The extracellular matrices, such as the haemolymph, in insects are at the centre of most physiological processes and are protected from oxidative stress by the extracellular antioxidant enzymes. In this study, we identified two secreted superoxide dismutase genes (PxSOD3 and PxSOD5) and investigated the oxidative stress induced by chlorpyrifos (CPF) in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae). PxSOD3 and PxSOD5 contain the signal peptides at the N-terminus. Structure analysis revealed that PxSOD3 and PxSOD5 contain the conserved CuZn-SOD domain, which is mainly composed of β-sheets and has conserved copper and zinc binding sites. Both PxSOD3 and PxSOD5 are predicted to be soluble proteins located in the extracellular space. After exposure to different concentrations of sublethal CPF, MDA content in P. xanthodes larvae were increased in a dose-dependent manner; SOD and CAT activities were also higher in CPF-treated groups than that in the no CPF control, indicating that sublethal CPF induces oxidative stress in P. xanthodes larvae. Furthermore, PxSOD3 and PxSOD5 expression levels and haemolymph SOD activity in the larvae were downregulated by sublethal CPF at different concentrations. Our results suggest that the PxSOD3 and PxSOD5 are putative extracellular antioxidant enzymes that may play a role in maintaining the oxidative balance in the extracellular space. Sublethal CPF may induce oxidative stress in the extracellular space of P. xanthodes by reducing the gene expression and catalytic activity of extracellular SODs.

Western pundits have warned about the risks posed by Chinese companies for exporting surveillance technologies to Africa (Bartlett 2023) due to not only risks in the technology but also the exportation of authoritarian development. Scholars who perceive Chinese technology companies as state instruments that facilitate the state’s agenda to expand authoritarian digital development in Africa support this view (Cheney 2019; Gravett 2020; Khalil 2020; Mozur, Kessel, and Chan 2019). This view is contested by empirical findings arguing that Chinese companies primarily engage in digital capitalism, providing products that meet certain African states’ digital control and heterogenous development needs (Bagwandeen 2019; Gagliardone 2019).

This article analyses the use of adversarial questions in oral hearings conducted by the Parole Board of England and Wales. This is important because the Board is supposed to use an inquisitorial approach to oral hearings, so adversarial questions are examples of where Parole Board members deviate from this norm. The article outlines the work of the Parole Board, the process for carrying out oral hearings and the recent move to increased remote hearings following the Covid-19 pandemic. Using conversation analysis, the research casts light on the relationship between mode of hearing (remote vs. in-person) and adversarial questions and how discourses of blame and responsibility operate in the production of these challenging question types. A chi-square test reveals that adversarial questions are statistically significantly more common in remote hearings, although they remain low in frequency. The article concludes with thoughts on why remote hearings are more conducive to adversarial questions. (Accounts, adversarial questioning, conversation analysis, parole, responsibility)*

The transition in welfare states from compensatory to service-oriented models also implies a shift of the locus of action from the state to local administrations. Cities in particular seek space within national bounds to devise their own policy solutions targeted to city-specific needs as a more responsive government layer, with the prospect of providing more targeted service provision on the basis of locality and proximity principles. Whether such social innovation potential is met depends on scope conditions, such as the learning environment, the design of the decentralisation and the capacity of cities to scale up smaller projects. In this paper, we trace the policy process around local social investment innovations in Amsterdam across three domains: addressing teacher shortages, combatting energy poverty and integrating the long-term unemployed into the labour market. In each of the domains, Amsterdam emerged as a frontrunner and innovator, instigating broader change. The city is at the frontier of societal change and acts as ‘a stopgap’, filling gaps left by national policy default. Overall, the case of Amsterdam shows the importance in adopting a multi-level perspective in studying new dynamics in welfare state transitions.