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We undertook a qualitative descriptive study to explore participants’ perceptions of whether marital status shapes how functional social support (FSS) relates to memory.
Methods
Semi-structured interviews were conducted with 18 community-dwelling middle-aged and older people representing various marital status categories. Each interview was audio-recorded, transcribed verbatim, and thematically analyzed.
Findings
Participants did not perceive marital status to shape the FSS–memory relationship. Three themes emerged to explain this view: learning to cope – participants used alternatives besides a spouse to deal with memory challenges; context matters – factors such as marital satisfaction must be considered; and doing more harm than good – some spouses may provide excessive support, reducing participants’ autonomy to stimulate their own cognitive processes.
Discussion
These themes highlight that marital relationships are complex and that contextual factors such as marital quality and support adequacy should be considered to provide a comprehensive understanding of how social and marital dynamics shape cognitive trajectories in aging populations.
Use the electronic health record (EHR) to prospectively validate a risk prediction tool identifying patients at high-risk for carbapenem-resistant Enterobacterales (CRE).
Design:
Prospective, cross-sectional analysis.
Participants:
Adults admitted to two hospitals in Atlanta, Georgia.
Methods:
An EHR report calculated a CRE risk score on all admissions from 6/2024–3/2025. The risk score was determined from a prior model incorporating data from current and prior hospitalizations. Stool or perianal samples were cultured from a convenience sample of patients with the highest risk scores. A receiver operating curve analysis calculated sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV) of various risk scores that could be used as a “threshold” for CRE admission testing. Using the threshold with the greatest Youden’s index, we estimated the cost of implementing a CRE screening program.
Results:
Of the 853 patients approached, 342 (40%) consented. Eleven (3.2%) tested positive for CRE. Patients with CRE had a higher median CRE risk score (0.19% vs 0.04%) than those who tested negative. The AUC of the model was 0.66. Using a testing threshold of 0.16% yielded a 55% sensitivity, 84% specificity, 10% PPV, and 98% NPV. The number needed to screen to diagnose 1 patient with CRE was 12 patients, and the screening program approximately costs $8,015/month.
Conclusions:
An EHR-based risk prediction tool can detect patients likely to be colonized with CRE. In facilities with a low CRE prevalence, identifying a high-risk subset of patients to test could be a cost-effective infection prevention initiative.
American universities are increasingly threatened with cuts in government funding unless they eradicate diversity promoting programmes. To contextualize the targeting, this article reflects on two major organizational transformations in higher education in America: the rise and diffusion of university fundraising development offices and the emergence and growth of university diversity offices. The former was part of a long-term multiple stakeholder strategy that would make universities see themselves as less dependent on government. The latter reflected a more recent shift in the direction of valorizing diversity. Operating as organizational actors, universities launched both strategic initiatives. In retrospect universities underestimated their dependence on federal funding and overestimated public support for diversity promoting policies. American universities have both acquiesced and resisted the attacks on their institutional autonomy and the academic freedom of their professors. Calls for university leadership to save the university will ironically lead to more organization and greater management.
This article examines the role of Dutch merchants, entrepreneurs, and artisans in the circulation of technological knowledge, skills, and commercial expertise between the Low Countries and the Grand Duchy of Tuscany in the early seventeenth century. Focusing on projects promoted under Grand Duke Ferdinando I de’ Medici, it analyses attempts to introduce sugar refining, salt processing, and mill technologies into the port of Livorno. Rather than treating innovation as a simple transfer of techniques from one place to another, the article shows how technological circulation depended on the mobility of skilled actors, the mediation of commercial networks, and the support of political authorities. At the same time, it highlights the fragility of these processes: even under favourable legal and economic conditions, migrant ventures could fail or remain incomplete. By reconstructing the interactions between Dutch entrepreneurs, intermediaries, and Medici officials, the article argues that early modern technological innovation emerged from negotiation, adaptation, and the practical use of embodied expertise in a new environment. In this way, the Livorno case shows both the opportunities and the limits of migrant-driven innovation in the early modern Mediterranean and contributes to a broader understanding of how mobility shaped technological circulation on the ground.
We give new analogues of Andrews’ celebrated spt-function identity using basic hypergeometric transformations due to Verma and Jain [‘Transformations between basic hypergeometric series on different bases and identities of Rogers–Ramanujan type’, J. Math. Anal. Appl.76(1) (1980), 230–269].
