To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Italian ryegrass [Lolium perenne ssp. multiflorum (Lam.) Husnot] (referred to as L. multiflorum hereafter) is one of the most problematic grass weeds infesting agronomic and specialty crops across the United States. In 2023 to 2025, inadequate control of L. multiflorum populations (NY_R1, NY_R2, and NY_R3) with glyphosate was reported in Livingston, Ontario, and Genesee counties, New York. This research aimed to (1) confirm and quantify glyphosate resistance in these suspected glyphosate-resistant (GR) populations, (2) evaluate the efficacy of alternative postemergence herbicides, and (3) determine whether EPSPS gene amplification confers glyphosate resistance. A known glyphosate-susceptible (GS) population (AR_S) from Arkansas was included for comparison. Glyphosate dose–response assays indicated that NY_R1, NY_R2, and NY_R3 populations were 13-, 4-, and 5-fold resistant, respectively, relative to the AR_S population. Alternative postemergence herbicides, including clethodim, glufosinate, paraquat, and pinoxaden, provided 96% to 97% control and reduced shoot dry weight by 91% to 97% at 21 d after treatment (DAT). In contrast, nicosulfuron provided reduced control (63% to 74%) and limited biomass reduction (51% to 56%), suggesting possible resistance to acetolactate synthase (ALS)-inhibiting herbicides in three tested populations. Quantitative PCR analysis revealed that NY_R1 and NY_R3 had approximately 30-fold higher EPSPS gene copy numbers than AR_S, indicating gene amplification as a mechanism of glyphosate resistance. This study confirms the first case of GR L. multiflorum associated with EPSPS gene amplification in New York, underscoring the need for integrated, diversified weed management strategies to mitigate its spread.
Let M be a tame mouse modelling $\mathrm {ZFC}$. We show that M satisfies “$V=\mathrm {HOD}_x$ for some real x”, and that the restriction $\mathbb {E}^M\!\upharpoonright \![\omega _1^M,\mathrm {OR}^M)$ of the extender sequence $\mathbb {E}^M$ of M to indices above $\omega _1^M$ is definable without parameters over the universe of M. We show that M has universe $\mathrm {HOD}^M[X]$, where $X=M|\omega _1^M$ is the initial segment of M of height $\omega _1^M$ (including $\mathbb {E}^M\!\upharpoonright \!\omega _1^M$), and that $\mathrm {HOD}^M$ is the universe of a premouse over some $t\subseteq \omega _2^M$. We also show that M has no proper grounds via strategically $\sigma $-closed forcings. We then extend some of these results partially to non-tame mice, including a proof that many natural $\varphi $-minimal mice model “$V=\mathrm {HOD}$”, assuming a certain fine structural hypothesis whose proof was almost established in Closson [1], and has since been completed in the preprint [14].
An experiment was conducted in 2022 and 2023 at multiple locations in North Carolina to identify alternative herbicide combinations capable of providing effective preplant foliar weed control when glyphosate is unavailable. All combinations containing rimsulfuron + thifensulfuron provided 95% to 98% control of henbit, comparable to all glyphosate-based combinations. Treatments containing glyphosate achieved 100% control of common chickweed, and rimsulfuron + thifensulfuron combined with clethodim (90%) or 2,4-D (89%) were the only treatments that provided comparable control. Paraquat effectively controlled henbit and common chickweed, providing 91% and 87% control of these species, respectively. Although no treatment controlled annual bluegrass as effectively as glyphosate-based mixtures, paraquat alone, paraquat + 2,4-D, and clethodim + rimsulfuron + thifensulfuron each achieved ≥ 88% control. Saflufenacil was highly efficacious on purple cudweed, providing control comparable to glyphosate (≥ 97%). Tiafenacil alone provided limited control of most of the weed species evaluated in this study, but showed compatibility in mixtures, suggesting utility within diversified preplant foliar herbicide programs targeting specific weeds. While glyphosate remains available for use, incorporating one or more of these herbicides could enhance control of glyphosate-resistant weed biotypes and reduce selection pressure on glyphosate-susceptible weeds. Overall, rimsulfuron + thifensulfuron, paraquat, saflufenacil, tiafenacil, and clethodim, applied alone or in combination, offer practical preplant foliar options that can strengthen existing glyphosate-based programs and sustain effective winter annual weed control should glyphosate become limited or unavailable.
