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The entry into force of the amendments to the International Health Regulations 2005 (IHR 2005), on September 19, 2025, represents a pivotal moment in global health emergency governance history.1 The COVID-19 crisis revealed the inability of both developed and developing nations to protect their populations from the pandemic. Developing nations experienced disproportionate impacts due to insufficient financial resources and manufacturing capacity to obtain necessary health products for pandemic response.2 The neoliberal emphasis on economic efficiency and enforced trade liberalization through the World Trade Organization (WTO) framework, particularly mandatory product patent protection under the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) widened inequities in access to vaccines, therapeutics and diagnostics (VTDs), and increased dependency of developing countries on developed countries for this access.3
Explore the relationship between the severity of psychological distress symptoms and COVID-19-related bereavement, along with various sociodemographic factors and smoking/substance use behaviors during the COVID-19 pandemic.
Methods
This study used 962 Missouri residents’ (age: mean 44.8, SD 16.7, range 18-86 years; 67% [641] female) responses in the context of COVID-19 during 2022. Severity of psychological distress was measured using combined responses from PHQ-8 and GAD-7 scales and classified as moderate to severe using a cutoff score of ≥15 in PHQ-8 or ≥10 in GAD-7 scale. Predictors were bereavement (yes/no), current smoking (yes/no), and any substance use and polysubstance use (≥2). Logistic regressions adjusted for age, highest educational level, and employment status.
Results
Approximately 19% experienced loss due to COVID-19; 28% exhibited moderate to severe symptoms of psychological distress. Individuals who experienced COVID-19-related deaths were more likely to suffer from moderate to severe psychological distress symptoms (Adjusted Odds Ratios (AOR): 1.46; 95% CI:1.00, 2.12). Smoking (AOR:1.68; 95% CI: 1.20, 2.36) and polysubstance use (AOR: 2.44; 95% CI: 1.64, 3.65) also exhibited higher odds.
Conclusions
COVID-19 bereavement and smoking/substance use were linked to higher distress. Future research and strategies should integrate bereavement supports with substance-use screening/brief intervention in disaster mental-health services.
In recent years, the controversy between legal positivists and their opponents has been reframed as a debate on whether ‘legal facts’—aka facts about the ‘content of the law’—are determined by social or moral facts. This new framing ought to be resisted, for two reasons. First, it is biased against legal positivism, by making it the default picture that the ‘content of the law’ is not a set of legal norms atomistically individuated—which is essential to positivism—but a set of ‘facts’ (“the fact that Jones legally ought to pay $35 to Smith”) which can then be grounded holistically in moral facts. Second, talk of ‘legal facts’ has been instrumental in the recent metaphysical turn in jurisprudence, especially in the growing literature on grounding and law. Jurisprudes—of all stripes—should resist it, as it impoverishes and obfuscates many important philosophical questions about law.
The incorporation of algorithmic systems into organizations is reconfiguring decision-making processes and raising new ethical challenges related to transparency, impartiality, and accountability. This study maps the field of algorithmic ethics in organizational contexts through a co-citation–based bibliometric analysis of 1,437 Web of Science publications (search conducted on August 20, 2025). The analysis identifies 12 thematic clusters and reveals a robust intellectual structure, with high modularity (Q = 0.726) and a high weighted mean silhouette value (S = 0.894). The findings highlight the centrality of algorithmic management, responsible artificial intelligence, and explainability, as well as bridging works that connect technical, normative, and management-oriented perspectives. The study advances an integrative conceptual model and a future research agenda that point to the emergence of algorithmic ethics as an institutional logic of organizational governance. For managers, the results underscore the need to embed algorithmic ethics within organizational decision-making and control systems.
This is the first multimodal analysis of a real—not mock or hypothetical—jury deliberation and consists of two parts. The first part investigates the interactive contours of laughter and how it integrates with co-speech gesture to provide an authoritative stance to the juror’s narrative. The second part examines the multimodal interplay among poetics, gesture, and stance in pursuit of justice during deliberation. Rather than consider justice as an abstract or theoretical concept I demonstrate how it circulates in and through embodied conduct.
