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The accuracy, robustness and affordability of localisation are fundamental to autonomous robotic inspection within aircraft maintenance, repair and overhaul (MRO) hangars. Hangars typically have high ceilings and are predominantly steel-framed structures with metal cladding. Because of this, they are regarded as GPS-denied environments, characterised by significant multipath effects and strict operational constraints, which together form a unique challenging setting. The lack of comparative techno-economic benchmarks for localisation technologies in such environments remains a critical gap. Addressing this, the paper presents the first techno-economic analysis that benchmarks motion capture (MoCap), ultra-wideband (UWB) and a ceiling-mounted camera (CMC) system across three operational scenarios: robot localisation, asset monitoring and surface defect detection within a single-bay hangar. A two-stage optimisation framework for camera selection and placement is introduced, which couples market-based camera-lens selection with an optimisation solver, producing camera layouts that minimise hardware while meeting accuracy and coverage targets. The consolidated blueprints provide quantification of the required equipment and its performance: 15 global-shutter GigE cameras are adequate for drone localisation, 9 cameras meet the requirements for on-bay monitoring and 49 high-resolution cameras facilitate defect mapping of the upper airframe surfaces for midsize defects. Across these scenarios, the study reports indicative performance and cost envelopes: a MoCap installation delivers submillimeter localisation at an estimated £190k per bay, UWB delivers centimetre-level tracking for around £49k and the proposed CMC system layouts achieve task-specific coverage with costs in the £9k–£77k range. The analysis equips MRO planners with an actionable method to balance accuracy, coverage and budget, demonstrating that an optimised CMC system can deliver robust and cost-effective sensing for next-generation smart hangars.
There is growing concern regarding the increasing prevalence of synthetic opioids and their association with mortality and a range of health and social harms. Recognition, assessment and management of synthetic opioid use is a key challenge for practitioners working in hospitals, prisons and community services. This article gives an overview of the range and characteristics of synthetic opioids, key risks, the prevalence of synthetic opioid-related deaths in England, and prevention and management approaches. It highlights five areas critical to addressing the synthetic opioid crisis: improved access to medication for synthetic opioid addiction; increased naloxone availability and referral to addictions services following opioid overdose; strengthening prevention efforts targeting risk factors such as illicit drug markets and emerging trends in drug use; optimising pain management to reduce the use of prescription opioids and minimise the risk of associated synthetic opioid addiction; raising awareness among healthcare providers, patients and the general public about the dangers of synthetic opioids, including their potency, addictive nature and potential for overdose.
This case report details the diagnosis and surgical management of a 7 cm aortic root aneurysm occurring in a 12-year-old with cutis laxa type B, an extremely rare connective tissue disorder. Our patient underwent a Bentall procedure as primary treatment for the aneurysm and had a successful interventional treatment of a postoperative pseudoaneurysm.
To evaluate physician engagement with an antimicrobial stewardship program (ASP) at a tertiary hospital and identify areas for improvement in the delivery of stewardship interventions.
Design:
Cross-sectional survey study.
Setting:
A 1200-bed tertiary care public hospital in Portugal.
Participants:
Physicians with antibiotic prescribing privileges in inpatient settings. All physicians with active institutional e-mail addresses were invited to participate.
Methods:
An anonymous web-based questionnaire was administered between June and December 2024. The survey addressed six domains: (1) antibiotic knowledge; (2) awareness and use of local prescribing protocols; (3) access to antimicrobial use and resistance reports; (4) awareness of antibiotic restriction policies; (5) use of informal consultations with the stewardship team; and (6) participation in scheduled multidisciplinary case discussions.
Results:
A total of 154 prescribing physicians responded (response rate: 10%), including specialists (75.3%) and residents (24.0%). Most respondents were aware of institutional protocols (78.6%), but 66.9% reported rarely or never consulting them, citing accessibility and reliance on personal knowledge as key barriers. Participation in case discussions was limited (25.3%) but viewed as highly useful. Awareness of restrictive antibiotic policies was low; however, 69.5% indicated that these policies influenced their prescribing behavior. Respondents expressed strong interest in regular feedback on antimicrobial use and resistance trends.