Radiological incidents are rare, but can have significant public health consequences. Coordination across jurisdictions, government agencies, and different fields is critical to ensure an effective response that minimizes health impacts. State and local government agencies face challenges in responding to radiological incidents such as constrained resources, siloed communications, and gaps in workforce training and capacity. The National Alliance for Radiation Readiness (NARR) is a network of experts composed of 20 member organizations and 10 federal partners. The NARR seeks to advance the nation’s capacity for radiation readiness through expert input, workforce training and capacity building, and increase communication and collaboration.
The effectiveness of electroconvulsive therapy (ECT) for depression strongly depends on patient characteristics. Clinical factors may increase (e.g. age, psychotic symptoms) or decrease (e.g. episode duration) response rates.
Aims
This prospective study aimed to develop an instrument for the prediction of ECT response in patients with unipolar depression.
Method
N = 45 patients were assessed using the Göttingen Response to ECT Assessment Tool (GREAT; seven items, 0 to 14 points). Clinical outcome was measured using the Montgomery Åsberg Depression Rating Scale (MADRS). Response was defined as ≥ 50% MADRS-improvement or a clinical global impression improvement (CGI-I) score ≤ 2. Analyses were conducted between responders and non-responders.
Results
Results showed a high correlation between GREAT-score and dichotomous response (r = 0.585) as well as MADRS-improvement (r = 0.554, both p < 0.001). Receiver operating characteristic (ROC)-analysis yielded an area under the curve (AUC) of 0.841 (asymptotic significance: p < 0.001). A cut-off point at ≥7 points predicted ECT response in individual cases with 80% accuracy. GLM-analyses showed a significantly better MADRS-improvement for patients with a GREAT-score ≥ 7 v. < 7 (interaction-effect: p < 0.001).
Conclusions
Our prospective study shows that an instrument consisting of seven clinical items is able to predict ECT response in depression with good accuracy. Limitations include a relatively small sample size and the lack of further potential predictors suggested by recent studies. GREAT will thus be modified to further improve its accuracy. Currently, it may give clinicians a relevant estimate of the likelihood and the extent of the individual response to ECT.
Mental health challenges are common in autistic individuals but there is limited research, particularly among preschool children.
Aims
To ascertain the nature and occurrence of mental health challenges in autistic preschool children, as well as their association with autistic traits and cognitive and adaptive functioning.
Method
We conducted a secondary analysis of data collected from children attending Autism Specific Early Learning and Care Centres across six states in Australia. The primary outcome of mental health challenges was assessed using the Child Behaviour Checklist (CBCL). The severity of autism and autistic traits, such as social communication differences and repetitive behaviours, alongside cognitive and adaptive functioning, were used as exposure variables. Multivariable linear regression analyses examined the associations among mental health challenges, autistic traits, cognitive level and adaptive functioning, and adjusted for key sociodemographic covariates.
Results
Among 760 children, about 76% scored above the clinical range of CBCL total problem scores. Mental health difficulties were significantly associated with greater severity of autistic traits, social communication differences and repetitive behaviours, and lower verbal developmental functioning and adaptive functioning. Additionally, sociodemographic determinants, such as children who were older, female or with an autistic sibling, were associated with higher risk of mental health difficulties, whereas culturally and linguistically diverse status, higher parental education and family income were protective against mental health challenges.
Conclusions
Our findings provide useful insights into the high prevalence of mental health difficulties among autistic preschool children, highlighting the significant association with autistic traits, cognitive and adaptive functioning levels and sociodemographic risk factors.
This article analyses the Niobe allusion of Iliad 24 (599–620), providing solutions to grammatical, structural, and narratological problems therein. I show how attention to an often-overlooked and universally misinterpreted occurrence of τε in line 602 paves the way to a new understanding of the passage as a whole. In addition, a supposed problem with the ring structure of the passage is resolved without the need of editorial intervention.
The Spanish agricultural sector depends on seasonal agricultural migrant workers. This study aimed to examine the associations among dietary patterns, sociodemographic factors and food security among seasonal agricultural workers.