Intrinsically disordered proteins (IDPs) and disordered regions of folded proteins (IDRs) perform a plethora of cellular functions involving interactions with a variety of proteins, DNA, and RNA. Their flexibility enables them to interact with different cellular components. They can adopt molten globule as well as extended statistical coil structures depending on their amino acid residue sequence. They are generally more enriched in polar and charged residues, which generally facilitate solvation. This review article asks to what extent water as a solvent affects local (on a residue level) and global properties (size, Flory exponents) of IDPs. It introduces various aspects of protein hydration in the folded state as a benchmark and reference. The results of experimental and computational studies on short model peptides reveal how local structural propensities of residues are determined by water–backbone and water–side chain interactions. Ramachandran plots of individual amino acid residues are side-chain and neighbor-dependent. For unfolded oligo-peptides and IDPs (IDRs) the article discusses the intricated relationship between IDP hydration and global parameters (i.e., radius of gyration), which involves multiple parameters such as net charge, charge distribution, hydrophobicity, and the ionic strength of the aqueous solution. A review of experimental work that explored the strength of water–protein interactions and their influence on water dynamics reveals significant differences between water binding to folded and disordered proteins. Finally, The role of water in liquid–liquid mixing of short peptides and IDPs is delineated, which can lead to gelation and the formation of membrane-less droplets.
Some philosophers and legal theorists believe that certain fundamental normative phenomena cannot be adequately explained without appeal to second-order reasons—that is, reasons to act (or not to act) for certain reasons. Others are resistant to such an appeal. This resistance takes a robust form in the Credit Argument, which holds that, since we cannot act for a reason for a reason, the very idea of second-order reasons must be incoherent. In this paper, I do several things. Firstly, I clarify in just what sense the Credit Argument supposes it is not ‘possible’ to act for a reason for a reason. Secondly, I propose a novel typology of second-order reasons. Thirdly, using these insights, I demonstrate that the Credit Argument is weak at several points and should therefore be roundly rejected. This amounts to a partial defence of the appeal to second-order reasons in the explanation of fundamental normative phenomena.
Over the past 10 million years, coastal-marine settings along the Peruvian Margin have undergone profound geographic and oceanographic transformations, resulting in extensive changes in coastal-marine communities. While mollusk taxonomy research is slowly being integrated into ecosystem-wide analyses, which have historically centered on vertebrates, a long-term chronostratigraphically controlled analysis of molluscan diversity and compositional changes has not been undertaken for this region. We compiled a database covering 152 species, 97 genera, and 51 families of mollusk fossils from the Peruvian Margin (13–16°S) to assess long-term diversification patterns and faunal turnover from the late Miocene to the present. We identified two distinctive molluscan assemblages. The first, dating to the late Miocene (10–6 Ma), underwent a substantial shift during the Mio-Pliocene transition (6–4 Ma), culminating in a second assemblage more akin to modern counterparts. This shift resulted in an increase in diversity, with the younger assemblage (6–0 Ma) exhibiting greater genus richness than the former late Miocene assemblage. The turnover at 6–4 Ma was driven by peaks in bivalve origination (6–5 Ma) along with elevated extinction rates for gastropods (6–5 Ma) and bivalves (5–4 Ma). Ecological analyses revealed that no single ecological trait consistently changed during this interval, indicating that the turnover resulted from a broad reorganization of ecological strategies. We propose that the major molluscan turnover during the late Miocene–early Pliocene is associated with geomorphological changes related to the Andean uplift, the disappearance of semi-embayments, and a sea-level rise.
This article analyzes the parliamentary debates over three Canadian federal laws (2021-2024) on medical assistance in dying (MAID). It explores the factors that influenced Parliament’s decision to expand MAID eligibility to include mental illness in 2021 and to subsequently defer that eligibility on two occasions in 2023 and 2024. We argue that the expansion of MAID to include mental illness was partly driven by a looming judicial deadline and the government’s desire to avoid future Charter litigation, while the deferrals were driven by the perceived lack of readiness from key stakeholders, especially the provinces. This case study identifies broader dynamics of judicial-legislative interaction that can affect policy outcomes, including governments’ attempts at “future-oriented compliance” to pre-empt litigation rather than merely respond to it. It also demonstrates both how judicial deadlines can constrain legislative choice in unforeseen ways and how sunset clauses can foster policy uncertainty.