Conclusions:
Key areas for improvement in ASP implementation include enhancing access to protocols, expanding case-based discussions, clarifying communication around restrictions, and establishing regular feedback mechanisms. These findings may inform efforts to align ASP strategies with clinical realities in similar hospital settings.
Despite the high frequency and severity of fatigue among patients with advanced cancer receiving immunotherapy, there are limited treatment options available. The aim of the study was to explore the effects of the methylphenidate (MP) with standardized physical activity (PA) on cancer related fatigue (CRF).
Methods
In this pilot study, patients with advanced cancer with clinically significant CRF (<34 on Functional Assessment of Cancer Illness Therapy – fatigue scale, FACIT-F), on anti-PD1 immunotherapy were eligible. Patients were randomized to standardized PA with either patient-controlled MP 5 mg (MP + PA arm) or matching Placebo (Pl + PA arm) twice daily for 14 days. The primary outcome was the change in the FACIT-F score. Secondary outcomes included changes in fatigue dimensions (Multidimensional Fatigue Symptom Inventory-Short Form (MSFI-SF), Functional Assessment of Cancer Therapy – General (FACT-G), Patient-Reported Outcome Measurement Information System-Fatigue (PROMIS-F), and hospital anxiety and Depression Scale (HADS).
Results
Of the 40 randomized patients, 34 were evaluable. The FACIT-F scores significantly improved in both the arms with mean (SD) change, effect size (ES) of 11(14), 0.87(P < .001); and 9(12), 0.74(P = .04) in MP + PA, and Pl + PA arms respectively. We also found significant improvements in PROMIS-F, ES − 1.05(P = .003), MFSI-SF(global), ES − 1.32(P < .001), and HADS-depression, ES − 0.92(P = .004) in the MP + PA arm; There were no significant differences in adverse events between groups.
Significance of results
Our preliminary study found MP + PA was associated with significant improvement in CRF scores. The fatigue dimensions and depression scores significantly improved in the MP + PA arm. Further comparative studies using MP + PA for CRF are justified.
We show that a very general hypersurface of degree $d \geq 4$ and dimension $N \leq (d+1)2^{d-4}$ over a field of characteristic $\neq 2$ does not admit a decomposition of the diagonal; hence, it is neither stably nor retract rational, nor $\mathbb {A}^1$-connected. Similar results hold in characteristic $2$ under a slightly weaker degree bound. This improves earlier results in [44] and [33].
Although many online-based dietary surveys have been developed in recent years, systems that easily survey the dietary balance based on the Japanese diet are insufficient. This study aimed to evaluate the relationship between dietary balance scores from an online survey system based on the Japanese Food Guide Spinning Top, and nutrient/food intake calculated using the weighing method from dietary records (DRs), as well as to assess the system’s utility and applicability. An online dietary balance survey and semi-weighted DR assessment with food photographs were conducted in Japanese participants (n = 34). Registered dietitians entered the balance scores into the system based on the participants’ food photographs, and the scores were calculated using the system. Significant positive correlations (p < 0.001) were found between the online dietary balance scores and nutrient/food intake from DRs; especially for ‘grain dishes’ and carbohydrates (r = 0.704); ‘vegetable dishes’ and the vegetable dish group (sum of potatoes, vegetables, mushrooms, and algae) (r = 0.774); ‘main dishes’ and protein (r = 0.661); ‘milk’ and the milk and milk products group (r = 0.744); and ‘fruits’ and the fruits group (r = 0.748). Bland–Altman analysis showed that the dietary balance scores obtained by this system tended to underestimate the intake compared with the weighing method. Although there are limitations to the accurate estimation of nutrient and food intake, the online dietary balance scores obtained from the online dietary balance survey system were useful for understanding the dietary balance in the Japanese diet.
Herbicide resistance poses a significant challenge due to the increasing number of weeds resistant to multiple sites of action (SOAs). Recently, smooth pigweed populations resistant to glyphosate have been confirmed in the KwaZulu-Natal Province in the Republic of South Africa (RSA). This study evaluated herbicide products with different SOAs to provide alternative options for controlling glyphosate-resistant (GR) smooth pigweed populations. Dose-response assays for preemergence and postemergence herbicides were conducted under glasshouse conditions at the University of Pretoria, RSA. Seeds of GR smooth pigweed populations from Bergville and Winterton, and a glyphosate-susceptible (GS) population from Hendrina, were used. For the evaluation of preemergence herbicides (mesotrione, atrazine, imazethapyr, and acetochlor), seeds were sown in pots and herbicides were applied 12 hours after sowing. Postemergence herbicides (mesotrione, atrazine, tembotrione and atrazine tank mixture, and chlorimuron-ethyl) were tested on potted plants at the 6-leaf stage. Herbicides were applied at 0×, 0.5×, 1×, 2×, and 4×, where × is the recommended field rate for the herbicide products representing each SOA. Preemergence herbicides provided greater than 90% control across all populations. For postemergence herbicides, mesotrione effectively controlled all the GR populations, whereas the GS population from Hendrina exhibited reduced sensitivity (>50% survival). Atrazine was effective at rates higher than the recommended field rate in the GR populations. The tank mixture of tembotrione and atrazine had an additive effect compared to the sole application of mesotrione and atrazine. Chlorimuron-ethyl was only effective on the GS population. These results suggest that incorporating effective preemergence and postemergence herbicides into weed management programs could improve control of GR populations of smooth pigweed.
Strategies for optimising air-fuel interaction are critical in supersonic combustion. This research alters the fuel injector design by adjusting the strut corner base angle, allowing the fuel to contact the air transversely. This computational analysis uses the Reynolds-averaged Navier-Stokes (RANS) equations in conjunction with the Shear Stress Transport (SST) k-omega turbulence model and the eddy dissipation turbulence chemistry model. The validation has been conducted for the present simulation with the experimental data, comparing the pressure, temperature and Schlieren images. The standard DLR scramjet combustor model consists of a single strut (fuel injector) injecting parallel to the air stream, but in this research, the design of the strut base is changed to angles 30, 45 and 60 degrees to inject the fuel in a new method. This slanted strut base aids fuel injection into the airstream and permits the mixture to generate swirls behind the strut base, resulting in better mixing and 35% greater turbulence. This modification improves the reaction process’s spontaneity and generates 37% higher temperatures, increasing mixing and combustion efficiency by about 37% and 23%, respectively.
This study investigated the effect of group size on tail damage and growth performance in growing-finishing pigs with intact tails. A total of 432 pigs were housed indoors on fully-slatted floors and assigned to either small (nine pigs per pen) or large (18 pigs per pen) groups, with equal space and resource allocation per pig. No environmental enrichment was provided. From nine to 23 weeks of age, pigs were monitored weekly for tail injuries using a 5-point scale (0 = no injury, 4 = partial or total loss). The most severe score observed during each four-week period was used for analysis, and outbreaks were defined as the occurrence of one or more pigs per pen with a tail score ≥ 2. Group size did not influence average daily gain, feed intake, or feed to gain ratio. However, pigs housed in small groups experienced more frequent and severe tail injuries, including a higher proportion of removals due to tail wounds. In contrast, pigs in large groups were more likely to receive healed tail scores (score 1) or mild injuries (score 2), and experienced fewer removals. While these results suggest that tail damage may be less severe in larger groups, the total number of pigs affected by tail biting was similar across treatments. These findings highlight the importance of managing tail-damage severity and suggest that group size can influence welfare outcomes in systems where pigs are raised with intact tails.
Transition onset of high-speed boundary layers can move first downstream and then upstream with increasing nose-tip bluntness, which is called transition reversal. For the first time, our recent research reproduced the experimentally observed transition reversal by direct numerical simulation (DNS, Guo et al., J. Fluid Mech. vol. 1005, 2025, A5). As a continuation study, this work explores the effect of the form of free-stream disturbances, as the transition in the large-bluntness regime still remains poorly understood. The free-stream Mach number is 5 and the nose-tip radius 3 mm of the blunt plate exceeds the experimental reversal value. Three-dimensional broadband perturbation is carefully constructed through superimposition of planar fundamental waves in the free stream, which initiates the transition in DNS. For each Fourier component, the same perturbation strength is applied for slow/fast acoustic, vortical and entropic waves. All the cases present a ‘streak-turbulent spot’ two-stage transition scenario due to non-modal instabilities. The transition onset locations induced by entropic and slow/fast acoustic waves are close and significantly ahead of that by vortical waves. More evident impact of the disturbance form is manifested in the length of the transitional region, which is the shortest for entropic waves and the longest for vortical waves. Regarding the effect of the angle of incidence that mimics the tunnel environment, it alters the post-shock acoustic-wave structure and reduces the length of the transitional region. In the streaky stage, the form of free-stream disturbances changes the pronounced spanwise wavelengths on the blunt nose and the plate, where the two regions also differ from each other. In the turbulent-spot region, the shortest transitional region induced by the entropic wave is attributed to its largest mean spanwise spreading rate of the turbulent spot. From the perspective of energy budget, shear-induced dissipation dominates the heat transfer escalation in the transitional region. Overall, with significant leading-edge bluntness, the flight environment may tend to result in delayed transition onset compared with the tunnel counterpart.
What democratic institutions and practices do citizens prioritize, and how responsive are their preferences to competing concerns such as economic and physical security? We explore this through a conjoint experiment with over 35,000 respondents across thirty-two countries – spanning democracies and autocracies – who evaluate hypothetical countries varying in democratic features, cultural characteristics, economic prosperity, and physical security. Our findings reveal that citizens consistently prioritize free and fair elections, highlighting their salience as a core democratic value. However, executive constraints appear less central to citizens’ preferences, especially when set against the promise of economic prosperity. These patterns hold across a wide range of national and individual contexts. The results suggest that while elections remain symbolically and substantively important, many citizens are responsive to appeals that frame strong, unconstrained leadership as a pathway to economic prosperity – an emphasis often seen in electoral authoritarian regimes.
Dynamic, data-driven predictors of perioperative mortality risks in preterm/early-term neonates with CHD undergoing cardiac surgery in the first 24 months of life are limited.
Aims:
To identify risk factors of mortality in the first 24 months of life for pre/early-term neonates with CHD.
Methods:
Retrospective cohort study of patients <39 weeks of gestation undergoing cardiac surgery within 24 months of life from 2013–2020 at a tertiary care centre. Independent risk factors of mortality within 24 months of life were determined by multivariable Cox regression analysis.
Results:
Among the 205 neonates, 33 (16.1%) died within 24 months. Multivariable analysis revealed that high-frequency ventilation (hazard ratio = 5.15; 95% confidence interval): 2.51, 10.6; p < 0.001), extracorporeal membrane oxygenation support (hazard ratio = 5.77; 95% confidence interval: 2.67, 12.5; p < 0.001), and CHD with a palliated circulation (hazard ratio = 6.07; 95% confidence interval: 2.84, 13; p < 0.001) were significant independent risk factors of mortality at any time during the index hospitalisation or the first 24 months of life.
Conclusions:
Identifying and re-evaluating risk factors of mortality for preterm/early-term neonates with CHD at any time during the index hospitalisation or the first 24 months of life may guide resource allocation and therapeutic interventions.
Trial registration number and date of registration: IRB P00028833 5/2/2018. Retrospectively registered.
In the Sámi worldview, reindeer herders perceive the herd as a social unit consisting of individuals who vary in characteristics and social roles. Age, sex, physical appearance, personality and other social roles are acknowledged and recognized by the herders, who maintain their relationships with animals in different ways within herding tasks. Archaeological data, too, show that ancient reindeer herders were in contact with different kinds of reindeer, including wild reindeer, working reindeer and ‘ordinary’ herd reindeer. This paper uses zooarchaeological and ethnoarchaeological perspectives to examine the variety of life on the hoof at two fourteenth- to seventeenth-century Sámi sites in northern Finland. Archaeological data and zooarchaeological analyses will be used to assess hunting and herding practices as well as the characteristics of herd structure. Ultimately, the aim of this paper is to examine critically and characterize the variety of the relations prevailing between reindeer and ancient Sámi herders, thus contributing both to the study of culturally specific ontologies and the analytical possibilities of archaeological research to understand such ontologies.
