statistical analysis included descriptive measures and inferential testing using the Wilcoxon signed-rank test. The FI score for the initial version was 85.0%, indicating a reading level classified as “easy to understand.” After expert evaluation, the CVI reached 94%, reflecting high agreement among participants. In the revised version, the FI remained high at 84.7%, reinforcing the “easy to understand” reading level, while the CVI increased to 98% following the pilot test, demonstrating strong consensus among participants. A significant improvement in knowledge regarding healthy eating was observed after reading the comic book (p < 0.05). The comic book was validated for appearance, content and readability, showing a positive impact on caregivers’ knowledge about healthy eating practices. It represents an accessible and effective resource that can be integrated into community-based nutrition education programmes.
People living with dementia (PLWD) want – and have the right – to participate in research that impacts them. However, barriers in legislation, institutional practices, and/or biases may jeopardize inclusion.
Objective and Methods
Interviews with 33 Canadian dementia researchers were conducted to explore understandings of research consent with regard to dementia, research practices, and approaches in everyday research contexts.
Findings
Analysis of these interviews revealed challenges in negotiating the space between best practices and institutional requirements; gaps in knowledge, procedures, and guidelines on inclusion and consent; tensions regarding who should be involved in decision making; and how assumptions of presumed incapacity and/or the ‘protection’ of vulnerable groups create and/or sustain the exclusion of PLWD from research.
Discussion
Moving forward, findings suggest that advancing the meaningful inclusion of PLWD in Canadian dementia research will require clear, consistent standardized guidelines, flexible and ongoing consent processes, accessibility accommodations, and a stronger focus on rights-based practices.
Design optimisation of hybrid airships consisting of multi-lobed configurations is being projected as the next paradigm shift in implementing sustainable flight operations within the aeronautical industry. To that end, this paper discusses the effect of varying the relative placement of side-lobes pertaining to a tri-lobed airship hull geometry with respect to the middle-lobe. The paper makes use of a validated OpenFOAM® solver to underscore the aerodynamic impact of shifting the side-lobes in upstream, downstream, upward and downward directions with respect to the middle-lobe while retaining the same volume. These tri-lobed airship hull variants called as skewed tri-lobed hulls, have been comprehensively investigated through the usage of numerical solver (Reynolds-averaged Navier-Stokes) at high Reynolds number flow across various angles of attack. The investigations delineate significant impact of skewed side-lobes on the overall aerodynamics of the tri-lobed airships. Skewing the side-lobes in fore direction leads to drag mitigation at the expense of degraded aerodynamic efficiency owing to lift reduction. Contrarily, aft-skewness amounts to an aerodynamic efficiency enhancement of $ \approx 17{\rm{\% }}$ and improved pitch stability while marginally increasing the pressure drag liability. Aerodynamic efficiency enhancement is attributed to increased lifting force. Skewed upward and downward variants present an overall aerodynamic efficiency reduction. The paper further made use of detailed flow-field visualistion as well as pressure-coefficient distribution plots to underscore the underlying flow-physics related to aforementioned aerodynamic trends. These investigations emphasised the presence of varying three-dimensional relieving effect, intermixing between the three lobes as well as diverse flow separation characteristics downstream of the maximum diameter region leading to the aerodynamic variations thereof. The paper enhances aerodynamic understanding related to tri-lobed geometry that will be crucial in implementing future design changes to the baseline model for improved aerodynamic performance. Amalgamation of these inferences with an optimisation scheme could be implemented in future aerodynamic investigations to optimise tri-lobed geometry for enhanced aerodynamic utility.
In 2018, the UK government commissioned National Health Service Talking Therapies (NHS TT) services to provide integrated mental and physical health care for individuals with a long-term condition (LTC) and coexisting depression and/or anxiety. Nevertheless, evidence on the effectiveness of NHS TT in physical LTCs remains inconsistent.
Aims
This review aims to evaluate the impact of NHS TT on mental health outcomes among adults with physical LTCs.
Method
We conducted a systematic review and meta-analysis of quantitative studies published between 2008 and 2024. We used several databases for the search, including Embase, MEDLINE, Cochrane Library, NHS Evidence, PsycINFO, Bielefeld Academic Search Engine and ProQuest. We combined terms related to NHS TT, LTCs and mental health outcomes to identify eligible studies. The Population, Intervention, Comparison, Outcomes and Study framework guided the development of the inclusion criteria. We employed the random-effects model for meta-analysis and assessed heterogeneity bias using the I2 statistic, and the Newcastle–Ottawa scale to evaluate the overall quality of the evidence.
Results
Twenty-four studies met the inclusion criteria. The meta-analysis revealed a significant pre–post NHS TT intervention effect on reliable improvement (odds ratio 0.77, 95% CI: 0.60–0.98) and reliable recovery (odds ratio 0.80, CI: 0.68–0.95). There were no significant differences in NHS TT accessibility (e.g. treatment engagement) between participants with and without LTCs (odds ratio 0.97, 95% CI: 0.82–1.14). However, heterogeneity between the studies was high (>90%).
Conclusions
The observed evidence provides reassurance for individuals with LTCs engaging with treatment; however, the association with post-treatment distress is still of concern. Furthermore, extensive and rigorous research is needed to strengthen and guide service development for individuals with LTCs, thereby improving effectiveness.
To describe the prevalence, patterns, and quality indicators of antimicrobial use (AMU) in Burkinabe hospitals and identify priorities for stewardship.
Design:
Multicentre, cross-sectional point prevalence survey (PPS) following the Global Point Prevalence Survey protocol.
Setting:
Eight public hospitals across six cities in Burkina Faso (3 primary, 3 secondary, and 2 tertiary), February–June 2019.
Participants:
All inpatients present on the survey day at 8:00. Medical records were reviewed for those receiving systemic antimicrobial agents.
Methods:
Standardized ward- and patient-level data were collected on indications, agents, routes, and WHO AWaRe categories, alongside quality indicators (documented indication, stop/review date, guideline compliance, and targeted vs empirical therapy). Descriptive analyses compared hospital tiers.
Results:
Of 994 inpatients, 729 (73.3%) received ≥1 antimicrobial (range by tier: tertiary 69.7%, secondary 79.2%, primary 79.2%). Community-acquired infections accounted for 96.0% of therapeutic indications. Leading reasons were skin/soft tissue infections (12.2%), gastrointestinal infections (10.7%), and pneumonia (10.4%). Parenteral administration predominated. The most used agents were ceftriaxone (27.8%), metronidazole (15.7%), and gentamicin (9.4%). By AWaRe, Access agents comprised ∼ 50%, Watch agents ∼ 50% overall, with higher Watch use in tertiary hospitals; no Reserve antibiotics were recorded. Quality indicators were suboptimal: the indication was documented in 15.6%, the stop/review date was absent in 93.0%, and 41.1% of prescriptions were guideline-compliant. Therapy was largely empirical (98.5%). Prolonged surgical prophylaxis (>1 day) represented 86.8% of prophylaxis courses.
Conclusions:
Antimicrobial use (AMU) prevalence in Burkinabe hospitals is high, dominated by empirical therapy and Watch-class ceftriaxone. Deficits in prescribing quality and limited diagnostic use highlight urgent needs for context-adapted antimicrobial stewardship: enforce guideline-concordant care, curb prolonged prophylaxis and unnecessary Watch-class use, and expand affordable microbiology capacity to enable targeted therapy.
There is limited data describing statewide pediatric surge response during times of capacity strain.
Objective
Characterize the burden and response to a surge in pediatric respiratory admissions in Oregon in 2022.
Design, Setting, and Participants
This analysis utilized data from the Oregon Capacity System (OCS) and the state discharge database to describe patient characteristics, census changes, and admission pattern shifts during an RSV epidemic in 2022.
Main Outcome and Measure
Statewide pediatric census, weekly pediatric admissions, weekly admissions from non-children’s hospital emergency departments (EDs) to non-children’s hospitals.
Results
The median census in Oregon’s pediatric inpatient hospitals increased by 19% during the surge period (306 vs 364, P < 0.001), while the median pediatric intensive care unit census increased by 50% (24 vs 36, P < 0.001). Weekly elective pediatric admissions to children’s hospitals decreased by 33% (30 vs 20, P = 0.03). ED admissions to non-children’s hospitals increased by 160% (15 vs 39 per week, P = 0.02).
Conclusion and Relevance
As the statewide pediatric inpatient census increased, targeted reductions in elective admissions and increased utilization of non-children’s hospitals increased capacity during a respiratory surge. This analysis underscores the importance of real-time situational awareness and coordinated surge response between hospitals.
We tested whether people engage in proportional thinking when comparing the value of the lives of people in different countries, specifically, whether people consider a certain number of lost lives in a smaller country to be equivalent to the loss of a larger number of lives in a country with a larger population. We found evidence for this form of proportional thinking in Study 1, and in Studies 2–3 we further observed that it is modulated by motivated reasoning: In Study 2, there was more proportional thinking when it benefited the ingroup (1 ingroup life equals 4 outgroup lives) than when it benefited the outgroup (1 outgroup life equals 4 ingroup lives). In Study 3, there was more proportional thinking when it benefited the victim in a war (1 victim life equals 4 aggressor lives) than when both countries were victims. Study 3 also showed that this form of proportional thinking is more prevalent when thinking about collectives (1,000 lives in the smaller country are equivalent to 4,000 lives in the larger country) versus individuals (1 life in the smaller country is equivalent to 4 lives in the larger country).
The creation of the Administrative Review Tribunal represents a critical redesign of Australia’s federal administrative review system. In this article, we draw on a novel dataset from the Kaldor Centre Data Lab to question the government’s justifications for retaining separate codified procedures and other restrictive rules for the new tribunal’s migration and protection jurisdictions. Our data analysis reveals that historically, there is no evidence that the codification of procedures increases the efficiency or certainty of decision-making. This approach may in fact have the opposite effect, contributing to both inefficiencies and unfairness for applicants. The government’s decision to retain separate procedures for migration and protection applicants represents a missed opportunity and may undermine the new tribunal’s objectives.
In recent years, we have seen an immense expansion in recombinant DNA, especially in its use in gene therapy applications. Throughout its history, the United States set up several mechanisms of national safety and ethical oversight for rDNA to ensure that we proceeded with its use appropriately. As our knowledge and experience with it grew, there has been increasing pressure to decrease the oversight and monitoring requirements for its use. In 2019, the National Institutes of Health amended the NIH Guidelines for Research Involving Recombinant DNA Molecules eliminated three national mechanisms for guidance, monitoring, and review of this biotechnology. Four years later, we revisit these changes and their implications for a current emerging biotechnology: xenotransplantation. By better understanding the motivations for these mechanisms and analyzing the test case, we argue that these changes have worrisome implications for our ethical oversight of emerging biotechnologies both in the realm of gene transfer technologies and beyond.
A new sponge species (Demospongiae: Poecilosclerida: Podospongiidae) is described offshore from the Cape of Good Hope, on the southern edge of the Table Mountain National Park marine protected area. Podospongia capensis sp. nov. is compared to Podospongia natalensis, described by Kirkpatrick (1903) from the east coast of South Africa, as well as to all other Podospongia species described to date. The new species differs from P. natalensis in having a shorter, thicker stalk, lacking anisostrongyles as megascleres, and possessing a second category of large symmetrical aciculospinorhabds microcleres that are present in P. natalensis. Additionally, P. natalensis has larger oxeas and styles than those found in P. capensis sp. nov. Furthermore, the two species are geographically separated, with P. natalensis described from the Natal ecoregion, while P. capensis sp. nov. is described from the Southern Benguela ecoregion. The new species primarily differs from other congeners in external morphology and size of the oxeas and styles.
Botanical supplements occupy a regulatory grey area between food and medicine within the European Union, a situation that has given rise to a series of interrelated challenges. This paper highlights regulatory dysfunctions across several dimensions: definitional voids in EU food law, unclear food–medicine classification boundaries, fragmented market access rules, and inadequate safety monitoring systems. These regulatory gaps impose costs on business operators, restrict consumer access, and result in uneven protection across Member States. The article also focuses on safety concerns, which are, however only one element of this broader puzzle. To address such systemic difficulties, the paper proposes the introduction of harmonised pre-market notification and post-market surveillance mechanisms, with a specific focus on botanical supplements. These measures could help reconcile market accessibility with stronger consumer protection while supporting innovation. Admittedly, they may not resolve all regulatory challenges, particularly the thousands of health claims that remain on hold. Nevertheless, they might offer a practical foundation for addressing long-term, often overlooked safety concerns related to botanicals. It remains to be seen whether they could also contribute to resolving the interconnected regulatory issues in this sector, potentially paving the way for broader reform.
Fruit flies are the most serious problem in fruit production worldwide, causing severe losses in production and fruit quality. The use of parasitoids, especially Diachasmimorpha longicaudata (Ashmead) (Hymenoptera, Braconidae), is an important tool for suppressing the fruit fly population. The objectives of this study were to determine the exposure time, density, and ideal larval instar of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) and to verify whether the parasitoid’s previous experience affects its interaction with the host insect and the influence of these factors on the parasitism rate. In three bioassays, fly larvae were placed in ‘parasitism units’ to test different methods of exposure to female parasitoids. The variables included the previous experience of the female parasitoid with oviposition, the exposure time (30, 60, 120, 240, and 480 min) of the larvae to the parasitoid and the number (5, 10, 15, and 20) and instar (second and third) of the fly larvae. The flies and parasitoids that emerged were quantified, and the parasitism rate and sex ratio of the parasitoids were calculated. The results of the present study indicate that to increase the parasitism rate of D. longicaudata, third-instar larvae of C. capitata must be grouped into parasitism units of 20 larvae and exposed to a single female of the parasitoid for 8 h.