This article examines how the socio-indexical meanings of dialects/style are reconfigured through two-way parallel migration in Ningbo-Fenghua, China, focusing on the socio-indexical (re)valuation of Putonghua, Ningbonese, and Fenghuanese. Using two-phase matched-guise experiments and interviews, the study traces how mobility patterns and generational positioning mediate these meanings. Results show that, while Putonghua retains institutional prestige, it is often regarded affectively empty. In contrast, Fenghuanese and Ningbonese carry ambivalent, shifting values. Fenghua-born migrants reframe Fenghuanese as a resource for expressing intimacy, trust, and regionalism, while non-migrants view it as outdated. Ningbonese occupies a middle-ground, indexing familiarity, respectability, or obsolescence depending on context. Notably, younger speakers collapse dialectal distinctions, reframing both as ‘old speech’ tied to generation rather than place. These findings challenge Global North models that link indexical revaluation to elite cosmopolitanism, showing instead how meaning-making in the Global South can also emerge through administrative restructuring, regional absorption, and long-standing mobility patterns. (Indexicality, social meaning, Ningbo-Fenghua, migration and language, language attitudes).
The $q$-Weibull distribution, as a generalization of the Weibull distribution, plays an important role in the field of reliability theory, survival analysis, finance, engineering, medical science, etc. In contrast to the Weibull distribution, which is limited to describing monotonic hazard rate functions, the $q$-Weibull distribution offers the flexibility to model various behaviors of the hazard rate function, including unimodal, bathtub-shaped, monotonic (both increasing and decreasing), and constant. In this article, we investigated the stochastic comparison of extreme order statistics derived from independent, heterogeneous $q$-Weibull random variables using various stochastic orderings, including the usual stochastic order, hazard rate order, reversed hazard rate order, and likelihood ratio order. Some of these results are further extended to dependent setups by incorporating Archimedean copulas to model the dependence structure. Finally, we explored the behavior of extreme order statistics when the random variables are subjected to random shocks.
The nonlinear free-surface response of moonpools with recesses is investigated through both experimental and theoretical analyses. A theoretical model is developed to compute the natural frequencies using linearised potential flow theory and eigenfunction expansions. Four moonpool configurations with varying recess lengths are examined experimentally. The analysis reveals that larger recess lengths correspond to increasingly pronounced nonlinear responses. It is also shown that, for an incident wave group with suitable frequency content, the linear moonpool response can be significantly smaller than the second- and third-harmonic components. This effect is attributed to super-harmonic secondary resonance, characterised by $n \omega =\omega _{pq}$ ($n\geqslant 2$ and $p+q\geqslant 1$), where $n$ denotes the super-harmonic order, $\omega$ is the excitation frequency, and $p$ and $q$ are the longitudinal and transverse mode numbers, respectively. Here, $\omega_{pq}$ represents the sloshing frequency of the three-dimensional moonpool. Furthermore, it is found that, as the primary responses increase, cross-flow instability can lead to secondary resonance in non-symmetric modes. This occurs because the double and triple frequencies of the base mode approach the transverse or diagonal sloshing frequencies. Additionally, hard-spring Duffing effects for secondary resonance induced by super-harmonics are observed in cases with recesses, becoming more pronounced as the recess length increases, particularly when $h/l\lt 0.3368$, where $h$ is the water depth above the recess and $l$ is the moonpool length.
Let T be a bounded linear operator on a separable Banach space that satisfies geometric properties similar to those of $\ell ^p,\, p>1$. We prove that the smallest and the largest norm of weak cluster points of all maximizing sequences for T can only take the values $0$ or $1$. The three classes of bounded linear operators emerging from the dichotomy of these extremal norm values coincide with the partition, created by considering the norm-attaining property and if the essential norm equals the norm.
As the Canadian population ages, supporting older adults’ desire to age in their homes and communities is vital. Oasis is an older adult-driven program implemented within naturally occurring retirement communities (NORCs) that fosters social connections to support aging in place. While housing partners provide space for such programs, their perspectives are underexplored.
Objective
This study examined housing partners’ experiences (landlords, owners, superintendents) to understand benefits, barriers, and facilitators of implementing the Oasis in different NORC settings.
Methods
We interviewed 11 housing partners via Zoom and analysed data using thematic analysis.
