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The global financial crisis exposed the sovereign-bank nexus as a driver of financial instability and an impediment to economic growth. Little attention has been paid to the interaction of banking regulation and public finance. This study analyzes the interaction between the prudential regulation of banks’ capital requirements and constitutional fiscal rules. We hypothesise that a conflict occurs between the regulatory privileged treatment of sovereign bonds held by banks and the market exposure logic enshrined in constitutional fiscal rules. This is particularly problematic in currency unions such as the US and the euro area. Our legal analysis builds on an empirical econometric assessment showing that peripheral euro area governments increase their debt following a tightening in macroprudential capital regulation, laying bare the undesired interaction between banking regulation and constitutional rules.
Several independent reviews in the UK have recently investigated sustained, systemic failings by statutory services and government departments. These reviews document severe psychological impacts on people affected by these scandals, which have been exacerbated by miscarriages of justice, denials of accountability and lack of formal support. There is evidence that impacted people have significant, unmet mental health needs.
Aims
To explore the psychological support needs of people infected and affected by the infected blood scandal in England, their experiences of seeking support and how insights from this research could inform responses to people affected by similar failings, including the Hillsborough Disaster, Windrush Scandal and Post Office Horizon IT Scandal.
Method
We used a qualitative design involving semi-structured interviews with infected and affected people in England and with mental health practitioners to explore experiences, psychological impacts and perspectives on existing support services. Our analysis was thematic, adopting an empathetic interpretive orientation toward participants’ experiences.
Results
We identified significant unmet mental health needs among infected and affected people, including those who had been in contact with NHS or private psychological support services. Historically, infected and affected people have rarely accessed effective mental health support.
Conclusions
Insights from the Infected Blood Inquiry and the subsequent development of a bespoke psychological support service could inform the setting up of skilled, tailored psychological support for people affected by other severe, systemic state failings. This response could address complex, unmet mental health needs and increase understanding of the psychological impacts of scandals resulting from systemic, statutory failings.
Verification of the coincidence between the radiation and mechanical isocentres is an essential quality assurance (QA) procedure for linear accelerators (linacs) in radiotherapy. Ensuring this alignment is critical for accurate beam targeting, especially in conformal and intensity-modulated radiotherapy techniques.
Objective:
This study aimed to evaluate the feasibility and effectiveness of using computed radiography (CR) with a bare imaging plate (IP) to assess the coincidence between radiation and mechanical isocentres, as a practical QA method, especially applicable in resource-limited settings.
Materials and Methods:
The study was conducted on a Precise linac installed at Bac Ninh General Hospital No2. A Fujifilm IP and an FCR Prima T2 reader were used. Mechanical isocentre marking was performed via 1 monitor unit (MU) open-field exposure. Radiation isocentre verification involved multiple exposures with narrow rectangular fields at various gantry, collimator and couch angles. The latent images were processed using FCR View software to analyse displacement diameters between mechanical and radiation centres.
Results:
The CR system demonstrated sufficient sensitivity to detect exposures as low as 1 MU. Deviations (diameters) were 0·44–1·04 mm with expanded uncertainty U up to 0·44 mm (k = 2). All measurements were within the ±2 mm tolerance recommended by American Association of Physicists in Medicine (AAPM) for non-stereotactic systems.
Conclusion:
The use of a bare IP in CR offers a reliable and low-cost alternative for verifying the coincidence of radiation and mechanical isocentres. This method is suitable for routine QA procedures in clinical environments lacking access to radiochromic film or electronic portal imaging devices.
This study employed a cross-lagged panel network model to examine the longitudinal relationships between problems of sleep, internalizing and externalizing problems in adolescents.
Methods:
This study gathered data at four different time points (T1, T2, T3, and T4) for students enrolled in Grades 7 and 8, with an interval of approximately six months between each time point. The present sample comprised 1,281 Chinese adolescents, including 636 girls, with a mean age of 12.73 years (SD = 0.68) at baseline. Cross-lagged panel network modeling was used to estimate longitudinal relationships between symptoms at adjacent time points. Network replicability was assessed by comparing the T1→T2 network with the T2→T3 network and the T2→T3 network with the T3→T4 network.
Results:
The anxious/depressed symptom emerged as the most predictive of other symptoms and were also the most prospectively influenced by other symptoms. Cross-cluster edges predominantly flowed from internalizing and externalizing symptoms to sleep problems. Additionally, externalizing symptoms exhibited distinct patterns: aggression predicted more sleep and internalizing symptoms, whereas delinquent behavior predicted fewer of these issues.
Conclusions:
These findings suggest that mental health problems contribute to later sleep disturbances, with internalizing symptoms playing a central role in adolescent psychopathology.
Direct numerical simulations of two-phase, free-surface flow past a fully submerged, fixed circular cylinder are conducted for transitional Reynolds numbers $400 \leqslant {\textit{Re}} \leqslant 2000$, with Weber number ${\textit{We}} = 1000$, Froude number ${\textit{Fr}} = 1$ and a fixed gap ratio $G = 0.5$. This parameter combination corresponds to the gas entrainment regime characterised by the production of multiscale gas bubbles through interface breakup in the wake, which is of particular interest for its implications in enhancing gas transfer and mixing in environmental and engineering flows, such as air–water gas exchange processes in rivers and oceans, and the design and performance of naval and offshore structures. For ${\textit{Re}}= 400$, the jet forced through the $0.5D$ gap where $D$ is the diameter of the cylinder, efficiently convects opposite-signed vorticity downstream, suppressing the classical von Kármán instability and yielding a quasisteady recirculation bubble. The jet’s stabilising influence, however, breaks down once ${\textit{Re}} \approx 500$: periodic vortex shedding re-emerges and the wake becomes unsteady in spite of the continuing jet. The corresponding dimensionless shedding frequency Strouhal number $St$ grows with ${\textit{Re}}$ as $0.52-72.7{\textit{Re}}^{-1}$. The onset of unsteadiness first shortens the mean separation length but then drives it towards a saturation plateau for higher ${\textit{Re}}$ values. Surface rupture in the turbulent wake fragments entrained air into a multiscale bubble population whose number density follows $S_b(R_{\textit{eff}}) \propto R_{\textit{eff}}^{-6}$, consistent with gravity–capillary breakup in breaking waves, where $R_{\textit{eff}}$ represents the effective radii of the bubbles. Intermittency in entrainment corresponding to vortex shedding contrasts sharply with the finger-like structures observed under laminar conditions, underscoring the role of turbulent mixing. The coupled analysis of vorticity transport, shear-layer instability and bubble statistics elucidates how momentum exchange and air entrainment over a submerged body are governed under non-turbulent and turbulent conditions.
We assessed inpatient antibiotic use over six fiscal years at Tanzania’s national cardiac referral hospital. Overall use was 29.9 defined daily doses per 100 bed-days. Carbapenems were dominant. Reserve agents comprised 47.0%, and watch agents comprised 31.7%. Patterns indicate missed access targets and a need to strengthen stewardship in cardiac care.
Maternal affect contributes to children’s psychosocial adjustment. How maternal daily affect intensity and dynamics (i.e., inertia and variability) are associated with adolescents’ psychopathological symptoms, however, remains unclear. This preregistered study examined (1) associations of maternal day-to-day positive and negative affect intensity, inertia, and variability with psychopathological symptoms in adolescence and young adulthood, and (2) how mother–adolescent affect congruency moderates these associations. Mother–adolescent dyads (N = 488) reported positive and negative affect in 75 daily assessments across ages 13 – 17 years. Adolescents rated their psychopathological symptoms at ages 14 – 18, 20, and 27 years. Maternal affect intensity was associated with adolescent psychopathological symptoms, while maternal affect dynamics were inconsistently associated with symptoms in young adulthood. Mother–adolescent affect congruency only moderated the effects of positive affect intensity and variability, in that high-congruent adolescents reported lower internalizing symptoms at age 20 than low-congruent adolescents. No other interaction effects were found. While maternal affect intensity and dynamics seem to contribute to youth psychopathology, evidence for the role of mother–adolescent affect congruency remained limited.
