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Ketamine and esketamine produce rapid and sustained antidepressant effects in persons with treatment-resistant depression (TRD). Although it is posited that these effects are largely attributed to N-methyl-D-aspartate receptor antagonism, the potential involvement of the opioid system remains unclear. This systematic review investigates whether ketamine and esketamine antidepressant efficacy is mediated through the opioid system.
Methods
We conducted a systematic search of preclinical and clinical studies investigating the potential involvement of the opioid system in the antidepressant effects of ketamine and esketamine. Database searches on PubMed, Cochrane Library, Embase and PsycINFO occurred from inception to September 27, 2025.
Results
16 studies were identified: 12 clinical (n = 790) and 4 preclinical studies. Clinical designs included randomized controlled trials, case reports, pre-post studies and observational cohort studies. Preclinical studies utilized animal models of depression. Only one study examined esketamine. Naltrexone (nonselective opioid antagonist) attenuated ketamine’s effects in three studies, while four reported no such effect and one reported mixed evidence. Genetic markers of opioid receptor subtypes (i.e., OPRM1 and OPRD1) were examined in three studies, but results were inconclusive, potentially due to limited evidence. Separately, opioid use was not associated with ketamine response. Few studies directly examined opioid receptor subtypes.
Conclusions
The reported mixed findings suggest that the opioid system may exert a partial mediating effect of ketamine in TRD. However, given the inconsistent attenuation of ketamine’s antidepressant effects by opioid receptor antagonists, the opioid system likely functions as a context-dependent modulator rather than a primary mediator, particularly at standard antidepressant doses.
This paper examines the history-making of the first two Raffles Professors of History at the University of Malaya, C.N. Parkinson and K.G. Tregonning, to demonstrate the impact Malaya’s decolonisation had on the historiographical practices of the university’s History Department. It argues that both historians, animated by Malaya’s decolonisation, attempted to re-frame Malayan history – through adopting a ‘world-historical’ and ‘autonomous history’ framework respectively – to meet what they perceived were the needs of a post-independence multiracial Malaya. Although both historians claimed to be producing histories for an independent Malaya, and while their frameworks were indeed methodologically innovative, both historians ultimately produced histories that continued to frame Malayan history using western frameworks. They were thus partially decolonised historians writing partially decolonised histories for a partially decolonised Malaya.
Working closely with a detailed 1582 register of the free Afro-Peruvian population of Cusco, Peru, this article explores how the strategic representations of individual registrants reflect the intersectional impact of unfree labor practices and increasing racial marginalization in the early colonial Andes. The growing population of free Afro-Peruvian men and women navigated practices and policies that promoted racial inequalities and coerced labor based on race, class, and gender. The 1582 registry reflects municipal attempts to subject Cusco’s free Afro-Peruvians to ordinances that acknowledged the relative independence of skilled workers (oficiales), while requiring others to reside and serve in the homes of Spanish masters (amos). Analyzing entries for the nearly 150 people registered reveals ways that intersectional status and identity affected the experience of registration and the strategies for providing personal information to the Spanish notary. The declarations and omissions contained in the document highlight personal choices that people made to preserve their independence and that of their families. The social and economic independence displayed by many oficiales contrasts with the silence of individuals who lived and worked in the households of wealthy and powerful Spaniards, navigating unequal and enmeshed relationships. The range of individual experiences and statuses evident in the 1582 registry helps explain why the restrictive goal of the proceeding failed in the following years, as well as why a free Afro-Peruvian community did not flourish in Cusco during the later colonial period.
This paper presents a reliability-constrained Bayesian optimization framework for structural design under uncertainty, addressing challenges in stochastic optimization where the objectives and constraints are defined implicitly by potentially expensive numerical models. Our approach explicitly accounts for parameter uncertainty using results from Bayesian quadrature for uncertainty propagation in Gaussian process surrogate models. The method accommodates arbitrary probability distributions and employs gradient-based optimization for acquisition function maximization, strategically selecting sample points to minimize numerical model evaluations. We demonstrate our algorithm’s superior performance over random search and conventional Bayesian optimization through both an analytical test function and a prestressed tie-beam design case study, showing its practical applicability to structural optimization problems.
Bilinguals vary in their daily-life language use and switching behaviours, which are also frequently studied in relation to other processes (e.g., executive control). Measuring daily-life language use and switching often relies on self-reported questionnaires, but little is known about the validity of these questionnaires. Here, we present two studies examining test–retest reliability and validity of language-use questionnaires (relative to Ecological Momentary Assessment, Study 1) and language-switching questionnaires and tasks (relative to recorded daily-life conversations, small-scale Study 2). Test–retest reliability and validity of the LSBQ (Anderson et al., 2018) were high and moderate, respectively, suggesting this questionnaire can capture daily-life language use well. Although only examined with a small sample size, Study 2 suggested relatively low validity of most language-switching questionnaires, with short language-production tasks potentially offering a more valid assessment. Together, these studies suggest that tools are available to reliably capture language use and switching with (a certain degree of) validity.
