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Children associated with armed forces or armed groups (‘child soldiers’) experience conflict in highly differentiated ways, including in their exposure to gender-based violence. Cognisant of that reality, this article seeks to enrich current understandings of gender-based violence against female child soldiers by focussing on one relatively under-examined type: reproductive violence against female child soldiers. It revisits relevant cases from three jurisdictions which have most engaged with female child soldiers: the International Criminal Court, Special Court for Sierra Leone, and Colombian national courts. In each jurisdiction, the author closely examined publicly available court records, in order to detect references to (mostly uncharged) acts of reproductive violence against girls in armed groups. Forms of reproductive violence against child soldiers identified through this method include forcible impregnation and/or forced pregnancy, forced maternity, forced contraception and forced abortion, being forced to bear children before being sufficiently developed themselves, and the denial of reproductive health care. The article then explores how such reproductive violence might be charged as war crimes and crimes against humanity in future cases. This lens on child soldiers is especially timely, given the recent ‘reproductive violence’ turn in the field of international criminal law.
Predictions of the pedestal temperature profile calculated using a model for electron-temperature-gradient (ETG) turbulent electron heat transport Field et al. (2023 Philos. Trans. R. Soc. A, vol. 381, p. 20210228) are compared with the pedestal structure of H-mode plasmas in JET-Be/W (with Be wall and W divertor) over scans of the deuterium–tritium (D:T) isotope mix and hydrogenic gas fuelling rate Frassinetti et al. (2023 Nucl. Fusion, vol. 63, p. 112009). Predictions for the electron temperature at the location of the density pedestal top $T_e(\psi _N^{n_{e,top}})$ (where $\psi_N$, is the normalised poloidal flux) are found to agree well with measured values over both scans across the full range of D:T ratio. However, the pedestal top temperature $T_{e,ped}$, typically located somewhat inside the density pedestal top, is under-predicted by as much as a factor ${\sim} 2$. This implies that the ETG heat flux scaling appropriate for the steep-density gradient region, on which the model is based, is not applicable where the density gradient is weak. This difference might be attributed to a difference between the physics of the ETG turbulence in regimes where the density gradient is either strong or weak, which are thought to be dominated by either the ‘slab’ or ‘toroidal’ branches of ETG turbulence. Other branches of turbulence might also play a role in the electron heat transport, particularly in regions of weak-density gradient. As in the experiment, the predicted $T_e$ across the pedestal decreases with the ratio of separatrix to pedestal density $n_{e,sep}/n_{e,ped}$, which increases with the gas fuelling rate. Results from three models combining the ETG heat flux model with the EPED1 pedestal (EPED) model (Snyder et al., Phys. Plasmas, 2009, vol. 16, p. 056118) are also presented, including one which also incorporates the density pedestal prediction mode of Saarelma et al. (Nucl. Fusion, 2023, vol. 63, p. 052002), this model providing a complete prediction of the pedestal profiles.
Psychedelics such as psilocybin are known for their hallucinogenic properties and have also been reported to produce long-lasting therapeutic effects in depression and possibly also other psychiatric disorders. Several lines of evidence suggest that psilocybin exerts its effects through activation of 5-HT2A receptors located postsynaptically to serotonergic neurons, e.g., in the frontal cortex, parts of the limbic system, including the amygdala and hippocampus, and striatum. The present study was conducted to shed further light on psilocybin-induced changes in gene expression.
Method:
Samples from the medial prefrontal cortex, cingulate cortex, hippocampus, amygdala, and striatum were collected from 24 male Wistar rats 90 minutes after they had been injected with either saline or psilocybin (2 mg/kg) and subjected to multi-region transcriptional profiling using 3prime-RNASeq technology.
Results:
Nfkbia and Sgk1 were upregulated in all the studied regions, Ddit4 was upregulated in four regions, and Gpd1, Apold1, Sox9, Tsc22d3, and Slc2a1 were differentially expressed in two regions. Other cases of differentially expressed genes were region-specific.