Contemporary deterrence scholarship remains disproportionately focused on military instruments, often neglecting the strategic utility of diplomacy, information, and economic statecraft. Our study addresses this imbalance through a new methodology for analysing how authoritarian states respond to the range of foreign policy tools: diplomatic, information, military, and economic (the DIME framework). Using a state’s propaganda, official statements, and media (POSM) to capture target states’ reactions to adversarial DIME actions, we offer an innovative analytical framework that enhances understanding of deterrence dynamics beyond the military sphere. Within the framework, we use computational text analysis, statistical analysis, and data visualisation to create a replicable process for analysing POSM big data. Applying this methodology to a case study of China, we find that Beijing’s POSM-based responses to information tools – such as public criticism of censorship and information control by NGOs – are more negative than to diplomatic, military, or economic tools. Our methodology contributes to deterrence theory and policy through its insight into non-military effects and by offering a scalable process for empirical analysis ripe for AI implementation. For policymakers, our process and findings hold implications for crafting more effective and sustainable deterrence strategies in an increasingly complex international security environment.
Future water demand modeling is of crucial importance for stakeholders, particularly in the era of rapidly changing climate and socioeconomic conditions. The modeling results can be applied to develop effective adaptation strategies that ensure equitable and sustainable allocation of water to various economic sectors, including institutional, commercial, industrial (ICI), residential and agricultural. However, a comprehensive review of existing future water demand modeling methods that consider both climatic and socioeconomic factors as well as the major economic sectors is currently lacking. This review article contributes to fill this knowledge gap while introducing a more streamlined and comprehensive methodological approach for conducting literature reviews in the environmental sciences domain. At the core of this method is a new framework designed to support research questions formulation and literature search strategies named STAR (Systems, Trouble/Treatment, Alternative, Response). In addition, it presents a data-requirement-based metric as well as a new nomenclature for classification of surveyed methods and approaches to guide the selection process of future water demand modeling methods. Furthermore, it proposes a hybrid modeling approach made up of three components (computational intelligence, dynamic systems and probabilistic scenarios) in the form of a theoretical workflow for future water demand modeling. The proposed workflow ensures broad applicability, making it adaptable not only to water demand management but also to a wide range of challenges across the environmental sciences.
In two fields that are currently of high political salience and strategic significance – the regulation of digital platforms, and the regulation of environmental and human rights impacts in global value chains – the EU has taken a strikingly similar regulatory approach. In the 2022 Digital Services Act and the 2024 Corporate Sustainability Due Diligence Directive, it has charged large companies with managing risks to various public values and concerns. In this contribution, we critique this shared regulatory approach. First, we argue that regulating dominant corporations via risk management obligations actually reinforces their power in three ways: it is inherently deferential to corporate power and profitability; it reinforces technocratic framings of policy problems which discourage political contestation of economic governance; and it allows corporations to evade responsibility by framing negative impacts of their activities as external problems against which they protect the public. Second, these problem framings shape the implementation as well as the content of regulations. Specifically, they direct compliance and enforcement efforts to procedure over substance; and create significant practical barriers to public and private enforcement. We conclude by discussing the implications of our analysis in the context of the EU’s current deregulatory agenda.
In recent years, evidence for extraterrestrial life has focused mainly on the following sections, meteorites, space probes, radio telescopes, and extraterrestrial intelligence and civilization. Biochemical studies on meteorites have tried to trace fossilized microorganisms or organic molecules in living structures. Images and atmospheric information obtained from various planets by space probes have been used to uncover the habitability of other celestial bodies in the solar system. Observations of radio telescopes that receive the waves emitted by cosmic objects and display them on their screens have pave the way to estimate the habitability of heavenly bodies. As the last one, claims related to extraterrestrial intelligence and civilization have been repeatedly reported in different periods of history. All of this evidence points to the possibility of extraterrestrial life, but how close we are to confirming or disproving this hypothesis is still debatable. However, recent advancements in artificial intelligence, particularly in machine learning, have significantly enhanced the ability to analyze complex astrobiological data. This technology optimizes the processing of meteoritic data, differentiates astronomical signals, and reinterprets historical evidence, opening new frontiers in the search for extraterrestrial life. In this review, we have attempted to present the above-mentioned evidence in detail to provide a suitable understanding of the level of our extraterrestrial knowledge.
Statistical structure and the underlying energy budget of wall-shear-stress fluctuations are studied in both Poiseuille and Couette flows with emphasis on its streamwise component. Using a dimensional analysis and direct numerical simulation data, it is shown that the spectra of streamwise wall dissipation for $\lambda \lesssim 1000 \delta _\nu$ are asymptotically invariant with the Reynolds number (${\textit{Re}}$), whereas those for $\lambda \gtrsim \delta$ decay with ${\textit{Re}}$ (here, $\lambda$ is a nominal wall-parallel wavelength, and $\delta _\nu$ and $\delta$ are the viscous inner and outer length scales, respectively). The wall dissipation increases with ${\textit{Re}}$ due to the increasing contribution of the spectra at $1000 \delta _\nu \lesssim \lambda \lesssim \delta$. The subsequent analysis of the energy budget shows that the near-wall motions associated with these wall-dissipation spectra are driven mainly by turbulent transport and are ‘inactive’ in the sense that they contain very little Reynolds shear stress (or turbulence production). As such, turbulent-transport spectra near the wall are also found to share the same ${\textit{Re}}$-scaling behaviour with wall dissipation, and this is observed in the spectra of both the wall-normal and inter-scale turbulent transports. The turbulent transport underpinning the increase of wall dissipation with ${\textit{Re}}$ is characterised by energy fluxes towards the wall, together with inverse energy transfer from small to large length scales along the wall-parallel directions.
The welfare of fast-growing broiler chickens (Gallus gallus domesticus) raised in intensive farming systems is of global concern for the public, animal advocates and animal welfare scientists. This study investigated the animal husbandry factors which affect broiler chicken welfare on farms in West Java, Indonesia. Foot-pad dermatitis (FPD) and hock burn (HB) were used as welfare indicators with data collected from 14 farms across West Java. Welfare Quality® data were collected from 150 chickens from six locations on each farm, a total of 2,104 chickens, alongside data on the husbandry management and micro-climate inside the chicken house. Cumulative Link Mixed Models (CLMM) were employed using the ordinal package in R to analyse environmental predictors of welfare indicators. Litter quality and breed of chicken were predictors of FPD, whereas litter quality, bodyweight, light intensity, humidity, wind and CO2 predicted HB. There was wide variation in the FPD scores between farms. Sampling locations at the door end of the chicken houses showed consistently worse litter scores, welfare outcomes, and higher variation in micro-climate compared to areas near the negative pressure fans. Chickens were usually sent for slaughter at 32 days, which resulted in better welfare outcomes compared to other countries reported in the literature, where chickens are usually slaughtered at an older age and heavier bodyweight. This research could form the basis for better welfare standards on broiler chicken farms in Indonesia.