Findings
Four themes emerged: (i) perceived benefits of Oasis program: building social connections and promoting health among older adults, (ii) transforming the building, (iii) Site Coordinator is the ‘secret sauce’, and (iv) starting up and sustaining Oasis: facilitators and challenges.
Discussion
Findings emphasize expanding NORC-based programs like Oasis and sustaining investment in healthy aging.
Contact precaution policies are used to prevent the spread of pathogenic organisms. We aimed to test whether AI-assisted cameras could monitor aspects of compliance with these policies. Testing in both simulated and real patient care settings yielded exceptional sensitivity and good specificity, indicating potential to monitor adherence to contact precautions.
The notion of faithful flatness of a module over a commutative ring is studied for two R-modules M arising in functional analysis, where R is a Banach algebra and M is a Hilbert space. The following results are shown:
If X is a locally compact Hausdorff topological space, and $\mu $ is a positive Radon measure on X, then $L^2(X,\mu )$ is a flat $L^\infty (X,\mu )$-module. Moreover:
• If $\mu $ is $\sigma $-finite, then for every finitely generated, nonzero, proper ideal $\mathfrak {n}$ of $L^\infty (X,\mu )$, there holds $\mathfrak {n}L^2(X,\mu )\subsetneq $$L^2(X,\mu )$.
• If X is the union of an increasing family of Borel sets $U_n$, $n\!\in \! {\mathbb {N}}$, such that for each $n\in {\mathbb {N}}$, $\overline {U_n}$ is compact and $\mu (U_{n+1}\setminus U_n)>0$, then $L^2(X,\mu )$ is not a faithfully flat $L^\infty (X,\mu )$-module.
In addition, it is shown that the classical Hardy space $H^2$ is a flat, but not a faithfully flat $H^\infty $-module, which answers a 2005 question of Alban Quadrat.
This article revisits the history of Muslim Turkish society, questioning its essentialist portrayal as a “religious society,” with religiosity narrowly defined through Sunni Islamic doctrines. It examines the content of Sunni folk Islam through the Mevlid, Karbala, and Ebâ Müslim books published by İstanbul Maarif Kitaphanesi until the 1980s, as well as their political appropriation by elite actors during the early Cold War period. I argue that Sunni and Alevi religiosity shared key elements beyond saint veneration, particularly praising the Prophet through Nur Muhammad, love of Ahl Al-Bayt, and mourning for Karbala. Using these books as religious media through a material approach to religion, I maintain that they made Muhammad and Ahl Al-Bayt “accessible,” “tangible,” and “sense-able” in the world in oral, pictorial, and scriptural forms. Since the publishers, editors, authors, readers, and listeners of these books were descendants of Turkish speakers dating back to the twelfth century, I propose the term “Islam in Turkish” as a conceptual framework to capture these shared elements. I argue that this concept, denoting a vernacular form of religiosity, has the potential to replace the modern category of Turkish folk Islam and contribute to global critical discussions on Islam.
Recent scholarship devotes considerable attention to how social identities influence vote choice. However, group sympathies or group affect constitute another, often overlooked subjective component of the relationship between social groups and vote choice. Based on reference group theory and drawing on ANES data as well as recent Danish and Austrian election surveys, we examine how voters’ sympathies with a range of groups are related to party choice across time and space. We find that group sympathies are related to vote choice in all three countries, even when controlling for objective group memberships and social identities. Across time, most relationships are stable or strengthening and comparable in strength to the relationship between group memberships and party choice. The relationship between group sympathies and vote choice is, furthermore, conditioned by perceived linkages between groups and parties. Hence, analyses of the role of social groups in voting also need to include group sympathies to grasp the full influence of social groups.
For Global South countries who faced vaccine inequity during the COVID-19 pandemic, the development of an equitable Pathogen Access and Benefit Sharing (PABS) system is considered to be “at the heart of the political bargain”1 of a pandemic agreement, and is critically important to prevent a repetition of vaccine inequity in future pandemics. These countries want to ensure that they have equitable access to pandemic products developed using genetic sequence data (GSD) or digital sequence information (DSI) from their geographies. A repeat of pandemic history, where GSD was uploaded from the Global South (such as from China, and from Botswana in the case of the Omicron variant), with Global South countries receiving a lower proportion of vaccine supply, would be abhorrent.