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People with schizophrenia develop more chronic diseases at a younger age and die younger than people in the general population. It has been hypothesized that this excess morbidity and mortality could be partially due to accelerated aging in schizophrenia. If true, this would motivate the development of ‘gero-protective’ interventions to reduce chronic disease burden in schizophrenia. However, it has been difficult to test this hypothesis, in part, due to the limited ability to measure aging in samples of people with schizophrenia.
Methods
We utilized a novel neuroimaging biomarker of the longitudinal pace of aging, DunedinPACNI, to test for accelerated whole-body aging in schizophrenia across four neuroimaging datasets (total N = 2,096, 48% female) accessed through the Lieber Institute for Brain Development, the University of Bari Aldo Moro, and the North American Prodrome Longitudinal Study – 3.
Results
We found consistent evidence of faster DunedinPACNI in schizophrenia compared with controls. In contrast, youth at clinical-high risk for psychosis did not have faster DunedinPACNI compared to controls. Unaffected siblings of patients also did not have faster DunedinPACNI than controls. Faster DunedinPACNI in schizophrenia was not explained by tobacco smoking or antipsychotic medication use.
Conclusions
The results support the hypothesis that schizophrenia is accompanied by accelerated aging. Results were inconsistent with some of the most obvious explanations for accelerated aging in schizophrenia (familial risk, smoking, and iatrogenic medication effects). Research should aim to uncover why people who have schizophrenia age rapidly, as well as the utility of early disease-risk monitoring and anti-aging interventions in schizophrenia.
Understanding the connection between active galactic nuclei and star-formation (the AGN-SF connection) is one of the longest standing problems in modern astrophysics. In the age of large integral field unit (IFU) surveys, studies of the AGN-SF connection greatly benefit from spatially resolving AGN and SF contributions to study the two processes independently. Using IFU data for 54 local active galaxies from the S7 sample, we present a new method to separate emission from AGN activity and SF using mixing sequences observed in the [NII]$\unicode{x03BB}$6 584 Å/${\mathrm{H}}\unicode{x03B1}$ vs. [OIII]$\unicode{x03BB}$5 007 Å/${\mathrm{H}}\unicode{x03B2}$ Baldwin–Phillips–Terlevich diagram. We use the new decomposition method to calculate the ${\mathrm{H}}\unicode{x03B1}$ star-formation rate and AGN [OIII] luminosity for the galaxies. Our new method is robust to outliers in the line ratio distribution and can be applied to large galaxy samples with little manual intervention. We infer star-formation histories using pPXF, conducting detailed recovery tests to determine the quantities that can be considered robust. We test the correlation between the AGN Eddington ratio, using the proxy $L\mathrm{[O{III}]}/\sigma_*^4$, and star-formation properties. We find a moderately strong correlation between the Eddington ratio and the star-formation rate. We also observe marginally significant correlations between the AGN Eddington ratio and the light-weighted stellar age under 100 Myr. Our results point to higher AGN accretion being associated with young nuclear star-formation under 100 Myr, consistent with timelines presented in previous studies. The correlations found in this paper are relatively weak; extending our methods to larger samples, including radio-quiet galaxies, will help better constrain the physical mechanisms and timescales of the AGN–SF connection.
Crisis Resolution Teams (CRTs) are being piloted in Ireland as community-based, intensive, short-term services providing rapid intervention for individuals experiencing acute mental health crises. This perspective highlights a group over-represented in emergency care pathways: autistic adults without intellectual disability. For many autistic adults, crises can emerge from burnout, transition pressures and sensory or communication overload, often presenting with heightened distress or suicidality. In systems with limited onward pathways, brief-episode crisis care can become part of a cycle of repeated contacts, with limited scope to address enduring neurodevelopmental needs. We outline pragmatic adaptations: autism-informed workforce education; proactive crisis and safety planning; clear crisis service boundaries with connected pathways for ongoing support; and cross-sector coordination across health and social services. Embedding lived-experience and data capture in learning-sites can drive improvement. Aligned with the Crisis Resolution Service Model of Care and autism policy, these steps can improve safety, equity and continuity of care.