This study examines intergroup bias among members of the Swedish-speaking minority in Finland—a high-status ethnolinguistic minority group. Drawing on social identity theory and intergroup threat theory, the study explores ingroup favoritism and identifies key predictors of individual-level bias. Using survey data from 1,096 Swedish-speaking Finns, the study uses trait-based evaluations of both ingroup and outgroup members. Results show that intergroup bias is prevalent, particularly in the form of ingroup favoritism for positive traits. Analyses reveal that strong ethnolinguistic identity and perceived intergroup threat significantly predict higher levels of bias, while language identity, Finnish language proficiency, and intergroup contact show no consistent relationships. These findings suggest that even in socially stable and egalitarian contexts, perceived threats to group identity can sustain intergroup bias.
New parties have emerged across European democracies, forcing established parties to develop strategies to campaign against them. But how do supporters want their established parties to respond to these new parties? Using survey experiments in 14 European countries, we examine how party supporters react to responses their preferred parties might take to the rise of a hypothetical new party. Our results primarily highlight that voters care about substantive representation. They endorse accommodative responses towards a new party offering a policy they agree with. Thus, the extent to which party responses bind supporters to established parties is highly contingent on the distribution of policy positions among their supporters. Often, established parties must walk a precarious tightrope, balancing the need for unity with some degree of tolerance for dissent. Hence, our results explain why parties accommodate the position of new parties, despite recent evidence that doing so can be electorally detrimental.
This talk examines how corpus linguistics and artificial intelligence treasure the potential to reshape contemporary language learning ecologies. It argues that the rapid normalisation of generative AI has intensified the need for pedagogical models that combine low-friction access to language support with transparent methods grounded in attested usage. Drawing on ecological perspectives and recent empirical research, the talk shows how AI-driven environments expand opportunities for language learning while creating risks related to opacity and over-reliance. Corpus linguistics, data-driven learning and corpus literacy offer a complementary foundation by providing traceable evidence, reproducible analyses, and practices that foster learners’ critical judgement. Two convergence scenarios are proposed: AI as an extension of DDL, and corpus literacy as the operational core of critical AI literacy. Together, these scenarios illustrate how open-box pedagogies can reconcile responsiveness and accountability, ensuring that AI-mediated learning remains anchored in transparent processes and empirically grounded language knowledge.
Analyzing topics and emotions in social media activism offers valuable insights into the competing voices that shape digital discourse. However, existing research has largely neglected the influence of geographic and linguistic diversity on public dialogue during crises. To address this gap, it is essential to recognize the varied perspectives of local communities and language groups. Doing so helps uncover specific local needs, ensures more inclusive representation, and supports the development of solutions that are responsive to the local context. We leverage machine learning models to analyze 1,036,111 public tweets from the #NoMore movement, including tweets containing #NoMore, #EthiopiaPrevails, and #SayNoMore. Our analysis examined the differences in content, emotional responses, and user influence by comparing tweets from Ethiopia and the United States (US), as well as those written in English and Amharic. The findings reveal distinct societal perspectives, emotional expressions, and opinion dynamics. Ethiopian users emphasized local issues with higher fear and joy responses, while users from the US leaned toward peace-related themes with spikes in anger. Amharic tweets focused on domestic concerns with greater emotional intensity than English tweets. These insights help surface region and language-specific perspectives often marginalized in mainstream coverage, paving the way for more inclusive and effective approaches to societal challenges.
How and to what extent can populism emerge in a new democracy where strong populism politics has not previously existed? Contrary to earlier findings that the effects of populism on voting have been minimal in South Korea, the 2022 presidential campaigns were marked by populism rhetoric and mobilisations, raising questions about the sudden rise of populism politics. This paper argues that even in a new but consolidated democracy that has been relatively free from the threat of populism, populism can influence elections when politicians mobilise economic grievance and political dissatisfaction, and when voters with latent populist attitudes resonate with such appeals. To support this argument, this paper analyses all official campaign speeches and assesses their level of populist rhetoric with holistic grading methods. Quantitative analysis of pre- and post-election surveys shows that, while populist attitudes did not significantly influence vote choice before the campaign, voters with stronger populist attitudes were more likely to vote for the candidate who delivered more populist speeches after the campaign began. These findings demonstrate that populist voting can be activated even in political contexts without a strong historical presence of populism.