Conclusion:
Whereas psilocybin was not found to alter the expression of genes encoding enzymes, transporters, or receptors implicated in the serotonergic signaling, or those specifically involved in the regulation of the synaptic activity of other neurotransmitters, a common denominator for many of the genes impacted by psilocybin is that they have previously been found to be activated by glucocorticoids.
Human genetic data are simultaneously deeply personal, familial, and strategically valuable, raising regulatory challenges that individual-centered privacy frameworks only partially address. This is highlighted by the recent high-profile bankruptcy filing by 23andMe, which triggered widespread public concerns extending beyond consumer privacy interests to potential national security risks. To address this, this paper proposes a three-layer diagnostic model for more comprehensive analysis of genetic data governance: (1) individual privacy as sensitive personal data; (2) relational and group (privacy) interests reflecting genetic data’s shared nature; and (3) the state or strategic layer treating genetic information as a national asset relevant to public health and security. Drawing on comparative examination of select jurisdictions and critical review of scholarship, this integrated framework offers researchers, policymakers, and private actors a practicable pathway to navigate the complex governance challenges posed by genetic data.
This article describes the nineteenth-century landscape of surface water distribution in cities of the U.S. West, focusing on its persistence after the advent of modern water mains, based on studies of San Antonio, Texas; Los Angeles, California; Salt Lake City, Utah; and Phoenix, Arizona. These systems of ditches, acequias, zanjas, and canals began as the primary urban water supply, then later comprised a secondary system complementing the mains. Ditch networks shrank in the twentieth century, but this ostensibly obsolete waterscape survived for decades and in many places to the present. Ditches persisted because they continued to serve the purposes of their users, because sanitary reforms abated their former pollution, and because new categories of utility emerged in amenity, heritage, and ecosystem services. The study takes the perspective of users as well as providers and finds, in contrast to conventional stories of hydraulic modernity, a continuing example of “water plurality.”
The Phonomaton, a public web-facing facility, computes phonological derivations based on a user’s underlying representations and rules. The tool allows a formal implementation of phonological analyses using familiar methods and lets students interactively explore the mechanics of feature systems and serial derivations. We demonstrate a number of the program’s features and end with a discussion of its implementation in the classroom.
With the rise of digital and online technologies, subtitling practices once reserved for traditional media to regiment language are now available to ordinary netizens. This article explores the nature of these practices and the publics they project in digital media, focusing on a viral remix video that uses on-screen text to ridicule a Hong Kong government official for his Cantonese-accented Mandarin. Through parodic revoicing, the subtitles in the video mock the official’s linguistic blunders and create a series of incongruities to provoke humor intended for Cantonese-speaking Hongkongers. These subtitles, despite reproducing standard language ideology, bring into being a vernacular counterpublic organized around Cantonese and undermine the legitimacy of the public figures in the video. This article not only prompts us to reconsider the commonly assumed link between standard languages and national publics but also reveals subtitling practices in participatory media as potential sites where ideological reproduction and political resistance intersect. (Subtitling, counterpublic, Mandarin Chinese, Hong Kong, China)
Before the planters arrived, the Mississippi River Delta was a swampy jungle. In his 1941 memoir Lanterns on the Levee, William Alexander Percy, a prominent member of the regional plantation elite, described what the Delta might have looked like in those early days, with an emphasis on the area’s fluid nature. “A still country it must have been then, ankle-deep in water, mostly in shadow, with mere flickers of sunshine, and they motey and yellow and thick like syrup.”1 But in the early nineteenth century, news had started to spread about the fertility of the Delta soil. The younger sons of plantation families in the eastern states, looking for new land to plant staple crops, began to move west, turning the Deep South of the United States into the vertex of the cotton frontier. In Mississippi they settled near the river, which provided transportation, information, and recreation, in the form of leisure trips to New Orleans. “The real highway was the river,” Percy wrote in his personal history of the Mississippi Delta. The steamer Pargo regularly arrived on Sunday mornings in the Delta town of Greenville. Most people would be in church then, but when the Pargo’s whistle blew, the men immediately stood up from the pews and made for the riverfront, to hear the latest news and gossips.2 Knowledge was an important cargo aboard riverboats like the Pargo.3
Early-onset sepsis (EOS) is a significant cause of neonatal morbidity and mortality. Due to fear of missing cases, many newborns are unnecessarily exposed to antibiotics. We implemented the neonatal EOS calculator to reduce over-utilization of antibiotics and decrease costs.