This study offers a systematic and theory-informed integrative synthesis of research at the intersection of artificial intelligence (AI) and entrepreneurship. Although interest in this domain has expanded rapidly, existing research remains fragmented, technology centered, and weakly connected to theories of entrepreneurial decision-making. To address this gap, the study adopts a hybrid review design that combines a systematic literature review with bibliometric co-word analysis and thematic synthesis. Based on 372 articles indexed in the Web of Science (WoS) Core Collection (2010–2025), the analysis maps the intellectual structure, thematic landscape, and temporal evolution of AI–entrepreneurship research. Four thematic quadrants are identified, reflecting core applications, transversal foundations, isolated specializations, and peripheral themes. The synthesis shows that AI is largely conceptualized as a functional input, while cognitive and behavioral dimensions of entrepreneurial judgment remain marginal. Building on these insights, the article proposes a cognitively informed research agenda to guide future work.
The nonreligious—atheists, agnostics, and nones—are on track to become America’s largest religious group between 2030 and 2040. The group’s rapid growth is largely attributed to widespread disaffiliation from Christian traditions across racial and ethnic identities. However, a significant portion of the population is now 2nd generation nonreligious, meaning that they not only never identified with a faith tradition but were raised in a nonreligious household by nonreligious parents. A significant body of work in psychology shows differences between those who convert away from religious identification and lifelong nonbelievers across intersecting identities. Yet, no work exists examining how this distinction impacts ideology or political beliefs that affect how voters’ identities interact with political outcomes. This study investigates the ideological and political differences between ex-Christian members of the nonreligious community and lifelong nonbelievers across multiple facets of identity, using data from the 2020 Collaborative Multiracial Post-Election Survey (CMPS).
This article explores changes and continuities in the lives and perspectives of Black South Africans at the beginning of the twentieth century, as portrayed in the Setswana-language newspaper Koranta ea Becoana. In studies of African responses to British colonization, scholars have tended to focus on evidence of nascent African nationalism in the English writings of Africans, but Koranta and other vernacular sources indicate that Africans during 1890–1910 were equally concerned with celebrating and preserving their various cultural and political traditions, advocating for a multiethnic liberalism that would not oblige them to choose between becoming either “Black Englishmen” or disenfranchised “Natives.”
Wood density (WD) is a crucial anatomical trait influencing forest carbon storage. However, dynamic global vegetation models (DGVMs) typically assume a fixed species-level WD, neglecting environment-driven variability. In this proof-of-concept study, we explore the potential impact of dynamic WD on tree- and forest-level carbon storage by integrating a simple temperature-response function of WD into the DGVM LPJ-GUESS from Smith et al., 2014.
Simulations along a temperature gradient show that incorporating environmentally responsive WD can substantially alter simulated stand structure and carbon stocks. Overall, our model experiments illustrated that sites with higher WD had more, but smaller trees, which stored less carbon compared to the standard model. The strongest effects were predicted to appear before canopy closure, where per-tree carbon deviated by up to 32%. This exploratory study suggests the need to represent a mechanism for dynamic WD to better assess ecological feedbacks to forest carbon storage predictions, particularly in young and regenerating forests.
Societal pronatalist ideologies link womanhood to motherhood and create social pressures that often cause psychological distress when unmet. While previous research has documented the impact of these external pressures, much less is known about how women’s internal belief systems shape their responses to societal expectations. Recognising this gap, we examined the perspectives and concerns about motherhood and childlessness among child-free Greek women, their psychological distress and the potential mediating role of early maladaptive schemas (EMS) in this relationship. To provide context, we compared these findings with those of mothers, considering both their mental health and their assessments of similar issues after becoming parents.
Method
We conducted an online, cross-sectional survey comparing child-free Greek women and mothers aged 30–50 years. Through custom-designed questionnaires, we evaluated concerns about motherhood and childlessness among child-free women, and we asked the mother group to assess the same aspects post-motherhood. Mental health was assessed using Depression, Anxiety and Stress Scale 21, while EMS were measured with the Young Schema Questionnaire. We used mediation analysis to examine whether EMS mediated the connection between pronatalist pressures and mental health outcomes.
Results
The study included 1341 women, comprising 503 without children and 838 with children. Child-free women, who were predominantly involuntarily child-free, tended to be younger, more educated and had lower household incomes than mothers. They also reported more diverse sexual orientations, higher levels of depression and anxiety and elevated scores on EMS, which appear to exacerbate distress caused by societal pronatalist pressures. In contrast, mothers were typically older and more financially stable. Although they reported fulfilment from motherhood, they also faced challenges, including demanding caregiving responsibilities and financial or logistical barriers to having more children. Mothers’ psychological profiles were characterised by lower EMS scores and less overall distress.
