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Knowledge synthesis involves bringing together findings from individual research studies to answer a specific question or explore a particular topic, often at a global level. People with lived or living experience of health conditions or of accessing healthcare services (PWLE), such as patients and their families or friends, can provide valuable perspectives throughout this process. PWLE involvement can help shape the design and conduct of a knowledge synthesis to better reflect real-world concerns through a process called patient engagement. Patient engagement is the meaningful and active involvement of PWLE throughout the research process. While previous research shows that PWLE can contribute meaningfully when appropriate supports are in place, there is limited practical guidance on how to enact patient engagement in knowledge syntheses. This tutorial paper aims to guide researchers and PWLE who would like to engage in knowledge syntheses together. Building on existing research, our team (comprised of PWLE, researchers, and an academic librarian) shares lessons we have learned from working together throughout the stages of a knowledge synthesis. We present considerations for successful patient engagement when research teams are: (1) planning to engage, (2) recruiting PWLE, (3) establishing roles and rapport, (4) supporting capacity development, (5) conducting the knowledge synthesis, and (6) mobilizing findings. We also identify 12 common barriers to patient engagement and offer strategies to address them, alongside recommendations for integrating PWLE across every stage of the knowledge synthesis process.
This article adopts an integrated practice-led and practice-based methodology, framed through an essayistic approach to comics-based research, using our own artistic practices, one from Serbia and one from India, as case studies. Through works addressing the fall of democratic values, memories of conflicts, rise of nationalism, and ecological devastation, we examine how urgency shapes creation, reflection, and the mediation of memory in comics-making. Rather than a reactionary impulse, we conceptualize urgency as a relational and iterative condition that unfolds through political-ethical, epistemic, and aesthetic dimensions, and one that structures how artists act, think, and draw in response to crises. In our practices, drawing functions as both an act of remembering and a form of thinking: essayistic comics-making materializes a dialogue between immediacy and reflection, as well as between lived experience and its critical rearticulation. We argue that through this interplay, comics-making becomes a mode of situated knowledge production, where memory, testimony, and critique are interwoven. The essayistic form enables urgency to be inhabited rather than merely depicted, turning the creative process itself into a reflective space of resistance and inquiry. By tracing how these dynamics operate within specific socio-political contexts, this paper expands the understanding of comics-making as a medium of embodied memory and a method of research that translates lived urgency into thought and form.
A microstrip low-pass filter with sharp roll-off and excellent suppression in both the near- and far-stopbands is proposed. The design incorporates a stepped-impedance hairpin-type resonator (SIHTR) along with a pair of asymmetric T-shaped resonators (TSRs). While the SIHTR offers a tunable 3 dB cutoff frequency and roll-off rate (ROR), its near-stopband suppression degrades at higher ROR values. To address this limitation and further extend the stopband bandwidth, two TSRs with distinct resonant frequencies are positioned at the input and output ports. By fixing their resonant frequencies and fine-tuning their stopband characteristics, the overall suppression bandwidth and stopband attenuation are significantly enhanced. The proposed filter features a compact layout, high selectivity, a wide stopband, and excellent out-of-band suppression performance. Measured results demonstrate an insertion loss of less than 1 dB and a return loss of greater than 15.1 dB in the passband from DC to 7.5 GHz. The 3 dB cutoff frequency is 8.23 GHz, and the transition band is 34.58 dB/GHz from -3dB to -40dB. In the stopband, attenuation exceeds 31.5 dB across the frequency range from 9.17 GHz to 40 GHz.
The papers in this volume point to an analysis of synaesthesia which is not merely grounded in firstness, the free unconstrained play of fancy, cross-modal iconism, and metaphoric slippage of adjectives randomly from one body to another, but to the way synaesthesia is transitive, grounded in affective encounters between bodies (secondness), leaping from one body to another related body, involving indexicality, metonyms, hence “synaesthetic encounters.”
The exhibition False Witnesses (Shuhud al-Zur) by Dia al-Azzawi at Saleh Barakat Gallery in Beirut, from September 11 to October 31, 2025, is the kind of show one usually would only see at a museum (Figures 1, 2). It consists of several large-scale works that invite an almost immersive viewing experience, in which seeing requires physical movement and the artwork dominates the perceptual space of the viewer. The works offer a critical reflection on power and violence in Iraq over the past two decades.
Philanthropic organizations, as crucial intermediaries between the government and society, significantly contribute to public service delivery. This study examines how organizational features influence their effectiveness, especially exploring the impact of professional capacity and organizational resources. Based on the panel data of 259 philanthropic organizations in Shanghai from 2010 to 2022, we use two-way fixed effects models to examine the impact of professional capacity, financial scale, and annual income on public service delivery, as measured by the number of charitable projects, project expenditures, and the number of beneficiaries. The finding shows that professional capacity notably improves public service delivery. We also find that financial scale moderates the relationship, while annual income mediates it. The results advocate that policies should facilitate capacity building and resource support altogether to maximize philanthropic organizations’ contributions to public service delivery.
This article examines efforts to remake the European economy in the late twentieth century through innovations in organized business and industrial policy. By narrating the development of the “Big 12 Roundtable” and the European Strategic Program on Research in Information Technology (ESPRIT) in the 1970s and 1980s, we show how the executive institution of the European Commission responded to global competitive pressures by creating “business forums”—groups of business elites organized by policymakers to serve as policy consultants—and by developing extensive technology and research programs to support the development of European technology firms. We then trace how the Big 12 Roundtable laid the foundation for other business forums, including the European Round Table of Industrialists (ERT), and how ESPRIT paved the way for the framework programs that have been hallmarks of European industrial policy and investment in research and development for half a century. Consequently, this article expands the business historical genealogy of organized business in Europe and contributes a new history of European industrial policy.
Meta-analysis is a widely used statistical tool for estimating the diagnostic accuracy of tests across multiple studies. Existing methods and available R packages primarily focus on a single diagnostic test, typically under the assumption that all studies include a gold standard. Greater efficiency can be achieved by modeling multiple diagnostic tests together and drawing on studies with or without a gold standard reference test across diverse designs. To address this challenge, recent work has extended both the Bayesian hierarchical model and the Bayesian hierarchical summary receiver operating characteristic model to the framework of network meta-analysis of diagnostic tests, enabling simultaneous comparison of multiple tests when some data are missing. Despite the importance of these methods, their computational complexity has limited their broad application. This article introduces NMADTA, an R package that implements these models with user-friendly functions. The package allows researchers to evaluate the accuracy of multiple diagnostic tests simultaneously and provides comprehensive graphical displays of the results.
This article examines how the devolved legislatures of Scotland, Wales and Northern Ireland have developed distinct institutional, normative and conflict-based constitutional identities that position them as constitutional actors within the UK’s territorial order. Moving beyond analyses focused solely on competence allocation and the Sewel Convention, it argues that devolved identity is articulated through institutional design, claims to democratic legitimacy and episodes of contestation with Westminster. Disputes arising from Brexit, the UK Internal Market Act 2020, rights-based legislation and the Northern Ireland Protocol reveal how devolved institutions frame authority in terms of popular sovereignty, civic nationhood, consent and parity of esteem. While parliamentary sovereignty remains legally intact, these developments expose a widening gap between doctrinal hierarchy and constitutional practice. The article contends that the UK now operates as a differentiated constitutional system in which authority is legally centralised yet politically dispersed across multiple constitutional sites.
The gut–liver axis represents a bidirectional communication network for maintaining metabolic and immunological homoeostasis. Alterations in this axis allow bacterial products to reach the liver via the portal vein, promoting inflammation, oxidative stress and lipid accumulation. In this scenario, the consumption of bioactive compounds has become prominent due to its antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of camu-camu (Myrciaria dubia) extract, an Amazonian fruit rich in phenolic compounds, on intestinal morphology, barrier-related gene expression and hepatic outcomes of chicken (Gallus gallus) embryos exposed to dextran sulfate sodium (DSS). Fertile eggs were divided into three groups (n 20/group): water (control), DSS (1·5 %), and camu-camu (10 %) + DSS (1·5 %). On the seventeenth day of embryonic development, treatments were injected into the amniotic fluid, and samples were collected at hatching (twenty-first day). Results showed that camu-camu was associated with changes in intestinal histomorphology, increasing villus height, surface area and the number of goblet cells, along with increased expression of selected barrier-related genes (MUC2, CLDN-1 and ZO-2). In the liver, camu-camu significantly reduced NF-κB expression compared with the DSS and water-treated groups, consistent with modulation of inflammatory-related gene expression. Furthermore, the decreased expression of iNOS, CAT and SOD-1 indicates modulation of oxidative stress-related gene expression markers. Histological analysis indicated alterations in hepatic morphology, including reduced lipid droplets and inflammatory infiltrates. These findings indicate that camu-camu is associated with changes in intestinal histomorphology, selected barrier-related gene expressions, hepatic histology and inflammatory- and oxidative stress-related gene expression markers.
Whether the Lambert–Amery glacial system (LAGS) will remain near mass balance this century while adjusting to geometric change remains an open question. We couple the ice-flow model Úa to the PICO sub-shelf melt parameterization for 2020–2100 under ten high-emissions scenarios, two control experiments and targeted pinning-point perturbations. By 2100, unperturbed absolute trajectories across the twelve applied forcings contribute $-11.4$ to $1.9$ mm to sea level relative to the common 2020-relaxed state; member-specific transient-minus-2020-constant diagnostics isolate the response to post-2020 forcing evolution, which spans $-3.84$ to $+4.66$ mm. With SMB held time-invariant over the model domain, using time-evolving rather than time-invariant 2020 basin-mean ocean conditions increases the 2100 contribution by $1.50$ mm. Minimizing the dynamic buttressing contribution of all pinning points adds an almost forcing-invariant $0.82$ mm. Across ten single-point experiments, the 2100 sea-level response is proportional to grounding-area loss. Paired perturbed–unperturbed simulations have nearly identical shelf-integrated basal melt but distinct sea-level contributions, showing that the additional response is driven primarily by reduced buttressing rather than melt-forcing changes. Overall, LAGS remains close to mass balance under the applied forcing protocol, while time-evolving ocean forcing and pinning-point weakening modulate the magnitude of the 2100 sea-level response. Dynamically important pinning points are priorities for long-term monitoring.
In this paper, we study a nonlinear free boundary problem modelling the growth of radially symmetric tumours. The tumour consists of a central necrotic core, an intermediate quiescent layer and an outer proliferating shell. The evolution of tumour layers and the movement of the tumour boundary are totally governed by external nutrient supply and conservation of mass. The three-layer structure generates three free boundaries with discontinuous nutrient consumption rates and cell growth rates. We develop a nonlinear analysis method to clarify the interactive relationships among free boundaries. By carefully studying the dependence of the critical-state tumour growth rate on the external nutrient concentration, we reveal the evolutionary mechanism in tumour growth and the mutual transformation of its internal structures. The existence and uniqueness of the radial stationary solution is proved, and its globally asymptotic stability towards different dormant tumour states is established.
We study the optimal stopping of an $\alpha$-dimensional Bessel bridge for the payoff $\phi(x)=x^n$, where $\alpha,n \in (0,\infty)$. As a special case we consider the Brownian excursion with the identity function as the payoff ($\alpha=3,n=1$). For the Brownian excursion we can give an explicit solution but in the general case we provide a complete solution via a power series expansion.
With nearly one in six children globally living in conflict zones, evidence-based mental health and psychosocial support (MHPSS) is crucial. This systematic mapping review with narrative synthesis followed the PRISMA 2020 guidelines to synthesize fifty-six studies examining in-country interventions for conflict-affected youth under 25 from 1990 to 2025. The studies were mostly conducted in the global South and utilized various methods, including Teaching Recovery Techniques, trauma-focused cognitive behavioural therapy, and school-based programmes.
The findings were mixed. While twenty-five studies reported positive outcomes regarding post-traumatic stress symptoms (PTSS), anxiety and social functioning, the effects often diminished over time, and long-term data (>6 months) remains scarce. The review identified three critical success factors: multilayered stepped-care models, task-sharing with trained lay workers, and family engagement. To be effective, cultural adaptation and age-appropriate tailoring were essential; efforts in this regard ranged from play-based interventions for younger children to structured therapies for adolescents.
The evidence base is limited by methodological heterogeneity and short follow-up periods. To bridge the research–practice gap, future efforts must prioritize longitudinal evaluations and stronger collaboration between researchers and humanitarian actors to ensure that interventions effectively mitigate the long-term impacts of conflict.
Face-to-face communication often involves multiple iconic cues (gestural, suprasegmental and segmental) to convey meaning. Previous research shows that gestural and suprasegmental iconicity cues, as well as gestural and segmental iconicity cues, often co-occur, suggesting that speakers combine visual and acoustic forms of iconicity to reinforce meaning. This study investigates whether listeners can simultaneously utilize both suprasegmental and segmental iconic cues in the same speech stimuli to associate sounds with meaning. Finnish-speaking participants were presented auditorily with pseudowords consisting of suprasegmental and segmental iconicity cues referring to shape-related concepts (Experiment 1) or magnitude-related concepts (Experiment 2). The study showed that these two dimensions of acoustic iconicity are processed relatively independently, yet in parallel, for linking the speech signal to meaning.
To explore the primary health care experiences of Indian immigrants living with chronic illnesses in Australia.
Background:
Primary health care is integral for managing health issues for people living with chronic illnesses. Despite Indian migrants being the largest overseas-born population in Australia to use primary health care services for their chronic illnesses, at this time, limited literature reports on their experiences in Australia.
Methods:
A qualitative exploratory approach was adopted for this study. Through purposive sampling, 11 participants were recruited, and data was collected using semi-structured interviews. The interviews were transcribed verbatim and thematically analysed.
Findings:
Three themes and six sub-themes emerged from the thematic analysis. The first theme ‘being a mix of experiences’ presented participants’ positive and negative experiences related to communication, compassion, quality of care and length of consultations. The second theme ‘facilitators to accessing primary health care services in Australia’ described the benefits of telehealth and having a common cultural background as that of the general practitioner. Meanwhile, the third theme ‘barriers to accessing primary health care services in Australia’ identified unavailability of preferred GPs and waiting times and delays for in-person appointments as barriers that hindered access to PHC services in Australia.
Conclusion:
Primary health care experiences of Indian immigrants with chronic illnesses in Australia were a mix of positive and negative experiences, similar to that of other immigrants. Faster accessibility and compassionate services among migrants were highlighted to be needing extra attention by way of further research and acknowledging the unique diversity of individuals.
In toroidal confinement systems, the scrape-off layer (SOL) magnetic field exhibits characteristics analogous to those of a magnetic mirror configuration, particularly in the edge plasma region. Therefore, linear plasma devices have advanced divertor simulation studies. To further promote divertor simulation studies, a new divertor simulator, ‘Pilot GAMMA PDX-SC (PGX-SC)’ has been developed, incorporating a pair of superconducting coils that generate a simple magnetic mirror configuration. An electrode-biasing system was installed on the PGX-SC to regulate the plasma potential. The system comprises three concentric basing plates installed at the east end of the main chamber of PGX-SC, in conjunction with a DC-stabilised power supplies for each basing plate. This system can also measure the floating potentials and electrode currents by connecting a resistor to each plate in the absence of an external power supply. Preliminary experiments were conducted to investigate the effect of plasma by applying a bias to the electrode plates. Applying a voltage to the inner electrode increased the plasma potential at the outer electrode. This result suggests the feasibility of controlling the peripheral plasma potential using concentric biasing plates. When voltage was applied to the outer electrode, the amplitude of the fluctuating current decreased. These results collectively indicate the capability of plasma control employing concentric biasing plates.
Australian government herbariums and museums are repositories of flora and fauna specimens collected from across Australia. This has occurred since before Australia was colonized and to the present time, often by explorers and researchers using Indigenous people’s traditional knowledge to identify and locate culturally significant species. The colonial legacy of Australia is embedded in ex situ collections of biological specimens and related data, which mostly predate international treaties promoting benefit-sharing with Indigenous peoples for using their traditional knowledge. Collections of culturally significant biological specimens and associated data should be recognized as cultural property and managed according to Indigenous data sovereignty principles including for attribution and nomenclature. This article presents an example of Australian native tobacco biodiscovery in Australia and pathways for integrating principles of Indigenous data sovereignty for decolonization of ex situ collections and for promoting a rights-based approach.
We classify the sets of natural numbers n for which certain dynamical systems $(X,f)$ on a compact metric space X have a periodic point of (least) period n. Interest in this question dates back to Sharkovskii’s theorem for continuous maps on intervals of the real line, but it also ties to checkable conditions for Krieger’s embedding theorem for symbolic dynamical systems. Given a system for which the logarithmic derivative of the Artin–Mazur zeta function is rational, we use the Skolem–Mahler–Lech theorem to classify for which n the system has a periodic point of (not necessarily least) period n. Moreover, we build on work on finitely presented (FP) systems and their relationship to symbolic dynamics to classify the set of least periods, that is, periodic orbit lengths, for arbitrary FP systems, extending a known classification for shifts of finite type. We also provide several constructions to realize any such least period sets.