Design:
Quality improvement study.
Setting:
Neonatal Intensive Care Unit (NICU).
Patients:
Infants born at ≥34 weeks’ gestation were divided between two periods: the pre-EOS calculator time frame and the post-EOS calculator time frame.
Intervention:
We changed our EOS evaluation for inborn infants by implementing the EOS-calculator and decreasing “rule-out sepsis” time frame from 48 to 36 hours for infants started on antibiotics.
Results:
1,306 infants, with similar demographics, were included: 814 in pre-EOS calculator time frame and 492 in post-EOS calculator time frame. Following our interventions, the percentage of NICU admissions ≥34 weeks’ gestation started on antibiotics decreased from 62% to 51% (P < .01). In the chorioamnionitis subgroup, antibiotic starts decreased by 50% (P < .01). There was a reduction in days of therapy per 1,000 NICU (168 vs 110, P < .01) and total (93 vs 57, P < .01) patient days. Fewer patients had blood cultures drawn (84% vs 67%, P < .01) with a decrease in infants treated for culture-negative sepsis (7% vs 3%, P < .01). NICU and hospital length of stay reduced by 1 day (P < .01), equivalent to a savings of $916,000 to $1.84 million per 1,000 NICU patients in costs and savings of $5.82 million to $12.5 million per 1,000 NICU patients in charges.
Conclusions:
Antibiotic usage significantly decreased, with substantial savings after implementation of the EOS calculator, without significant negative effects.
This article examines three key cases decided by the CERD Committee to show how the semantic conundrum of the International Convention on the Elimination of All Forms of Racial Discrimination (ICERD) becomes an obstacle in extending protection against racial discrimination to various racialized groups. It is argued that the wording of Article 1 of ICERD creates a tripartite classification of semantics, in which meaning generated through different protected grounds obscures the conception of racial discrimination. This places constraints on the Committee’s ability to decide in favour of racialized non-citizens. The article proceeds to examine the jurisprudence of direct, indirect, and positive discrimination in the context of Article 1. It contends that while the semantic conundrum of ICERD confines racial discrimination to limited grounds, using the forms of discrimination can yield positive results. This is shown by re-examining the three cases, this time using the lens of forms of discrimination. It is argued that this approach can enable the Committee to transcend the semantic conundrum of ICERD and arrive at more nuanced conclusions.
Cardiac complications significantly contribute to mortality in Duchenne muscular dystrophy patients. Early detection of cardiac involvement is crucial for optimising therapeutic interventions. This study aimed to evaluate the role of N-terminal pro-brain natriuretic peptide in detecting cardiac involvement, as assessed by real-time three-dimensional (four-dimensional) and three-dimensional speckle-tracking echocardiography in patients with Duchenne muscular dystrophy.
Material and methods:
This cross-sectional study enrolled individuals under 21 years. Participants underwent clinical evaluation, real-time three-dimensional echocardiography, three-dimensional speckle-tracking echocardiography, and simultaneous measurement of serum N-terminal pro-brain natriuretic peptide levels. Correlation analysis between echocardiographic parameters and N-terminal pro-brain natriuretic peptide was performed.
Results:
The study comprised 38 Duchenne muscular dystrophy patients with a mean age of 9.40 ± 4.13 years. Moderate significant correlations were observed between N-terminal pro-brain natriuretic peptide and echocardiographic parameters, including basal anterolateral and inferolateral longitudinal strain, apical septal longitudinal strain, and basal anterolateral and inferolateral radial strain (p < 0.05). Subgroup analysis based on N-terminal pro-brain natriuretic peptide (<125 pg/ml vs. ≥125 pg/ml) revealed impaired basal anterolateral longitudinal strain in patients with high N-terminal pro-brain natriuretic peptide.
Conclusion:
This is the first study that includes N-terminal pro-brain natriuretic peptide in conjunction with real-time three-dimensional echocardiography and three-dimensional speckle-tracking echocardiography for assessing cardiac involvement in Duchenne muscular dystrophy patients. The observed correlations between N-terminal pro-brain natriuretic peptide levels and regional contraction parameters hold promise for its relevance as a biomarker for cardiac dysfunction. Prospective studies with a larger population with a broader range of disease severity are necessary in patients with Duchenne muscular dystrophy.
This article examines the trajectory of two Native American songs transcribed by French Jesuits in the seventeenth century, their subsequent inclusion in printed books in the eighteenth and nineteenth centuries, and their use by historians and entertainers in the twentieth century. The study focuses on how these songs, initially part of Native American oral and aural tradition, were transformed into primary-source evidence for historical research and racialized entertainment. This is an intellectual and cultural history that uses history-of-the-book and bibliographical methodologies to understand the discipline of history’s formation in the academy. The article argues that converting these songs into written musical notation inherently altered their meaning and context. It highlights how transcribing music by ear involves subjective interpretation and the loss of crucial performative elements. Furthermore, reproducing these songs in printed form further distanced them from their original cultural context, making them susceptible to misinterpretation and appropriation. The fact that these changes occurred as history was founded as a discipline is crucial to understanding the argument. The study employs a multidisciplinary approach, drawing on historical documents, musical scores, and popular-culture materials. It examines the role of women scholars, such as Emma Helen Blair and Edna Kenton, in making these sources accessible to a broader audience through their work on primary-source anthologies. However, it also points out the unintended consequences of this accessibility, as the songs were increasingly decontextualized and used to perpetuate romanticized and inaccurate portrayals of Native American culture. The work of Blair and Kenton is central to the formation of history as a discipline in the academy, especially as they worked with and for men like Reuben Gold Thwaites and Frederick Jackson Turner. The research concludes that the transformation of these songs into historical sources and entertainment props reflects the complex relationship between scholarship, popular culture, and the representation of Native American culture in the twentieth century. It raises critical questions about authenticity, ownership, and access to Indigenous cultural expressions. Finally, this study emphasizes the importance of considering notated music as a historical primary source, acknowledging its limitations and potential for misinterpretation.
A clinical case is presented to discuss a framework for use of advanced diagnostics for central nervous system infections. Advantages, limitations, and diagnostic stewardship strategies are discussed for each modality: multiplex molecular meningitis/encephalitis panel, plasma microbial cell-free DNA sequencing, and cerebrospinal fluid metagenomic next generation sequencing.
A ten-year retrospective review of 176 pneumococcal bloodstream infections found broad-spectrum antimicrobial use despite high penicillin susceptibility. Complications occurred in 15%, and ICU admission in 10%. Only 22% had pneumococcal vaccination recommended at discharge. Findings reveal missed opportunities for Antimicrobial Stewardship and preventative care in invasive pneumococcal disease management.
There are various types of nominal appositives. One is predicative, as in She invited Lulu Moppet, an old friend, to the party; one is specificational, as in She invited an old friend, Lulu Moppet, to the party; and a further type is equative, as in She invited Reginald Kenneth Dwight, Elton John, to the party. This paper argues that each type of nominal appositive comes from a reduced copular clause of a certain kind. Such a copular clause is base-generated as the complement of a categoryless functional head, like a low conjunct or a modifier. The combination of the reduced copular clause and the functional head is merged with, and categorized by, the matrix clause. Thus, a nominal appositive is not base-generated in the same proposition-denoting expression where its anchor occurs. Explicit steps of derivation for building a nominal appositive construction are proposed. The proposed syntactic derivations rule out unacceptable positions of nominal appositives. The research explores the general syntax of non-argument-taking relations.
In 1927, the city of Santa Barbara, California, began construction of a rubble mound breakwater to create a protected yacht harbor. The initial breakwater was an L-shaped structure that left a gap between the short “arm” of the breakwater and the shore, and engineers believed this configuration would allow sand to continue its normal movement along the coast.1 The engineers who designed the structure acknowledged that, “The design of a harbor on a sandy coast is one of the most difficult problems of engineering.” They anticipated some shoaling of the harbor and erosion of the beach to the east, particularly during storms.2 Their report framed the breakwater as an experiment in which trial-and-error would lead to an ideal harbor for the city, but they downplayed both risks and costs involved, including projecting that “the annual cost for maintenance will be negligible.”3 This optimism would prove badly misguided, as sand almost immediately began to fill the new harbor.
The establishment of rapid response teams (RRTs) has gained increasing prominence due to the growing threats of emerging infectious diseases, natural disasters, and other public health emergencies. As a center for Hajj and a regional hub for commerce and travel, the Kingdom of Saudi Arabia (KSA) faces distinct challenges. This study explores the Ministry of Health’s main reasons and challenges in establishing RRTs.
Methods
We employed a cross-sectional qualitative design, utilizing in-depth interviews with key stakeholders and document analysis to explore the historical process of establishing RRTs in KSA and the challenges encountered.
Results
Specialists’ insights revealed that the concept of RRTs was formally introduced and applied following the initiation of the Field Epidemiology Training Program (FETP) in KSA in 1989. However, its primary implementation began after the Middle East respiratory syndrome (MERS) outbreak in 2014. Identified challenges included a lack of trained personnel and resource availability due to unclear governance. There is a need for real-time data collection and technological solutions, improved inter-agency collaboration and information sharing, and governance.
Conclusions
The establishment of RRTs in KSA is estimated to have started with the initiation of the FETP. The challenges encountered provide valuable lessons for future emergency responses.
Inflammation has been implicated in psychosis, but its role in individuals at clinical (CHR) and genetic (GHR) high-risk remains unclear. We therefore conducted a network meta-analysis (NMA) to compare circulating cytokine levels across CHR, GHR, and healthy control (HC) groups.
Methods
We systematically searched multiple databases up to February 2025, extracting cytokine levels (plasma/serum) from CHR, GHR, and HC groups. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were estimated using random-effects models. Given that no direct head-to-head comparisons between CHR and GHR were available, indirect comparisons were performed through the common comparator (HC). The transitivity assumption was assessed by comparing key study and participant characteristics across comparisons.
Results
Thirty studies were included (CHR: 1601, GHR: 675, HC: 1980). NMA estimates indicated higher IL-6 levels in CHR compared with GHR, while IL-6 and IL-1β levels were lower in GHR compared with HC. In pairwise subgroup analyses, CHR converters showed higher IL-13 levels than non-converters. The evidence network was sparse and star-shaped, with all CHR–GHR estimates relying exclusively on indirect comparisons.
Conclusions
This study represents the first NMA to synthesize cytokine alterations in individuals at high risk for psychosis using indirect evidence. Elevated IL-6 in CHR individuals suggests immune activation, whereas reduced IL-6 in GHR may reflect a distinct immune profile. Increased IL-13 levels in converters highlight potential involvement of Th2-related pathways during transition to psychosis. However, the sparse nature of the evidence network necessitates cautious interpretation of the findings, and larger, standardized multi-center studies are required for confirmation.
Early-onset frontotemporal dementia (EO-FTD) presents before age 65 and is frequently misdiagnosed as psychiatric or behavioural disorders, delaying care.
Objective
This scoping review synthesizes research on EO-FTD’s earliest cognitive symptoms from patients, companions (family and friends), healthcare professionals, and cognitive tests to promote early detection.
Methods
A systematic search of six databases (Medline, Embase, CINAHL, PsycInfo, Scopus, and Proquest Dissertations and Theses) identified 2197 studies of which 16 met inclusion criteria, encompassing 663 EO-FTD participants.
Findings
A total of 35 unique cognitive symptoms were identified. Memory, attention, and executive dysfunction were most frequently reported. Symptom terminology varied widely, often mirroring cognitive test phrasing, limiting clinical applicability. Many studies relied on cognitive test scores rather than detailed symptom descriptions, with patient and companion reports underrepresented.
Discussion
The findings underscore the need for standardized nomenclature, improved assessment tools, and greater inclusion of patient and companion perspectives to enhance EO-FTD early diagnosis and intervention strategies.