We highlight the complete transition from liquid-wall-film instability of an annular gas–liquid flow inside a nozzle to spray formation at the trailing edge, aiming to identify two distinct flow regimes of ripple waves and disturbance waves and to clarify their distinct fragmentation mechanisms. Experiments conducted under strictly controlled boundary conditions support our theoretical analysis, revealing that the onset of disturbance waves coincides with the liquid-film Weber number (${\textit{We}}$) of unity, marking a significant change in following fragmentation dynamics. For ${\textit{We}}\lt 0.5$, the liquid wall film forms three-dimensional ripple waves driven by the superposition of Kelvin–Helmholtz and Rayleigh–Taylor (RT) instabilities, with no disturbance waves present. At the trailing edge, the liquid film temporarily accumulates, extends into isolated ligaments along the axial direction via RT instability, and subsequently fragments into droplets through Plateau–Rayleigh instability, displaying a weak coupling between ripple wave dynamics and fragmentation. In contrast, for ${\textit{We}}\gt 0.5$, disturbance waves with long wavelengths and large amplitudes become prominent, superimposed on the base ripple waves. As these disturbance waves reach the trailing edge, they are spontaneously ejected as liquid sheets at the same frequency, forming transverse rims through RT instability and rapidly disintegrating into fine droplets. This regime demonstrates a direct coupling between disturbance-wave dynamics and fragmentation.
This study investigated the dose difference (DD) in the surrounding dose area using the real-time motion tracking (RTMT) system in tomotherapy.
Method:
Seven stereotactic ablative body radiotherapy treatment plans with a single lesion were used for the investigations. Each treatment plan was evaluated for the Gamma passing rate (GPR) analysis in a static target motion using the ArcCHECK® phantom. Subsequently, each plan was matched with 8 clinical respiratory cycles to simulate moving target motion. The DD was calculated through point-to-point comparison and expressed as the frequency of the DD levels. The DD frequency was analysed for significant correlations with the target travelling distance, target size and respiratory frequency.
Result:
The GPR for criteria of 3%/2mm and 3%/3mm revealed values of 97·8 ± 1·9% and 99·5 ± 0·6%, respectively, for static motion. The highest frequency of DD was in the 5 – 10% range. A significant correlation was found between the target travelling distance and the frequency of percent DD at the 2·0 – 3·0% and 10·0 – 15·0% levels, as well as between target size and the frequency of percent DD at the 0·0 – 4·0% and 10·0 – 25·0% levels. Finally, no significant correlation was found between the frequency of percent DD and respiratory frequency.
Conclusion:
RTMT introduced the DD in the surrounding treatment area. The DD was found to be up to 15·0% at 119·5 mm (water-equivalent distance) from the phantom centre. The DD was varied depending on the target travelling distance and size, but it did not depend on the respiratory frequency.
Our ability to measure evolution by natural selection in the fossil record is limited by the near impossibility of estimating the fecundity and thus relative fitness of most fossil organisms. Neocheilostome bryozoans are an important exception, because they have calcified larval brood chambers known as ovicells that provide an approximate estimate of the colony’s sexual fecundity. This clade has a rich fossil record dating back ~100 million years, providing potential opportunities to observe changes in relative fitness and natural selection through many past intervals of environmental change. However, neocheilostome fossil specimens are often highly fragmented, and fragments are not necessarily randomized subsets of a colony. To make use of the majority of the neocheilostome fossil record, we need to test the effect colony organization has on our methods of inferring colony fecundity from fragmented specimens.
In this study, we measure colony fecundity in a population of Recent neocheilostome bryozoan specimens of the species Parasmittina eccentrica Winston & Jackson, 2021 and quantify the nonrandom spatial arrangement of ovicells due to colony organization. We then simulate fragmenting these specimens and test the statistical robustness of standard methods one might use to reconstruct fecundity from fossil specimens. We find that ovicells are clustered and concentrated at mid-distances from the ancestrula (the oldest part of the colony). As a result, estimates of a colony’s fecundity from a single fragment have higher variance than would be expected if ovicells were randomly distributed. When estimating average population fecundity, observed variance among fossil fragments is a better estimator of sample variance than methods that assume spatial independence (such as a binomial distribution), especially for fragment sizes of 8 mm or less. While there is much to be learned about neocheilostome ovicell arrangement across taxa and environments, we can robustly estimate fecundity from small fossil fragments even in extinct neocheilostome species.
The concept of heteronomy, as developed by Kant, has long remained underutilized in constitutional theory. The present article takes as its point of departure Kant’s transcendental formulation of the balance between autonomy and heteronomy as a crucial element in the safeguarding of individual freedom and the integrity of the constitutional order. Kant developed his argument in two stages. In the transcendental, ahistorical stage, he constructs autonomy as a form of self-binding to certain universal maxims, which renders his constitutional theory a duty-based one, in which moral autonomy amounts to self-heteronomy. At this juncture, Kant maintains his principled objection to constitutional heteronomy as reflected in his argument about majority-decision, his rationale for a system of separation of powers that ensures legislative supremacy, and his anti-paternalistic account of law. In the pragmatic, historical stage, Kant’s arguments appear to have been shaped by his engagement with the political developments of the late 18th century. The adoption of an anthropological mode of thought led his constitutional theory to evolve towards a form of coercive heteronomy. A number of paternalistic attitudes can then be identified, including Kant’s endorsement of monarchy as a superior route to republicanism, his argument for constrained republican representation without universal right to vote, and his opposition to the right to resist oppression. While this article aims to provide an internal critique of Kant’s theory of constitutional heteronomy, it also underscores the timeliness of his contribution to the field, as it sheds early light on one of the formative dilemmas that continues to plague liberal constitutionalism today.
This work presents a comprehensive analysis of steady cone-jet electrospray (SCJ-ES) that captures the full range of its steady jet scales within the Taylor-cone electric field. We identify three fundamental regions, each governed by distinct scaling laws and dominant physical mechanisms: (i) the transition region, characterised by the balances that fix the emitted current; (ii) the charge convection-dominated region, where surface charge transport dominates total charge transport and the Taylor field drives jet acceleration; and (iii) the ballistic region, where the jet attains a fixed cylindrical scale before undergoing Rayleigh breakup into charged droplets. This refined theoretical framework harmonises existing models, particularly those using the Taylor–Melcher leaky dielectric model as an electrokinetic approximation for SCJ-ES. Notably, our newly proposed spatial scales achieve a remarkable collapse of published experimental SCJ-ES jet profiles. We also apply this framework to study the charge of resulting droplets using extensive literature data, observing significant differences between weak and strong electrolytes, consistent with recent findings.
Late-season escapes of Palmer amaranth and waterhemp (both are Amaranthus species) pose a significant challenge in cotton production due to their high fecundity, herbicide resistance, and ability to replenish the weed seedbank at harvest. While harvest weed seed control (HWSC) has been adopted in grain systems, its feasibility in cotton remains unknown due to differences in cotton harvesting equipment design. Therefore, this study aimed to determine the fate of Amaranthus spp. seeds during harvest with cotton pickers and stripper harvesters, and evaluated the efficacy of an impact mill to destroy a range of weed seeds present in different types of cotton debris. Along with the seed cotton, cotton strippers removed 52% of the Amaranthus seeds, compared with just 7% with pickers, which are then cleaned at the cotton gin. About 85% of the seeds were retained on the plant after harvest by the pickers, and about 15% by the strippers. Seeds shattered to the ground accounted for 8% with pickers and 18% with strippers. Additionally, the cotton stripper’s field cleaner mechanism removed 15% of the weed seeds. Together, seeds collected in seed cotton, retained on the plant, or separated by field cleaners (in strippers) represent points for HWSC implementation. Different types of cotton debris were then run through a stationary weed-seed impact mill with a known number of seeds for seven weed species to determine seed destruction efficacy. The stem debris had a 29% moisture content, which is too high for the impact mill and caused mill clogging; however, seed kill levels of 98% were achieved in bur debris and gin debris types, values similar to those reported in grain systems. Together, these findings provide a framework for incorporating HWSC practices into cotton, offering growers and processors a way to reduce weed seedbank inputs.