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Although bronze bells from the Zhou dynasty (c. 1046–256 bce) have been widely studied, their roles within their ontological contexts remain underexplored. This article integrates archaeological evidence, textual records and posthumanist theories to reconsider how the capacities of ancestors and bells were configured and how the personhood of living and deceased elites was embodied in the Zhou worlds. Focusing on the tomb (M190) of Lord Qiu of Zeng (r. c. 675–650/650–625 bce), the study examines how the Zhou ontologies instantiated in this specific case. Qiu’s inscribed bell set was originally commissioned to emulate ancestral de and invoke their numinous power against the competing Chu state. However, the haphazard deposition of the bells and the deliberate disintegration of their rack in his tomb suggest a subsequent derealization of their capacities following the rapprochement between Zeng and Chu. In this funerary context, Qiu’s personhood was re-embodied alongside the reconfiguration of the capacities of ancestors, bells and burial goods, demonstrating how the relationship between the living, deceased, ancestors and ritual media shifted in response to changing historical circumstances.
This article develops an innovative quantitative analysis of the drivers of state–NGO relations in the field of human rights, specifically focusing on their political drivers. Drawing on cross-national survey data from 2,000+ reported interactions between NGOs, national and EU governmental actors in 26 EU Member States, we examine how national governments’ political orientation, the level of politicisation of human rights issues, and multilevel governance dynamics shape the frequency and nature of state-NGO and EU-NGO interactions. Our multilevel regression models show that NGOs’ relations with conservative governments are less collaborative, though not less frequent, than with progressive ones. For highly politicised human rights issues, interactions between governmental actors and NGOs are less frequent and less collaborative. NGOs facing conservative governments report more frequent and more collaborative interactions with EU institutions, consistent with multilevel ‘venue-shopping’ strategies. These findings highlight the role of political context in shaping European human rights governance.
In July 1954, while making glacier mass-balance measurements in Northwest Greenland just below the boundary of the dry-snow facies, a team led by C.S. Benson documented a rain-on-snow event triggered by an atmospheric river. This produced extensive surface melt and notable ice layers, lenses and percolation columns in the snowpack that were tracked in subsequent years in snow pits dug nearby. Since 2000, numerous surface-melt events in the dry-snow facies have been documented by satellite observations. We compare and contrast the 1954 event with recent melt events to highlight challenges in monitoring melting in Greenland. Satellite sensors can accurately map melt extent across the ice sheet but cannot reliably quantify the melt intensity. Snow pit and ice core measurements can assess melt intensity but are too localized to capture melt extent. Reanalysis of the 1954 event adds an additional caveat: the extensive surface-melt event produced features only on two of the four sides of a large snow pit, evidence that the notable 1954 event could easily be missed in an ice core extracted years later. This suggests that analysis of historical melt events, using ice cores, probably underestimates both the spatial extent and temporal frequency of past melt events.
Structures in tokamak plasmas are elongated along the direction of the magnetic field and short in the directions perpendicular to the magnetic field. Many tokamak simulation codes take advantage of this by using a field-aligned coordinate system. However, field-aligned coordinate systems have a coordinate singularity at magnetic X-points where the poloidal magnetic field vanishes, which makes it difficult to use field-aligned coordinate systems when simulating the core and scrape-off layer simultaneously. Here, we present an algorithm for grid generation and computing geometric quantities in a standard field-aligned coordinate system that avoids the singularity and allows one to conduct two-dimensional gyrokinetic axisymmetric simulations in X-point geometries. Convergence tests of advection, boundary value problems and geometric quantities all show greater than first-order convergence even in the vicinity of the X-point. We also demonstrate the geometric consistency of our algorithm with an example simulation of the spherical tokamak for energy production, which shows machine-precision particle conservation.
The rapid advancement of the miniaturization techniques for high-frequency transceivers, radars, and communication systems operating in the D-band (110–170 GHz) has positioned circular dielectric waveguides (CDWGs) as a promising transmission-line alternative. Yet, their potential has not been fully exploited. This work fills this gap by introducing novel, compact CDWG-fed lens antenna solutions that deliver excellent gain and impedance matching performance. A low-loss, low-cost, and flexible CDWG made of low-density polyethylene is used to excite dielectric lens antennas of various sizes, contours, and materials, enabling a systematic evaluation of the impact of lens geometry on antenna performance. Through detailed electromagnetic simulations and experimental validations, lenses of different sizes and contours are designed. The proposed CDWG-lens configuration achieves measured broadband matching better than 17 dB and stable high gain across 115–130 GHz. Measured gains of 21–23 dBi for lenses with diameter of 10.6 mm and gain factor of 27–28 dBi for lenses with diameter of 20 mm confirm the high aperture efficiency and novelty of this approach. A strong agreement between the simulation and the measurement results is also observed. These compact and efficient lens antennas combined with the advantages of CDWG feed, can be integrated as a part of advanced system applications in the D-band frequency range like radar sensing and communications.
Schizophrenia spectrum disorders (SSD) are complex illnesses influenced by genetic, biological and psycho-social factors, necessitating large clinical deep-phenotyped cohorts. Here, we describe the Region Midt Schizophrenia (RMS) Cohort, which aims to establish such a large, representative cohort with long-term follow-up, enabling large-scale studies on SSD aetiology and prognosis.
Methods:
The RMS cohort includes patients aged ≥15 years diagnosed with a first-episode SSD recruiting at 6 Danish psychiatric hospitals. Baseline and follow-up assessments at 1, 2, 3 and 12 months and 2, 3, 5 and 10 years cover sociodemographic measures, psychotic and negative symptoms, adverse childhood experiences (ACEs), level of functioning, sleep, actigraphy, cognition, side effects and medication adherence. Blood is collected at baseline and months 3 and 12 and at years 2, 3, 5 and 10 enabling comprehensive molecular analyses, for example, genetics and omics. Age-and sex-matched healthy controls will complete a baseline assessment including blood draw. Participants give informed consent for linkage with Danish nationwide register-based data.
Status and perspectives:
By February 23rd, 2026, a total of 131 participants with SSD have been recruited (109 with schizophrenia, median age 25 years (IQR 8), 54% females). Retention rates at 1, 2, 3 and 12 months are 86%, 80%, 78% and 75%, respectively. Our vision is continuous recruitment of 100 participants/year, establishing a large, deep-phenotyped and representative clinical cohort with long-term follow-up. The RMS cohort will serve as the basis for several studies on aetiological and prognostic factors and is designed to match with similar international cohorts enabling further collaborations.
Concussion, a common injury in contact sports, often leads to oculomotor symptoms. The King-Devick (K-D) is a rapid number naming test that evaluates saccadic eye movements, visual tracking, and processing speed. We studied the effects of age and dyslexia status on K-D outcome. The aim was to determine the threshold for a clinically meaningful change in K-D test outcome in adolescent athletes.
Methods:
A total of 1506 Finnish athletes (mean age = 16.3, SD = 1.6) were assessed with K-D before the season. Twenty-eight percent (n = 416) participated in two consecutive baseline assessments one year apart, enabling reliable change analysis. Furthermore, results from 28 concussed athletes, assessed using the K-D test 3 days post injury, were compared to their own baseline data.
Results:
We found that older athletes were faster in the K-D test, and dyslexic athletes (n = 95) were significantly slower than healthy controls. When evaluated 3 days post-concussion, 54% of the studied athletes were slower in the K-D test as compared to individual baseline. The clinically significant increase in the K-D test time, performed in Finnish, was 4.4 sec. The odds ratio for significantly decreased performance post-concussion was 3.3-fold, as compared to healthy controls.
Conclusions:
Age, dyslexia, and spoken language affect K-D test performance, so they should be addressed when clinically using the K-D test. Taking this into account and by using specific thresholds, the K-D test could be a cost-effective method in assessing the athletes’ functional vision both at baseline and after concussion.
In this work, we investigate the dynamics of particles accelerated by electromagnetic wave pulses under the effects of a radiation reaction as described by the Landau–Lifshitz model. The radiation reaction breaks the invariant used to predict both the critical carrier amplitude required for efficient particle acceleration and the particle’s final ejection velocity. Moreover, it alters the dynamical regimes predicted by models that neglect it. Numerical simulations of single-particle dynamics, performed using both the full dynamical equations and the canonical averaged formulation, support the analytical results.
The 2023 revision of the EU Horizontal Guidelines introduced a dedicated framework for sustainability-oriented cooperation agreements, marking the first systematic attempt to integrate environmental objectives into EU competition law. Yet, almost two years after they entered into force, DG COMP has not received a single request for informal guidance under the new provisions. This policy commentary explains this apparent policy failure by reconstructing the process through which sustainability concerns entered EU competition policy after the 2019 European elections and the European Green Deal. Drawing on historical-institutionalist process tracing, we show that the resulting adjustments were shaped by political urgency rather than gradual policy learning, and that the 2023 Guidelines reflected cautious compromise rather than transformative change. We then analyse why uptake has remained negligible: multinational firms face steep cross-border enforcement risks, particularly from jurisdictions such as the United States, where sustainability agreements can trigger antitrust liability. We conclude by assessing the EU’s strategic options (retreat, international convergence, or domestic regime stabilisation) and argue that the last of these offers the most realistic path.
This article identifies a potential authorial signature in the opening lines of Lucan’s Bellum Ciuile. The adjacent letters LVCAN appear in a central position of emphasis in the poem’s first two lines and constitute the core of a signature that can be extended in multiple directions to form longer intexts such as LVCANI SVM (‘I am Lucan’s’), LV(canus) AN(naeus) M(arcus), LVCANI MVSIS (‘with the Muses of Lucan’) and LVCANI M. VIS CERA DEXTRA (‘the power of M. Lucanus with his right hand on the wax’, or ‘the power of M. Lucanus on the wax on the right-hand side’). The article proposes that this multiform signature is accompanied by signposts to help identify it and that it engages with models of such wordplay in Aratus, Lucretius, Virgil and Ovid.
Scholars have increasingly discussed the concept of European Militant Democracy, that is, the EU’s defense of Article 2 TEU values against defiant Member States. But does EU law have anything to say about national militant democracy, specifically on measures such as bans of political parties? The possible role that EU law has to play in this area has so far been overlooked. Using the proposed ban of the AfD as an example, this Article discusses whether and under what circumstances EU law is applicable to national party bans. Arguing that national political parties fulfill an essential function for representative democracy in the EU, the Article finds that EU law is applicable to national party bans both within the context of elections to the European Parliament as well as in purely internal situations. Arguing that the concept of democracy in Article 2 TEU nevertheless allows for militant democratic measures such as party bans, this Article then carves out specific standards that national party bans must comply with as a matter of EU Law.
Esketamine has demonstrated efficacy in treatment-resistant depression (TRD), but medium-term real-world functional outcomes remain understudied. This study described 6-month depressive symptoms and functional trajectories during routine esketamine treatment, focusing on functional outcomes and remission correlates.
Methods
In this prospective multicenter study, 60 patients with TRD initiating intranasal esketamine augmentation were assessed at baseline, Month 1, Month 3, and Month 6 using the Montgomery-Åsberg Depression Rating Scale (MADRS) and Sheehan Disability Scale (SDS). Mixed-effects models, Turnbull interval-censored time-to-remission analysis, logistic regression, and ROC analyses were performed.
Results
MADRS and SDS improved significantly at all follow-up time points (p < 0.001). At Month 6, symptomatic response and remission rates were 78.3 and 46.7%, while functional response and remission rates were 78.3 and 33.3%, respectively. Turnbull estimates showed cumulative functional remission rates of 5.0, 15.0, and 33.3% at Months 1, 3, and 6, respectively. MADRS-SDS correlations decreased over time, supporting partial symptomatic-functional dissociation. Higher baseline SDS (OR = 0.73, 95% CI: 0.59–0.89) and more previous antidepressant trials (ADTs; OR = 0.53, 95% CI: 0.35–0.82) were associated with lower odds of Month 6 functional remission; bootstrap internal validation supported coefficient stability. ROC-derived thresholds were considered sample-dependent and not clinically validated. Cumulative esketamine dosage was associated with functional response but not remission.
Conclusions
Depressive symptoms and functioning improved progressively over 6 months during esketamine treatment in routine clinical care. Functional remission followed a slower trajectory than symptomatic remission and had partly distinct correlates, supporting functional monitoring as a distinct TRD outcome.
Obtaining predictive low-order models is a central challenge in fluid dynamics. Data-driven frameworks have been widely used to obtain low-order models of aerodynamic systems; yet, resulting models tend to yield predictions that grow unbounded with time. Recently introduced stability-promoting methods can facilitate the identification of bounded models, but tend to require extensive brute-force tuning even in the context of simple academic systems. Here, we show how recent theoretical advances in the long-term boundedness of dynamical systems can be integrated into data-driven modelling frameworks to ensure that resulting models will yield bounded predictions of incompressible flows. Specifically, we propose to solve a particular set of convex semidefinite programming problems to (i) certify whether a system admits a globally attracting bounded set for the chosen modelling parameters, and (ii) compute a model with the optimal (tightest) bound on this globally attracting set. We demonstrate the approach via integration within the sparse identification of nonlinear dynamics (SINDy) modelling framework. Application on two low-order benchmark problems establishes the merits of the approach. We then apply our approach to obtain a low-order (six-mode) model of unsteady separation over a NACA-65(1)-412 aerofoil at ${\textit{Re}}=20\,000$ – a flow that has been notoriously difficult to model using data-driven methods. The resulting model is found to accurately predict the dynamics of unsteady separation, with model predictions remaining bounded indefinitely. We anticipate this work will benefit future efforts in modelling strongly nonlinear flows, especially in settings where physically viable long-term forecasts are paramount.
This study examined age-specific associations between parent-reported executive function (EF) difficulties and internalizing/externalizing symptoms in children with neurofibromatosis type 1 (NF1), a genetic condition underrepresented in psychiatric research.
Methods:
Cross-sectional data of 1,049 observations from 803 children with NF1 (Mage = 10.58 years, SD = 3.84, range = 3–18; 47.5% female; 67.5% from higher-education households; 36.6% with familial NF1) across nine U.S. and Australian institutions were integrated. Parents rated EF difficulties using the Behavior Rating Inventory of Executive Function and internalizing/externalizing symptoms using the Child Behavior Checklist and the Behavior Assessment System for Children. Time-varying effect modeling estimated age-specific associations between EF and internalizing/externalizing symptoms and tested moderation by sex and parental education.
Results:
Poorer functioning in all EF domains was associated with greater internalizing and externalizing symptoms from ages 3 to 18. The associations were largely consistent across ages as well as sex and parental education subgroups with a few differences: (1) emotional control and cognitive flexibility problems were more strongly associated with internalizing symptoms during middle and late adolescence; (2) inhibitory control was more strongly linked to externalizing symptoms in childhood; (3) stronger associations between EF and internalizing symptoms were observed among males in early adolescence.
Conclusions:
Parental complaints of EF difficulties are robustly linked to internalizing and externalizing problems from early childhood to late adolescence in children with NF1. Further longitudinal and experimental studies are needed to determine the directionality of these associations and whether EF represents a viable target for intervention.
Antimicrobial stewardship programs (ASPs) promote optimal antimicrobial use in pediatrics; however, data describing structure, personnel effort allocation, and activity distribution across regular and after-hours workflows remain limited.
Methods:
We conducted a cross-sectional survey of pediatric ASPs across the U.S. from September to October 2024 using ASP/ID-related listservs. Respondents reported institutional structure, personnel effort allocation, initiatives, and participation in an after-hours ASP on-call model, with additional details from programs reporting on-call participation.
Results:
Twenty-two pediatric ASP responses were included, most from academic medical centers (81.8%) and programs covering 101–250 beds (41%). Median physician full-time equivalents (FTEs) increased with institutional size, ranging from 0.1 for institutions with < 100 beds to 0.8 for those with >500 beds. Pharmacist FTEs were a median of 1 for institutions with ≤ 500 beds and increased to 2.25 for programs >500 beds. Most programs reported to Quality and Safety (45%) or discipline-specific departments (41%), with funding primarily attributed to Pharmacy (73%). During regular working hours, nearly all programs performed prospective audit and feedback (100%), responded to ASP-related inquiries (95.5%), and facilitated antimicrobial de-escalation (90.9%). Six programs (27.4%) reported participation in an ASP on-call model, most commonly providing remote coverage during evenings, weekends, and holidays. After-hours activities were largely limited to time-sensitive interventions, including preauthorization and responding to inquiries.
Conclusions:
Pediatric ASPs demonstrate variability in structure, personnel effort allocation, and stewardship activities. ASP on-call coverage remains uncommon and is typically focused on time-sensitive interventions, reflecting targeted deployment of stewardship resources outside regular working hours.
While the disease and economic impact of gram-negative bacilli bloodstream infections (GNB-BSI) are high, treatment strategies, including transitioning from intravenous antimicrobial therapy (IVAT) to oral stepdown antimicrobial therapy (OSAT) are still in their nascent stage of development.
Methods:
A systematic review and meta-analysis evaluated the clinical effectiveness of OSAT compared with IVAT for GNB-BSI. Medline and Embase were searched from January 1980 to March 2025, along with the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and reference lists of eligible studies. Randomized controlled trials and observational studies comparing OSAT with IVAT were included. Three investigators screened studies, extracted data, assessed study quality, and risk of bias, following PRISMA guidelines, ROBINS-E for observational studies and RoB 2 for randomized trials. Certainty of evidence was assessed using the GRADE framework.
Results:
Sixteen studies involving 4,858 patients who received OSAT and 4,961 patients who received IVAT were extracted for review. The pooled risk ratio for mortality and treatment failure in the primary analysis which included studies adjusting for confounders (n = 3) was 0.95 (95% confidence interval [CI]: 0.42, 2.14; I2 = 8%) and 1.11 (95% CI: 0.22, 5.51; I2 = 59%), respectively. The GRADE assessment for the primary analyses rated the evidence as very low to moderate certainty. Outcome definitions varied substantially across studies, potentially affecting pooled estimates.
Conclusions:
Although an imbalance in the baseline characteristics of patients with GNB-BSI across the studies warranted closer attention, OSAT may be as effective as IVAT for GNB-BSI without compromising clinical outcomes. Nevertheless, high-quality RCTs are needed before making definitive recommendations.
We propose a methodology to infer collision operators from phase space data of plasma dynamics. Our approach combines a differentiable kinetic simulator, whose core component in this work is a differentiable Fokker–Planck solver, with a gradient-based optimisation method to learn the collisional operators that best describe the phase space dynamics. We test our method using data from two-dimensional particle-in-cell simulations of spatially uniform thermal plasmas, and learn the collision operator that captures the self-consistent electromagnetic interaction between finite-size charged particles over a wide variety of simulation parameters. We demonstrate that the learned operators are more accurate than alternative estimates based on particle tracks, while making no prior assumptions about the relevant time scales of the processes and significantly reducing memory requirements. We find that the retrieved operators, obtained in the non-relativistic regime, are in excellent agreement with theoretical predictions derived for electrostatic scenarios. Our results show that differentiable simulators offer a powerful and computational efficient approach to infer novel operators for a wide range of problems, such as electromagnetically dominated collisional dynamics and stochastic wave–particle interactions.
This article integrates Triple-helix and institutional logics perspectives to diagnose how professional, market and state logics generate risks in university research, and how hybrid governance can mitigate them. Conceptually, it advances a cross-level risk analysis (individual, organizational, system) and a triple-temporal mitigation design that aligns short-term relational routines, mid-term interface infrastructures and long-term institutional and policy change. The synthesis extends existing work on selective coupling and institutional complexity by linking specific risk mechanisms to sequenced interventions. It further refines research on boundary organizations and intermediaries by positioning interface roles within system-level coordination, and clarifies how openness, sovereignty and mission pressures map across logics within responsible research and innovation and open-science agendas. Overall, the study offers a parsimonious and actionable framework for steering collaborative research under conditions of institutional plurality.