Experts step into global governance most prominently in times of crisis. But if crisis governance at international organizations (IOs) involves the construction of specific temporal horizons, how do these horizons affect the constitution of expert authority? This article argues that expertise produced under such conditions – to meet a demand for ‘timely’ knowledge – differs substantively from other kinds of expertise. Crisis governance thus contributes in notable ways to the pluralization of expertise. The article examines this phenomenon in the case of the relatively recent proliferation of rapid response mechanisms (RRMs). By examining the making and implementation of RRMs at two major IOs – the World Health Organization and the World Food Programme – the article offers a new understanding for how RRMs have become part of institutional repertoires of expertise. Based on this, it contends that RRM-based timeliness claims a shift in expert knowledge production from credentialed individuals to infrastructures and standardized procedures; second, they prioritize large homogenous datasets over consultation and contestation among different experts; and third, they streamline expert selection such that experts are recruited from existing intra-institutional pools rather than third parties. Jointly, these shifts speed up monitoring and reaction capabilities, but also risk eroding important checks on expert overconfidence.
Epidemiological evidence on the incidence and remission of anxiety and depressive disorders is limited. We estimated age- and sex-specific incidence and remission rates of moderate-to-severe anxiety and depressive symptoms using the illness-death model.
Methods
The German National Cohort (NAKO) is a cohort of over 200,000 participants aged 19–74 at baseline. Prevalence of probable cases, estimated with the Generalized Anxiety Disorder Scale and the Patient Health Questionnaire data 2014–2019 across five regions, was related to general mortality rates and disorder-specific mortality rate ratios in the illness-death model. The partial derivative of prevalence was modeled as a function of incidence and remission, with parameters estimated via least-squares optimization through 2,000 bootstrap resamples.
Results
The highest incidence rates (per 1,000 person-years) occurred at ages 19–21 for anxiety symptoms: 4.07 (95% CI: 0.00–7.57) in women and 2.55 (0.00–4.94) in men; and at ages 28–34 for depressive symptoms: 4.41 (0.00–9.81) in women and 3.30 (0.00–7.34) in men, all in Hamburg. Remission rates (per 100 person-years) were highest at older ages. For anxiety symptoms, rates peaked at 71.8 years in women (4.10 [0.00–11.94]) and 64.2 years in men (3.00 [0.00–9.23]) in Freiburg. For depressive symptoms, the highest observed was at 74.0 years, both among women (6.61 [0.00–15.50] in Münster) and men (3.58 [0.00–11.51] in Berlin).
Conclusions
Incidence and remission rates of anxiety and depressive symptoms can be estimated from prevalence and mortality data, revealing regional, sex-, and age-related variation. Validation with longitudinal data is warranted.
This review examines barriers and facilitators to implementing infection prevention and control (IPC) practices in behavioral health settings. Among 63 studies identified, environmental design, staffing/training limitations, patient behaviors, and therapeutic conflicts were common barriers. Facilitators included targeted training, collaboration, and adaptable IPC policies, underscoring the need for tailored interventions.
The objective of the current study was to evaluate 30 previously uncharacterised pure plant secondary metabolites (PSM) for effects on in vitro gas production (GP) and methane concentration. Purified compounds (n = 4) were incubated in buffered rumen fluid for 48 h at a rate of 25 mg per g substrate. Gas production was measured using ANKOM RF pressure analysers and gas composition was measured using gas chromatography. Dry matter and fibre digestibility and volatile fatty acid (VFA) concentrations were determined. Data were analysed using a linear mixed model with fixed effect of treatment, random effect of experimental run and blank as a covariate and Dunnett’s test to compare each treatment to a control. Sabenine, apigenin, galangin, isoliquiritigenin, quercetin, rutin, vitexin, abscisic acid and uridine reduced methane concentration, with a tendency for reduction by kaempferol. Sabenine, thymol, apigenin, quercetin, rutin, vitexin, abscisic acid and uridine reduced methane production, with the greatest reduction occurring for rutin (81.8 %), vitexin (81.7 %) and thymol (80.5 %). Eight compounds increased methane production compared to control, with stigmasterol having the greatest increase (173.0 %). Out of the compounds that reduced methane emissions, a reduction in fibre digestibility was observed for all except quercetin and thymol. Minimal effects of PSM on VFA profile were observed, with myrtenal increasing proportion of acetate, alpha-humulene, alpha-longipinene and beta-caryophyllene increasing proportion of propionate and thymol, apigenin, hyperoside and verbenone increasing proportion of butyrate. Results suggest that quercetin and thymol warrant further exploration as potential feed additives to reduce methane emissions.
To evaluate the impact of a tailored organizational intervention on the support for family caregivers.