Electrical effects are known to play an important role in particle-laden flows, yet a holistic view of how they modulate turbulence remains elusive due to the complexity of multifield coupling. Here, we present a total of 119 direct numerical simulations of particle-laden turbulent channel flow that reveal a striking ability of electrical effects to induce turbulence relaminarisation and markedly alter wall drag. As expected, the transition from turbulence to laminar flow is accompanied by abrupt changes in the statistical properties of both the fluid and particulate phases. Nevertheless, with increasing electrical effects, the wall-normal profiles of the mean streamwise fluid velocity and mean local particle mass loading exhibit opposite trends in the turbulent and laminar regimes, arising from the competition between turbophoresis and electrostatic drift. We identify three distinct flow regimes resulting from the electrical effects: a drag-reduced turbulent regime, a drag-reduced laminar regime, and a drag-enhanced laminar regime. It is revealed that relaminarization originates from the complete suppression of the streak breakdown in the near-wall self-sustaining cycle, followed by the sequential inhibition of other subprocesses in the cycle. In the turbulent regime, increasing electrical effects induce opposing trends in Reynolds and particle stress contributions to drag, yielding a non-monotonic drag response. In laminar regimes, by contrast, the drag coefficient increases monotonically as the Reynolds stress vanishes and particle-induced stress becomes dominant.
The present study examined developmental pathways beginning in pregnancy and extending into early childhood that contribute to child emotion regulation (ER). Leveraging data from a sample of 157 mixed-sex couples, who largely identified as White and non-Hispanic/Latino, and their typically developing children (50.3% female), we examined whether parental emotion-related socialization behaviors (ERSBs; i.e., general emotion talk, specific supportive and nonsupportive responses to children’s negative emotions) at preschool age (child age 3) mediated the link between parental trauma-related distress spanning pregnancy to toddler age (2-years postpartum) and child maladaptive ER at the transition to formal schooling (age 5). Chronic elevations in maternal trauma-related distress contributed directly and indirectly to child maladaptive ER at age 5, and maternal nonsupportive responses emerged as a potential pathway driving the intergenerational transmission of emotion dysregulation. In contrast, paternal trauma-related distress neither undermined ERSBs nor contributed to child maladaptive ER. Instead, chronic elevations in paternal trauma-related distress predicted more supportive responses to children’s negative emotions. Results highlight the utility of repeated screening for trauma-related distress and prevention and early intervention efforts targeting parental trauma-related distress and nonsupportive responses to children’s negative emotions. These strategies may help promote adaptive ER at school entry and reduce risk for later psychopathology.
This article offers new insights on Africa-China relations and discourses of authenticity and intellectual property by examining the trade and consumption of Chinese-made fashion goods in Mozambique from an ethics perspective. Ethnographic fieldwork in southern Mozambique between 2017 and 2024 shows that many traders and consumers see Chinese counterfeits as beneficial and desirable, enabling them to participate in fashion systems from which they have long been excluded. For traders and consumers in Mozambique, it is ethically right to supply and purchase functional, adequate-quality, and aesthetically pleasing counterfeits. These goods are evaluated less in terms of legality than through pragmatic, everyday judgments about quality, care, and access. The Mozambican case complicates dominant narratives of Chinese-African trade and global intellectual property governance, showing how ethics of access and quality shape everyday globalization.
We investigate the effect of inertial particles on Rayleigh-Bénard convection using weakly nonlinear stability analysis. An Euler–Euler/two-fluid formulation is used to describe the flow instabilities in particle-laden Rayleigh–Bénard convection. The weakly nonlinear results are presented near the critical point (bifurcation point) for water droplets in the dry air system. We show that supercritical bifurcation is the only type of bifurcation beyond the critical point in particle-laden Rayleigh–Bénard convection. Interaction of settling particles with the flow and the Reynolds stress or distortion terms emerges due to the nonlinear self-interaction of fundamental modes breaking down the top–bottom symmetry of the secondary flow structures. In addition to the distortion functions, the nonlinear interaction of fundamental modes generates higher harmonics, leading to the tendency of preferential concentration of uniformly distributed particles, which is completely absent in the linear stability analysis. Further, we show that in the presence of thermal energy coupling between the fluid and particles, the difference between the horizontally averaged heat flux at the hot and cold surfaces is equal to the net sensible heat flux advected by the particles. The difference between the heat fluxes at hot and cold surfaces increases with an increase in particle concentration.