Conclusions
This study revealed distinct demographic and psychological profile differences between child-free women and mothers. Our findings underscore that women’s mental health in the context of reproduction is shaped by a complex interaction of social pressures, psychological schemas and structural factors. Specifically, EMS – particularly in the domains of Emotional Deprivation, Mistrust/Abuse and Vulnerability to Harm – were identified as a key mechanism, mediating the relationship between pronatalist pressures and psychological distress. Furthermore, occupational disparities emerged as a significant stressor, affecting both child-free women in high-pressure careers and mothers who were home-makers.
Suicidal ideation following trauma exposure is frequently associated with depressive and post-traumatic stress disorder (PTSD) symptoms; however, the interactive effects of depression and distinct PTSD symptom clusters on suicidal ideation remain poorly understood.
Aims
To examine whether specific PTSD symptom clusters – namely intrusion, avoidance and hyperarousal – moderate the association between depressive symptoms and suicidal ideation, and whether these effects vary across different trauma types.
Method
Medical records of 127 psychiatric out-patients with a history of at least one traumatic event were analysed. All participants had completed the Hamilton Rating Scale for Depression, the Impact of Event Scale-Revised, and the suicidal ideation item of the Beck Depression Inventory II. Trauma types were categorised into early versus late, single versus multiple, and interpersonal versus non-interpersonal.
Results
Hierarchical regression analyses identified a significant moderating effect of avoidance symptoms on the relationship between depression and suicidal ideation (β = 0.19, P = 0.012), whereas intrusion and hyperarousal symptoms did not show such effects. Specifically, higher levels of avoidance were associated with a stronger positive relationship between depression and suicidal ideation. This moderating effect was observed only among individuals with late (β = 0.28, P = 0.002), single (β = 0.29, P = 0.002) or non-interpersonal trauma (β = 0.34, P = 0.018); it was not evident among those with early, multiple or interpersonal trauma.
Conclusions
These findings underscore the relevance of targeting avoidance symptoms to mitigate suicidal ideation, particularly in individuals with late-onset, single-incident or non-interpersonal trauma exposure. Exposure-based therapeutic interventions may offer particular benefit for reducing suicidal ideation among trauma-exposed individuals with depressive symptoms.
The interaction between socioeconomic status, place of residence, and life expectancy remains poorly understood. This study advances this understanding using administrative data from the German Pension Insurance combined with multiple data sources on place characteristics. I provide novel estimates for remaining life expectancy at age 65 by lifetime earnings quintiles and geographic areas (NUTS2), revealing substantial heterogeneity in the link between lifetime earnings and life expectancy across NUTS2 regions in West Germany. Subsequently, I conduct a correlational analysis differentiated by socioeconomic status to investigate which place factors are associated with longevity and examine whether the interaction has changed over time. Strikingly, the correlations between place factors and life expectancy are largely homogeneous in magnitude and direction for individuals at the top and the bottom of the lifetime earnings distribution. Furthermore, I find suggestive evidence that the importance of place for the life expectancy of low-income individuals has decreased over time.
In [24, 26] Guichard and Wienhard introduced the notion of $\Theta $-positivity, a generalization of Lusztig’s total positivity to real Lie groups that are not necessarily split.
Based on this notion, we introduce in this paper $\Theta $-positive representations of surface groups. We prove that $\Theta $-positive representations of closed surface groups are $\Theta $-Anosov. This implies that $\Theta $-positive representations are discrete and faithful and that the set of $\Theta $-positive representations is open in the representation variety.
We further establish important properties on limits of $\Theta $-positive representations, proving that the set of $\Theta $-positive representations is closed in the set of representations containing a $\Theta $-proximal element. This is used in [3] to prove the closedness of the set of $\Theta $-positive representations.
As private companies assume a growing role in climate adaptation, their strategies may harm society and ecosystems unless grounded in responsible business conduct. This Element offers a new perspective on responsible business conduct in climate adaptation, presenting a theoretical framework that explains how regulatory and political factors external to firms influence their consideration of societal needs when adapting to climate change. Using a novel quantitative and qualitative dataset, the Element shows that the world's largest mining companies have primarily addressed climate risks through conventional corporate social responsibility strategies rather than procedural components of responsible business conduct, such as risk assessments, participation, and transparency. The results suggest this outcome is best explained by a combination of weak governance, lax voluntary standards, and civil society advocacy. This title is also available as Open Access on Cambridge Core.
'Humanism' is among the most powerful terms in historical and contemporary political, religious, and philosophical debates. The term serves to position itself in ideological conflicts and to cement a claim to interpretation, but is highly contradictory. This Element addresses 'humanism' in its striking contradictions. Contemporary definitions are confronted with the historical contexts the term 'humanism' is applied to. Based on Niethammer's invention of 'humanism' as an anti-enlightenment pedagogical concept (1808), the book does not present a mere conceptual history, but rather a theoretically oriented discourse, an examination of the front positions, between which humanism has been constructed. In this way, its 'impossibility' is shown, which is rooted in its strict contextuality. Secondly, historiographical alternatives to this dilemma are pointed out, in order to finally give suggestions not only for an ethical-normative work of the historian of humanism, but for dealing with 'humanism' in general, in connection with discourse-theoretical suggestions. This title is also available as open access on Cambridge Core.
This article examines the evolving dynamics of migration control in the European Union, where traditional state borders are being redefined. As governance shifts to private and local actors, healthcare access increasingly serves as a tool of internal bordering, regulating migrant mobility and social rights within different welfare state models. Focusing on the experiences of free-moving EU migrants in Germany, Sweden, and the UK (an EU member at the time of this study), the research shows how healthcare provision selectively includes or excludes migrants. The findings reveal that these bordering strategies vary by welfare state model: the liberal welfare state model, as seen in the UK, aligns more closely with the EU’s ideal of free mobility, while the social-democratic model, exemplified by Sweden, struggles to accommodate this type of mobility, highlighting significant tensions in the EU’s commitment to universal access.
Trazodone is commonly used in the treatment of major depressive disorder (MDD) in adults. This study aimed to establish consensus on the clinical scenarios and patient profiles for which trazodone treatment is considered suitable.
Methods
A two-round Delphi process was conducted across eight European countries. Statements regarding trazodone were rated by a panel of 32 experts for agreement or disagreement using a 9-point Likert scale; those with <70% agreement among panelists were revised and reassessed by the panel.
Results
There was strong consensus agreement on 68 out of 91 statements (75%) related to trazodone. According to the panel, trazodone is well tolerated, with low anticholinergic activity, minimal impact on sexual function, weight neutrality, and low potential for clinically relevant drug–drug interactions. Consensus agreement supported trazodone use across a broad spectrum of patients with MDD, including those with insomnia, anxiety, psychomotor agitation, substance use, physical comorbidities, neurological conditions, and treatment-resistant depression; consensus agreement was also achieved for trazodone use in elderly patients, and those experiencing adverse effects with other antidepressants.
Conclusions
This study suggests that trazodone is useful in the treatment of MDD across multiple patient profiles. These findings offer practical guidance to support individualized and evidence-based decision-making in clinical practice.
Ultrafast vortex beams are essential in many scientific and industrial fields owing to their unique spatial and temporal characteristics. We demonstrate a passively mode-locked ytterbium-doped yttrium aluminum garnet (Yb:YAG) thin-disk oscillator that directly generates high-power femtosecond vortex beams with excellent beam quality. Using Kerr-lens mode-locking assisted by a semiconductor saturable absorber mirror, we achieve 594 fs Laguerre–Gaussian vortex pulses with 50 W average power at a 68.5 MHz repetition rate, representing the highest power reported for a femtosecond vortex oscillator. By replacing the planar output coupler with a coated axicon, we further realize stable mode-locking and efficient generation of first-order Bessel vortex beams. This compact and integrated design eliminates external mode converters, enabling robust generation of high-power ultrafast structured light. The demonstrated source provides a promising platform for precision material processing, strong-field vortex dynamics and quantum optical studies.
This study aimed to analyse the patterns, trends, genomic characteristics, and key determinants of dengue virus (DENV) infections and associated deaths in South Asia from 2000 to 2023. We collected data from the World Health Organization dengue surveillance dashboard and the health ministries of respective countries, and publicly available data from eight South Asian (SA) countries. Descriptive measures, data visualization techniques, and time series analysis were used to identify key patterns and trends of DENV. A time-scaled phylogenetic analysis was carried out to explore the genomic epidemiology and evolution of DENV. A generalized linear model (GLM) was fitted to identify climatic, demographic, and socioeconomic factors. Between 2000 and 2023, SA countries showed a sharp increase in dengue cases and deaths, contributing to 6.5% of cases and 11.07% of deaths caused by DENV globally. The total cases in the region are projected to grow by approximately 40%, and total deaths by 61% by 2033. The predominant genotypes were DENV2/II, DENV3/I, and DENV3/III. GLM underscores climatic, demographic, and socioeconomic factors associated with DENV infection and deaths. The findings urge intensified public health measures emphasising the need for comprehensive interventions, including vector control, climate adaptation, and strengthened healthcare systems to de-escalate the situation.
We investigate the occurrence of flow circulation in an open triangular cavity filled with a gas at highly rarefied conditions. The cavity is subject to an external shear flow that is in either the circular or linear direction at its inlet. The problem is studied analytically in the free-molecular limit and numerically based on the direct simulation Monte Carlo (DSMC) method. The corner walls are modelled based on the Maxwell boundary condition, as either specular or diffuse. The results are obtained for arbitrary values of the outer flow speed and corner angle. Remarkably, it is found that multiple recirculation zones occupy the corner domain in the absence of molecular interactions. In the specular-corner set-up, such topologies occur at non-large outer-flow speeds and distinct corner-angle intervals of $[\pi /(n+1),\pi /n]$ with $n=3,5,\ldots$. In the diffuse-wall case, the cavity flow field contains two recirculation zones at sufficiently low corner angles for both circular and straight outer flows. With increasing angles, the straight-flow configuration differs, reducing the number of vortices to one and then none. The results are rationalised based on ballistic particle kinematics, suggesting insight into the relation between the microscopic description and the hydrodynamic (observed) generation of circulation. The effects of molecular collisions on the corner flow pattern, as well as more elaborate gas-surface interaction models, are inspected based on DSMC calculations, indicating visible impacts on the macroscopic flow structure at large Knudsen numbers.
The hydrodynamic performance of oscillating elastic plates with tapered and uniform thickness in an incompressible Newtonian fluid at varying Reynolds numbers is investigated numerically using a fully coupled fluid–structure interaction computational model. By leveraging the acoustic black hole effect, tapered plates can generate bending patterns that vary from standing wave to travelling wave oscillations, whereas plates with uniform thickness are limited to standing wave oscillations. Simulations reveal that although both standing and traveling wave oscillation modes can produce high thrust, travelling waves achieve significantly higher hydrodynamic efficiency, and this advantage is more pronounced at higher Reynolds numbers. Furthermore, regardless of the oscillation mode, tapering leads to greater hydrodynamic performance. The enhanced hydrodynamic efficiency of travelling wave propulsion is associated with the reduced amount of vorticity generated by tapered plates, while maintaining high tip displacements. The results have implications for the development of highly efficient biomimetic robotic swimmers, and more generally, the better understanding of the undulatory aquatic locomotion.
While rapid health technology assessments (HTA) are important for decision makers, there is no universally accepted definition or standardized methods. The objective of this study was to analyze the content and conduct of published rapid and mini-HTA reports.
Methods
We conducted a cross-sectional analysis of rapid and mini-HTA reports identified from the International HTA Database (2014–April 2024) and supplementary searches of HTA agency websites. We extracted descriptive data on rapid HTA products; specifically, which traditional HTA domains were included or omitted, evidence synthesis methods, and approaches to interest-holder (formerly known as stakeholder) engagement. Data analysis was conducted in Stata.
Results
We included 203 rapid HTA reports. Most frequently included HTA domains were clinical effectiveness (99 percent) and safety (82.3 percent). Legal aspects (12.3 percent) and budget impact analyses (10.8 percent) were less frequently reported. Across reports reviewing clinical effectiveness (n = 201), generic literature searches were the most predominantly self-reported evidence synthesis method (37.8 percent), with updates (1.5 percent) and overviews (2 percent) of systematic reviews less common. Cost-utility analyses were the most commonly self-reported form of economic evaluation (36.2 percent). Additionally, public consultations (68 percent) were the most commonly reported ways to engage with interest holders.
Conclusion
Our analysis highlights variations across rapid HTA reports and will contribute to wider research aiming to establish a clearer definition and framework of rapid HTAs and inform when and how rapid HTAs are performed. Clearer reporting and justification of simplifications in rapid HTA reports are needed.