Methods
A convergent mixed-methods study was conducted in 17 organizations (6 hospices, 5 home care organizations, 3 nursing homes, 2 hospitals, 1 transmural organization) between November 2021 and August 2023. The intervention comprised a structured practice improvement trajectory during which each organization conducted a structured workshop to define organization-specific goals to improve their support for family caregivers and to develop an action plan to achieve those goals. The action plan was implemented over 1 year with intermittent evaluations. Pre- and post-intervention surveys were distributed among healthcare professionals (paired) and bereaved family caregivers (non-paired) to assess provided and received support. Data were analyzed with mixed models and regression analyses. Post-intervention focus groups with project team members and final evaluation reports were analyzed with qualitative content analysis.
Results
Survey respondents were 97 healthcare professionals (83% nursing staff), 123 family caregivers pre-intervention, and 99 family caregivers post-intervention. Only healthcare professionals of home care organizations reported a significant increase in attending to family caregivers’ wellbeing and needs (scale 0–20; β = 3.65; 95%CI: 1.33–5.97). Family caregivers’ reports of healthcare professionals attending to their wellbeing and needs did not change (scale 0–2; β = 0.17; 95%CI: −0.04–0.38). Across settings, healthcare professionals evaluated the care they provided more positively post-intervention (scale 0–8; β = 0.65, 95%CI: 0.38–0.97). In home care, family caregivers also evaluated care more positively (scale 0–8; β = 2.12; 95%CI: 0.89–3.34). Four focus groups and 17 evaluation reports indicated improvements at 3 levels: the support for family caregivers (increased awareness of healthcare professionals, changes in work processes, more structured support), the healthcare team (more skills, confidence, available tools), and the organization (fostering sustainability).
Significance of results
A tailored organizational intervention can strengthen the support of family caregivers in healthcare organizations.
This article presents and discusses a table of audiovisual transformations based on practice-based experience. The transformations were designed to reinforce the link between sound and object by considering what a particular audio process would look like if translated into visual form. The creative work involves installations that focus on objects integrated with projection mapping and electroacoustic sound. Examples of other artists who create object-based works are introduced, followed by a discussion around how electroacoustic music can influence audiovisual approaches. Screen and installation-based audiovisual theory expands on this and links to a two-part table of transformation strategies. The first part of the table describes process-based links that were created to imagine how certain electroacoustic studio techniques would translate to alter visual material. The second part describes broader conceptual links between audio and visual elements. The findings offer an insight into how electroacoustic practice can inform audiovisual composition choices. Whilst the intended use was for sound installations, there is significant scope for others to adopt and adapt the transformation strategies beyond this, including visual artists who wish to work with sound and those seeking to further theorise audiovisual relationships in a variety of settings.
This study conducted an approximate replication of Teravainen-Goff (2023) to validate the Intensity and Perceived Quality of Engagement Scale for university students in the Japanese EFL context. Teravainen-Goff (2023) developed this scale based on an action-oriented definition of engagement and proposed a novel approach to measuring engagement among secondary school language learners in the UK. The study identified an 18-item, five-factor structure from a pool of 36 items through exploratory factor analysis (EFA). In this replication, we examined the validity and reliability of Teravainen-Goff’s scale in a different context, focusing on the replicability of the EFA results. We undertook this replication because engagement is context-dependent and EFA results can vary across samples. We compared the factorial structure with that of the initial study while modifying the target language and participant demographic. Results revealed a 22-item, six-factor structure with good fit. Although the same underlying factors emerged, several notable differences were observed. This approximate replication provided stronger evidence for the psychometric properties of the scale in a new context. Transparent documentation of modifications to the initial study and systematic comparison offered a promising approach to building robust evidence for engagement research and improving the rigour of questionnaire-based research overall.
Nd,Y:CaF2 (NYCF) crystals are exceptional gain materials for high-power laser drivers; however, laser-induced damage remains a substantial challenge that restricts their broader application. In this study, by establishing an in situ testing system for photothermal weak absorption and the laser-induced damage threshold (LIDT), the relationship between the photothermal weak absorption characteristics of NYCF and its LIDTs was analyzed. A fully connected neural network was employed to facilitate deep learning of these relationships, thereby enabling non-destructive evaluation of NYCF via photothermal weak absorption. Moreover, this study examined both the effect of spot size during testing and the influence of crystal orientation on the evaluation outcomes. The underlying mechanisms were further elucidated by investigating NYCF’s thermal mechanical properties and damage characteristics. This work not only offers a rapid, non-destructive method for evaluating the laser damage resistance of NYCF using artificial intelligence but also enhances the understanding of its damage mechanisms.