Design:
A cross-sectional multicentre study. The dietary pattern was evaluated according to the Spanish Society of Community Nutrition recommendations for the adult population. Descriptive analysis was disaggregated according to sex. Multi-adjusted logistic models were used to assess the association between dietary patterns and explanatory variables.
Setting:
Work sites and temporary accommodations in four Spanish provinces: North Spain: Lleida and La Rioja, and South Spain: Almeria and Huelva.
Participants:
Male and Female Seasonal Agricultural Migrant Workers (n 623).
Results:
The final sample consisted of 609 migrant agricultural workers. Of these, 36 % were female, and 61 % were classified as North African. Overall, 40 % of the participants adhered to the evaluated dietary pattern. Adherence was positively associated with North African nationality, being married or cohabiting and low socio-economic status. Not skipping meals due to economic constraints and receiving food aid emerged as key factors contributing to greater adherence to the assessed dietary pattern.
Conclusions:
This study provides an initial insight into the dietary pattern of seasonal agricultural migrant workers in Spain. The findings indicate that external socio-economic and structural factors primarily shape their dietary habits. Policies aimed at enhancing food security, and other food coping strategies, such as access to food aid, are crucial for improving dietary adherence to a healthy dietary pattern.
Individual loss reserving methods have undergone substantial development in the past decade, driven by increased accessibility to granular-level insurance claims data. This paper presents a micro loss reserving model tailored for multi-coverage insurance policies, where a single insurance claim might trigger payments from multiple coverage types. We employ a copula-based multivariate regression approach to jointly model the settlement time and loss amount, effectively capturing the dependence among various types of loss amounts and their correlation with the settlement time. We stress the importance of considering both types of dependence for accurate reserving prediction and uncertainty quantification. Furthermore, we propose computationally efficient algorithms for parameter estimation and dynamic prediction. Through numerical experiments and real data analysis, we demonstrate the effectiveness of our proposed multivariate predictive model in loss reserving applications.
Entry to higher education coincides with a period of accelerated psychosocial and brain development. Student need for acceptable and accessible well-being and mental health support is straining university resources.
Aims
To evaluate the acceptability and impact of a digital mental health literacy course tailored for undergraduates and delivered as an accredited interdisciplinary elective.
Method
Analyses included pre–post course survey data from enrolled students and longitudinal U-Flourish Well-Being Survey data from a comparison sample of non-course takers over the same period (2021–2024). Linear mixed-effects models examined associations between course participation and 12-week changes in mental health literacy, psychosocial risk factors, well-being and common mental health concerns.
Results
Pre–post course survey data (N = 2884) supported high acceptability, improvements in resilience (+0.06; 95% CI 0.03–0.08, p < 0.001) and self-compassion (+0.65; 95% CI 0.46–0.84, p < 0.001), and a reduction in brooding (−0.31; 95% CI −0.44 to−0.18, p < 0.001). Taking the course was associated with a reduction in anxiety (β = −0.41; 95% CI −0.55 to −0.27, p < 0.001) and cannabis use (proportional odds ratio 0.82; 95% CI 0.75–0.90, p < 0.001), improvement in sleep quality (β = 0.79; 95% CI 0.61–0.97, p < 0.001) and evidence of a protective effect on well-being (β = 0.24; 95% CI 0.11–0.36, p < 0.001) and depressive symptoms (β = −0.37; 95% CI −0.52 to −0.21, p < 0.001), compared with non-course takers. Effects differed by gender, with women benefitting most, but were comparable across minoritised student subgroups.
Conclusions
Mental health literacy delivered as an accredited undergraduate interdisciplinary course is highly acceptable and associated with improvement in psychological coping and positive effects on student mental health and well-being. Future research should focus on more diverse student samples, underlying mechanisms and sustained effects.
Mussel cells from three age groups (i.e., 2–4, 5–6, and ≥ 10 years) were tested for lysosomal membrane stability (LMS – membrane permeability and proton pump function), autophagic rate, and intralysosomal reactive oxygen species (ROS). LMS was significantly reduced in haemocytes and digestive cells of the hepatopancreas (digestive gland) in the two older groups of mussels, while autophagy in haemocytes was reduced in the oldest age group. ROS generation was measured in digestive cells and was reduced in the oldest age group. Age-related decline in LMS and autophagy may be related to dysfunction of the PI3P-Akt-mTOR signalling pathway. Lysosomal autophagy can also be a source of ROS generation as the degradation product lipofuscin (age/stress pigment) accumulates in autolysosomes and residual bodies; and lipofuscin-associated iron can generate ROS. Previous investigation found age-related increased lipid peroxidation in digestive gland cells, whereas this study only assessed ROS generation in the lysosomal compartment of digestive cells and may reflect increased lysosomal and autophagic dysfunction. Principal component analysis, multidimensional scaling, and cluster analysis showed that the three age groups were significantly different from each other, with the oldest mussels showing the greatest degree of cellular dysfunction. The anti-oxidative protective role of autophagy and possible links to lysosomal and autophagic dysfunction in ovarian oocytes and fecundity reduction with age are discussed in the context of increased fragility in health of older animals (e.g., digestion, autophagic recycling and repair & innate immunity). Consequently, it is recommended that young mussels should be used in environmental biomonitoring with LMS.
Compensatory policies for the losers of trade are a key feature of the liberal economic order established after the Second World War. Legislators have a variety of policy options to choose. But do political elites and the public have the same attitudes toward compensatory policies? We expect an elite–public gap with the public relatively less supportive of spending policies and more supportive of tax cuts and trade restrictions than political elites. Moreover, we reason that ideology should matter more for elites than the public. Unique data from a survey with legislators in 19 European countries and public opinion surveys in three countries allow us to test this argument. We find that elites and the public indeed differ in their attitudes toward compensatory policies. However, these differences pale in comparison to variation in support for various compensatory policies. These findings shed light on the politics of compensation and on the political attitudes of elites and the public more broadly.
Fast sampling photometry is a key observable for characterising fireballs, particularly their fragmentation episodes, which are strongly connected to the internal structure of the meteoroid and its physical properties. Accurate photometric measurements remain a challenge due to the large dynamic range required (upwards of 10 stellar magnitudes), driving operational complexity and cost. We have developed a system using an all-sky camera operating at up to 500 frames per second (FPS), featuring a novel implementation of detection localised auto-brightness control. The large data throughput is managed by custom software that performs transient detection, region-of-interest saving, and real-time photometry. We present results from two field deployments: the first validates the system’s photometric accuracy against conventional 30 FPS cameras, while the second demonstrates the successful implementation of detection localised auto-brightness control in capturing a bright, magnitude $-15$ fireball with minimal saturation. With the detection localised auto-brightness control, the system achieves an effective dynamic range between apparent magnitudes of approximately $-3$ to $-17$, allowing it to capture light curves with minimal saturation for most fireballs, excluding rare superbolides. The resulting high-quality light curve enabled a successful semi-empirical fragmentation analysis verifying the system’s ability to provide data for detailed physical modelling. The primary application for this validated system will be as a core component of the Global Fireball Observatory’s next-generation instrumentation. The intention is to deploy it in a hybrid observatory, operating alongside a dedicated high-resolution astrometric camera. This configuration will allow the network to simultaneously capture precise trajectory data for orbit and fall-line calculations and acquire complete, unsaturated high dynamic range light curves at high temporal resolution for detailed physical analysis, combining the strengths of both systems.
This paper studies a time-switching advection-diffusion system modelling the competition between Aedes albopictus and Aedes aegypti mosquitoes in heterogeneous environments. The switching mechanism is induced by periodic releases of sterile Ae. albopictus mosquitoes, which are active only during their sexual lifespan within each release period. By defining a minimal release amount and four critical release period thresholds, we establish the periodic dynamics of the system, providing new insights into optimal control strategies of mosquitoes. Specifically, the trivial steady state is globally asymptotically stable if sterile releases are sufficiently frequent and abundant, which ensures the eradication of both Aedes species. For less frequent sterile releases, we prove the global asymptotic stability of the two semi-trivial periodic solutions and demonstrate the existence of a coexisting periodic solution, indicating cases where mosquito control fails. Numerical simulations are presented to validate our theoretical findings.
The UK has recently introduced regulations to prevent design features of online gambling products that may ‘encourage problem gambling behaviour’. One change has been to prohibit win-associated and celebratory audiovisual effects following monetary losses in online slots, intended to disable a misleading design feature known as ‘losses disguised as wins’ (LDWs). We assessed 26 popular online slots available to UK consumers. Contrary to regulatory guidance, 17 used win-associated sounds following LDWs, and 18 used sound effects following LDWs that we judged as ‘celebratory’. To independently validate our appraisal of these sound effects, we asked 400 UK-based gamblers to assess whether a selection of sound effects recorded from commercially available online slots communicated a positive outcome. In every case, the average consumer classifications of the recorded sounds were consistent with our own, validating our initial assessments. These results suggest that the misuse of celebratory sound effects in online slots still occurs in the UK market, despite this regulation. We argue that this is in part due to ambiguities in regulatory guidance that have enabled operators to technically comply with the regulation while circumventing its intended effect. We conclude by offering suggestions to amend and improve this regulation.
We present a multiphase study of the star-formation-driven outflow in the Virgo galaxy NGC 4383, combining ALMA CO(2–1) data with deep MeerKAT Hi imaging and MUSE spectroscopy obtained as part of the Multiphase Astrophysics to Unveil the Virgo Environment (MAUVE) program. Our previous work revealed a spectacular ionised outflow, but the effect of the outflow on the cold phase remained unclear. Our analysis shows that potentially outflowing molecular gas is detected only within the inner $\sim$1 kpc above the disc, where CO clouds exhibit disturbed kinematics and spatial correspondence with the ionisation cone. At larger heights, the CO surface brightness rapidly drops, indicating that the molecular phase contributes little to the mass of outflowing gas. In contrast, the Hi distribution shows plumes a few kiloparsecs above the disc that are aligned with the ionised cone, and complex kinematics suggestive of parts of the atomic phase being entrained in the outflow. However, the extended and warped Hi disc associated with NGC 4383 complicates the unambiguous identification of outflowing atomic gas and, most importantly, the quantification of outflowing mass and loading factor. Independent support for a cold component in the outflow comes from dust extinction features associated with the outflow and coincident with Hi plumes. Despite significant uncertainties in the estimate of the mass of cold gas associated with the outflow, these results suggest that the atomic phase likely dominates the cold outflow above $\sim$1 kpc. The observed cold gas velocities remain below the velocities of the ionised phase, suggesting that NGC 4383 does not host a large-scale escaping wind but more likely a galactic fountain, in which feedback redistributes material within the halo and regulates ongoing and future star formation.
Psychological distress is one of the major public health challenges during the emerging adulthood period, which is a developmental stage characterized by major life transformations and instability. Emerging adults are more vulnerable to psychological distress as they frequently deal with different pressures about relationships, work, education and identity exploration. The rising prevalence of psychological distress can impair physical health and wellbeing along with the initiation of harmful behaviors such as substance use.
Aim
The study aims to explore the prevalence and associated factors of psychological distress among emerging adult students, comparing female and male participants.
Method
Data were collected from 957 emerging adults in 12 institutions under Mangalore University in the Udupi district of Karnataka, India, pursuing bachelor’s degrees. Along with the sociodemographic pro forma, the Kessler Psychological Distress Scale (K10) was used to measure psychological distress, the World Health Organization’s Alcohol, Smoking and Substance Involvement Screening tool (WHO ASSIST version 3.0) was used to measure substance use, and the Adverse Childhood Experiences Scale was used to identify adverse childhood experiences. Univariate and multivariate regression analysis were employed to understand the determinants of psychological distress among participants.
Results
Female participants reported a higher risk of experiencing psychological distress compared to male participants. Overall, 27.06% of participants experienced psychological distress, with 11.8% likely to have mild, 9.71% moderate and 5.53% severe mental disorders. While adverse childhood experiences were reported to be a major factor associated with psychological distress among both the groups (AOR 6.218, 95% CI (3.546, 10.901), p < 0.001, for female), (AOR 1.965, 95% CI (1.073, 3.601), p = 0.029, for male) substance use pattern during the COVID19 pandemic was also predicted higher psychological distress among male participants.
Conclusion
In the study setting, psychological distress was prevalent among emerging adults, with a higher incidence among females. Adverse childhood events and substance use further elevated vulnerability. These findings highlight the critical need for culturally relevant and gender-sensitive mental health interventions.