Beginning in 1998 under the first Tri Council Policy Statement (TCPS 1), Canadian political science has been increasingly subject to standardized institutional ethics review for work involving human participants. Some contend that this ethics regime has overburdened the social sciences with clinically-oriented and legally risk-averse processes. In turn, this may create an ethics chill that pushes social scientists, particularly graduate students, away from human participant research. To date, however, there has been no empirical demonstration of this phenomenon within political science. Has Canadian institutional research ethics review under TCPS chilled human participant-driven research production in political science doctoral theses? This article tests the ethics chill hypothesis using an original dataset of English and French political science PhD dissertations across 11 Canadian universities from 1990 to 2019. Its results suggest no concrete evidence of an ethics chill under TCPS.
We aimed to examine advice interactions among family physicians using social network analysis (SNA) by categorizing advice interaction according to the five advice dimensions.
Background:
Inter-individual interactions for information exchange is a powerful tool for the pursuit of solutions to issues. These interactions may involve advice-seeking.
Methods:
The whole network approach was adopted and face-to-face research was conducted with 139 family physicians. Data were analysed using social network software, UCINET and visualized using the NETDRAW software. To examine the multidimensional advice networks, the frequency, density, reciprocity (dyad) measures were used. The Quadratic Assignment Procedure was used in UCINET to measure the correlations between the dimensions of advice. The Girvan–Newman algorithm was used to examine clustering in the advice network.
Findings:
Density values in the advice dimensions were very low. This indicates that the network was sparse, with limited interactions among family physicians in terms of giving and receiving advice. The strength of the ties in the dimensions was realized through validation, solutions, problem reformulation, meta-information, and legitimization, respectively. The results showed that the relationships between the dimensions were moderately, positively and significantly correlated. The advice network exhibited high modularity. Family physicians tended to seek advice from colleagues at the family health centers where they worked. We presented a visual representation of advice networks in primary healthcare settings. Identifying multidimensional advice networks through social network analysis can provide insight into how information is disseminated among family physicians. Our findings could contribute to decision makers in developing solution-oriented processes.
Prostate cancer (PCa) exhibits profound metabolic reprogramming, including dysregulation of the urea cycle (UC), an emerging driver of tumour growth, therapy resistance, and immune modulation. In normal physiology, the UC detoxifies ammonia via urea production. In PCa cells, however, altered expression of UC enzymes such as argininosuccinate synthase 1 (ASS1), arginase (ARG) and ornithine decarboxylase (ODC1) reroutes metabolites towards other pathways, including polyamine and nucleotide synthesis. These changes enhance proliferation, facilitate metabolic plasticity and influence the tumour microenvironment.
Methods
This review summarises mechanistic insights into UC dysregulation in PCa, with emphasis on its interplay with the tricarboxylic acid (TCA) cycle, choline metabolism, and polyamine synthesis.
Results
We critically evaluate current therapeutic strategies such as arginine deprivation (PEGylated arginine deiminase, ADI-PEG 20, PEGylated recombinant human arginase 1, PEG-BCT-100), ODC1 inhibition (α-difluoromethylornithine, DFMO), and glutaminase blockade (CB-839) and discuss their integration with other therapies, including androgen deprivation. Furthermore, we explore the challenges and the usefulness of UC metabolites as diagnostic and prognostic biomarkers for early detection of PCa as well as for a follow-up of patients during therapy.
Conclusions
We conclude that UC dysregulation represents a targetable metabolic vulnerability in PCa. However, successful translation will require combinatorial therapeutic approaches and rigorous validation of UC-based biomarkers in prospective clinical trials.
The aim of this study was to examine the relationship between e-healthy diet literacy and sustainable nutrition behaviours in pregnant women.
Design:
This study was a descriptive correlational study.
Setting:
Data were collected via self-report using a Personal Information Form, the e-Healthy Diet Literacy Questionnaire (e-HDLQ) and the Sustainable Nutrition Behavior Scale (SNBS).
Participants:
The study population consisted of all pregnant women living in Konya/Türkiye, and the sample included 290 pregnant women over the age of 18 years who voluntarily agreed to participate and were able to read and understand Turkish, the language of the questionnaire.
Results:
The total e-HDLQ score of the participants was 29·37 (sd 6·91) (min = 13, max = 46), and the total SNBS score was 109·18 (sd 17·07) (min = 37, max = 145). Weak but statistically significant associations were observed between the total e-HDLQ score and the SNBS sub-dimensions of food preference (r = 0·119) and food purchase (r = 0·117) (P < 0·05). Additionally, weak but statistically significant associations were identified between the e-HDLQ appraising sub-dimension and the total SNBS score (r = 0·125), its food preference sub-dimension (r = 0·134), and food waste reduction sub-dimension (r = 0·119) (P < 0·05). Multiple linear regression analyses showed that age, education level, history of having a low-birth-weight baby and food preference and food purchase sub-dimensions positively predicted e-HDLQ, whereas knowledge of nutrition and seasonal and local food consumption sub-dimension were negatively associated. For SNBS, the appraising sub-dimension positively predicted behaviour, while higher education level was negatively associated.
Conclusions:
The study shows that pregnant women’s e-healthy diet literacy is weakly but significantly associated with various aspects of sustainable nutrition behaviours.
We investigate the dynamical role of internal vibrational modes in the self-dual Abelian-Higgs model, focusing on how Derrick-type breathing excitations modify vortex dynamics and scattering processes. While unexcited BPS vortices follow geodesic motion leading to the well-known $90^\circ$ scattering, initially excited vortices experience vibration-induced forces arising from the spectral flow of internal modes as the inter-vortex distance changes. This mechanism intensifies the resonant energy transfer between translational and vibrational channels, producing non-adiabatic dynamics, superelastic collisions and fractal structures in scattering diagrams.
The aim of this study was to investigate the predictive validity of a proposed revision of the Nutri-Score and the current Nutri-Score by investigating associations between the diet quality scores measured in mid-pregnancy and the risk of dispensed prescription of medications for hypertension up to 11 years following delivery and blood pressure mid-pregnancy. The study population (n 70 730) were participants in the Norwegian Mother, Father and Child Cohort Study. Food intake was assessed in mid-pregnancy using a validated FFQ. Nutritional scores for each food item were calculated based on content of energy, sugars, saturated fat, salt, fibre, protein, fruit, vegetables and legumes. Diet quality scores were derived using energy-weighted means of nutritional scores. Anti-hypertensive medications were registered in the national prescription database. We estimated hazard ratios (HRs) with 95 % CIs using Cox regression models. During a mean follow-up of 6 years, 4736 (6·7 %) women were dispensed prescription for medications for hypertension. There was a non-linear association between diet quality and hypertension medication. Compared with the median diet quality score, poorer diet quality (90th percentile of the score) was associated with higher risk of medications for hypertension (HR = 1·08, 95 % CI 1·02, 1·14) and cross-sectional high diastolic blood pressure (OR = 1·18, 95 % CI 1·03, 1·32). Both diet quality scores yielded similar results overall. Poorer diet quality during pregnancy, assessed with a proposed version, and the current Nutri-Score, was associated with a higher risk of medications for hypertension, indicating its usefulness as a valuable tool for guiding consumers and improving public health.
Arising from the 2024 European Political Science (EPS) annual debate, this article examines the role of expertise in transnational governance (TNG) with a focus on political science. It explores how transnational governance reconfigures the spaces and contexts for expert engagements in global policy making and transnational administration. In these evolving spaces of jurisdiction, the democratic potential, accountability, and legitimacy of expert knowledge are not only shrouded from the Global Majority but cannot be assumed to be inevitable. The article outlines some meanings attached to TNG and suggests democratic considerations cannot be conceived or operationalised in the same ways as at nation-state levels of governance. First, TNG is a series of overlapping but fragmented transnational spheres of public sector activity as well as hybrid public-private jurisdictions where democratic principles are yet to be normalised and embedded. Second, the accountability and legitimacy of sources of expertise in the policy sectors of TNG can be counter-swayed by latent features of ‘epistocracy’, or expert rule, in transnational policy communities.
Dust storms are pervasive across much of the inland and arid regions of California. These extreme meteorological and air pollution events affect the state’s environment and economy, as well as the health of the nearly 5 million people living in dust-prone areas. Developing effective strategies to address the deleterious impacts of dust storms requires a clear understanding of their causes, spatial and temporal variability, and the efficacy of mitigation techniques. This review synthesizes the current state of knowledge on dust storms in California, including where they occur, the landscape and climatic factors governing their geographic distribution, drivers of historical and projected future changes, and their impacts on human health, the economy and natural systems. This work assesses existing approaches for mitigating and adapting to dust storms and identifies critical gaps in understanding that currently limit effective responses within the state. This review is intended as a resource for researchers, community-based organizations, state agencies and policymakers engaged in addressing dust impacts in California. While the focus is regional, the environmental processes, societal impacts and management challenges discussed here are broadly applicable to drylands, making this work relevant beyond California.
What does training look like such that one’s improvisation can be experienced as spontaneous? In this paper, I explore how the aesthetics of “freestyle” in street dance are constituted by empirically achieved bodily capacities contingent upon recognitions. Through examining the pedagogy of freestyle, I show how semiotic labor registers the apparent solipsism of freestyle in street dance into reflexive accounts of sensory-affective capacities selected for cultivation, scaffolded through the deployment of terms like “feeling” and “relation” within participation frameworks. I suggest that ethnographic approaches to the relationship between discursive and non-discursive dimensions of aesthetic-social practices, such as street dance, need to remain both affectively attuned to and semiotically informed, attending to how sensory-affective experiences are rendered discernible and enactable within intersubjective spaces. In addition to exploring these semiotic processes, I also gesture toward the evaluative dimensions of street dance through my fieldwork in a local community in the US and my participation in its transnational scene.
Acute liver failure is a rare disease characterized by acute presentation of liver injury in the absence of cirrhosis that poses significant morbidity and mortality. Neurological manifestations, including hepatic encephalopathy, cerebral edema and intracranial hypertension, are frequent. The incidence of intracranial hypertension in acute liver failure has declined, which is a likely reflection of the impact of early and adequate intervention, but it holds a poor prognosis. This review summarizes the key concepts relating to pathophysiology, diagnosis and management of intracranial hypertension in acute liver failure. Clinical and biochemical predictors aid in early recognition and use of prophylactic or targeted management. Validated invasive and noninvasive intracranial pressure monitoring are important in the management of intracranial hypertension. The use of invasive intracranial pressure monitoring in acute liver failure has been limited due to the expected risk of hemorrhage secondary to coagulopathy. The risk associated with invasive monitoring is better assessed with the use of viscoelastic testing when compared to conventional coagulation tests. Management of intracranial hypertension includes strategies that target the reduction of cerebral blood volume and cerebral volume.
Collective action involving natural resources can be politically consequential. But organisers confronting resource interests or even just operating in natural resource-dependent areas face substantial obstacles. This paper tests three arguments about why such activists can nonetheless sometimes succeed: that local party dynamics are important to dispute outcomes, that small-scale and persistent campaigns have the best results, and that peacefully disruptive tactics are especially impactful. We conduct our analysis using a new dataset comprised of 1,525 reports of actions and their immediate outcomes from the Appalachian state of West Virginia, one of the United States’ major coal producers and a longstanding site of coal-related social conflict. Our results regarding parties and movement participation and persistence are mixed. And, while we find a significant negative correlation between disruption and concessions, we observe very different patterns for labour versus environmental actions: disruption appears to work for the former but not the latter.
To celebrate the 10th anniversary of BJPsych Open, this Editorial highlights papers published in BJPsych Open over the past decade that have focused on university student mental health. Common mental disorders are increasing in young people and those going on to higher education make up an important and sizeable sector of this population. At the same time, success in university studies is a major determinant of individual and societal health and prosperity. As a field of inquiry, university student mental health research gained momentum through the COVID-19 pandemic and associated campus closures, pivot to remote learning and social restrictions. Although research describing student well-being and mental health burden align globally, not enough is known about determinants that inform sustainable and scalable prevention and early intervention. Furthermore, research evidence should inform university policies, practices and benchmarks to ensure responsive and effective student well-being and mental health support that underpins academic and life success.
Established pharmaceutical innovation theory holds that companies and patents are essential for developing new treatments. Yet, it does not adequately explain numerous clinical trials conducted by hospitals and universities. This paper introduces a new, complementary theory that describes a parallel system of innovation, focused on new uses of already authorised drugs, particularly once generics are available. These trials are driven by incentives previously associated with “open science” and “user innovation” rather than by patents and cost 90 per cent less than commercial equivalents. This “hidden” research system could regularly provide society with affordable treatments.