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This study provides quantitative evidence on UK public attitudes towards stateless people, comparing them with attitudes towards refugees and asylum seekers. A cross-sectional UK survey (n = 385) was conducted. Network analysis modelled associations between social policy attitudes and prejudice towards stateless people, refugees, and asylum seekers, alongside other variables, including political orientation and perceived threat. Social policy attitudes were more restrictive towards stateless people than refugees, but less restrictive than towards asylum seekers. Prejudice towards stateless people was not significantly different to that towards refugees or asylum seekers. Prejudice and social policy attitudes were highly interrelated between all three groups, with political orientation and perceived threat the strongest predictors. Findings demonstrate similarities in UK public attitudes towards stateless people, refugees, and asylum seekers. Awareness-raising interventions and interventions addressing political and threat-based narratives may be most effective in reducing discrimination and fostering inclusion of stateless people.
This article contains editions of three new copperplate charters of the kings of Valkhā who, in the late fourth and early fifth centuries ce, ruled a territory situated to the north of the Vākāṭaka kingdom along the Narmadā river. Ramesh and Tewari, the editors of the famous Bagh hoard of plates discovered in 1982, furnished a straightforward chronology of five successive Valkhā rulers on the basis of 32 plates known to them. However, one of the plates edited here flatly contradicts the sequence they proposed. It turns out that the dating of several previously known Valkhā charters is also controversial. It has been suggested by other scholars that there were, in fact, two kings of Valkhā by the name of Rudradāsa as well as two by the name of Bhuluṇḍa. A reinvestigation of old data combined with the newly edited plates confirms the former and shows a high likelihood of the latter.
Due to the extractive nature of quarrying activities, quarry workers are relatively invisible within the archaeological record. Through a focus on quarry implements, we argue that scholars can identify the individuals involved in the quarrying process as well as evaluate the economic and political networks tied to the extraction of limestone resources. In the Maya region, studies of quarrying tools are evaluated based on contextual and use-wear studies; however, quarrying tools are frequently recovered from mixed assemblages. To increase the identification of quarry workers within the archaeological record, we advance a limestone-quarrier tool kit, which emerges from previous archaeological, experimental, and ethnoarchaeological research. We evaluate this toolkit using a case study from Xultun, Guatemala to consider the multiple sociopolitical identities held by Classic period Maya quarry workers.
The study presents a novel approach to address challenges posed by singularities in robotic arm motion, focusing on Cartesian path planning and geometric path adherence. Recognizing limitations in traditional singularity avoidance methods, the research proposes a comprehensive strategy: reconstructing motion patterns in singular regions through singularity-consistent representations, applying arc-length reparameterization to Cartesian geometric paths, and incorporating path curvature as a dynamic weighting factor for sampling interval adjustment. This method achieves a balance between joint velocity smoothness and geometric tracking accuracy in Cartesian space, significantly enhancing the robot’s ability to adhere to prescribed geometric paths, particularly near singularities. Experimental results demonstrate the efficacy of the proposed approach in facilitating smooth singularity transitions, improving joint velocity continuity, and enhancing geometric path adherence. The study contributes to robotic arm path planning by offering a practical solution for applications requiring precise trajectory following and effective singularity handling.
A ParasiteBlitz event offers a brief, intense opportunity to discover diverse parasite species and to reveal life cycles of heteroxenous parasite taxa. In this study, we describe Monomyxum ligophori n. sp., a hyperparasitic myxozoan (Monomyxidae) proliferating in two dactylogyrid monopisthocotylan flatworms (Ligophorus saladensis, Ligophorus mugilinus) infecting mugilid fishes (Mugil cephalus, Mugil curema) on the Atlantic coast of North America. Furthermore, we used DNA barcoding to infer the parasite’s complex life cycle, matching its hyperparasitic myxospore stages with actinospore stages infecting the polychaete Streblospio benedicti found in the same locality during the ParasiteBlitz and also reported previously from the same region. Thus we report the first life cycle of a myxozoan that most likely does not require a vertebrate host. Hyperparasitic myxozoans are rare with only five species reported worldwide to infect flatworms. This study provides more information on the previously discussed host specificity towards monopisthocotylan hosts of these monomyxid myxozoan hyperparasites. Notably, Monomyxum ligophori n. sp. was detected in two out of four gill-infecting parasitic flatworms (being absent in Ligophorus uruguayensis and Metamicrocotyla macracantha) found infecting the same fish individuals during the ParasiteBlitz. Our molecular data and phylogenetic analysis support the previously suggested common origin of Monomyxum species infecting monopisthocotylan flatworms, and contribute to understanding the life cycle and host interactions of this unique hyperparasitic myxozoan lineage.
There is an increasing number of patients with cancer and acute ischemic stroke (AIS). We aim to compare outcomes in patients treated with thrombolysis for AIS with a history of cancer to those without.
Methods:
This is a post hoc analysis of the Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT) trial, evaluating tenecteplase versus alteplase in patients with AIS within 4.5 h of onset. ICD-10 codes via administrative data linkage were used to identify a history of cancer. Primary outcome was modified Rankin Scale (mRS) 0–2 at 90 days. Other outcomes included mRS 0–1 at 90 days, return to pre-stroke function, mortality and bleeding. Analysis was done using logistic regression for binary outcomes adjusted for age, stroke severity, presence of cancer history and time from onset to needle. A generalized linear regression model was used for numeric outcomes, with effect measures reported as adjusted risk ratios (aRR).
Results:
Of the 1577 patients enrolled, 37 (2.35%) had a prior diagnosis of cancer. At 90 days, cancer patients were less likely to achieve 90-day mRS 0–2 (aOR of 0.33 [95% CI 0.15–0.75]) and had higher mortality (aOR 3.75 [95% CI 1.76–7.75]) as compared to those without cancer. Length of stay was longer in patients with cancer than those without cancer (median 11.5 days [IQR 7–24.5] vs 5 days [IQR 3–11], respectively, aRR 2.76 [95% CI 2.58–2.94]).
Conclusion:
Patients with AIS and a history of cancer had worse functional outcomes, prolonged length of stay and higher rates of mortality as compared to those with no diagnosis of cancer.
In this retrospective case series, we present two patients with primary lateral sclerosis (PLS) and spasticity-related gait impairment. Both patients were assessed with 6-min walk tests (6MWT) and timed up and go (TUG) at baseline and after 4 weeks of oral levetiracetam. Following levetiracetam therapy, Patient 1 improved 27.3% (148.5 to 189 m) on 6MWT and 26.1% (23–17 s) on TUG. Patient 2 improved 18% (90 m in 4:29 min to 112 m in 6 min) on 6MWT and 10% (46–41 s) on TUG. Larger prospective trials of levetiracetam for spasticity and gait may be considered in PLS.
The burden of cancer worldwide is rising, with 20 million new cases diagnosed in 2022. In Europe, 1.2 million women are diagnosed with cancer annually and an estimated 600,000 women die from cancer each year. International research and data from Ireland demonstrate that women with cancer face a particular set of challenges, including increased psychological distress compared to men. As a result, Ireland’s Model of Care for Psycho-Oncology could usefully place greater emphasis on gender-specific provisions which address the increased psychological needs of women. To date, Ireland has made some progress in recognising the physical and mental healthcare needs of women and developing gender-informed policies. It is essential that such policies are implemented fully so as to reduce and eliminate disparities in care. A more tailored, gender-informed approach would also help ensure the provision of gender-aware psycho-oncological care for all women and men as they navigate their cancer journeys.
To address the possible occurrence of a finite-time singularity during the oblique reconnection of two vortex rings, (Moffatt and Kimura 2019, J. Fluid Mech., vol. 870, R1) developed a simplified model based on the Biot–Savart law and claimed that the vorticity amplification $\omega _{{max}}/\omega _0$ becomes very large for vortex Reynolds number $Re_{\varGamma } \geqslant 4000$. However, with direct numerical simulations (DNS), Yao and Hussain (2020a, J. Fluid Mech.vol. 888, pp. R2) were able to show that the vorticity amplification is in fact much smaller and increases slowly with $Re_{\varGamma }$. This suppression of vorticity was linked to two key factors – deformation of the vortex core during approach, and formation of hairpin-like bridge structures. In this work, a recently developed numerical technique called log-lattice (Campolina & Mailybaev, 2021, Nonlinearity, vol. 34, 4684), where interacting Fourier modes are logarithmically sampled, is applied to the same oblique vortex ring interaction problem. It is shown that the log-lattice vortex reconnection displays core compression and formation of bridge structures, similar to the actual reconnection seen with DNS. Furthermore, the sparsity of the Fourier modes allows us to probe very large $Re_{\varGamma } = 10^8$ until which the peak of the maximum norm of vorticity, while increasing with $Re_{\varGamma }$, remains finite, and a blow-up is observed only for the inviscid case.
This article investigates the organization of a transnational criminal enterprise through a detailed case study of Operation Singapore, a network producing and trafficking falsified pharmaceuticals from China to the United Kingdom. Drawing on law enforcement records, court transcripts, digital communications, and expert interviews, the study maps the structure and strategies of this criminal enterprise. It applies Peter Reuter’s theory of criminal organization, and Niles Breuer and Federico Varese’s typology of network forms to show how functional roles shape organizational structure: production was hierarchical and security-driven, while distribution was decentralized and transactional. Trust was not based on kinship or ethnicity but constructed through moral appeals and restricted information flows. The case reveals how criminal actors exploit legal frameworks and commercial infrastructures to mask illegal activity and blur boundaries between legal and illegal markets. These findings challenge static models of organized crime and call for a more dynamic, relational understanding of criminal enterprise.
In a propensity-matched cohort of adult cardiac or neurosurgical procedures (n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (−0.6%, 95% CI−2.3 to 1.1; p = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation.